Study protocol for an observational research study with an embedded N-of-1 design: Increasing the availability of goal-oriented cognitive rehabilitation for people living with deme... by Caoimhe Hannigan, Antoine Lemercier, Garret McDermott, Helena Lydon, Sean P Kennelly, Michelle Kelly

“…<h4>Background</h4>Goal-Oriented Cognitive Rehabilitation (GREAT-CR) is an evidence-based early intervention for people with mild-moderate dementia that improves goal attainment and functional outcomes. …”
Get full text

Perceived social support on objective measured sedentary behavior of stroke patients: the mediating role of exercise self-efficacy by Jianing Wei, Fanjiayi Yang, Xiaofang Dong

“…IntroductionAs stroke patients may have impaired motor function, there may have increased sedentary behavior. …”
Get full text

Stem-Cell Niches in Health and Disease: Microenvironmental Determinants of Regeneration and Pathology by Boris Yushkov, Valerii Chereshnev, Elena Korneva, Victoria Yushkova, Alexey Sarapultsev

“…Emphasis is placed on how aging, inflammation, fibrosis, and metabolic stress disrupt niche function, converting supportive environments into autonomous drivers of pathology. …”
Get full text

Molecular Dynamics of Apolipoprotein Genotypes APOE4 and SNARE Family Proteins and Their Impact on Alzheimer’s Disease by Yuqing Wang, Xuefeng Liu, Pengtao Zheng, Qing Xie, Chenxiang Wang, Chaoyang Pang

“…This work highlights the perturbations in synaptic function mediated by APOE4, which may offer novel insights into the molecular underpinnings of AD. …”
Get full text

Social support and adolescent mental health in Kenya: a parallel mediation analysis of perceived control and gratitude by Ming Zhao, Heng Miao, Li-Li Zhu, Xiao-Han Zhang, Li-Wei Zang

“…These psychological resources function as parallel pathways linking social connections to well-being. …”
Get full text

The Emotional and Social Impact of Hearing Loss by Harsh Nawal, Diptanshu Mukherjee, Shamima Yasmin, Saumendra Nath Bandyopadhyay

“…   Introduction Hearing loss affects not only auditory function but also significantly impacts a person's emotional and social functions. …”
Get full text

The importance of good adherence to methotrexate in the treatment of rheumatoid arthritis by Ćeranić Jelena, Kisić-Tepavčević Darija, Ristić Gorica

“…Methotrexate affects the function of almost all cell types involved in inflammation (neutrophils, monocytes, Tand B-cells, endothelial cells, and fibroblast-like synovium). …”
Get full text

The health care needs of multidimensional frail elderly patients with multimorbidity in primary health-care settings: a qualitative study by Linlin Zhao, Bingjie Chang, Qinghua Hu, Xiaolei Chen, Juan Du, Shuang Shao

“…Appropriate policies and measures should be taken, such as integrating multidimensional frailty assessments into current multimorbidity management protocols, developing personalized interventions centered on patient needs, conducting family function assessments and caregiver training programs, and enhancing the integration of social resources.…”
Get full text

A serial mediation model of physical exercise and loneliness: the role of frailty and depression by Song Gu, Shiling Liu

“…Physical exercise has been widely recognized as an effective intervention to improve both the physical and mental health of older adults. …”
Get full text

Auditory processing and its cognitive correlates in older adults with mild cognitive impairment by Leelavathi Thamizhmani, Kanaka Ganapathy, Hari Prakash Palaniswamy, Arivudai Nambi Pitchaimuthu, Prabha Adhikari M. R.

“…Research should also examine the impact of tailored auditory training on cognitive function in MCI to inform interventions. Trial registration The study was registered in the Clinical Trials Registry of India (CTRI/2023/06/054277) on 21/06/2023 ( http://ctri.nic.in/ ).…”
Get full text

Comprehensive characterization of multi-omics landscapes between gut microbial metabolites and the druggable genome in sepsis by Jun Liu, Tong Li, Li Xin, Xingyu Li, Jianbo Zhang, Peng Zhu

“…Key findings were validated by molecular dynamics (MD) simulation, microscale thermophoresis (MST), and functional assays in a murine cecal ligation and puncture (CLP) model of sepsis.ResultsWe evaluated 190,950 metabolite-protein interactions, linking 114 sepsis-related GIK targets to 335 gut microbial metabolites, and prioritized indole-3-lactic acid (ILA), a metabolite enriched in Akkermansia muciniphila, as a promising therapeutic candidate. …”
Get full text

Predicting depression risk in middle-aged and elderly adults in China using CNN-BiLSTM-Attention mechanism and LSTM+SHAP framework by Shengxian Bi, Gang Li, Huawei Tan, Yingchun Chen, Dandan Guo

“…SHAP analysis for the LSTM and CNN-BiLSTM-Attention models identified health status and functionality as key factors influencing depression risk in middle-aged and elderly individuals, with pain, gender, sleep duration, and IADL (Instrumental Activities of Daily Living) being the most significant factors. …”
Get full text

Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies by Claire E. L. Smith, Andrew J. Streets, Alice V. R. Lake, Subaashini Natarajan, Sunayna K. Best, Katarzyna Szymanska, Magdalena Karwatka, Thomas Stevenson, Rachel Trowbridge, Gary Grant, Sushma N. Grellscheid, Richard Foster, Ciaran G. Morrison, Georgia Mavria, Jacquelyn Bond, Albert C. M. Ong, Colin A. Johnson

Get full text

Concept and Characteristic of Urban Landscape Layering, and Design Approach Towards Urban Regeneration by Jinyu ZHANG, Yuan XU, Yufan ZHU

“…Urban landscape evolves through a nonlinear process of accumulation, with physical structures, functions, and meanings continuously transforming. …”
Get full text

Portugal’s Wattle and Daub Constructive Legacy by Kátia Soares, Isabel Torres, Ana Velosa

“…The commitment to technical and scientific innovation for appropriate interventions in buildings with wattle and daub walls requires a comprehensive and authentic approach to pre-existing structures. …”
Get full text

Selective Plasticity of Hippocampal Sub‐Regions in the Amnestic Mild Cognitive Impairment After Acupuncture by Jinhuan Zhang, Bin Yan, Yongfeng Liu, Ting Liu, Liyu Hu, Xiaohui Zhan, Xinbei Li, Chengcheng Zhu, Jinping Xu, Haibo Yu

“…Conclusion: These results suggested that acupuncture could selectively induce structural plasticity in hippocampal subregions associated with cognitive effects in patients with aMCI, which provided potential biomarkers—particularly the right subiculum body—for effective and timely interventions for aMCI. …”
Get full text

Clinical decision support in the electronic health record: a primer for antimicrobial stewards and infection preventionists: work smarter so end users don’t work harder by Mary Rochelle Smith, Julie J. Lee, Marisa Holubar, Jorge L. Salinas, Mindy M. Sampson, Richard J. Medford, Amy Chang

“…This primer article aims to provide ASP and IP professionals with a practical framework for the development, design, and evaluation of CDS interventions. Setting: Large academic medical center design: Established frameworks of CDS evaluation, “Five Rights” of CDS and the “Ten Commandments of Effective Clinical Decision Support”, were applied to two real-world examples of CDS tools, a Vancomycin Best Practice Advisory and a Clostridioides Difficile order panel, to demonstrate a structured approach to developing and enhancing the functionality of ASP/IP CDS interventions to promote efficacy and reduce unintended consequences of CDS. …”
Get full text

Sociological Analysis of the Phenomenon of Honor Killing with the Social Interpretation Approach by Afshar Kabiri

“…In these contexts, honor killings function as a technique of social control, with women's sexuality and social behavior being key markers of communal honor. …”
Get full text

Diagnosis and Management of Giant Hepatic Hemangioma: The Usefulness of Contrast-Enhanced Ultrasonography by Masaki Maruyama, Osamu Isokawa, Koki Hoshiyama, Ayako Hoshiyama, Mari Hoshiyama, Yoshihiro Hoshiyama

“…The major advantage is the real-time observation of the vascular structure and function of the Kupffer cells. By this procedure, we can carefully follow the tumor growth or character change in a hemangioma and decide the timing of therapeutic intervention, since abdominal pain, abdominal mass, consumptive coagulopathy, and hemangioma growth are the signs for the therapeutic intervention. …”
Get full text

Validation of the World Health Organization’s Disability Assessment Schedule 2.0 for children with mental disorders in specialized health-care services by Lina Díaz-Castro, Miriam Arroyo-Belmonte, Paloma Suárez-Brito, María Elena Márquez-Caraveo, Consuelo Garcia-Andrade

“…The validation of reliable assessment tools is crucial for identifying functional impairments and guiding interventions in this population. …”
Get full text