Butylated hydroxytoluene (BHT) induces zebrafish spinal cord defects and scoliosis by inhibiting the hedgehog pathway by Hao Cheng, Yulian Li, Fasheng Liu, Shanshan Zhu, Li Chen, Huiqiang Lu, Xiaowen Shi, Ling Huang

Get full text

Evaluation of SCORED as a diagnostic tool for early detection of chronic kidney disease (CKD) and End-stage renal disease (ESRD): A hospital-based study by Osama F Mosa

“… Background: Chronic Kidney Disease (CKD) and End-Stage Renal Disease (ESRD) are significant public health problems characterized by structural or functional anomalies of the kidneys. CKD is considered one of the ma-jor non-communicable diseases and its prevalence is increasing rapidly in Saudi Arabia. …”
Get full text

CORRELATION BETWEEN MRI-BASED BRAIN VOLUME CHANGES AND COGNITIVE DECLINE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT: A PROSPECTIVE OBSERVATIONAL STUDY. by Karishma Khushalrao Surpam

“…This study aimed to assess the relationship between structural brain volume changes and cognitive decline among patients diagnosed with Mild Cognitive Impairment (MCI). …”
Get full text

An overview of the integration and development trends between arts and psychotherapy by Yuxing Xie, Xianhua Sun

“…Its core mechanism lies in promoting individuals to achieve emotional release, cognitive reconstruction, and social function recovery through the creative expression of art forms, which has given rise to the important practical field of art therapy. …”
Get full text

Current Understanding of Pulmonary Fibrosis: Pathogenesis, Diagnosis, and Therapeutic Approaches by Dinglu Cui, Xiangguo Che, Rongxian An, Lei Li, Xinying Cui, Long Jiang, Jingchun Jin

“…In terms of treatment, modern medications such as pirfenidone and nintedanib can inhibit the progression of PF to some extent and improve lung function. However, there is no drug that can significantly improve PF, except for lung transplantation. …”
Get full text

Psychometric assessment of scales used to evaluate sexual assault prevention programming in the United States Air Force. by Kathryn E L Grimes, Nichole M Scaglione, Marni L Kan, Leah Frerichs, Christopher M Shea, Angela M Stover

“…We refined each scale based on factor analysis results and assessed internal consistency reliability by computing Cronbach's coefficient alpha for each scale in the overall sample, by sex, and by tailored SCC intervention group.<h4>Results</h4>We identified a two-factor structure for the Date Rape Attitudes scale; subscale reliability was moderate within the overall sample and among males, though low among females. …”
Get full text

Birth prevalence and associated factors of congenital anomalies among neonates born at a public hospital in Awi Zone, Northwestern Ethiopia: institutional based cross-sectional stu... by Tsegaye Mehare, Yewbmirt Sharew

“…Abstract Background Congenital Anomalies, also known as birth defects, are structural, functional, or metabolic abnormalities present at birth or later in life that can result in physical or developmental impairments. …”
Get full text

Determinant Factors of Stress in Caregivers of Patients With Schizophrenia: Cross-Sectional Study by Isymiarni Syarif, Hasnawati Amqam, Saidah Syamsuddin, Veni Hadju, Syamsiar Russeng, Yusran Amir

“…Strengthening these dimensions is essential to mitigating the psychological toll of caregiving and sustaining caregivers’ functional well-being. Evidence increasingly supports that empowering caregivers through structured support systems and educational initiatives can substantially alleviate stress-related burdens and improve care continuity for individuals with schizophrenia.…”
Get full text

ID071 Early stimulation strategies for children aged 0 to 3 years old with cerebral palsy: overview of systematic reviews by Aurélio Matos Andrade, Juliana da Motta Girardi, Rhaila Cortes Barbosa, Valdenize Tiziani, Flavia Tavares Silva Elias, Indyara de Araujo Morais, Priscilla Lemos Gomes

“…The interventions resulted in significant improvements in child development, body functions and structures, and functional abilities of activities and participation, such as locomotor movements, gait pattern, postural control, balance, muscle tone, joint mobility, visual and auditory functions, fine and gross motor skills, execution of activities of daily living, self-initiated movements, self-care, visual perception, interaction, face-to-face contact, vocalization and communication. …”
Get full text

Advanced smart assistance with enhancing social interaction and daily activities for visually impaired individuals using deep learning with modified seagull optimization by Sana Alazwari, Hussah Nasser AlEisa, Mohammed Rizwanullah, Radwa Marzouk

“…Machine learning (ML) models, pattern detection, and statistical analysis are extensively adopted to identify subtle changes and process sensor information in structural response that might indicate corrosion, cracks, or other structural problems. …”
Get full text

Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy by Zhibo Hu, Yu Zhou, Cailing Gao, Junfen Liu, Congqing Pan, Jun Guo

“…Results In vitro, AS-IV led to a significant reduction in blood urea nitrogen (BUN), urine albumen-to-creatinine ratio (UACR), serum creatinine (CREA), and hyperglycemia in db/db mice and lessen the pathological alterations in the kidney. Moreover, pyrin structural domain of the NLR family pyrin domain containing 3 (NLRP3), cleaved-caspase-1, gasdermin D (GSDMD), IL-18, and IL-1β were down-expressed and podocyte markers podocin and nphs1 were up-regulated following AS-IV intervention. …”
Get full text

Preserving heritage through a novel framework for the adaptive reuse of Mediterranean earthen houses by Ihab Khalil, Doğa Üzümcüoğlu

“…Four representative cases —Alhambra in Spain, Ghadames in Libya, KTMMOB Chamber of Architects Main Building in North Cyprus, and Sheikh Hilal Beehive Houses in Syria— were analyzed based on six key dimensions: preservation of structural and aesthetic integrity, functional adaptation and minimal intervention, environmental efficiency and structural reinforcement, flexibility and adaptability, community engagement and cultural relevance, and compliance with documentation and economic revitalization. …”
Get full text

Bringing a Systems Approach to Living Donor Kidney Transplantation by Anna Horton, Katya Loban, Peter Nugus, Marie-Chantal Fortin, Lakshman Gunaratnam, Greg Knoll, Istvan Mucsi, Prosanto Chaudhury, David Landsberg, Michel R. Pâquet, Marcelo Cantarovich, Shaifali Sandal

“…Conclusion: Our findings suggest that interventions that account for full-system function, particularly macro-level coordination between governing organizations can improve LDKT delivery. …”
Get full text

Neural Correlates of Motor Recovery after Robot-Assisted Training in Chronic Stroke: A Multimodal Neuroimaging Study by Cheng Chen, Kai Yuan, Xin Wang, Ahsan Khan, Winnie Chiu-wing Chu, Raymond Kai-yu Tong

“…We adopted EEG-informed fMRI technique to understand the functional regions sensitive to training intervention. …”
Get full text

Early corticospinal tract sub-pathway lesion load and integrity predict post-stroke motor outcomes by Xin Wen, Wentao Zeng, Chiyin Li, Yue Qin, Yanqiang Qiao, Tao Lu, Wanghuan Dun, Ming Zhang, Junya Mu

“…These findings highlight the pivotal role of non-M1 tracts in post-stroke motor function, particularly the PMd tracts, as a potential intervention target to enhance motor recovery.…”
Get full text

Academic and non-academic life stressors and perceived levels of stress in Brazilian undergraduate health professions students by Karolina Murakami, Maria Paula Panuncio-Pinto, Jair Lício Ferreira Santos, Luiz Ernesto de Almeida Troncon

“…Abstract Background Entrance into and permanence in higher education programs in health professions may be associated with a variety of academic and personal challenges that often function as significant sources of stress, which may influence students’ well-being and performance. …”
Get full text

Effect of cognitive-only and cognitive-motor training on preventing falls in community-dwelling older people: protocol for the smart±step randomised controlled trial by Catherine Sherrington, Barbara Toson, Jessica Turner, Jacqueline Close, Daina L Sturnieks, Jasmine Menant, Michael Valenzuela, Kim Delbaere, Robert D Herbert, Amit Lampit, Kathryn Broadhouse, Daniel Schoene, Stephen R Lord, Daina Sturnieks, Stephen Lord, Rob Herbert, Cameron Hicks, Mayna Ratanapongleka, Natassia Smith, Carly Chaplin, Bethany Halmy, Angeliki Stivactas, Ashley Woodbury, Dinaz Parekh, Matthew Hand, Isabella Hoi Kei leung, Polly Barr, Jennifer Davis

“…This is despite good evidence of improvements in fall-related cognitive and physical functions following both intervention types. This manuscript describes the study protocol for a three-arm randomised controlled trial to evaluate the effectiveness of home-based cognitive and cognitive-motor training interventions, compared to a minimal-intervention control group, in preventing falls in older people. …”
Get full text

Advantages of long-term combination pharmacotherapy with a beta-blocker and eplerenone in patients with ST-segment elevation acute coronary syndrome by O. A. Osipova, V. P. Mikhin, A. I. Golovin, O. N. Belousova, D. N. Perutsky, P. K. Alferov, S. L. Konstantinov

“…The advantages of long-term combination pharmacotherapy of nebivolol and eplerenone in HFmrEF patients after STE-ACS on both structural and functional cardiac parameters were established.…”
Get full text

Continuity of care in lumbar disc herniation: a systematic review and meta-analysis providing a deeper look into postoperative efficacy by Ying Lin, Ying Lin, Qiaoling Chen, Qiaoling Chen, RouMei Wang, Bing Zhang, Bing Zhang, Rui Huang, Yiguang Bai, Yiguang Bai

“…Additionally, the Japanese Orthopedic Association (JOA) score of the experimental group was significantly higher than that of the conventional control group at 3 months post-operation [SMD = 1.70, 95%CI (1.01, 2.39), p &lt; 0.01].ConclusionOur meta-analysis indicates that continued care interventions significantly alleviate postoperative pain, enhance lumbar function, reduce anxiety, and improve overall functional recovery in LDH patients. …”
Get full text

Transoral laser resections of oral cavity and oropharyngeal tumors by M. V. Bolotin, A. M. Mudunov, R. I. Azizyan, O. A. Saprina

“…Transoral CO2 laser resections make possible to perform rather large radical surgical interventions with a satisfactory functional and cosmetic results, without deteriorating the long-term results of treatment.…”
Get full text