Lactylation-mediated miRNA regulation in cancer therapy resistance by Yiyi Shou, Ruiqi Liu, Hao Xiong, Xiaoyan Chen, Luanluan Huang, Ran Huang, Hailong Sheng, Haibo Zhang, Yanwei Lu, Haiwei Guo

“…Herein, we present a comprehensive and structured assessment of this emerging interdisciplinary field. …”
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Construction of Clinical Predictive Models for Heart Failure Detection Using Six Different Machine Learning Algorithms: Identification of Key Clinical Prognostic Features by Qu FZ, Ding J, An XF, Peng R, He N, Liu S, Jiang X

“…Fang Zhou Qu,1 Jiang Ding,2 Xi Feng An,3 Rui Peng,4 Ni He,5 Sheng Liu,1 Xin Jiang5 1Medical School, Xizang Minzu University, Xianyang, People’s Republic of China; 2Institute of Electrical Power Systems, Graz University of Technology, Graz, Austria; 3The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China; 4Affiliated Nanhua Hospital, University of South China, Hengyang, People’s Republic of China; 5Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, People’s Republic of ChinaCorrespondence: Xin Jiang, Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, Shanxi Province, People’s Republic of China, Email 18560453060@163.comPurpose: Heart failure (HF) is a clinical syndrome in which structural or functional abnormalities of the heart result in impaired ventricular filling or ejection capacity. …”
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Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex by Gisele Eva Bruch, Gisele Eva Bruch, Lidiane Dal Bosco, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, Daniela M. Barros

“…Polyethylene glycol-functionalized single-walled carbon nanotubes (SWCNT-PEG) have been studied for many biomedical applications because of their unique physicochemical properties. …”
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Physical activity and neuroinflammation: a bibliometric analysis of research progress and future perspectives by Yeting Zhang, Huangyan Li, Jiangxi Yang, Huan Ma

“…It provides a systematic scientific basis for scholars to understand the field, optimize research directions, and develop intervention strategies.…”
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Lateral Collateral Ligament Repair With Reconstruction Augmentation by Patrick Szukics DO, Frantz Lerebours MD, Jose Robaina MD, Gautam Yagnik MD, James Ross MD

“…The graft reinforced the repaired structures, enhancing overall knee stability. Discussion/Conclusion: Early surgical intervention for acute LCL injuries with distal avulsions is crucial for restoring knee stability. …”
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Comparative analysis of early outcomes of the first 150 cases of posterior approach robotic‐assisted radical prostatectomy and identification of the learning curve: A single‐surgeo... by Li June Tay, Henry Y. C. Pan, Leigh James Spurling, Philip Dundee

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Effects of Home-Based Pulmonary Rehabilitation on Dyspnea, Exercise Capacity, Quality of Life and Impact of the Disease in COPD Patients: A Systematic Review by Diêgo Mendes Xavier, Endi Lanza Galvão, Alenice Aliane Fonseca, Glaciele Maria de Souza, Vanessa Pereira Lima

“…The objective was to systematically compare a structured program with HBPR or a control group for participants with COPD. …”
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Major depression among pregnant women attending a tertiary teaching hospital in Northern Uganda assessed using DSM-V criteria by Jerom Okot, Henry Ochola, Nozuko P. Blasich, Michael Job Aeku, Pebalo Francis Pebolo, Felix Bongomin, Simple Ouma

“…Data were collected using a validated semi-structured questionnaire. MD was evaluated using DSM-V criteria and was defined as having (1) at least two weeks of either persistent low mood or excessive sadness, (2) plus additional symptoms from the MD diagnostic criterion A, for a total of at least five MD symptoms, and (3) the symptoms caused significant distress or problem and significantly altered behaviour or functionality. …”
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A higher burden of post-stroke depression and anxiety and their predictors among stroke survivors in the Amhara Regional State, Ethiopia, in 2024: a prospective multicenter study by Biruk Lelisa Eticha, Ermias Solomon Yalew, Destaw Marie Merawie, Samuel Teferi Chanie, Kaleb Assegid Demissie, Biruktawit Lelisa Eticha

“…These mental disorders are linked to several modifiable risk factors and lead to severe functional impairment or premature death. There is a lack of evaluation, prevention, and treatment of these prevalent mental illnesses. …”
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Lactiplantibacillus plantarum IOB602 Postbiotic Ameliorates Depression-like Behaviors by Regulating Neuroendocrine Factors and Gut Microbiota in Mice by JING Zhaoxuan, LIANG Peixin, HAN Xuemei, ZHANG Yihua, DENG Langni, JIA Longgang, WANG Yanping, GENG Weitao

“…Analysis of the gut microbiota revealed that postbiotic intervention modulated the structure and composition of the gut microbiota in mice under CUMS, notably increasing the relative abundance of Erysipelotrichaceae and Dubosiella and reducing the relative abundance of Firmicutes and Staphylococcaceae. …”
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Is inspiratory muscle training (IMT) an acceptable treatment option for people with chronic obstructive pulmonary disease (COPD) who have declined pulmonary rehabilitation (PR) and... by Cath O’Connor, Rod Lawson, Judith Waterhouse, Gary H Mills

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A mixed-methods pilot study of domiciliary nasal high-flow therapy for breathlessness in people with chronic obstructive pulmonary disease who do not qualify for domiciliary long-t... by Natasha Smallwood, Amy Pascoe, Catherine Buchan, Aaron K. Wong, David Currow, Brian Le

“…Secondary outcomes: breathlessness (dyspnoea), fatigue, quality of life, physical function, sleep, tolerability and safety. Acceptability was also assessed through semi-structured interviews. …”
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Analysis of Echocardiography Indicators Depending on the Type of Surgical Correction of the Mitral Valve in Patients with Ischemic Heart Disease by Volodymyr S. Moroz, Vasyl V. Lazoryshynets

“…As a result of the study, echocardiographic differences in the structure of the mitral valve were established, which influenced the selection of the intervention volume. …”
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Where there is no nurse: an observational study of large-scale mentoring of auxiliary nurses to improve quality of care during childbirth at primary health centres in India by Swati Srivastava, Krishna D Rao, Nicole Warren, Kaveri Mayra, Aboli Gore, Aritra Das, Saifuddin Ahmed

“…This study examines if a long-term mentoring programme improved the ability of auxiliary nurse-midwives (ANMs), who function as paramedical community health workers, to provide quality care during childbirth, and how they compared with staff nurses.Design Quasi-experimental post-test with matched comparison group.Setting Primary health centres (PHC) in the state of Bihar, India; a total of 239 PHCs surveyed and matched analysis based on 190 (134 intervention and 56 comparison) facilities.Participants Analysis based on 335 ANMs (237 mentored and 98 comparison) and 42 staff nurses (28 mentored and 14 comparison).Intervention Mentoring for a duration of 6–9 months focused on nurses at PHCs to improve the quality of basic emergency obstetric and newborn care.Primary outcome measures Nurse ability to provide correct actions in managing cases of normal delivery, postpartum haemorrhage and neonatal resuscitation assessed using a combination of clinical vignettes and Objective Structured Clinical Examinations.Results Mentoring increased correct actions taken by ANMs to manage normal deliveries by 17.5 (95% CI 14.8 to 20.2), postpartum haemorrhage by 25.9 (95% CI 22.4 to 29.4) and neonatal resuscitation 28.4 (95% CI 23.2 to 33.7) percentage points. …”
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Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats by María Elena Quintanilla, Daniela Santapau, Eugenio Diaz, Ignacio Valenzuela Martinez, Nicolas Medina, Glauben Landskron, Antonia Dominguez, Paola Morales, David Ramírez, Marcela Hermoso, Belén Olivares, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer

“…Among the different protective molecules that could mediate this communication, short chain fatty acids (SCFAs) have emerged as attractive candidates, since these gut microbiota-derived molecules have multi-target effects that could normalize several of the functional and structural parameters altered by chronic alcohol abuse. …”
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The effect of preoperative oral carbohydrate administration on postoperative glucometabolic response, subjective well being and quality of life in patients undergoing colorectal su... by Murat Urkan, Cemile Celebi, Ulvi Mehmet Meral, Ikbal Cavdar

“…Postoperative albumin levels were significantly higher and CRP levels significantly lower in the intervention group at 24 h. The SF-36 physical functioning score was significantly higher in the intervention group compared to the control group (82.00 ± 11.81 vs 61.40 ± 16.17, p < 0.001). …”
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Strategies to Optimize Management of Outpatient Worsening Heart Failure: A National Consensus from India by Sandeep Seth, Vijay Kumar Chopra, Raja Ram Mantri, Sunil K. Modi, Sanjay Mittal, Jayagopal Pathiyil Balagopalan, Vinayak Aggarwal, Rajiv Mehrotra, Sundeep Mishra, B. S. Vivek, Sanjiv Aggarwal, B. C. Kalmath, Harmanpreet Singh, Ajay Mahajan, Preeti Gupta, Anwar Ansari, Suvro Banerjee, Samir Kubba, Pravin Kahale, Arvind Das, Sanjeeva Gupta, Biju Govind, Prashant Mishra, Mukesh Goel, Vishal Rastogi, S. N. Pathak, Kamal Sharma, Amit Sharma, K. V. Srikanth, M Kathiresan, Dilip Kumar, Vivek Mahajan, Vikas Kumar, Roshan Kumar, Mohit Bhagwati, Kapil Mehta, Ankit Bansal, Hemant Khemani, Johan Christopher, Gajendra Goyal, Rituparna Baruah, Arindam Pande

“…Outpatient (OP) management of WHF offers an alternative to hospitalization, as many patients experience a gradual onset of symptoms, allowing timely intervention. However, OP WHF is often underrecognized and excluded from clinical trials, highlighting the need for structured guidance. …”
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AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel disease by Liying Lu, Keying Xu, Huiheng Qu, Lele Song, Yanan Song, Yanjun Wu, Xia Sun, Jingwen Kong, Qian Wen, Jiazheng Jiao, Zhanju Liu, Jiazeng Xia, Lixing Zhan

“…Some polar proteins have been reported to perform functions other than maintaining cell structure. In this study, we reported that the polar protein AF6 expressed by intestinal epithelial cells (IEC) can regulate the expression of MHCII in epithelial cells, thus affecting the cross dialogue between IECs and immune cells, and promoting the secretion of IgA by B cells to play a protective function. …”
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MODULATION AS A MULTIMODAL TRANSLATION STRATEGY OF GRAPHIC NOVEL PERSEPOLIS BY M. SATRAPI by Anna V. Khodorenko

“…It shows that these techniques function within the broader framework of the modulation strategy, facilitating the pragmatic adaptation of the original text. …”
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Human placental mesenchymal stem cells ameliorates premature ovarian insufficiency via modulating gut microbiota and suppressing the inflammation in rats. by Shudan Liu, Ting Wang, Yuanyuan Liu, Yiwei Li, Junbai Ma, Qikuan Hu, Hao Wang, Xiaoxia Zhang

“…Then, we evaluated the effects of PMSC intervention on POI rats: Compared to the untreated MOD group, the estrous cycle of rats in the PMSC group gradually became regular, the ovarian weight and ovarian index were significantly increased, and the ovarian tissue structure was improved by showing an increase in the number of follicles and a decrease in the number of atretic follicles. …”
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