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881
Mitochondrial metabolism and cancer therapeutic innovation
Published 2025-08-01“…Although targeting mitochondrial function represents a promising therapeutic strategy, mitochondrial heterogeneity and adaptive resistance mechanisms complicate interventional approaches. …”
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882
Development and validation of the laziness assessment scale
Published 2025-01-01“…Laziness, a behavioural construct with implications in psychological, social, and organizational contexts, has garnered attention owing to its impact on human functioning. Limited research has explored how this construct affects individuals' functioning as the subjective nature of laziness necessitates a reliable measurement tool. …”
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883
Assessing the impact of seawater blockade on coastal lake degradation using Chironomidae larvae
Published 2025-03-01“…Abstract Coastal ecosystems, such as lakes and lagoons, are unique and valuable water bodies whose proper functioning depends on hydrological connectivity with the sea or ocean. …”
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884
Adapting sensory integration theory terminology into Estonian based on the assessment tools Evaluation in Ayres Sensory Integration, Sensory Profile 2, and Adolescent/Adult Sensory...
Published 2025-08-01“…The adaptation of the tests provided the possibility of establishing the basis for a functional and professional sensory integration theory terminology in Estonian.…”
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885
Neuroplastizität und Sport
Published 2015-02-01“…Sports and exercise can influence brain structure and function on a variety of levels. Adult hippocampal neurogenesis, synaptic plasticity, dendritic complexity and angiogenesis are among the basic mechanisms that are induced by exercise in ani mal models. …”
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886
Application of «wide awake» аnesthesia for improvement of results of a tendon–muscular transposition on the hand
Published 2018-04-01“…High efficacy of a «wide awake» аnesthesia in nonvolume function–creating interventions, performed with addition of sliding and active structures and necessitating close intraoperative cooperation with the patient, was proved.…”
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887
Androgens as the “old age stick” in skeletal muscle
Published 2025-04-01“…Abstract Aging is associated with a reduction in skeletal muscle fiber size and number, leading to a decline in physical function and structural integrity—a condition known as sarcopenia. …”
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888
Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells
Published 2025-03-01“…This review summarizes the current research on these processes in the context of tissue regeneration and therapeutic interventions.…”
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889
Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics
Published 2025-09-01“…Structured abstract: Background: Alveolar regeneration is essential for maintaining lung function and enabling recovery following lung injury. …”
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890
Postoperative Physical Therapy for Cervical Total Disc Replacement: A Case Report
Published 2025-06-01“…# BACKGROUND AND PURPOSE Cervical total disc replacement (CTDR) was developed to decompress nervous structures, preserve spinal biomechanics, and reduce postoperative complications such as nonunion or fracture. …”
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891
Research progress of connexin 43 in cardiovascular diseases
Published 2025-08-01“…This review summarizes the role of Cx43 in cardiac diseases, explores its functional changes under electrophysiological and pathological conditions, and evaluates its impact on disease progression, providing theoretical insights for mechanistic studies and clinical interventions in cardiovascular diseases.…”
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892
Pulsed exposure mode of the 445 nm semiconductor laser in phonosurgery: an experimental study
Published 2023-08-01“…The study presents the results of an experimental study devoted to the choice of the most optimal mode of pulsed contact laser exposure of semiconductor laser with a wavelength of 445 nm in phonosurgery, which implies maximum preservation of anatomically and functionally significant structures of the larynx combined with a radical approach to the pathological process. …”
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893
'Special k' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine.
Published 2013-01-01“…To date however, we know nothing of a role for Ketamine in modulating both structure and function of the human renal proximal tubule. …”
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894
Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier
Published 2024-12-01“…These mechanisms include the restoration of gut microbiota structure, upregulation of intestinal epithelial cell proliferation and differentiation, enhancement of tight junction protein expression, promotion of mucin secretion by goblet cells, and the immunosuppressive functions of regulatory T cells (Treg) and M2 macrophages. …”
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895
Hybrid 2-[18F] FDG PET/MRI in premanifest Huntington's disease gene-expansion carriers: The significance of partial volume correction.
Published 2021-01-01“…Striatal atrophy and hypometabolism has been described in HD as far as 15 years before clinical onset and therefore structural and functional imaging biomarkers are the most applied biomarker modalities which call for these to be exact; however, most studies are not considering the partial volume effect and thereby tend to overestimate metabolic reductions, which may bias imaging outcome measures of interventions.…”
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896
Exercise-Induced Neuroplasticity: Adaptive Mechanisms and Preventive Potential in Neurodegenerative Disorders
Published 2025-04-01“…Exercise directly impacts pathological features of neurodegenerative diseases by reducing protein aggregation, attenuating excitotoxicity and oxidative stress, and enhancing mitochondrial function. Clinical evidence consistently demonstrates associations between physical activity and reduced neurodegenerative risk, with intervention studies supporting causal benefits on cognitive function and brain structure. …”
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897
Challenges in managing ossifying fibroma of the maxilla: A case report
Published 2024-09-01“…Multidisciplinary discussion was required to determine the best approach in the management of this case, focusing on complete excision of the tumor while preserving function and aesthetics. In the context of recurrent or extensive disease, reconstructive techniques using local or distant flaps can be important to restore postoperative structure and function. …”
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898
De macrostructuur van het boek Samuël en de theologische implicaties daarvan
Published 1997-12-01“… 1) There are two formal indications for structuring the Book of Samuel. a) The forms of government of the leading persons constitute the main structure. …”
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899
Automated Soma Detection in Whole-Brain Imaging via Post-Tracing Multi-Furcation Morphometry
Published 2025-01-01“…Accurate single-neuron morphology reconstruction is essential for understanding brain structure and function. A critical step in this process is the detection of somas in 3D brain images, which remains a challenge due to the complex structure of the brain and the large amount of whole brain imaging data [1]. …”
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900
Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities
Published 2025-08-01“…Super-enhancers (SEs) are dynamic chromatin structures that function as epigenetic hubs, orchestrating cell-type-specific transcriptional programs crucial for immune cell differentiation, functional specialization, and adaptive responses. …”
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