Effects of a Digital Functional Exercise Program on the Disease Activities and Physical Capabilities of Patients With Ankylosing Spondylitis: Protocol for a Randomized Controlled T... by Xingkang Liu, Xiaojian Ji, Lidong Hu, Tianyu Jiang, Ang Min, Lulu Zeng, Yiwen Wang, Meihui Zhao, Jian Zhu, Feng Huang, Changshui Weng, Zheng Zhao

“… BackgroundAnkylosing spondylitis (AS), a chronic inflammatory disease, causes spinal stiffness, functional impairment, and reduced quality of life. …”
Get full text

Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) protein-derived antioxidant peptides: mechanisms of action and structure-activity relationship in Caco-2 cell models by Yiming Zhou, Xuanming She, Zhidong Chen, Yun Wei, Ying Xiao, Xiaoli Zhou

Get full text

In Silico Identification and Functional Impact of Deleterious Nonsynonymous Single-Nucleotide Polymorphisms (nsSNPs) in Type 2 Diabetes–Associated Genes in South Asian Populations... by Md. Hafizur Rahman, Md. Numan Islam, Md. Golam Rabby, Salina Shaheen Parul, Md. Mahmudul Hasan, Mrityunjoy Biswas

“…The nsSNPs are genetic variations that alter amino acids within proteins, affecting protein structure and function. This study investigated seven candidate genes associated with T2D pathogenesis from genome-wide association studies (GWASs) catalog datasets. …”
Get full text

Rehabilitation of the lower extremities, standing and walking function in people with spinal cord injury or disease: Guideline of the German-Speaking Medical Society for Spinal Cor... by Irrgang, Sophie, Himmelhaus, Sandra, Allek, Kirstin, Bartholet, Claudio, Bersch-Porada, Ines, Curt, Armin, Huber, Burkhart, Kuhn, Daniel, Kynast, Karen, Weidner, Norbert, Scheel-Sailer, Anke

“…Recommendations on assessments were grouped to the categories “activity and participation” or “body functions/body structures”. Recommendations on interventions were labeled with outcomes standing, walking, strength, range of motion, pain and muscle tonus. …”
Get full text

Remediation Program with Working Memory and Reading for Students with Learning Difficulties: Elaboration and Pilot Study by Isabella Nicolete Xavier, Simone Aparecida Capellini

Get full text

Effects of Maillard reaction and its product AGEs on aging and age-related diseases by Huan Peng, Yuqi Gao, Chenye Zeng, Rui Hua, Yannan Guo, Yida Wang, Zhao Wang

“…Despite certain advantages based on Maillard reaction products (MRPs) found in some food for health and storage application have appeared, however, the MR occurring in human physiological environment can produce advanced glycation end products (AGEs) by non-enzymatic modif ication of macromolecules such as proteins, lipids and nucleic acid, which could change the structure and functional activity of the molecules themselves. …”
Get full text

Effects of aerobic exercise on body composition and exerkines in colorectal cancer survivors by Eunhan Cho, Miranda Chodzko, Stephanie L. E. Compton, Shengping Yang, Steven Heymsfield, Guillaume Spielmann, Guillaume Spielmann, Justin C. Brown, Justin C. Brown, Justin C. Brown, Justin C. Brown, Justin C. Brown

“…This study investigated whether a 12-week structured exercise training intervention increases IL-7 and IL-15 in colorectal cancer survivors.MethodsSixty colorectal cancer survivors were randomized to a moderate-intensity home-based aerobic exercise group (150 min/week) or a control group for 12 weeks. …”
Get full text

Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…We found strong evidence that cognitive function was lower in CBHF compared to CHU across multiple domains. …”
Get full text

Effect of the Nrf2/HO-1 pathway on aluminum-induced liver injury by Xi Wei, Yueling Luo, Dongjie Yuan, Dong Li, Yixi Nong, Biaoliang Wu, Xiaojie Qin

“…Chronic exposure to aluminum (Al) can lead to the accumulation of Al in the liver, which negatively impacts liver structure and function. Oxidative stress is extensively identified as a key contributor to Al toxicity. …”
Get full text

Electroacupuncture Improves Ovarian Function in Rats With Tripterygium Glycoside-Induced Diminished Ovarian Reserve by Promoting the Polarization of M2 Macrophages and Inhibiting I... by Jia Luo, Yantong Qin, Yaoyao Zhu, Yaoli Yin, Meihong Shen

“…EA intervention reduced the oestrous cycle disorder rate in the rats compared with that in the DOR group, leading to an increase in growing follicles, a reduction in atretic follicles (AFs) and an enhancement of both the capillary (Cap) network and corpus luteum (CL) structure. …”
Get full text

Effects of device-assisted practice of activities of daily living in a close-to-normal pattern on upper extremity motor recovery in individuals with moderate to severe stroke: stud... by Justin M. Drogos, Carolina Carmona, Riegele Arceo, Jun Yao

“…The focus on the more impaired chronic stroke population provides the opportunity to improve the rehabilitation of this overlooked population. Functional and structural measures using advanced imaging techniques offer the possibility to further delineate recovery and compensation at the neuronal level. …”
Get full text

Human-Prosthetic Interaction (HumanIT): A study protocol for a clinical trial evaluating brain neuroplasticity and functional performance after lower limb loss. by Elke Lathouwers, Bruno Tassignon, Alexandre Maricot, Ahmed Radwan, Maarten Naeyaert, Hubert Raeymaekers, Peter Van Schuerbeek, Stefan Sunaert, Johan De Mey, Kevin De Pauw, Kevin De Pauw

“…<h4>Background</h4>Lower limb amputation contributes to structural and functional brain alterations, adversely affecting gait, balance, and overall quality of life. …”
Get full text

Engineering a Dual-Function Starch–Cellulose Composite for Colon-Targeted Probiotic Delivery and Synergistic Gut Microbiota Regulation in Type 2 Diabetes Therapeutics by Ruixiang Liu, Yikang Ding, Yujing Xu, Qifeng Wu, Yanan Chen, Guiming Yan, Dengke Yin, Ye Yang

Get full text

Training Cognitive Functions Using DUAL-REHAB, a New Dual-Task Application in MCI and SMC: A Study Protocol of a Randomized Control Trial by Elisa Pedroli, Francesca Bruni, Valentina Mancuso, Silvia Cavedoni, Francesco Bigotto, Jonathan Panigada, Monica Rossi, Lorenzo Boilini, Karine Goulene, Marco Stramba-Badiale, Silvia Serino

“…Results: The expected outcome is an improvement in cognitive and motor functioning after the experimental training. Conclusion: This study will advance the literature on non-pharmacological interventions and innovative technological tools for cognitive trainings in the early stages of cognitive decline.…”
Get full text

Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing by Jie Yang, Qingyu Han, Liping Li, Ruiping Zhang

“…Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. …”
Get full text

Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas e... by Xinwen Dong, Yaguang Su, Zheng Luo, Cuiying Li, Jie Gao, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren

“…FMT improved intestinal structure and up-regulated expression of tight junction proteins Claudin-1, Occludin, and ZO-1, potentially contributing to its protective effects on both brain and gut.ConclusionTransplantation of gut microbiota from healthy rats significantly enhanced cognitive function in male rats with traumatic brain injury caused by a gas explosion, through the modulation of gut microbiome composition and the improvement of both gut and brain barrier integrity via the gut-brain axis. …”
Get full text

Reliability and Accuracy of Ultrasonographic Muscle Thickness Measurements: Evaluating Key Postural Stabilisers in Rehabilitation by Arkadiusz Żurawski, Natalia Barańska, Aleksandra Tomala, Edyta Majorczyk, Joanna Macierzyńska

“…Its capacity to provide real-time visualisation of muscle structure and function underpins its utility in clinical practice and scientific research. …”
Get full text

Roles of Psychological Flexibility, Parenting Competence, and Asthma Management Self-Efficacy in the Functioning Outcomes of Parents of Children with Asthma Co-Occurring with Atten... by Yuen Yu Chong, Pui Tik Yau, Joycelyn Yee Man Kwan, Wai Tong Chien

“…Baseline data were analyzed from 130 parents (mean age = 40.3 years, SD = 5.5; 88.9% mothers) of children diagnosed with both asthma and ADHD (mean age = 8.0 years, SD = 2.2; 74.6% boys), who were participating in a randomized controlled trial evaluating an Acceptance and Commitment Therapy (ACT)-based parenting intervention. An adjusted structural equation model revealed that greater parental psychological inflexibility was significantly associated with poorer family functioning (β = −0.61, 95% CI [−0.74, −0.33], <i>p</i> < 0.001) and increased psychological maladjustment (β = 0.48, 95% CI [0.32, 0.63], <i>p</i> < 0.001), accounting for intercorrelations with parenting competence and parental asthma management self-efficacy. …”
Get full text

Emotion dysregulation and impulsivity as overlapping symptoms in adult Attention-Deficit/Hyperactivity Disorder and Borderline Personality Disorder: severity profiles and associati... by Eszter Kenézlői, Lívia Balogh, Szilvia Somogyi, Evelyn E. Lévay, Zsuzsa Halmai, Zsófia Nemoda, Zsolt S. Unoka, János M. Réthelyi

“…Our aims were to describe their differences in the above conditions, investigate their associations with childhood traumatization, and to explore the potential mediation of emotion dysregulation and impulsivity between childhood traumas and personality functioning. Methods Young adults between 18 and 36 years diagnosed with aADHD (n = 100) and BPD (n = 63) were investigated with structured clinical interviews, while age-matched healthy controls (n = 100) were screened for psychiatric disorders. …”
Get full text

Evaluation of eight-style Tai chi on cognitive function in patients with cognitive impairment of cerebral small vessel disease: study protocol for a randomised controlled trial by Bin Chen, Hong-Jia Zhao, Hui Liang, Rui Xia, Xiaoyong Zhong, Xinghui Yan

“…At the same time, fMRI and P300 will be measured the structure and function of brain regions related to cognitive function at baseline and 24 weeks after randomisation. …”
Get full text