Modern approaches to treating drug-resistant epilepsy - ketogenic diet, innovative drugs and neurosurgery by Robert Rzenno, Monika Brzozowska, Wiktoria Wardal, Natalia Furlepa, Karolina Wojciechowska, Marcelina Matuszewska, Katarzyna Wicha, Natalia Sidz, Magdalena Tomaszewska, Wiktoria Jedlikowska

“…Diagnostic procedures currently involve electroencephalography (EEG) to assess brain activity, along with advanced imaging techniques like MRI and CT scans to detect any structural abnormalities. Available treatments encompass a range of drug therapies, surgical options, neurostimulation, and dietary interventions.   …”
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Experiences of support to return to work after stroke: longitudinal case studies from RETAKE trial by Diane Trusson, Katie Powers, Kathryn Radford, Audrey Bowen, Kristelle Craven, Jain Holmes, Rebecca Lindley, Christopher McKevitt, Julie Phillips, Ellen Thompson, Caroline Watkins, David J Clarke

“…Objectives This article aims to understand participants’ experiences of being supported to return to work and explores the social and structural factors which support, or act as barriers to, implementation of the Early Stroke Specialist Vocational Rehabilitation intervention. …”
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Socioeconomic status and lifestyle as factors of multimorbidity among older adults in China: results from the China Health and Retirement Longitudinal Survey by Wei Gong, Wei Gong, Wei Gong, Xiaoxiao Hu, Huimin Cui, Huimin Cui, Yuxin Zhao, Yuxin Zhao, Hong Lin, Hong Lin, Hong Lin, Peng Sun, Peng Sun, Jianjun Yang, Jianjun Yang

“…Subgroup analyses showed variated associations by age and sex, with psychological and geographic factors playing a larger role among those aged ≥80.ConclusionThis study demonstrated the feasibility and interpretability of using machine learning to model complex risk patterns of multimorbidity. Socioeconomic and functional variables were dominant factors associated with multimorbidity, suggesting structural roots of health inequality. …”
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Advances in development of antiviral strategies against respiratory syncytial virus by Ge Yang, Guangyu Jiang, Jiandong Jiang, Yuhuan Li

“…In recent years, substantial progress has been made in understanding the structure and function of RSV proteins and the interactions between RSV with host factors which is helpful to the discovery of new therapeutic targets and the development of novel interventions. …”
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Investigation of Tongqiao Huashuan Granules’ effect on hippocampal neuron autophagy in vascular dementia rats via the PI3K/Akt-mTOR signaling pathway using network pharmacology and... by Xiaoqu Jiang, Shuyao Yu, Shuaifeng Yao, Sikai Wang, Jing Cai, Zhongsheng Tang, Shijie Zhu

“…The Gene Ontology (GO) functional enrichment analysis yielded a total of 569 items (BP: 366, CC: 97, MF: 106). …”
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ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit by Anaïs Lamy, Ewerton Macarini-Bruzaferro, Thibaud Dieudonné, Alex Perálvarez-Marín, Guillaume Lenoir, Cédric Montigny, Marc le Maire, José Luis Vázquez-Ibar

“…In this work, we have used a recombinantly-produced P. chabaudi ATP2 (PcATP2), to gain insights into the function and structural organization of this essential transporter. …”
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Exercise Promotes Neuroplasticity in Both Healthy and Depressed Brains: An fMRI Pilot Study by Joanne Gourgouvelis, Paul Yielder, Bernadette Murphy

“…Exercise as an ad-on treatment for MDD is a promising therapeutic strategy shown to improve mood, cognitive function, and neural structure and function. To advance our understanding of how exercise impacts neural function in MDD, we must also understand how exercise impacts healthy individuals without MDD. …”
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Lower RXRA and TFRC expression despite higher mineral and vitamin intake in diabetic pregnant women with pregnancy-specific urinary incontinence by Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, Matheus Naia Fioretto, João Paulo de Castro Marcondes, Igor de Carvalho Deprá, Camila Renata Corrêa, Danielle Cristina Honorio França, David Rafael Abreu Reyes, Sérgio Luis Felisbino, Angélica Mércia Pascon Barbosa, Marilza Cunha Vieira Rudge, M.V.C. Rudge, A.M.P. Barbosa, I.M.P. Calderon, F.P. Souza, T. Lehana, C.F.O. Graeff, C.G. Magalhães, R.A.A. Costa, S.A.M. Lima, M.R.K. Rodrigues, S.L. Felisbino, W.F. Barbosa, F.J. Campos, G. Bossolan, J.E. Corrente, H.R.C. Nunes, J.F. Abbade, P.S. Rossignoli, C.R. Pedroni, Á.N. Atallah, Z.I. Jármy-Di Bella, S.M.M. Uchôa, M.A.H. Duarte, E.A. Mareco, M.E. Sakalem, N.M. Martinho, D.G. Bussaneli, M.I.G. Orlandi, C. Pascon, T.D. Dangió, C.V.C. Rudge, F. Piculo, G.M. Prata, R.E. Avramidis, C.N.F. Carvalho, A.B.M. Magyori, G.T.A. Nava, T.C.D. Caldeirão, R.H.L. Shetty, D.R.A. Reyes, F.C.B. Alves, J.P.C. Marcondes, M.L.S. Takemoto, C.B. Prudencio, F.A. Pinheiro, C.I. Sartorao Filho, S.B.C.V. Quiroz, T. Pascon, S.K. Nunes, B.B. Catinelli, F.V.D.S. Reis, R.G. Oliveira, S.M.B. Costa, M.O. Menezes, N.J. Santos, E.M.A. Enriquez, L. Takano, A.M. Carr, G.A. Garcia, L.F. Iamundo, H.C.M. Bassin, V.P. Barbosa, M. Jacomin, A.J.B. Silva, I.O. Lourenço, J. Marostica de Sá, I.P. Caruso, L.T. Rasmussen, V.K.C. Nogueira, J.T. Ribeiro-Paes, D.C.H. França, H.V.M. Bastos, M.L.A. Heliodoro, M.N. Kuroda, H.L. Carvalho

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What is the pathophysiology of inflammation-induced cortical injury in the perinatal brain? by Sharmony B. Kelly, Alistair J. Gunn, Rodney W. Hunt, Robert Galinsky

“…These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period, leading, in the long term, to impaired neurodevelopment. …”
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Advancing Medical Catheter Navigation: Design, Optimization, and Control of a Magnetic Tractor Beam (MTB) Handheld Device by Chayabhan Limpabandhu, Zion Tsz Ho Tse

“…The progress of medical procedures towards minimally invasive techniques has led to notable advancements in medical device engineering, particularly in the navigation and control of catheters within complex anatomical structures. This study introduces a novel handheld device using the Magnetic Tractor Beam (MTB) that aims to improve the accuracy and safety of catheter navigation during lung interventions. …”
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Effectiveness of Core Stability and Balance Training on Postural Control in Children with Down Syndrome: A Narrative Review by Bryan V. Catama, Dorothy D. Silva, Marlon Y. Palbusa

“…Future research should explore structured, hybrid interventions that maximize postural improvements and functional mobility for children with DS. …”
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Multimodal physical therapy approach for the management of patients with temporomandibular disorder: Randomized control trial by Ramesh Chandra Patra, Biswajit Kanungo, A. Yashudas, Patitapaban Mohanty, Gurleen Kaur

“…Conclusions: Findings suggest that a multimodal treatment of cranio-mandibular stabilisation and structured manual therapy significantly decreases pain and improves mechanical tenderness and active mouth function in TMD patients. …”
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The involvement of the synaptic vesicle cycle in homocysteine induced neurotoxicity in vitro and in vivo by Meng Wang, Xiaoshan Liang, Keqing Jin, Yinyue Liu, Suhui Luo, Qiang Zhang, Xuan Wang, Zhiping Dong, Xumei zhang

“…Moreover, synaptic structural impairment was observed within the hippocampal. …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. …”
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Potential hepatoprotective role of Amphora coffeaeformis algae against diazinon-induced hepatotoxicity in adult Sprague–Dawley rats by Hager Ali Fathy, Sahar Hassan Orabi, Ahmed Farag Elkirdasy, Eman Mohamed Abd El Fattah, Reda M. S. Korany, Hanem Kamal Khalifa, Mohamed Mohamed Ahmed

“…The hepatoprotective effects were assessed through serum liver and kidney function biomarkers, hepatic oxidative stress markers, and histopathological and immunohistochemical analyses of liver tissue. …”
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Alterations in ganglion cell and nerve fiber layer in Leber hereditary optic neuropathy across clinical stages by Michael Oeverhaus, Mareile Knetsch, Ying Chen, Leyla Jabbarli, Carmen Nolden, Anja Eckstein, Nikolaos E. Bechrakis, Philipp Rating

“…As the condition progresses, there is a decline in visual function, accompanied by noticeable structural alterations. …”
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Selenium and Coenzyme Q₁₀ Supplementation and Sex Differences in Cardiovascular Mortality Results from a Prospective Randomized Double-Blind Placebo-Controlled Trial in... by Urban Alehagen, Jan Olav Aaseth, Lutz Schomburg, Trine B. Opstad, Anders Larsson, Jan Alexander

“…The higher prevalence of structural CVD and smoking in males may have contributed to the observed greater supplementation benefits in females. …”
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A patient-centered qualitative evaluation of meaningful change on the NSAA and PUL in Duchenne Muscular Dystrophy by Aviva Gillman, Teofil Ciobanu, Louise Barrett, Evan W. Davies, Alexander P. Murphy, Alex Johnson, Jessica Mills, Phoebe Heinrich, Krystian Przydzial, Bethany Ewens, Gerrit Vandenberg, Stefan Cano, Anna Mayhew

“…The aim of this study is to understand meaningful change in functional abilities as measured by the NSAA and PUL at different ability levels from the perspective of individuals with DMD, caregivers of individuals with DMD, and clinicians.MethodsThe study utilized a non-interventional, descriptive, cross-sectional qualitative design consisting of 69 semi-structured interviews, including individuals with DMD (n = 18), caregivers of individuals with DMD (n = 51), and neuromuscular physiotherapists (n = 2) to understand meaningful change on the NSAA and PUL.ResultsThe results for both instruments indicated that: (i) items that are meaningful differ based on ability level; (ii) maintaining function in lower and upper limbs is the ultimate goal; (iii) meaningful change is often reported in relation to gain or loss of specific function, as opposed to number of total points on the scale; and (iv) losing one scale point corresponds to either a partial or full loss in function and activity, which has differing impacts on daily life.ConclusionThe perception of meaningful change in DMD as measured by the NSAA is influenced by ability levels and ambulatory function, with participants describing their need to maximize certain abilities, maintain function, and retain independence. …”
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Enhanced analysis of the genomic diversity of Mycobacterium bovis in Great Britain to aid control of bovine tuberculosis by Prizam Sandhu, Javier Nunez-Garcia, Stefan Berg, Jo Wheeler, James Dale, Paul Upton, Jane Gibbens, R. Glyn Hewinson, Sara H. Downs, Richard J. Ellis, Eleftheria Palkopoulou

“…The predicted function and associated processes of the genes harbouring these SNPs are discussed with potential implications for phenotypic/functional differences between the identified clades. …”
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Post‐Translational Modifications in Cilia and Ciliopathies by Jie Ran, Jun Zhou

“…In addition, accumulating evidence has shown that PTMs are essential for modulating ciliary structure and function, and that dysregulation of these modifications leads to the development of ciliopathies. …”
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