Diminished AdipoR1/APPL1 Interaction Mediates Reduced Cardioprotective Actions of Adiponectin against Myocardial Ischemia/Reperfusion Injury in Type-2 Diabetic Mice by Chao Ren, Wei Yi, Bo Jiang, Erhe Gao, Jiali Liang, Bo Zhang, Zhe Yang, Dezhi Zheng, Yong Zhang

“…APPL1 is a signaling protein with multiple functional structural domains and plays an important role in the APN signaling pathway. …”
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Patient acceptability of intravitreal complement inhibitors in geographic atrophy (GA): protocol for a UK-based cross-sectional study by David P Crabb, Deanna J Taylor, Christiana Dinah, Mandeep Sekhon, Jamie Enoch, Arevik Ghulakhszian

“…The correlation between acceptability and functional and structural biomarkers of GA will be established. …”
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Predicting depression in healthy young adults: A machine learning approach using longitudinal neuroimaging data by Ailing Zhang, Haobo Zhang

“…This study aimed to develop predictive models for depression in young adults using machine learning (ML) techniques and longitudinal data from the Beck Depression Inventory, structural MRI (sMRI), and resting-state functional MRI (rs-fMRI). …”
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Physiological Mechanisms Driving Microcirculatory Enhancement: the Impact of Physical Activity by Jianyu Li, Guochun Liu, Dong Zhang, Keying Zhang, Chunmei Cao

“…Physical activity also ameliorates inflammation markers and oxidative stress levels, upregulates the expression of silent information regulator 2 homolog 3, genes for hypoxia-inducible factors under hypoxic conditions, and induces favorable changes in multiple hemodynamic and hemorheological parameters. These structural and functional adaptations optimize myocardial blood flow regulation during exercise and improve both oxygen transport and utilization capacity, which are beneficial for the rehabilitation of chronic disease patients. …”
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Artificial intelligence Defect Detection Robustness inReal-time Non-Destructive Testing of Metal Surfaces by Chaoyu Dong, Jovian Sanjaya Putra, Andrew A. Malcolm

“…Metal surfaces play a critical role in a wide range of industries. Their structural integrity, durability, and functionality depend heavily on their quality, making surface inspection a vital process. …”
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An Unusual Congenital Heart Disease: Giant Left Atrial Appendage by Julio C. Sauza-Sosa, Erika L. De la Cruz-Reyna, Carlos N. Velazquez-Gutierrez

“…Cardiac magnetic resonance corroborated the huge left atrial appendage (Figure 1B). No other structural or functional heart abnormalities were diagnosed. …”
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RETROSPECTIVE ANALYSIS OF IMPLANT USAGE IN THE TREATMENT OF PATIENTS WITH DENTAL ARCH DEFECTS by V.M. Luchynskyi

“…Prospects for further research include the investigation of the structural and functional condition of the jaws to develop more effective therapeutic approaches to dental implantation. …”
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Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease: Innovative therapies and their translation by Shimin Pang, Zhili Ren, Hui Ding, Piu Chan

“…We identify key processes, including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids. Importantly, structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormal α-synuclein expression and gastrointestinal dysmotility, which could serve as an initiating event in Parkinson’s disease. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Multimodal magnetic resonance imaging (MRI) was acquired for each participant at baseline (before TMS treatment) with T1-weighted (structural MRI) and resting state (task-free) functional MRI (rsfMRI). …”
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Chronic Persistent Asthma: A Review of Medicines in the Step-Up Approach by Elvis Irusen

“…We now have extensive insights into their structure, regulation, receptors and mechanisms of action. …”
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A scoping review on exercise prescription in hemophilia: A pathway for enhanced mobility and reduced bleeding risk by Abhishek Sharma, Aksh Chahal, Richa Hirendra Rai, Bartosz Maciej Wójcik, Nidhi Sharma

“…Exercise has emerged as a therapeutic intervention to enhance physical capacity and minimize bleeding risks among individuals with hemophilia. …”
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The relationship between symptoms of gender dysphoria and social anxiety in transgender young adults: a network analysis by Jiaqi Li, Yi Feng, Wenbang Niu, Shicun Xu, Yajun Bu, Yuanyuan Wang

“…In transgender women’s network structure, “Distressing bodily functions” was positively connected to “Hard time working,” while it was positively linked to “Nervous speaking” in that of the non-binary group. …”
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Algorithms of optimization and standardization of surgical care in destructive forms of Charcott foot by K. A. Koreyba, E. P. Krivoshchekov, N. A. Lysov, L. N. Gatina, P. S. Lukin

“…The developed approach to the reconstruction of bone elements of the foot ensures an increase in the efficiency of regenerative processes of bone structures. 2. The introduction of this technique significantly reduces the rehabilitation period for patients with restoration of the supporting function of the lower extremities due to targeted surgical intervention in the area of affected tissues.…”
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Leverage, entrenched managers, and moderating effect of main shareholder’s influence by Bruno José Canassa, Lucas Allan Diniz Schwarz, Maurício Ribeiro do Valle

“…ABSTRACT This study associated the leverage of Brazilian listed companies with their managers’ search for protection against the risk of main shareholder’s intervention. Although the literature has pointed out that managers might increase leverage in order to protect themselves against takeovers, it had not yet investigated the use of debt as a defense against the risk of intervention by the company’s main shareholder. …”
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Holistic Education for a Resilient Future: An Integrated Biomimetic Approach for Architectural Pedagogy by Lidia Badarnah

“…Bloom’s Taxonomy provides a scaffold for learning progression, while the Function–Structure–Behavior (FSB) schema enhances the establishment of cross-disciplinary bridges to enable students to address complex design challenges. …”
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The impact of maximal oxygen uptake (VO₂max) on athletic performance and health - a review by Julia Charkot, Wojciech Bieńkowski, bartlomiej kusy, Michał Bieńkowski, Mikołaj Charkot, Piotr Kucharczyk, Irmina Jaszczuk, Patrycja Retman

“… Introduction and purpose: Maximal oxygen uptake (VO₂max) is a key indicator of aerobic capacity, widely used in sports science and clinical diagnostics. It reflects the functional efficiency of the cardiovascular, respiratory, and muscular systems. …”
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Aflatoxin Exposure-Caused Male Reproductive Toxicity: Molecular Mechanisms, Detoxification, and Future Directions by Dongyun Ye, Zhihui Hao, Shusheng Tang, Tony Velkov, Chongshan Dai

“…Exposure to AFB₁ can disrupt the structure and functionality of reproductive organs, leading to gametogenesis impairment in males, subsequently reducing fertility. …”
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Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis by Michael Vincent DiCaro, Brianna Yee, KaChon Lei, Kavita Batra, Buddhadeb Dawn

“…The findings of this systematic review and meta-analysis may shed light on the efficacy of MSC therapy in improving cardiac functional and structural parameters and reducing adverse cardiac events following acute MI. …”
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Mechanism of Electroacupuncture at Baihui and Shenting Alleviating Cerebral Ischemia-reperfusion Injury via Regulating BNIP3L-Mediated Mitophagy by ZHONG Xiaoyong, LI Cheng, WANG Fang, CHEN Bin, LIANG Hui, RUAN Su

“…However, the neurological scores of rats in the electroacupuncture group reduced after electroacupuncture intervention, which was significantly different from the model group and electroacupuncture+3-MA group (<italic>P</italic>&lt;0.05). 2) The results of HE staining showed that the cell body of neurons in the sham operation group was large, polygonal (multiple protrusions), the nucleus was lightly colored, and the characteristic structure of Nissl body could be seen in the cytoplasm. …”
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Impact of cardiac rehabilitation on anxiety, depression, and health-related quality of life in cardiovascular patients by Estrella García-Sánchez, Mirian Santamaría-Peláez, Jerónimo J. González-Bernal, Josefa González-Santos, María Azucena Sedano García, Inmaculada De Juana Velasco, Jesús Sánchez Hernández, Héctor García Pardo, Jessica Fernández-Solana

“…Baseline anxiety and depression levels influenced changes in specific health-related quality of life dimensions, such as social functioning and role limitations due to physical health (p < 0.05). …”
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