Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness by Martina Cacciatore, Francesca Giulia Magnani, Filippo Barbadoro, Camilla Ippoliti, Mario Stanziano, Mario Stanziano, Letizia Clementi, Anna Nigri, Lorenzo Nanetti, Silvia Marino, Fabio La Porta, Lucia Francesca Lucca, Francesco Prada, Francesco Prada, Matilde Leonardi

“…IntroductionConsciousness relies on both cortical and subcortical structures and their feedforward and feedback pathways. …”
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Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning by Zi-hang Li, Shi-pian Li, Shi-pian Li, Ya-hao Li, Yu-cheng Wang, Zhen-yu Tang, Kai-yang Xu, Xiao-rong Li, Zhen Tan, Jiao-yi Pan, Jin-tao Liu, Hong Jiang, Zhi-jia Ma, Yu-xiang Dai, Yu-xiang Dai, Yu-xiang Dai, Peng-fei Yu

“…IntroductionAging is characterized by gradual structural and functional changes in the body over time, with intervertebral disc degeneration (IVDD) representing a key manifestation of spinal aging and a major contributor to low back pain (LBP).MethodsThis study utilized bioinformatics and machine learning approaches to identify aging-related biomarkers associated with IVDD in whole blood samples. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Treatment with insulin is aimed at replicating the function of the pancreas to manage hyperglycaemia and avoid hypoglycaemia. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…A physicochemical, structural, and molecular comparison was conducted with exosomes (EXOs) released from the same batch of cells. …”
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Postbiotics Regulate Intestinal Microbiota and Reduce Amyloid β-Protein Deposition in the Brain, Thereby Ameliorating Cognitive Impairment in Rats with Alzheimer’s Disease by XIAO Ling, TANG Linlin, SONG Xiaoyan, ZHANG Yihua, HAN Xuemei, LÜ Houjiao, LIANG Wu, WANG Yanping, GENG Weitao, JIA Longgang

“…The results showed that all three postbiotics could significantly improve the learning and memory capacities of AD rats, significantly reduce the content of Aβ in hippocampal tissues, and decrease the LPS levels in feces, serum, and hippocampal tissues and the relative mRNA transcription levels of TLR4, NLRP3 and MyD88 in brain tissues. Intervention with the postbiotics regulated the structure and composition of the intestinal microbiota. …”
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Characterization of Load Components in Resistance Training Programs for Kidney Transplant Recipients: A Scoping Review by Jhonatan C. Peña, Lilibeth Sánchez-Guette, Camilo Lombo, Edith Pinto, Carlos Collazos, Blanca Tovar, Diego A. Bonilla, Luis A. Cardozo, Luis Andres Tellez

“…Resistance training (RT) has been shown to produce beneficial effects, including on quality of life, renal function, physical fitness, and survival rates in kidney transplant for 24 recipients. …”
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Landscape Analysis and Assessment of Ecosystem Stability Based on Land Use and Multitemporal Remote Sensing: A Case Study of the Zhungeer Open-Pit Coal Mining Area by Yinli Bi, Tao Liu, Yanru Pei, Xiao Wang, Xinpeng Du

“…Following rehabilitation efforts, the landscape patch density, landscape separation, and landscape fragmentation in the Zhungeer open-pit coal mining area exhibited a declining trend, leading to a more uniform distribution of landscape patches and improved structural balance. By 2020, the adaptability index had risen to 0.35836, achieving 93.69% of the restoration level observed prior to mining operations in 1985, thus indicating an improvement in ecosystem stability and the restoration of ecological functions, although rehabilitation efforts display a temporal lag of 10 to 15 years. …”
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End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…Stroke is one of the leading causes of mortality and morbidity worldwide, and it demands precise diagnostic tools for timely intervention and improved patient outcomes. Neuroimaging data, with their rich structural and functional information, provide a fertile ground for biomarker discovery. …”
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Alpha-1 Antitrypsin as a Regulatory Protease Inhibitor Modulating Inflammation and Shaping the Tumor Microenvironment in Cancer by Siyu Xiang, Liu Yang, Yun He, Feng Ding, Shuangying Qiao, Zonghua Su, Zheng Chen, Aiping Lu, Fangfei Li

“…Therefore, in this review, we have elucidated the pivotal roles of AAT in inflammation and the tumor microenvironment, including the structure and molecular properties of AAT, its molecular functions in the regulation of the inflammatory response and tumor microenvironment, and its clinical implications in cancer including its diagnosis, prognosis, and therapeutic intervention. …”
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Regulation of intestinal flora by Suaeda salsa extract ameliorates hyperglycemia in a mouse model of type 2 diabetes mellitus by Xuemei Yin, Yinzi Sui, Zhengyan Chu, Suqing Han, Xiaodong Ge, Tingting Liu, Feng Zeng, Ligen Chen, Rong Shao, Wei Xu

“…Taken together, these findings demonstrate that SSE can alleviate T2DM and its complications by improving glycemia-related indicators and modulating the structure of intestinal flora.…”
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Correlation between mitral annular plane systolic excursion (MAPSE) at different degrees of ejection fraction in patients with diabetes mellitus by Muhammad Rido, Khalid Saleh, A. Makbul Aman, Syakib Bakri, Haerani Rasyid, Andi Alfian Zainuddin

“…Diabetic cardiomyopathy is characterized by myocardial structure and function abnormality in the absence of other cardiovascular risk factors. …”
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Effectiveness of epidural steroid injections in managing lumbar radicular pain: A prospective study by Bhagat SIngh, Bharath Vadivelkumar, Prem Kumar Kothimbakkam, Vijayashankar Murugesan, Thirumal Ranganathan

“…The study demonstrates meaningful functional improvements and pain relief in the majority of patients, supporting ESIs as a valuable non-surgical intervention in clinical practice.…”
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Individualized transcranial temporal interference stimulation (tTIS) for cognitive impairments and negative symptoms in patients with schizophrenia: a study protocol for a randomiz... by Shuzhe Wang, Junhao Chen, Linxuan Wang, Jingxuan Liu, Lijun Wang, Wenjie Sun, Shen Li, Jie Li

“…We hypothesize that participants receiving active tTIS will demonstrate significantly greater improvements in cognitive function and negative symptoms compared to those receiving sham stimulation. …”
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Genetic variants and molecular profiling of 46,XY gonadal dysgenesis using whole-exome sequencing by Ning Zhang, Ning Zhang, Ning Zhang, Shuoming You, Shuoming You, Jingjing Guo, Jingjing Guo, Xingyu Chang, Xingyu Chang, Junjun Qiu, Junjun Qiu, Keqin Hua, Keqin Hua

“…The variants were confirmed via Sanger sequencing, and detailed functional prediction of the discovered genetic variants was conducted. …”
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Predictors of pain reduction following manual therapy in patients with temporomandibular disorders: a protocol for a prospective observational study by Alison B Rushton, Nicola R Heneghan, Deborah Falla, Giacomo Asquini, Andrea Edoardo Bianchi, Giulia Borromeo, Matteo Locatelli

“…Manual therapy, like other recommended conservative treatments included in clinical guidelines, is commonly used to treat patients with TMD to reduce pain and improve function. However, outcomes may be variable. The aim of this study is to identify predictors associated with pain reduction in patients with TMD following manual therapy by analysing a combination of patient-reported outcome measures and clinical tests. …”
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Experiences and perceptions of employees and healthcare professionals on a multidisciplinary program for the secondary prevention of low back pain by Lisa Bernaers, Tine Marieke Willems, Gia Hien Lam, Morgane Mahy, Dorina Rusu, Christophe Demoulin, Dominique Van de Velde, Lutgart Braeckman

“…Three major themes were identified: functional and work-related outcomes, content-related factors, and duration and continuation. …”
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Conformational Propensities of a DNA Hairpin with a Stem Sequence from the c-MYC Promoter by Arees Garabet, Iztok Prislan, Nataša Poklar Ulrih, James W. Wells, Tigran V. Chalikian

“…The results have implications for the modulation of such transitions as a means of therapeutic intervention.…”
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Assessment of right ventricular endocardial fibroelastosis in fetuses with critical pulmonary stenosis and pulmonary atresia with intact ventricular septum by Yue Wang, Gang Luo, Yi Sun, Taotao Chen, Silin Pan

“…Among the ten patients who underwent fetal cardiac intervention (FCI), the restoration of the TV z-score was more significant in Grade 2 RV EFE fetuses than in Grade 1 EFE fetuses. …”
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Muscle-to-action mapping for intuitive training of muscle synergies in post-stroke upper-limb rehabilitation by Hangil Lee, Jeong-Ho Park, Joon-Ho Shin, Jinsook Roh, Hyung-Soon Park

“…Functional improvements were reflected in the Fugl-Meyer Assessment for the Upper Extremity and Wolf Motor Function Test scores, which increased by 3.36 and 6.45 points, respectively. …”
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Innovative approach to IOL-bag complex fixation with Siepser’s scleral sliding knots in pseudoexfoliation syndrome by Dario Furgiuele, Piera Giunta, Michele Rinaldi, Luca D’Andrea, Ciro Costagliola

“…This novel surgical technique may represent a viable, economic, and durable solution to restore dislocations of IOLs accessible from the anterior chamber that respect the cornea and restores visual function without damaging ocular structures.…”
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