Novel FGF21 analogues through structure-based optimization for therapeutic development by Guo Yiqing, Bao Yuxuan, Chen Zhichao, Rao Zhiheng, Luo Yongde, Ye Sheng, Liu Si

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Effect of Jin's Three-Needle Therapy Combined with Behavioral Intervention on Preschool Children with Mild-to-Moderate Autism Spectrum Disorder by HONG Yu, KANG Jie, GUO Jingmin, LIU Guihua, OU Ping, CHEN Xiaofang, HUANG Longsheng

“…ObjectiveTo explore the clinical efficacy of Jin's three-needle therapy combined with behavioral intervention on core symptoms and anxiety disorder of preschool children with mild-to-moderate autism spectrum disorder (ASD).MethodsA total of 109 preschool children with mild-to-moderate ASD who were treated in the Child Health Center of Fujian Maternity and Child Health Hospital from January 2018 to December 2018, were divided randomly into control group and observation group by the rand function of Excel software, with 55 cases and 54 cases respectively. …”
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Functional outcome measures for distal radius fractures: A systematic review by Briony Norton, Benjamin Bugden, Karen PY Liu

“…Objective: This systematic review aimed to identify and describe the utility of functional outcome measures reported in intervention trials between 2010 and 2020, and to map these measures to the International Classification of Functioning, Disability and Health (ICF) model. …”
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Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model by Ruiqi Zhang, Yu’e Yang, Ruyue Li, Yuan Ma, Shaohan Ma, Xiuxin Chen, Bowei Li, Bei Li, XinYi Qi, Chunfang Ha

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Photobiomodulation improves functional recovery after mild traumatic brain injury by Andrew R. Stevens, Mohammed Hadis, Abhinav Thareja, Freya G. Anderson, Michael R. Milward, Valentina Di Pietro, Antonio Belli, William Palin, David J. Davies, Zubair Ahmed

“…Our results demonstrate that 810 nm PBM optimally improved functional outcomes after mTBI, reduced markers associated with apoptosis and astrocyte/microglial activation, and thus may be useful as a potential regenerative therapy.…”
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More than a chatbot: a practical framework to harness artificial intelligence across key components to boost digital therapeutics quality by Amit Baumel

“…The rapid advancement of Artificial Intelligence (AI)-powered large language models has highlighted the potential of AI-based chatbots to create a new era for digital therapeutics (DTx)—digital behavioral and mental health interventions. However, fully realizing AI-potential requires a clear understanding of how DTx function, what drives their effectiveness, and how AI can be integrated strategically. …”
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The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases by Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida

“…Therefore, it is important to analyze the complex functions of DCs within TLS in order to enhance our fundamental understanding of immune regulation but also as a possible route to create innovative clinical interventions designed for the specific needs of patients with diverse pathological diseases.…”
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Effect of Succinate-Containing Infusion Solution
on Cellular Structures in Children in the Perioperative Period by V. V. Lazarev, K. R. Ermolaeva, V. S. Kochkin, L. E. Tsypin, T. G. Popova, D. V. Nikolaev, A. A. Bologov, N. N. Vaganov

“…Results. 1.5% Reamberin solution was found to contribute to earlier and significant improvement in the function of cellular structures in children in the perioperative period.…”
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Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model by Andrea W. D. Stavenuiter, Karima Farhat, Margot N. Schilte, Piet M. ter Wee, Robert H. J. Beelen

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Platinum-Induced Ototoxicity in Pediatric Cancer Patients: A Comprehensive Approach to Monitoring Strategies, Management Interventions, and Future Directions by Antonio Ruggiero, Alberto Romano, Palma Maurizi, Dario Talloa, Fernando Fuccillo, Stefano Mastrangelo, Giorgio Attinà

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Mechanisms of the impact of exercise intervention on college students' mental health: a longitudinal experimental study using swimming as an example by Wen Wang, Linling Yu, Le Huang, Xing Gao

“…IntroductionWith the growing prevalence of mental health issues among college students, there is a pressing need for effective and accessible intervention strategies. This study explores the potential of swimming as a structured intervention to improve students' emotional well-being, social adaptation, and academic stress management.MethodsA 15-week swimming intervention program was implemented among 44 college students, who were randomly assigned to either an experimental group (swimming intervention) or a control group (no intervention). …”
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The Effect of Nordic Walking Intervention (NORDIN-JOY) on Individuals with Intellectual Disabilities and Their Families: A Multicenter Randomized Crossover Study by Daniel González-Devesa, Carlos Ayán-Pérez, Eva González-Devesa, Jose Carlos Diz-Gómez

“…Additionally, the feasibility and cost-effectiveness of both programs, as well as the average weekly physical activity levels during the six months following the intervention, will be evaluated; Results: The results of this study are anticipated to provide valuable insights into the effects of structured exercise interventions on individuals with intellectual disabilities. …”
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Development of a complex multidisciplinary medication review and deprescribing intervention in primary care for older people living with frailty and polypharmacy. by Eloise Radcliffe, Alejandra Recio Saucedo, Clare Howard, Claire Sheikh, Katherine Bradbury, Paul Rutter, Sue Latter, Mark Lown, Lawrence Brad, Simon D S Fraser, Kinda Ibrahim

“…The intervention's guiding principles were developed and intervention functions proposed, discussed and refined through an iterative process in four online co-design stakeholder workshops.…”
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Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease by Ann Carolin Hausmann, Christian Rubbert, Silja K. Querbach, Vivien Lorena Ivan, Alfons Schnitzler, Christian Johannes Hartmann, Julian Caspers

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Multicomponent Exercise and Functional Fitness: Strategies for Fall Prevention in Aging Women by André Schneider, Luciano Bernardes Leite, José Teixeira, Pedro Forte, Tiago M. Barbosa, António M. Monteiro

“…Future research should explore long-term retention of benefits and optimize intervention strategies. This study highlights the critical role of tailored exercise programs in promoting active aging, improving functional capacity, and reducing healthcare burdens associated with fall-related injuries.…”
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Longitudinal Causal Inference of Cognitive Function and Depressive Symptoms in Elderly People by Ping Yao

“…</p><p> <strong>Discussion</strong>: our results indicate that if intervention to reduce 1 points of depressive symptoms were made at two years prior to assessing cognitive function, they would result in average improvement in cognitive function of 0.12, 95% CI [0.06, 0.18],P&lt;.0001. …”
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Examining the Relationship of Home and Child Care Chaos to Children’s Executive Functions by Figen Eroğlu Ada, Feyza Çorapçı, Elif Aysimi Duman

“…The study discusses these findings in terms of practical applications for intervention programs that aim to support the executive functions of children who are exposed to high levels of environmental chaos.…”
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Structure-based mechanism of RyR channel operation by calcium and magnesium ions. by Alexandra Zahradníková, Jana Pavelková, Miroslav Sabo, Sefer Baday, Ivan Zahradník

“…The proposed mechanism of RyR operation provides a new interpretation of the structural and functional data of mammalian RyR channels on common grounds. …”
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Structural Defects Associated with Craniectomy Induce Neuroinflammation and Blood–Brain Barrier Permeability by Aria W. Tarudji, Brandon Z. McDonald, Evan Curtis, Connor Gee, Forrest M. Kievit

“…While craniectomies are commonly used in TBI research, inadvertent dura disruption can result in structural deficits, impacting cellular function and neurobehavioral outcomes. …”
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Structure and oxygen saturation recovery of sparse photoacoustic microscopy images by deep learning by Shuyan Zhang, Jingtan Li, Lin Shen, Zhonghao Zhao, Minjun Lee, Kun Qian, Naidi Sun, Bin Hu

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