Exploring prevention and control mechanisms of youth substance use: a case of North Wollo and Waghimra, Northeast Ethiopia by Sindew Asmare Wedi, Biruk Beletew Abate, Biruk Beletew Abate, Tesfa Anmut Asres, Mohammed Aragaw Abera, Sentayehu Oljira Bekele, Ashenafi Kibret Sendekie, Ashenafi Kibret Sendekie

“…This study recommends making evidence-based interventions and installing functional networks among sectors to deal with common issues. …”
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Exploring perceptions of dignity among older adults living in nursing homes: a qualitative study by Kejimu Sunzi, Hui Luo, Lina Yin, Yadi Li, Xin Zhou, Cheng Lei

“…Between June and December 2023, we conducted semi-structured interviews with 35 nursing-home residents in western China (aged 65–92 years; length of stay 1 to > 7 years). …”
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Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization by Maya Bolger-Chen, Manuela Lopera Higuita, Casie A. Pendexter, Mohammadreza Mojoudi, Korkut Uygun, Shannon N. Tessier

“…Similarly, the use of adenosine as a pharmacological intervention was found to decrease both edema formation and inflammatory responses. …”
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VULVAR AND VAGINAL GRAFT VERSUS HOST DISEASE IN A PATIENT WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION by Esra Pirinççi, M. Orhan Ayyıldız, Abdullah Karakuş, Reyhan Gündüz

“…Incidence and severity of genital GVHD in women should be included in GVHD intervention studies.…”
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Investigating the eye in Down syndrome as a window to Alzheimer’s disease: the REVEAL protocol – a clinical cross-sectional study by Henrik Zetterberg, Tunde Peto, Imre Lengyel, Kathryn Saunders, Sarah Atkinson, André Strydom, Julie-Anne Little, Elaine Murray, Jamie Mitchell, Aoife Mary Louise Hunter, Lajos Csincsik

“…The REVEAL study aims to examine changes in the structure and function of the eye in individuals with DS compared with those with mild cognitive impairment (MCI) and cognitively healthy control (HC) individuals. …”
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Serum Concentrations of Osteogenesis/Osteolysis-Related Factors and Micro-RNA Expression in ST-Elevation Myocardial Infarction by Tomasz Jadczyk, Tomasz Francuz, Wojciech Garczorz, Malgorzata Kimsa-Furdzik, Mieczyslaw Dutka, Ewa Gaik, Katarzyna Gruszczynska, Marcin Syzdol, Wojciech Wanha, Radoslaw Kurzelowski, Joanna Fluder, Zdenek Starek, Wojciech Wojakowski

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Biomarker Evolution in Pediatric SMA: Insights from CSF pNF-H Dynamics and SMN2 Copy Number During Nusinersen Therapy by Mihaela Badina, Gabriel Cristian Bejan, Andrada Mirea, Corina Sporea, Madalina Cristina Leanca, Georgiana Nicolae, Ioana Elena Cioca, Maria Veronica Morcov, Angelo Pellegrini, Elena-Nicoleta Bordea

“…This study evaluates cerebrospinal fluid (CSF) phosphorylated neurofilament-heavy chain (pNF-H) levels as predictive markers of motor function in 73 pediatric SMA patients undergoing nusinersen treatment. pNF-H, a structural component of neurons, is released into the CSF and serum during neuronal damage or degeneration. …”
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CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype by Antoine de Zélicourt, Abdallah Fayssoil, Mbarka Dakouane‐Giudicelli, Isley De Jesus, Ahmed Karoui, Faouzi Zarrouki, Florence Lefebvre, Arnaud Mansart, Jean‐Marie Launay, Jerome Piquereau, Mariana G Tarragó, Marcel Bonay, Anne Forand, Sophie Moog, France Piétri‐Rouxel, Elise Brisebard, Claudia C S Chini, Sonu Kashyap, Matthew J Fogarty, Gary C Sieck, Mathias Mericskay, Eduardo N Chini, Ana Maria Gomez, José‐Manuel Cancela, Sabine de la Porte

“…Here, we identified that deletion in mdx mice of CD38, a NAD+ glycohydrolase‐producing modulators of Ca2+ signaling, led to a fully restored heart function and structure, with skeletal muscle performance improvements, associated with a reduction in inflammation and senescence markers. …”
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One-stage Closure of the Small Non-growing Bladder Plate: New Insight into the Anatomy of Exstrophy - Trapezoid Interpubic Ligament (TIPL) by Vasily V. Nikolaev, Nikita V. Demin

“…Conclusion: TIPL dissection enables one-stage closure in SNGBP patients who were previously considered unsuitable for this method. Early intervention supports bladder development and favorable functional outcomes. …”
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Circular economy strategies for adaptive reuse of residential building by Cristiana Cellucci

“…However,  the traditional approach of carrying out timely interventions aimed at responding to individual problems, be they of a structural, energetic, functional nature, relating to the building, the context or the single component is not entirely effective in terms of reformulation of the building characteristics. …”
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Navigating loneliness: the interplay of social relationships and coping skills by Eric Cornelis Schoenmakers, Tina ten Bruggencate

“…Implications for loneliness interventions are discussed.…”
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Evaluation of the factors that impact upper limb coordination in children with cerebral palsy: A narrative review by Sara Di Benedetto, Andrea Battaglino, Vanesa Abuín-Porras, Eleuterio A. Sánchez-Romero, Raquel Cantero-Tellez, Kristin Valdes, Jorge Hugo Villafañe

“…Conclusion: Factors that include body structures and functions, time and age of the child, the relationship between factors, and assessment tools can influence the assessment and presentation of upper limb coordination in children with CP. …”
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Cerebellar microglia: On the edge between neuroinflammation and neuroregulation by Marina S. Dukhinova, Jingwen Guo, Enwei Shen, Wanting Liu, Wanqi Huang, Ying Shen, Luxi Wang

“…These immune cells communicate with intrinsic and systemic factors and contribute to the structural and functional compartmentalization of the cerebellum. …”
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Osteocalcin and metabolic syndrome by Consolim-Colombo Fernanda M., Lopes Heno Ferreira

“…We explore osteocalcin's dual functions: its canonical role in bone mineralisation and structural integrity and its emerging significance as an endocrine regulator of energy homeostasis. …”
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“Proteinjury”: a universal pathological mechanism mediated by cerebrospinal fluid in neurodegeneration and trauma by Vladimir F. Lazarev, Bashar A. Alhasan, Irina V. Guzhova, Boris A. Margulis

“…This review explores the mechanisms underlying the formation of pathogenic protein complexes in CSF, the diagnostic potential of CSF protein biomarkers, and the prospects for rehabilitation therapies aimed at preventing secondary damage mediated by pathogenic protein structures in CSF. Based on the findings discussed in this review, we conclude that proteinjury represents a universal and critical mechanism in the progression of various neurodegenerative disorders, and a deeper understanding of this phenomenon may provide new insights for the development of targeted interventions to improve clinical outcomes.…”
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Modeling prebunking strategies to contain misinformation spread by Giorgio Martalò, Marco Menale, Romina Travaglini

“…Following a classical epidemiological approach, the population is structured into interacting functional subsystems, representing individuals with different susceptibility levels. …”
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Data-Driven Approaches in Antimicrobial Resistance: Machine Learning Solutions by Aikaterini Sakagianni, Christina Koufopoulou, Petros Koufopoulos, Sofia Kalantzi, Nikolaos Theodorakis, Maria Nikolaou, Evgenia Paxinou, Dimitris Kalles, Vassilios S. Verykios, Pavlos Myrianthefs, Georgios Feretzakis

“…These techniques were applied to identify clusters based on gene length and distribution according to resistance class, offering insights into the resistance genes’ structural and functional properties. Data preprocessing, such as filtering and normalization, was conducted prior to applying machine learning methods to ensure consistency and accuracy. …”
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Preventive effect of the neurodynamic mobilization technique on delayed onset of muscle soreness: a randomized, single-blinded, placebo-controlled study by Ugur Sozlu, Selda Basar, Rabia Semsi, Esedullah Akaras, Aylin Sepici Dincel

“…Abstract Background The neurodynamic mobilization (NM) technique is an intervention designed to restore homeostasis by mobilizing the nervous system and its surrounding structures. …”
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Comparative analysis of combined exercise programs in middle-aged obese males: impact on energy expenditure, body composition, and metabolic rate by Gerasimos V. Grivas

“…Additionally, respiratory function showed a large improvement. No significant differences were observed between SCG and ICG in energy expenditure, resting metabolic rate, total daily energy expenditure, macronutrient composition, or health indices after the intervention (p > 0.05).ConclusionIn conclusion, both SCG and ICG are effective strategies for improving metabolic health, respiratory function, and body composition in middle-aged obese males. …”
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Exercise and tissue fibrosis: recent advances in therapeutic potential and molecular mechanisms by Zheng Zhao, Yongjia Zhu, Dongfeng Wan

“…It is characterized by an excessive accumulation of extracellular matrix (ECM), resulting in tissue hardening, structural remodeling, and loss of function. This pathological phenomenon is a common feature in the end stage of numerous chronic diseases. …”
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