Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ by Jinsai Shang, Douglas J Kojetin

“…Biochemical and NMR data show that covalent inhibitors weaken—but do not prevent—the binding of other ligands via an allosteric mechanism, rather than direct ligand clashing, by shifting the LBD ensemble toward a transcriptionally repressive conformation, which structurally clashes with orthosteric ligand binding. …”
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Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis by Jing Shi, Zhenzhen Feng, Qian Song, Aijia Wen, Tianyu Liu, Liqiao Xu, Zonghang Ye, Simin Xu, Fei Gao, Liuxiang Xiao, Jiapeng Zhu, Kalyan Das, Guoping Zhao, Jie Li, Yu Feng, Wei Lin

“…In the present study, we determine three cryo-EM structures of Mycobacterium tuberculosis (Mtb) PhoP-dependent transcription activation complexes (PhoP-TACs) and build one preliminary cryo-EM structure model of Mtb PhoP-dependent transcription repression complex (PhoP-TRC). …”
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“Top secret. Keep in secret”. Minutes of the previously unknown commission of l. D. Trotsky for the schism of the Russian Orthodox Church (may — october 1922) by Sergei Ivanov

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The Structural Deciphering of the α3 Helix Within ZmHsfA2’S DNA-Binding Domain for the Recognition of Heat Shock Elements in Maize by Yantao Wang, Zhenyu Ma, Guoliang Li, Xiangzhao Meng, Shuonan Duan, Zihui Liu, Min Zhao, Xiulin Guo, Huaning Zhang

“…Heat shock transcription factor (Hsf) plays a pivotal role in regulating plant growth, development, and stress responses. Hsf activates or represses target gene transcription by binding to the heat shock element (HSE) of downstream genes. …”
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Yakut period of service of bishop Sofroniy (Arefiev) by Inna Yurganova

“…The data gathered in this article are supposed to complement and make more precise our information about Bishop Sofroniy (Arefi ev) and, on the whole, the information about archpriests of the Russian Orthodox Church, about victims of political repression in the fi rst half of the 20th century.…”
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Major nuclear locales define nuclear genome organization and function beyond A and B compartments by Omid Gholamalamdari, Tom van Schaik, Yuchuan Wang, Pradeep Kumar, Liguo Zhang, Yang Zhang, Gabriela A Hernandez Gonzalez, Athanasios E Vouzas, Peiyao A Zhao, David M Gilbert, Jian Ma, Bas van Steensel, Andrew S Belmont

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Extensive folding variability between homologous chromosomes in mammalian cells by Ibai Irastorza-Azcarate, Alexander Kukalev, Rieke Kempfer, Christoph J Thieme, Guido Mastrobuoni, Julia Markowski, Gesa Loof, Thomas M Sparks, Emily Brookes, Kedar Nath Natarajan, Stephan Sauer, Amanda G Fisher, Mario Nicodemi, Bing Ren, Roland F Schwarz, Stefan Kempa, Ana Pombo

“…Conditional knockouts of Polycomb enzymatic subunits, Ezh2 or Ring1, show that one-third of ASE genes, including histone genes, is regulated through Polycomb repression. Our work reveals highly distinct 3D folding structures between homologous chromosomes, and highlights their intricate connections with allelic gene expression.…”
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Features of the Party System of the Republic of Equatorial Guinea by GRISHINA Nina Vladimirovna

“…In 1975, the population faced mass repressions, and the state administration as a system almost disappeared. …”
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High-affinity promotor binding of YhaJ mediates a low signal leakage for effective DNT detection by Myeongbin Kim, Ryun Kang, Hye Min Park, Eun Bi Cho, Hye Rim Lee, Seong Eon Ryu

“…Such biosensors would decrease the damage to personnel who approach landmine fields. By the structure determination of the DNA-binding domain (DBD) of YhaJ and the structure-guided mutagenesis, we found that the mutation increasing the DNA binding affinity decreases the signal leakage in the absence of an effector, resulting in a significant enhancement of the response ratio for the DNT metabolite detection. …”
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La reforma de los servicios de salud en México y la dinamización y politización de los intereses: una aproximación Health care reform in Mexico and the dynamics and politicization... by Raquel Abrantes Pêgo

“…The text first looks at the government-engendered power structure that has dominated the health care sector and that has benefited certain social groups, encouraged their development, and incorporated them into its power structures while simultaneously marginalizing or repressing others. …”
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Noncoding function of super enhancer derived Cpox pre-mRNA in modulating neighbouring gene expression and chromatin interactions by Bingning Xie, Ann Dean

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“In the centre and in the regions”. Features of the campaign to confiscate Church valuables, and the organisation of a schism in Turkestan diocese (1922–1923) by Ekaterina Ozmitel

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Transcriptome Analysis Reveals Genes Responsive to Three Low-Temperature Treatments in <i>Arabidopsis thaliana</i> by Bricia Ruiz-Aguilar, Natalia B. Torres-Serrallonga, María Azucena Ortega-Amaro, Arianna Duque-Ortiz, Cesaré Ovando-Vázquez, Juan Francisco Jiménez-Bremont

“…Gene ontology analysis revealed that DEGs highly enriched were found in biological processes such as “RNA secondary structure unwinding” and “rRNA processing” induced at the three low temperatures, whereas processes related to photosynthesis were repressed. …”
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A subset of Polycomb-targeted transcription factor genes become hypermethylated yet upregulated in colorectal cancer by Min-Kyeong Kwon, Goeun Park, Dayoung Go, Donghyun Park, Sridhar Hannenhalli, Sun Shim Choi

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Synthesis and Characterization Al2O3/Novolac/Fiberglass Nanocomposite: Modification of Thermal Stability and Thermal Insulation Properties by Mohsen Rezaei Qazviniha, Farideh Piri

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Terrorism as non-conventional security threat by Zirojević Mina

“…Endeavoring to establish the essence and the basic structural characteristics of the contemporary forms of terrorism the author firstly analyses different attempts to define the phenomenon itself as one of the most significant forms of the non-unconventional security threats. …”
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Impact of acute metal stress in Saccharomyces cerevisiae. by Dagmar Hosiner, Susanne Gerber, Hella Lichtenberg-Fraté, Walter Glaser, Christoph Schüller, Edda Klipp

“…Although considered as essential cofactors for a variety of enzymatic reactions and for important structural and functional roles in cell metabolism, metals at high concentrations are potent toxic pollutants and pose complex biochemical problems for cells. …”
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La manifestation du 13 juin 1849 à Paris, la dernière journée révolutionnaire de la Deuxième République by David Stefanelly

“…But the supporters of a democratic and social Republic were defeated and had to face terrible repression from their conservative adversaries who built « the reduced Republic (June 1849-December 1851) » through a series of structural laws on education and universal suffrage.…”
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E. JUNGER AND THE ASSERTION OF THE NAZI GOVERNMENT: AN INTELLECTUAL'S SURVIVAL STRATEGY DURING THE YEARS OF NAZI DOMINATION. by Artamoshin Sergey Viktorovich

“…As a result of the formation of Hitler's Nazi-conservative coalition cabinet in the German state, the process of structural transformation of the state towards the Fuhrer state, assuming total control and management of the entire life of society, began. …”
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Judges under stress: Legal complexes and a sociology of hope by Terence Halliday

“…Fourth, it argues that evidence on legal complexes can move scholarship on judges under stress from static frameworks of social structures to the dynamics of a sociology of hope where structural resourcefulness and repertoires of action multiple the opportunities for resisting stress. …”
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