Effectiveness of Core Stability and Balance Training on Postural Control in Children with Down Syndrome: A Narrative Review by Bryan V. Catama, Dorothy D. Silva, Marlon Y. Palbusa

“…Future research should explore structured, hybrid interventions that maximize postural improvements and functional mobility for children with DS. …”
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Multimodal physical therapy approach for the management of patients with temporomandibular disorder: Randomized control trial by Ramesh Chandra Patra, Biswajit Kanungo, A. Yashudas, Patitapaban Mohanty, Gurleen Kaur

“…Conclusions: Findings suggest that a multimodal treatment of cranio-mandibular stabilisation and structured manual therapy significantly decreases pain and improves mechanical tenderness and active mouth function in TMD patients. …”
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A patient-centered qualitative evaluation of meaningful change on the NSAA and PUL in Duchenne Muscular Dystrophy by Aviva Gillman, Teofil Ciobanu, Louise Barrett, Evan W. Davies, Alexander P. Murphy, Alex Johnson, Jessica Mills, Phoebe Heinrich, Krystian Przydzial, Bethany Ewens, Gerrit Vandenberg, Stefan Cano, Anna Mayhew

“…The aim of this study is to understand meaningful change in functional abilities as measured by the NSAA and PUL at different ability levels from the perspective of individuals with DMD, caregivers of individuals with DMD, and clinicians.MethodsThe study utilized a non-interventional, descriptive, cross-sectional qualitative design consisting of 69 semi-structured interviews, including individuals with DMD (n = 18), caregivers of individuals with DMD (n = 51), and neuromuscular physiotherapists (n = 2) to understand meaningful change on the NSAA and PUL.ResultsThe results for both instruments indicated that: (i) items that are meaningful differ based on ability level; (ii) maintaining function in lower and upper limbs is the ultimate goal; (iii) meaningful change is often reported in relation to gain or loss of specific function, as opposed to number of total points on the scale; and (iv) losing one scale point corresponds to either a partial or full loss in function and activity, which has differing impacts on daily life.ConclusionThe perception of meaningful change in DMD as measured by the NSAA is influenced by ability levels and ambulatory function, with participants describing their need to maximize certain abilities, maintain function, and retain independence. …”
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A Review of Transcranial Electrical and Magnetic Stimulation Usefulness in Major Depression Disorder—Lessons from Animal Models and Patient Studies by Florin Zamfirache, Cristina Dumitru, Deborah-Maria Trandafir, Andrei Bratu, Beatrice Mihaela Radu

“…Chronic depression causes long-term structural and functional brain damage, making new effective therapies for depressed patients essential. …”
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Ethical considerations in prevention and management of non-communicable diseases: a narrative review by Elnaz Shahmohamadi, Aryan Ayati, Yasaman Sharifi, Pouya Ebrahimi, Ehsan Shamsi Gooshki, Shirin Djalalinia, Mahbube Ebrahimpur, Moloud Payab, Bagher Larijani

“…After refining the searched documents, we integrated related concepts and research, particularly emphasizing ethical considerations in NCD management. All four functional areas of NCD prevention (general health policymaking, social interventional, primary prevention, and secondary prevention) are affected by parallel associated factors of health determinants: environmental modification, lifestyle improvement and physiological characteristics, respectively. …”
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The role of social-psychological factors in the adoption of push-pull technology by small-scale farmers in East Africa: Application of the theory of planned behavior by Denis Waiswa, Beatrice Wambui Muriithi, Alice W. Murage, Dave Mwangi Ireri, Fredah Maina, Frank Chidawanyika, Fahri Yavuz

“…These insights underscore the need for tailored, context-sensitive interventions that integrate behavioral, social, and practical considerations. …”
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Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review by Quang La, Aiman Baloch, David F. Lo

“…ABSTRACT Background Aging significantly affects the structural and functional integrity of the blood–brain barrier (BBB), increasing the susceptibility of the central nervous system (CNS) to both primary and metastatic cancers. …”
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A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical studies by Xiao-Min Lv, Na Li, Lin-Wei Chen, Cheng Sun

“…These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function.ConclusionResveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. …”
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Cardiac Remodeling and Arrhythmic Burden in Pre-Transplant Cirrhotic Patients: Pathophysiological Mechanisms and Management Strategies by Charilila-Loukia Ververeli, Yannis Dimitroglou, Stergios Soulaidopoulos, Evangelos Cholongitas, Constantina Aggeli, Konstantinos Tsioufis, Dimitris Tousoulis

“…Structural changes, such as increased left ventricular mass, myocardial fibrosis, and ion channel dysfunction, further impair cardiac function. …”
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Lactobacillus Supplementation Modulates Rumen Microbiota and Metabolism in Yaks Under Fattening Feeding Conditions: A Comprehensive Multi-Omics Analysis by Jianlei Jia, Pengjia Bao, Ning Li, Siyuan Kong, Min Chu, Qian Chen, Ping Yan

“…However, the biological mechanisms by which rumen microbiota and its metabolites enable Lactobacillus to modulate rumen structure and maintain functional homeostasis under fattening feeding conditions remain poorly understood. …”
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Effect of acupuncture on episodic memory for amnestic mild cognitive impairment based on hippocampal subregion: study protocol of a randomized, controlled trial by Xinbei Li, Xingying Lu, Juan Ou, Hanqing Lyu, Yongfeng Liu, Jinhuan Zhang

“…BackgroundThe hippocampus is a key brain region for episodic memory, and impairment of episodic memory is the earliest feature of amnestic mild cognitive impairment (aMCI). Preserving the structure and function of the hippocampus plays a key role in preventing progression to Alzheimer’s disease (AD). …”
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Lactiplantibacillus plantarum IOB602 Postbiotic Ameliorates Depression-like Behaviors by Regulating Neuroendocrine Factors and Gut Microbiota in Mice by JING Zhaoxuan, LIANG Peixin, HAN Xuemei, ZHANG Yihua, DENG Langni, JIA Longgang, WANG Yanping, GENG Weitao

“…Analysis of the gut microbiota revealed that postbiotic intervention modulated the structure and composition of the gut microbiota in mice under CUMS, notably increasing the relative abundance of Erysipelotrichaceae and Dubosiella and reducing the relative abundance of Firmicutes and Staphylococcaceae. …”
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Analysis of Echocardiography Indicators Depending on the Type of Surgical Correction of the Mitral Valve in Patients with Ischemic Heart Disease by Volodymyr S. Moroz, Vasyl V. Lazoryshynets

“…As a result of the study, echocardiographic differences in the structure of the mitral valve were established, which influenced the selection of the intervention volume. …”
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Hand-Related Activities of Daily Living Challenges Among Individuals With Diabetic Peripheral Neuropathy: A Scoping Review by Noor Aziella Mohd Nayan, Chi-Wen Chien, Najihah Lokman, Mohammed Alrashdi, Ahmad Zamir Che Daud

“…The findings were categorised using relevant ICF codes linked to hand function issues. The analysis identified four major themes: (1) the impact of DPN on daily activities and participation; (2) sensory impairments affecting hand function; (3) muscle weakness and functional limitations; and (4) unaddressed areas, such as structural changes, driving, assisting others, and preparing meals. …”
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Hemodynamic homeostasis disequilibrium in critical illness by Jie Wang, Xiaoting Wang, Dawei Liu, Hui Lian, Guangjian Wang, Zewen Tong, Qingyu Deng, Qirui Guo, Qian Zhang, Yangong Chao, Wanhong Yin

“…Such balance is essential for sustaining cellular metabolism and maintaining the function of vital organs throughout embryonic development and the human lifespan. …”
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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…Background Renal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal. …”
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Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

“…To further assess the functionality of succinate dehydrogenase, structure-based studies were conducted. …”
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Preliminary observations of glucose metabolism dysregulation in pediatric Huntington’s disease by Federica Graziola, Federica Rachele Danti, Martina Penzo, Antonio Spagarino, Eleonora Minacapilli, Marco Moscatelli, Federica Zibordi, Caterina Mariotti, Giovanna Zorzi, Giovanna Zorzi

“…However, systemic biochemical indicators of glucose transport deficiency, including erythrocyte GLUT1 function and CSF glucose, were not significantly altered. …”
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Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC by Xin Yue, Zhen Xiang, Yang Yi, Xuecen Wang, Weilin Zhou, Weijian Wu, Wenjing Qin, Yuxuan Zhao, Xianzhang Bu, Zhenwei Peng

“…The TRIM14/USP14 complex facilitates the excision of pronounced K48-linked polyubiquitination at lysine residues 48 or 118 on GPX4, thereby preserving GPX4’s structural integrity and antioxidative function to counteract ferroptosis. …”
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The spectrum of embodied intersubjective synchrony in empathy: from fully embodied to externally oriented engagement in Parkinson's disease by Antonia Zepeda, Alejandro Troncoso, Daniela Pizarro, Constanza Baquedano, Rodrigo Gomez, Silvia Barria, Kevin Blanco, David Martínez-Pernía, David Martínez-Pernía

“…BackgroundParkinson's disease is a prevalent neurodegenerative disorder that not only affects motor function but also impairs empathy. While the neurobiological changes underlying these deficits are known, the impact of PD on the lived experience of empathy remains poorly understood. …”
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