Exploring the impact of APOE ɛ4 on functional connectivity in Alzheimer’s disease across cognitive impairment levels by Kangli Dong, Wei Liang, Ting Hou, Zhijie Lu, Yixuan Hao, Chenrui Li, Yue Qiu, Nan Kong, Yan Cheng, Yaqi Wen, Wanyin Ma, Wenbin Zheng, Jitian Guan, Yan Lin, Kai Huang, Lu Zhang, Siya Chen, Xiangyuan Ma, Renhua Wu, Naili Wei

“…Studies have shown that APOE ɛ4 mediates the modulation of intrinsic functional brain networks in cognitively normal individuals and significantly disrupts the whole-brain topological structure in AD patients. …”
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A diverse set of solubilized natural fibers drives structure-dependent metabolism and modulation of the human gut microbiota by Maria X. Maldonado-Gomez, Katharine M. Ng, Riley A. Drexler, Alexandria M. S. Conner, Cory G. Vierra, Nithya Krishnakumar, Hannah M. Gerber, Zachary R. Taylor, Jenna L. Treon, Megan Ellis, Jada K. A. Garcia, James P. Cerney, David G. Chapin, Robnet T. Kerns, Angela M. Marcobal, Steven M. Watkins, Matthew J. Amicucci

“…We performed a comprehensive structural characterization and functional evaluation of a unique and highly diverse set of new, highly soluble fibers with varied monosaccharide compositions, glycosidic linkages, and polymer lengths. …”
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Effects of Du Meridian Electroacupuncture Combined with Treadmill Training on Motor Function of Rats with Spinal Cord Injury by CHENG Mei, TIAN Yu, PENG Jing, YU Shuangqi, ZHANG Xuejun, DING Fan

“…Rats with death or BBB motor function scale score>2 were excluded, and finally eight rats were included in each group. …”
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Crystal structures of monomeric BsmI restriction endonuclease reveal coordinated sequential cleavage of two DNA strands by Rémi Sieskind, Sophia Missoury, Clément Madru, Isciane Commenge, Germain Niogret, Marcel Hollenstein, Yannick Rondelez, Ludovic Sauguet, Ahmed Haouz, Pierre Legrand, Marc Delarue

“…This comprehensive structural and functional study lays a foundation for rational enzyme redesign and potential applications in biotechnology.…”
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Development of a Structured Cooking Program for Clients at the Senior Care Centres: A Mix-Method Feasibility Study by Rachel Ng Min Wen, Grace Chua Mei En, Clement Hong, Therese Marie Tay, Tianma Xu

“…Participants demonstrated improvements in physical functions and community mobility immediately after the intervention and at a one-month follow-up. …”
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Effectiveness of a brief behavioural intervention on psychological distress among women with a history of gender-based violence in urban Kenya: A randomised clinical trial. by Richard A Bryant, Alison Schafer, Katie S Dawson, Dorothy Anjuri, Caroline Mulili, Lincoln Ndogoni, Phiona Koyiet, Marit Sijbrandij, Jeannette Ulate, Melissa Harper Shehadeh, Dusan Hadzi-Pavlovic, Mark van Ommeren

“…No adverse events were attributable to the interventions or the trial. Limitations of the study include no long-term follow-up, reliance on self-report rather than structured interview data, and lack of an attention control condition.…”
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Martial Arts and ADHD: A Narrative Review of Cognitive, Behavioral, and Epigenetic Effects by Carola Costanza, Francesco Paolo Colecchia, Rita Polito, Marcellino Monda, Marco Carotenuto, Giovanni Messina, Antonietta Monda, Nicola Mancini, Fiorenzo Moscatelli, Giuditta Bargiacchi, Maria Ruberto

“…The findings indicate that martial arts interventions were associated with improvements in attention, working memory, and inhibitory control, particularly in structured disciplines such as judo and taekwondo. …”
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A quasi-experimental investigation of scapular stabilization exercises on muscle coordination and functional recovery in scapular dyskinesia by Sneha M, Ramana K, Anahas Perianaika Matharasi A

“…Results: Post-intervention analysis showed significant improvements in scapular position and functional performance, with a statistically significant reduction in SPADI scores (p < 0.001). …”
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Prediction of the Functional Result of Surgery for the Full Thickness of the Macular Hole Based on the Analysis of the Safety of Retinal Tissue by E. M. Popov, D. S. Maltsev, A. N. Kulikov

“…To study the relationship between baseline optical coherence tomography (OCT) characteristics of preservation of the neurosensory retina and retinal pigment epithelium (RPE) and functional outcome after full thickness macular hole (FTHM) surgery.Materials and methods. …”
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Functional limitations and coping mechanisms of women aged 60 years and older with self-reported hand osteoarthritis by J. McIntyre, R.W.E. Joubert, S.S. Ramklass

“…Background: Hand osteoarthritis (HOA) is common in older women who seem to cope with the associated limitations in hand function. The importance of identifying coping mechanisms within a local context might have implications for intervention, especially with the introduction of National Health Insurance. …”
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Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report by Bo Liu, Bo Liu, Hui Sun, Hui Sun, Hui Sun, Qiannan Zhao, Qiannan Zhao, Qiannan Zhao, Li Li, Rong Tian, Su Lui, Su Lui, Su Lui, Hongru Zhu

“…Initially, the individual exhibited impaired general cognitive function, as indicated by an IQ score of 80 on the Standard Raven’s Progressive Matrices test, and demonstrated slightly reduced bilateral hippocampal volume compared to the normative reference, as determined through quantitative structural magnetic resonance imaging (qsMRI). …”
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Horticultural therapy impact on people with dementia by Adi Vitman-Schorr, Moran Chen, Ayelet Naveh, Tamar Hirshenzon Peiper, Orly Ganany Dagan

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A prospective study of cognitive impairment in Parkinson’s disease: clinical, neuropsychological, and neuroimaging correlates by Ahmed A. Gaballa, Nabil H. Elagouz, Ahmed E. Sarhan, Ahmed El-adawy

“…Conclusions: Cognitive impairment in PD is associated with advanced age, longer disease duration, metabolic factors, and structural brain changes. These findings suggest the potential for a predictive model to identify early cognitive decline in PD, enabling timely intervention and improved patient outcomes.…”
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Do executive functions and processing speed mediate the relationship between socioeconomic status and educational achievement? Analysis of an observational birth cohort study by Kate E. Mooney, Rachael W. Cheung, Sarah L. Blower, Richard J. Allen, Amanda Waterman

“…Children’s executive functions (including working memory and inhibition) and processing speed abilities may underlie these inequalities, however, the previous literature regarding this is limited. …”
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Relationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers by María Isabel Pastor-Orduña, Federico Palomar-Llatas, David Palomar-Albert, María Teresa Murillo-Llorente, Ignacio Ventura, Francisco Tomás-Aguirre, Marcelino Pérez-Bermejo

“…<i>Conclusions:</i> The study highlights the importance of a comprehensive approach to palliative care that addresses both the local aspects of the lesions and the patient’s systemic and functional status. These findings support the implementation of therapeutic interventions based on a structured perilesional tissue assessment to improve quality of life and prolong survival in terminally ill patients. …”
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A 14-week structured breathing program: an investigation into its impact on psychological health parameters in university students by Alexandru Florian Crișan, Camelia Corina Pescaru, Adelina Maritescu, Vlad Carunta, Emil Robert Stoicescu, Cristian Oancea, Elena Amăricăi, Roxana Ramona Onofrei

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Impact of AI-Powered Adaptive Learning Platforms on English Reading Proficiency: Evidence From Structural Equation Modeling by Jin Wu, Yiyun Wang, Fang Chen, Xueqi Yin, Yun He

“…This study examines the impact and mediating mechanisms of AI-powered adaptive learning platforms on enhancing English reading proficiency. Using structural equation modeling (SEM) on data collected from 118 undergraduate students, this study validates a chained mediation model in which learner engagement mediates the relationship between satisfaction with platform functionalities and perceived learning outcomes. …”
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Assessment of personality disorders in adolescents – a clinical validity and utility study of the structured interview of personality organization (STIPO) by C. Laczkovics, K. Czernin, A. Bründlmayer, M. Zeiler, W. Bangerl, C. Prause, P. L. Plener, S. Doering, V. Blüml, J. Carlitscheck, S. Bender, M. Krischer

“…New guidelines advise semi-structured interviews for the dimensional assessment of personality functioning. …”
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Metabolic and structural changes in lower-limb skeletal muscle following neuromuscular electrical stimulation: a systematic review. by Maurice J H Sillen, Frits M E Franssen, Harry R Gosker, Emiel F M Wouters, Martijn A Spruit

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Substrate-Induced Structural Dynamics and Evolutionary Linkage of Siderophore-Iron ABC Transporters of <i>Mycobacterium tuberculosis</i> by Aisha Farhana, Abdullah Alsrhani, Hasan Ejaz, Muharib Alruwaili, Ayman A. M. Alameen, Emad Manni, Zafar Rasheed, Yusuf Saleem Khan

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