Perinatal SSRI exposure impacts innate fear circuit activation and behavior in mice and humans by Giulia Zanni, Milenna T. van Dijk, Martha Caffrey Cagliostro, Pradyumna Sepulveda, Nicolò Pini, Ariel L. Rose, Alexander L. Kesin, Claudia Lugo-Candelas, Priscila Dib Goncalves, Alexandra S. MacKay, Kiyohito Iigaya, Praveen Kulkarni, Craig F. Ferris, Myrna M. Weissman, Ardesheer Talati, Mark S. Ansorge, Jay A. Gingrich

“…In mice and humans, early-life SSRI exposure alters the offspring’s brain structure and is associated with anxiety and depression-related behaviors beginning in puberty. …”
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The Effectiveness of Computerized Cognitive Training in Patients With Poststroke Cognitive Impairment: Systematic Review and Meta-Analysis by Min Gao, Lu Huang, Jiang Yi, Tianqi Zhang, Guangyao Zhu, Qi Zhang, Jiaxiao Tian, Rongxuan Zhao, Xiaoqin Duan, Zhongliang Liu

“…This review demonstrates CCT's effectiveness on cognitive function in patients with PSCI, though results vary due to differing intervention programs and CCT systems. …”
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A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development by Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu, Yuwen Ke

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Gaining insights into pet owner understanding/lived experience of canine chronic kidney disease using survey and social media data by Georgina Tarrant, Luke Boyden, Luke Boyden, Taranpreet Rai, Taranpreet Rai, Andrea Wright, Alasdair J. C. Cook, Kevin Wells, Kevin Wells

“…IntroductionChronic kidney disease (CKD) is a common and progressive condition in dogs characterized by irreversible damage to one or both kidneys over an extended period leading to gradual decline in kidney function. Early diagnosis is crucial to improve quality of life and increase survival through medical interventions.MethodsThis study investigated pet owner understanding of this condition using insights gained by comparing pet owner survey responses with bulk harvested social media discussions on canine CKD. …”
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Non-compaction of the ventricular myocardium associated with large patent ductus arteriosus: primary or secondary? by Wenyi Yang, Dan Yin, Kaijun Zhang, Ping Xiang, Xue Zhou, Min Zheng, Mi Li, Zhenli Cheng

“…Methods We retrospectively analyzed the clinical data of the patients with the diagnosis of NVM with large PDA from January 2015 to January 2022 who underwent the interventional occlusion. We collected the data of the non-compacted myocardium/compacted myocardium (N/C) ratio, the size of the heart, cardiac function measured on color Doppler echocardiography and electrocardiograph (ECG) before and after interventional occlusion. …”
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Metabolomics-driven exploration of sphingosine 1-phosphate mechanisms in refractory epilepsy by Xinyu Ben, Chang Li, Jiaqi Liu, Ting Liu, Jingyi Tong, Qifu Li

“…Additional omics analyses were conducted using cellular and animal models to explore the specific functions of S1P and related metabolic pathways. Our findings demonstrated that ACER3/SphK1/S1P play protective roles in maintaining mitochondrial structure and function. …”
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Lower-Limb Amputees and Family Caregivers: Challenges, Needs, and Strategies for Empowerment—A Qualitative Study by Diana Rodrigues, Luís Carvalho, Cristina Pinto

“…Tailored interventions such as peer support, home adaptations, and multidisciplinary care are essential for resilience, independence, and improved quality of life. …”
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Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases by Tian Tian, Monan Liu, Peter J. Little, Hans Strijdom, Jianping Weng, Suowen Xu

“…The GFRAL receptor is central to its function, mediating the anorexigenic and metabolic effects of GDF15. …”
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Risk factors associated with poor pain outcomes following primary knee replacement surgery: Analysis of data from the clinical practice research datalink, hospital episode statisti... by Hasan Raza Mohammad, Rachael Gooberman-Hill, Antonella Delmestri, John Broomfield, Rita Patel, Joerg Huber, Cesar Garriga, Christopher Eccleston, Rafael Pinedo-Villanueva, Tamer T Malak, Nigel Arden, Andrew Price, Vikki Wylde, Tim J Peters, Ashley W Blom, Andrew Judge

“…Results are presented as relative risk ratios and adjusted risk differences (ARD) by fitting a generalized linear model with a binomial error structure and log link function.<h4>Results</h4>Information was available for 4,750 patients from 2009 to 2016, with a mean age of 69, of whom 56.1% were female. 10.4% of patients had poor pain outcomes. …”
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Feasibility study protocol: implementing consultation-based high-quality palliative care services in intensive care units by Shin Hye Yoo, Ye Sul Jeung, Yejin Kim, Seyeon Kim, Yoon Sun Jung, Tae Jung Kim

“…The demand and acceptability of the intervention will be assessed through semi-structured interviews with family surrogates, followed by qualitative analysis.Ethics and dissemination This study will be conducted in accordance with the Declaration of Helsinki and applicable national laws and regulations. …”
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Barriers and facilitators to exercise in people with idiopathic inflammatory myopathies: a qualitative study by Natalie Li, Stephanie Frade, Lucinda Roper, Matthew JS Parker, Peter Youssef, Mandana Nikpour

“…People with IIM often present with reduced muscle strength, endurance, and aerobic capacity, directly impacting physical function and health-related quality of life. With emerging evidence supporting exercise in IIM, we sought to explore the experiences of exercise in people with IIM to further inform person-centered exercise interventions. …”
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Autological bone marrow concentrate for the treatment of early stages of femoral head avascular necrosis (literature review) by M. A. Panin, N. V. Zagorodnii, A. V. Boiko, A. S. Petrosyan

“…According to the overwhelming number of authors, the core decompression using autologous bone marrow cells is highly effective, significantly reducing the intensity of pain syndrome and improving the function of the hip joint. The results will be more encouraging with the further development of regenerative medicine, which will provide new samples of cellular preparations for bone tissue structure restoration.…”
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The modern aspects of patients’ nutritional support during rehabilitation by A. V. Shvets, О. М. Ivanko, Yu. M. Deputat, O. V. Gorishna, O. V. Rychka

“…With insufficient nutritional support, malnutrition syndrome occurs, which negatively affects the restoration of impaired functions. Along with this, the combination of rehabilitation nutrition and physiotherapeutic interventions increase probability to achieve desired goals of therapy. …”
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Rehabilitation Protocol for Children with Chest Tube for Pleural Effusion: A Quasi-Experimental Pre- and Post-test Study by Sanyal Kumar, Anjani Kumar, Sanjay Kumar Pandey

“…Results: Significant improvements were observed in PFTs, physical activity levels and QoL scores post-intervention (P < 0.05). Conclusion: The structured rehabilitation protocol was effective in enhancing respiratory function and overall recovery in paediatric patients with chest tubes for pleural effusion.…”
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Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis by Xinfeng Yu, Quanbin Zhang, Wentong Cui, Zheng Zeng, Wenzhe Yang, Chao Zhang, Hongwei Zhao, Weidong Gao, Xiaomin Wang, Dali Luo

“…Ventricle staining with H-E or Sirius Red was performed to investigate the structural changes in myocardium. Functional evaluation demonstrated that LMWF has a beneficial effect on DCM by enhancing myocardial contractility and mitigating cardiac fibrosis. …”
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Right ventricular outflow tract morphology and its clinical significance for invasive procedures by Marcin Jakiel, Rafał Jakiel, Jakub Batko, Edyta Dyngosz, Maria Kurek, Karolina Gutkowska, Jakub Hołda, Filip Bolechała, Marcin Strona, Mateusz K. Hołda

“…In conclusion, this study provides a detailed definition, along with anatomical and structural analysis of the RVOT, highlighting its complex morphology and its significant role in cardiac functionality and clinical interventions.…”
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The relationship between eHealth literacy and oral frailty among older adults: the serial mediating effects of self-efficacy and oral health by Jie Wu, Xin-xin Wang, Min Xu, Kang-ping Liu, Li-ling Xu, Ying Zhang

“…Abstract Background Oral frailty can cause many adverse consequences, including by impairing basic oral functions such as chewing and speaking; furthermore, it is closely related to overall systemic health. …”
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Sodium alginate microspheres loaded with Quercetin/Mg nanoparticles as novel drug delivery systems for osteoarthritis therapy by Jun Chen, Guoya Wu, Jian Wu, Zhijian Jiao

“…Abstract Background Osteoarthritis (OA) is the most prevalent arthritic disease characterized by cartilage degradation and low-grade inflammation, for which there remains a lack of efficacious therapeutic interventions. Notably, mitigating the impact of oxidative stress (OS) and inflammatory factors could help alleviate or hinder the advancement of OA. …”
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Genetically engineered MSC-derived hybrid cellular vesicles for ROS-scavenging and mitochondrial homeostasis in hepatic ischemia-reperfusion injury by Pu Shen, Kaijun Huang, Xuanlin Zhang, Guiyuan Yin, Meiting Qin, Hua Ma, Zhijin Fan, Yuhui Liao

“…This therapeutic cascade facilitated mitochondrial structural and functional restoration via multiple pathways: Resveratrol specifically activated PINK1-mediated mitophagy, as confirmed by increased LC3 and beclin-1 expression, thereby promoting selective clearance of depolarized mitochondria. …”
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Codesign with citizens to prevent cardiometabolic diseases in disadvantaged neighbourhoods: an interview study on needs and priorities among stakeholders in Sweden by Meena Daivadanam, Helle Mølsted Alvesson, Mats Martinell, Hedda Ottesen, Laran Matta, Jonas Idevall Hagren, Pia McAleenan

“…Additionally, the persistence of a siloed system structure of organisations and the risks associated with accessing target populations through local intermediaries added to the challenges.Conclusion This study highlights the lack of integration of organisational values and functions within and across organisations, hindering cross-sector collaboration and citizen engagement in prevention and health promotion activities. …”
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