The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise by Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim

“…Frailty syndrome, a condition marked by increased vulnerability due to age‐related physiological decline, exerts a profound impact on skeletal muscle structure and function. Despite its widespread prevalence, the underlying mechanisms contributing to frailty‐associated muscle deterioration remain poorly elucidated. …”
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Fermented foods affect the seasonal stability of gut bacteria in an Indian rural population by Kumaraswamy Jeyaram, Leo Lahti, Sebastian Tims, Hans G. H. J. Heilig, Antonie H. van Gelder, Willem M. de Vos, Hauke Smidt, Erwin G. Zoetendal

“…Abstract The effect of fermented foods on healthy human gut microbiota structure and function, particularly its seasonal preference and frequent long-term consumption, has been largely uncharacterised. …”
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Three-level global resource allocation model for HIV control: A hierarchical decision system approach by Semu Mitiku Kassa

“…When the impact of antiretroviral therapy (ART) is included in the model, it has been shown that the objective function of the lower level decision making structure is a non-convex minimization problem in the allocation variables even if all the production functions for the intervention programs are assumed to be linear.…”
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Incidental imaging detection of Kartagener syndrome in a female: A case report by Natasha Dhakal, MBBS, Prajwal Dahal, MD

“…The underlying pathophysiology involves reduced ciliary motility due to defects in ciliary structure and function within the respiratory tract and fallopian tubes. …”
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Reinitiating lung development: a novel approach in the management of bronchopulmonary dysplasia by Xuewei Cui, Jianhua Fu

“…Current management of BPD relies heavily on pharmacotherapies and alterations in ventilatory strategies. However, these interventions only mitigate BPD symptoms without addressing underlying alveolar, vascular, structural, and functional deficiencies. …”
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A Comparative Analysis of Effects of Rehabilitation Services on Symptomatology of Parkinson’s Disease-An Umbrella Review of Systematic Reviews and Meta-Analyses by Zobia Farooq, Rayan Aboakel, Rabeaa Sahar, Zareen Akhtar, Tahira Irshad, Jennifer Geller

“…Quality of included studies was assessed using JBI critical appraisal tool and results were reported after detailed data extraction.Results:The studies involved 9755 participants with a mean age of 61.6 years. Various interventions were assessed, including structured physical exercise, technology-based interventions, Tai Chi, cueing techniques, aquatic physiotherapy, and inspiratory and expiratory breathing training. …”
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Long-Term Exercise Mitigates Energy Expenditure and Inflammatory Responses Induced by Sleep Deprivation in Mice by Tian-Shu Zheng, Xin-Ran Gao, Chen Gu, Yu-Ning Ru, Rui-Ping Xu, Yu-Hang Yang, De-Hua Wang

“…<b>Background</b>: Sleep deprivation (SD), defined as the disruption or loss of normal sleep, negatively affects energy metabolism, immune function, and gut microbiota in both humans and animals. …”
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Rehabilitation of the Upper Extremity after Stroke: A Case Series Evaluating REO Therapy and an Auditory Sensor Feedback for Trunk Control by G. Thielman, P. Bonsall

“…Outcomes. With both interventions, clinically relevant improvements were found for measures of body function and structure, as well as for activity, for two participants. …”
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Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets by Gen Li, Wu He, Dao Wen Wang

“…Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune mechanisms in HF. …”
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Sexual dimorphism in the response to antidepressant therapy: Biological basis and clinical implications declaration of competing interests author contributions by Nedeljković Jelena, Stanić Dušanka, Petrović Jelena, Ivanović Ana, Ilić Miloš, Nikolašević-Stojković Gorana, Pejušković Bojana, Pešić Vesna

“…Neurobiological studies highlight gender-specific differences in brain structure and function, as well as in neurotransmitter systems, which may impact treatment efficacy and response variability. …”
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Identification of Keystone Plant Species for Avian Foraging and Nesting in Beijing’s Forest Ecosystems: Implications for Urban Forest Bird Conservation by Lele Lin, Yongjian Zhao, Chao Yuan, Yushu Zhang, Siyu Qiu, Jixin Cao

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Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission by Yingxin Sun, Junchen He, Junchen He, Lei Bao, Xiaoming Shi, Jinghong Wang, Qingwen Li

“…This, in turn, enhances mitochondrial function and cellular metabolism. This review synthesizes the current understanding of Drp1 structure and activation mechanisms, and analyzes the effects of exercise interventions on Drp1-mediated mitochondrial fission in different disease models to improve common chronic conditions. …”
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Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms by Qianke Yang, Shichong Lin, Zhuyun Zhang, Shuhao Du, Dan Zhou

“…BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. …”
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Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration by Yifei Zheng, Jiahui Yang, Xuanyao Li, Linjie Qi, Zhuo Zheng, Jiming Kong, Guohui Zhang, Ying Guo

“…Neuronal senescence, characterized by a progressive decline in structural integrity and function, is a hallmark of neurodegenerative diseases. …”
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Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review. by Alison J Davis, Toby O Smith, Caroline B Hing, Nidhi Sofat

“…Our meta-analysis of the two largest knee studies using risedronate 15 mg showed odds ratios favouring placebo interventions for the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain (1.73), WOMAC function (2.03), and WOMAC stiffness (1.82). …”
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Bupropion for the treatment of apathy in Huntington's disease: A multicenter, randomised, double-blind, placebo-controlled, prospective crossover trial. by Harald Gelderblom, Torsten Wüstenberg, Tim McLean, Lisanne Mütze, Wilhelm Fischer, Carsten Saft, Rainer Hoffmann, Sigurd Süssmuth, Peter Schlattmann, Erik van Duijn, Bernhard Landwehrmeyer, Josef Priller

“…In addition, we investigated the effect of bupropion on brain structure as well as brain responses and functional connectivity during reward processing in a gambling task using magnetic resonance imaging (MRI).…”
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A Framework for Healthcare Provision to Children with Intellectual Disability by Anish TS, Vijayakumar K, Anilkumar TV, Zinia T Nujum, Hisham Moosan

“…The objectives of this study were to evaluate the structure and functioning of ‘Buds’ schools, to identify the healthcare needs of the students, and to conceptualise a framework for healthcare provision.…”
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Spatial Complex Morphological Evolution and Influencing Factors for Mountain and Seaside Resort Tourism Destinations by Huiqiang Ma, Jianchao Xi, Qing Wang, Jiale Liu, Zhigang Gong

“…The study contributes to complex morphological evolution from the perspectives of external structure expansion and internal function reconstruction, revealing the spatial characteristics and explaining the influencing factors. …”
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Causal AI Recommendation System for Digital Mental Health: Bayesian Decision-Theoretic Analysis by Mathew Varidel, Victor An, Ian B Hickie, Sally Cripps, Roman Marchant, Jan Scott, Jacob J Crouse, Adam Poulsen, Bridianne O'Dea, Sarah McKenna, Frank Iorfino

“…ResultsThe causal AI recommendation system recommends intervention targets as a function of a user’s baseline presentation, the causal effects of the intervention on itself and other domains, and the utility function. …”
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Post‐Translational Modifications in Cilia and Ciliopathies by Jie Ran, Jun Zhou

“…In addition, accumulating evidence has shown that PTMs are essential for modulating ciliary structure and function, and that dysregulation of these modifications leads to the development of ciliopathies. …”
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