Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…These impairments may result from mechanisms including insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, leading to insufficient energy supply, altered synaptic plasticity, neuronal cell death, and functional and structural damage to reward networks. …”
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CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Methods Actinomycin D experiment and RNA digestion experiment were used to verify the circular structure characteristics of circWDR78. Proliferation and motility ability of circWDR78 was evaluated by in vitro functional experiment. …”
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Effects of Brassica rapa L. Polysaccharides on Bile Acid Metabolism and Intestinal Microbiota in Humanized Mice by ZHANG Mengying, TI Jiayi, LI Wei, BI Kaiyue, WU Yuhan, LI Yanbo, ZHAO Yu, WANG Wei

“…This study provides theoretical insights into the promotion of intestinal health and bile acid metabolism by BRAP1-1, offering new perspectives for the deep processing of B. rapa and the development of related functional foods.…”
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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…We will examine other behavioural readouts of relevance for psychosis as secondary outcomes, such as social interaction and cognitive function. We will synthesize the data using multi-level meta-analysis with a predefined random-effects structure, considering the non-independence of the data. …”
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Striving to integrate self-management into daily life: a qualitative meta-synthesis of the perspectives and experiences from head and neck cancer survivors by Hao Zhang, Li Yin, Qing Yang, Aiping Wang, Linyu Xu, Jianxia Lyu

“…This integration revealed 3 primary themes and 10 subthemes, specifically: (1) the management of disease-related and treatment-related symptoms and functional alterations in HNC, exploring self-management strategies such as coping with and monitoring physical and mental symptoms and adjusting to modifications in fundamental operations; (2) barriers and facilitators in the integration process of self-management, including psychological, emotional and cognitive disorders, the impact of symptom burden on patients’ motivation and capacity for self-management, structural impediments and facilitators; and (3) challenges in incorporating self-management into daily life and strategies for effective implementation, encompassing acceptance and adaptation as strategies for coping and thriving, proactive issue resolution, self-motivation and the employment of a diverse array of targeted strategies emphasising recovery.Conclusions Patients diagnosed with HNC must engage in extensive self-management throughout diagnosis and treatment, encountering numerous challenges when integrating self-management practices into their daily lives. …”
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Co-Designing, Developing, and Testing a Mental Health Platform for Young People Using a Participatory Design Methodology in Colombia: Mixed Methods Study by Laura Ospina-Pinillos, Débora L Shambo-Rodríguez, Mónica Natalí Sánchez-Nítola, Alexandra Morales, Laura C Gallego-Sanchez, María Isabel Riaño-Fonseca, Andrea Carolina Bello-Tocancipá, Alvaro Navarro-Mancilla, Jaime A Pavlich-Mariscal, Alexandra Pomares-Quimbaya, Carlos Gómez-Restrepo, Ian B Hickie, Jo-An Occhipinti

“…In addition, the lack of widespread digital interventions further deepens the digital health divide between the Global North and Global South, limiting equitable access to innovative MH solutions. …”
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Perspective of the family in the daily life with the squizo’s porter by Emanuel Martins da Silva, Maria Salete Bessa Jorge, Maria Veraci Oliveira Queiroz

“…The family has an essential function in the process of psychosocial rehabilitation of his member with squinzo’s diagnosis, cause he take part of health and sickening of the group. …”
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Planifier le désordre, se préparer à l’imprévisible by Gérard Dubey

“…But in surgery the symbolic function is never unrelated to experiential knowledge acquired over a long period of time. …”
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Evidence of the use of the Perme Intensive Care Unit Mobility Score in hospitalized adults: a scoping review by Maria Helena Lenard, Clovis Cechinel, Tissiane Bona Zomer, João Alberto Martins Rodrigues, Maria Angélica Binotto, Rossana Spoladore

“…The studies demonstrated the use of the Perme Score for description and reliability of the instrument, translation and cultural adaptation, association between functional mobility, clinical characteristics and outcomes, mobility assessment after interventions, mobility assessment and potential barriers to mobilization, and use of the score for validation of other instruments and various clinical profiles. …”
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Elucidating ATP’s role as solubilizer of biomolecular aggregate by Susmita Sarkar, Saurabh Gupta, Chiranjit Mahato, Dibyendu Das, Jagannath Mondal

“…Proteins occurring in significantly high concentrations in cellular environments (over 100 mg/ml) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically responsible for a wide spectrum of rising human diseases. …”
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Neurovascular Restoration by Treadmill Exercise Attenuates Age-Related Cognitive Decline in Mice by Jae Min Lee, Da-Eun Sung, You Jung Choi, Seung Geun Yeo, Youn-Jung Kim

“…These results highlight the potential of exercise intervention as a non-pharmacological strategy for treating age-related neurodegenerative diseases by preserving vascular and BBB structures and reducing neuroinflammation.…”
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Nascent actin dynamics and the disruption of calcium dynamics by actin arrest in developing neural cell networks by Sylvester J. Gates, Phillip H. Alvarez, Kate M. O’Neill, Kan Cao, Wolfgang Losert

“…The size and localization of actin dynamics adjusts to match functional needs throughout differentiation, enabling the initiation and elongation of processes and, ultimately, the formation of synaptic and perisynaptic structures. …”
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Advances in 3D printing combined with tissue engineering for nerve regeneration and repair by Weifang Liao, Yuying Shi, Zuguang Li, Xiaoping Yin

“…While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. …”
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Review: Enhancing the Bioavailability and Stability of Anthocyanins for the Prevention and Treatment of Central Nervous System-Related Diseases by Lan Zhang, Yan Wang, Yalong Cao, Fangxu Wang, Fang Li

“…Central nervous system diseases are highly complex in terms of etiology and pathogenesis, making their treatment and interventions for them a major focus and challenge in neuroscience research. …”
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Muscular robusticity and strength in the lower extremities in elite handball players by Annamaria Zsakai, Fanny Zselyke Ratz-Sulyok, Csilla Jang-Kapuy, Leonidas Petridis, Peter Bakonyi, Tamas Dobronyi, Istvan Juhasz, Tamas Szabo

“…The exploration and understanding of asymmetric structural and functional adaptations can help athletes and trainers in planning the training and training interventions to reduce the risk of injuries.…”
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Assessing the Impact of Physical Activity on Dementia Progression Using Clustering and the MRI-Based Kullback–Leibler Divergence by Agnieszka Wosiak, Małgorzata Krzywicka, Katarzyna Żykwińska

“…Dementia, including Alzheimer’s disease, is a neurodegenerative illness characterized by the progressive impairment of cognitive functions, posing a significant global health threat. …”
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The impact of sensory integration based sports training on motor and social skill development in children with autism spectrum disorder by Lingtao Wen, Zhixia Wu

“…While sensory integration-based interventions have shown promise, the specific impact of structured sports training incorporating sensory principles remains underexplored. …”
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Medical students’ attitudes towards healthcare for people with intellectual disabilities: an experience from Al-Jouf, Saudi Arabia by Adel Saber Alanazi

“…These findings suggest several specific interventions: (1) integration of structured PwIDs-focused modules within medical curricula, emphasizing both theoretical knowledge and practical skills; (2) implementation of mandatory clinical rotations with PwIDs populations to enhance experiential learning; and (3) development of communication training programs focusing on patient-doctor and interprofessional interactions. …”
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Perceptions of the impact of military life on relationships and Intimate Partner Violence and Abuse among UK military personnel. by Rebecca Lane, Filipa Alves-Costa, Rachael Gribble, Anna Taylor, Louise M Howard, Nicola T Fear, Deirdre MacManus

“…Our findings emphasise how difficulties with psychosocial functioning and communication, as well as deployment-related traumas and reintegration challenges, can influence relationships and IPVA behaviours among military personnel and veterans. …”
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Impacts of pollution on coral bacterial and metabolites diversity across Dapeng Cove of South China sea by Feng Yan, Zhiguang Niu

“…Beta diversity analysis (NMDS and ANOSIM) confirmed distinct microbial community structures, while KEGG pathway analysis indicated shifts in metabolic functions, with enrichment in xenobiotic biodegradation and anaerobic respiration in sewage-impacted areas. …”
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