Effectiveness of hand-arm bimanual intensive therapy including lower extremities in the rehabilitation of children with cerebral palsy: a systematic review protocol by Daniela Ebner-Karestinos, Rodrigo Araneda, Asfarina Zanudin, Ya-Lan Qu, Dzalani Harun, Siaw Chui Chai

“…The objective of this study is to systematically review the effectiveness of HABIT-ILE on upper extremity, lower extremity and trunk outcomes within the domains of body functions and structures, activity and participation of the International Classification of Functioning, Disability and Health in children with CP.Methods and analysis This study will be conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. …”
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Exercises Based on a Non-Immersive Virtual Reality Application for Upper Limb Rehabilitation by Cosmin-Ilie Cotia, Silviu Dan Mandru

“…In this study, we report on the development and preliminary evaluation of a VR-based rehabilitation application aimed at improving upper extremity function, including muscle strength, endurance, and joint mobility. …”
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Contribution of health system governance in delivering primary health care services for universal health coverage: A scoping review. by Resham B Khatri, Aklilu Endalamaw, Daniel Erku, Eskinder Wolka, Frehiwot Nigatu, Anteneh Zewdie, Yibeltal Assefa

“…<h4>Background</h4>The implementation of the primary health care (PHC) approach requires essential health system inputs, including structures, policies, programs, organization, and governance. …”
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“They knew how to take care of people”: a qualitative study on older adults with chronic low back pain perspectives of an exercise plus education program by Fabianna Resende de Jesus-Moraleida, Ana Carla Lima Nunes, Crislaine Silva Costa, Lara Figueiredo Vasconcelos, Nathalia Costa

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Non-clinical factors influencing discharge and admission decisions in the emergency department: a focus group study among Israeli physicians by Ofer Kobo, Itay Itzhaki, Michael J. Drescher, Jacob Glazer, Avi Israeli, Bruce E. Landon, Shuli Brammli-Greenberg

“…Physicians often weighed these elements alongside clinical indications for admission, particularly in borderline cases. Functional status and family support frequently influenced safe discharge decisions. …”
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Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer by Weiyu Su, Weiwen Wang, Guanghui Zhang, Lianhe Yang

“…This review aims to succinctly delineate the composition, structure, function, and expression of CBXs within tumour cells, with an emphasis on synthesizing and deliberating the CBXs-mediated activation of intracellular signalling pathways and the intricate mechanisms governing tumourigenesis and progression. …”
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Designing Gamified Intergenerational Reverse Mentorship Based on Cognitive Aging Theory by Sijie Sun

“…Based on Cognitive Aging Theory, this study proposes and validates an original paradigm called Structured Gamified Intergenerational Digital Reverse Mentorship to enhance digital literacy among the elderly. …”
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Separable sustained and selective attention factors are apparent in 5-year-old children. by Mette Underbjerg, Melanie S George, Poul Thorsen, Ulrik S Kesmodel, Erik L Mortensen, Tom Manly

“…The results are discussed in light of contemporary models of attention function. Given the potential advantages of early intervention for attention difficulties, the findings are of clinical as well as theoretical interest.…”
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The molecular etiology and treatment of glucocorticoid-induced osteoporosis by Cheng-Huan Peng, Wen-Ying Lin, Kuang-Ting Yeh, Ing-Ho Chen, Wen-Tien Wu, Ming-Der Lin

“…When bone formation and resorption are out of balance, abnormalities in bone structure or function may occur. Excess glucocorticoids disrupt the bone homeostasis by promoting osteoclast formation and prolonging osteoclasts' lifespan, leading to an increase in bone resorption. …”
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Impact of wearable-assisted walking on sarcopenia and body composition in older adults by Cheng-En Wu, Yankuba B. Manga

“…Methods Eighty healthy older adults (40 men and 40 women), aged 65 and above, were randomly assigned to either an intervention (experimental) group, which participated in a structured walking program utilizing wearable devices, or a non-intervention (control) group, which maintained their habitual activities. …”
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Segmentation of focal liver lesions and virtual resection based on computed tomography data by P. M. Zelter, A. V. Kolsanov, Yu. S. Pyshkina

“…The obtained results indicate that the use of the ‘Autoplan’ system plugins for planning an abdominal surgery allows doctors: 1) to carry out the segmentation of liver, focal lesions and blood vessels; 2) to determine the location of a focal formation in a particular segment, their combination; 3) to perform a virtual resection, evaluate the structures passing through it; 4) to choose the optimal tactics of intervention or  abandon it due to objective anatomical reasons.…”
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Modulatory effects of Lactiplantibacillus plantarum MA2 and its postbiotic on the adenine-induced chronic kidney disease by Weitao Geng, Dehua Wang, Jiangye He, Xinyuan Li, Longgang Jia, Yanping Wang

“…Chronic kidney disease (CKD) is one kind of illness with abnormal renal structure and function caused by many factors. Probiotics can be used to regulate intestinal microflora and enhance intestinal mucosal barrier, thus, intervention with probiotics may be regarded as one of the potential ways to protect against CKD. …”
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Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome by Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor, Raúl F. Pérez, Alfonso Peñarroya, Pablo Santamarina-Ojeda, Annalisa Roberti, Jennifer M. Kefauver, Carlota Álvarez-Díaz, Mar Rodríguez-Santamaría, José Luis Trejo, Laureano Tomás-Daza, Llorenç Rovirosa, Biola M. Javierre, Agustín F. Fernández, Mario F. Fraga

“…These findings reveal a dynamic behavior of the neuronal 3D chromatin structure over time, which can be modulated by external interventions.…”
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Volatile Organic Compounds in Biological Matrices as a Sensitive Weapon in Cancer Diagnosis by Arya Ghosh, Varnita Karmakar, Anroop B. Nair, Shery Jacob, Pottathil Shinu, Bandar Aldhubiab, Rashed M. Almuqbil, Bapi Gorain

“…This review provides an in-depth exploration of the structural, functional, and signaling mechanisms underlying odorant sensitivities and chemical odor detection in the excretory products of cancer patients, addressing current challenges in VOC-based cancer diagnostics and innovative strategies for advancement while also envisioning the transformative role of artificial olfactory systems in the future of cancer detection. …”
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Modeling Stromal Cells Inside the Tumor Microenvironment of Ovarian Cancer: In Vitro Generation of Cancer‐Associated Fibroblast‐Like Cells and Their Impact in a 3D Model by Jacopo Romoli, Paola Chiodelli, Patrizia Bonassi Signoroni, Elsa Vertua, Clarissa Ferrari, Elisabetta Giuzzi, Alice Paini, Elisa Scalvini, Andrea Papait, Francesca Romana Stefani, Antonietta Rosa Silini, Ornella Parolini

“…Notably, we observed the ability of CAF‐like cells to shape the intratumoral architecture and to contribute to functional changes in tumor cell behavior. This study highlights the importance of precise assessment of CAF for potential therapeutic interventions and further provides a reliable model for investigating novel therapeutic targets in OC.…”
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Remote Monitoring System of Patient Status in Social IoT Environments Using Amazon Web Services Technologies and Smart Health Care by Amer Tahseen Abu-Jassar, Hani Attar, Ayman Amer, Vyacheslav Lyashenko, Vladyslave Yevsieiev, Ahmed Solyman

“…Based on the proposed concept, the authors created a structural diagram of the experimental RPMS and its built prototype. …”
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A comprehensive and systematic review on resveratrol supplementation as a promising candidate for the retinal disease: a focus on mechanisms of action from preclinical studies by Xiao-Min Lv, Na Li, Lin-Wei Chen, Cheng Sun

“…These mechanisms resulted in enhanced amplitude of A/B waves, improved retinal thickness and visual function.ConclusionResveratrol has neuroprotective, anti-inflammatory and antioxidant effects through multiple mechanisms, thereby reducing retinal damage and maintaining the structure and function of the retina. …”
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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…We discuss the weight loss effects of diet-based interventions and healthy lifestyles for the treatment of NAFLD patients, highlighting their impact on the restoration of the intestinal barrier and GM structure. …”
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Does model type influence the effectiveness of combined action observation and motor imagery training for novices learning an Ankle Pick takedown? by Samantha Chye, Ashika Chembila Valappil, Ryan Knight, Andrew Greene, David Shearer, Cornelia Frank, Ceri Diss, Adam Bruton, Adam Bruton

“…Both the AOMIOTHER and Control conditions led to improved functional changes in mental representation structures while the structures for the AOMISELF condition became less similar to the reference structure over time.DiscussionCollectively, the largely null findings (n = 13, 92.86%) suggest that physical practice has the strongest influence on motor adaptations for this complex motor skill at these early stages of learning. …”
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Identifying Priority Areas for Planning Urban Green Infrastructure: A Fuzzy Artificial Intelligence-Based Framework by Leonardo Massato Nicacio Nomura, Adriano Bressane, Vitoria Valente Monteiro, Inara Vilas Boas de Oliveira, Graziele Ruas, Rogério Galante Negri, Alexandre Marco da Silva

“…The system’s modular structure, use of triangular membership functions, and incorporation of the gamma operator allow for adaptable prioritization across different planning horizons. …”
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