Continuity of care in lumbar disc herniation: a systematic review and meta-analysis providing a deeper look into postoperative efficacy by Ying Lin, Ying Lin, Qiaoling Chen, Qiaoling Chen, RouMei Wang, Bing Zhang, Bing Zhang, Rui Huang, Yiguang Bai, Yiguang Bai

“…Additionally, the Japanese Orthopedic Association (JOA) score of the experimental group was significantly higher than that of the conventional control group at 3 months post-operation [SMD = 1.70, 95%CI (1.01, 2.39), p < 0.01].ConclusionOur meta-analysis indicates that continued care interventions significantly alleviate postoperative pain, enhance lumbar function, reduce anxiety, and improve overall functional recovery in LDH patients. …”
Get full text

Predictors of Cognitive Defects and Its Prevention Capabilities in Premature Infants by Irina A. Belyaeva, Alexander A. Baranov, Leyla S. Namazova-Baranova, Kamilla E. Efendieva, Polina S. Arimova, Alexey I. Molodchenkov, Elena P. Bombardirova, Georgiy A. Karkashadze, Tatiana V. Turti, Elena A. Vishnyova

“…The data of longitudinal researches of the premature infants’ development until reaching their adulthood is presented. The structure of cognitive defects in this population is studied. …”
Get full text

Research progress on NAT10-mediated acetylation in normal development and disease by Da Qin, Qing Liu, Xiaochao Ma, Rui Wang, Tianyu Lu, Yue Yang, Ze Tang, Yanbo Zhu

“…This review summarizes the structural and functional roles of NAT10-mediated acetylation in physiological contexts, including cell division, differentiation, inflammation, aging, and viral infection, as well as its emerging roles in cancer. …”
Get full text

Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature O... by Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y

“…The expression changes of PTEN, Nrf2, and GPX4, which are associated with ferroptosis, were analyzed using immunofluorescence, Western blot, and quantitative reverse-transcription polymerase chain reaction.Results: hUCMSC-Exo intervention can significantly repair the ovarian tissue structure and functional abnormalities in the model rats, especially ferroptosis. …”
Get full text

Tropical infections and the gut microbiome: dysbiosis, recovery, and clinical implications by Biruk Demisse Ayalew, Muhammad Umar, Muhammad Saeed, Ahtisham Ali, Kaleb Assefa Berhane, Temesgen Mamo Sharew, Yonatan Abbawa Zewdie, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Abate Bane Shewaye

“…Therapeutic interventions, including probiotics and fecal microbiota transplantation (FMT), show promise in aiding microbiome restoration. …”
Get full text

Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights by Chen-Ying Zhu, Pei-Han Yu, Qi Sun, De-Fei Hong, Chang Yang, Hua Naranmandura

“…Additionally, future investigations employing integrated multi-omics approaches, advanced structural biology techniques, and AI-driven analyses will further unravel their precise regulatory mechanisms, paving the way for personalized therapeutic interventions, while critically evaluating their translational potential and clinical applications.…”
Get full text

Advances in cardiac organoid research: implications for cardiovascular disease treatment by Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

“…Consequently, the development of accurate models that simulate cardiac function holds significant scientific and clinical value for both disease research and therapeutic interventions. …”
Get full text

Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review by Dan Liu, Dan Liu, Dan Liu, Dan Liu, Xingwang Chen, Xingwang Chen, Xingwang Chen, Xingwang Chen, Shanjun Cai, Shanjun Cai, Shanjun Cai, Shanjun Cai

“…This review systematically summarizes the structural and functional properties of DP, explores their mechanism of action and experimental evidence in retinal neovascularization, and analyzes their potential as a new therapeutic strategy for retinal diseases. …”
Get full text

Quercetin‐Driven Akkermansia Muciniphila Alleviates Obesity by Modulating Bile Acid Metabolism via an ILA/m6A/CYP8B1 Signaling by Jiaqi Liu, Youhua Liu, Chaoqun Huang, Chuan He, Tongyudan Yang, Ruiti Ren, Zimeng Xin, Xinxia Wang

“…Here in this study, it is demonstrated that quercetin intervention significantly reverses obesity‐related phenotypes through reshaping the overall structure of microbiota, especially boosting colonization of the beneficial gut commensal Akkermansia muciniphila (A. muciniphila). …”
Get full text

Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus, characterized by microvascular dysfunction and progressive structural and functional deterioration of the heart. …”
Get full text

A comprehensive assessment of health indicators among tribal populations in Odisha, India (Odisha Tribal Family Health Survey): a community-based, cross-sectional studyResearch in... by Jaya Singh Kshatri, Kavitha AK, Tanveer Rehman, Haimanti Bhattacharya, Dinesh Bhuyan, Asit Mansingh, Uttam Kumar Sahoo, Moushumi Nayak, Swagatika Kanungo, Debdutta Bhattacharya, Sanghamitra Pati

“…Data collection involved the use of structured tools at the household and individual levels, anthropometric measurements, point-of-care tests (including blood pressure, random blood glucose, and haemoglobin levels, as well as haemoglobinopathy screening), and laboratory analyses of blood serum samples (for liver function, kidney function, and lipid and iron profiles). …”
Get full text

From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases by Kaixuan Chen, Longjun Chen, Yizhong Ma, Siqi Chen, Jinze Liu, Hangyu Zhou, Yuzhu Chen, Guanyi Liu

“…The skeletal system is an important support structure in the human body, and its homeostatic state is highly relevant to the development of a wide range of orthopaedic diseases. …”
Get full text

Unraveling a novel FBN1 variant in Marfan syndrome with dilated aortic root manifestation by Amirreza Sabahizadeh, Amir Askarinejad, Saranaz Seyed AliAkbar, Mahdieh Soveizi, Golnaz Houshmand, Hojjat Mortezaeian, Amin Elahifar, Majid Maleki, Samira Kalayinia

“…In silico analysis suggested a deleterious impact on protein structure and function, supporting their pathogenic classification. …”
Get full text

Analysis of results in patients after treatment using various segmental bone alloplasty techniques by Ya. O. Holovina, R. V. Malyk, O. Ye. Vyrva

“…Restoration of bone, adjacent joint and surrounding soft tissue integrity is an important factor in achieving full function of affected limbs in patients with bone tumors. …”
Get full text

Evaluating baculovirus as a vector for human prostate cancer gene therapy. by Stephanie L Swift, Guillermo C Rivera, Vincent Dussupt, Regina M Leadley, Lucy C Hudson, Corrina Ma de Ridder, Robert Kraaij, Julie E Burns, Norman J Maitland, Lindsay J Georgopoulos

“…BV was able to penetrate through three-dimensional structures, including in vitro spheroids and in vivo orthotopic xenografts. …”
Get full text

Speech Recognition in Noise: Analyzing Phoneme, Syllable, and Word-Based Scoring Methods and Their Interaction with Hearing Loss by Saransh Jain, Vijaya Kumar Narne, Bharani, Hema Valayutham, Thejaswini Madan, Sunil Kumar Ravi, Chandni Jain

“…These scoring methods provided a structured framework for refining clinical audiological diagnosis by revealing underlying auditory processing at multiple linguistic levels. …”
Get full text

Community nursing on subjective well-being of the elderly: evidence from CLASS data by Fulei Jin, Tao Chen

“…However, due to factors like the flow of the labor force, the miniaturization and flattening of family structures, the traditional function of family care has been continuously weakened, and it’s hard for families to take on the all-round care for the elderly. …”
Get full text

Cultural influences on physiotherapy engagement and outcomes in Guillain-Barré syndrome rehabilitation: a systematic review by Olawale Isreal Oshomoji, Johnson Olasunkanmi Ajiroba, Samuel Oluwaseun Semudara, Moses Ayomide Olayemi, Samuel Olumide Adeoye, Okechukwu Cosmas Ugwu, Love Immanuel Ojo

“…Abstract Background Guillain-Barré Syndrome (GBS) is a rare acute peripheral neuropathic disorder that often necessitates a long course of physiotherapy to regain locomotor function and overall life functioning. Although the efficacy of physiotherapy in GBS is beyond doubt, little is known about the role of culture in patients’ compliance and response to therapy. …”
Get full text

A qualitative study exploring experiences of treatment in paediatric rheumatology - children’s, young people’s, parents’ and carers’ perspectives by Kassie Gracella Putri, Sunil Sampath, Charlotte Lucy Richardson, Alice McCloskey, Adam Pattison Rathbone

“…Joint qualitative semi-structured interviews with CYP and PC were used to collect data. …”
Get full text

Transitional Housing and the Family Capacity Building Planner: An Urban Graduation Approach for Improving the Mental Health and Well-Being of Poor Households in Hong Kong by Siu-Ming Chan, Heng Xu, Yuen-Ki Tang, Kim Kwok, Ka-Man Leung

“…(1) Objective: This study aims to investigate how transitional housing and the FCBP programme function as infrastructure for improving mental health and building family capacity among low-income households in Hong Kong, introducing the Urban Graduation Approach, adapted from the rural Graduation Approach, as an adaptation of proven poverty-alleviation strategies to urban contexts. (2) Methods: We conducted in-depth, semi-structured interviews with 24 residents of transitional housing participating in the Family Capacity Building Planner (FCBP) programme, an important component of The Hong Kong Jockey Club’s Trust-Initiated Project—JC PROJECT LIFT in uplifting residents and enhancing their overall well-being, analysing their experiences through thematic analysis focused on housing transitions, service utilisation, and well-being outcomes. (3) Results: Transitional housing provides essential infrastructure for improving residents’ well-being through both physical improvements and integrated support services. …”
Get full text