Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review. by Alison J Davis, Toby O Smith, Caroline B Hing, Nidhi Sofat

“…Our meta-analysis of the two largest knee studies using risedronate 15 mg showed odds ratios favouring placebo interventions for the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain (1.73), WOMAC function (2.03), and WOMAC stiffness (1.82). …”
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Decannulation ahead: a comprehensive diagnostic and therapeutic framework for tracheotomized neurological patients by Rainer Dziewas, Tobias Warnecke, Bendix Labeit, Volker Schulte, Inga Claus, Paul Muhle, Anna Brake, Lena Hollah, Anne Jung, Jonas von Itter, Sonja Suntrup-Krüger

“…Main body Key diagnostic strategies for assessing decannulation readiness focus on airway protection, airway patency, bronchial secretion management, and cough function. These are collectively introduced as the A2BC criteria in this review. …”
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Application of infrared-beam laser therapy in the postoperative period in patients with nodular toxic goiter by S. M. Zavhorodnii, M. S. Gatia, M. A. Kubrak, M. B. Danyliuk

“…Thyroidectomy prevailed in the structure of surgeries in the main group (20 (57.1 %) cases). …”
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Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization by Maya Bolger-Chen, Manuela Lopera Higuita, Casie A. Pendexter, Mohammadreza Mojoudi, Korkut Uygun, Shannon N. Tessier

“…Similarly, the use of adenosine as a pharmacological intervention was found to decrease both edema formation and inflammatory responses. …”
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Identification of biomarkers and target drugs for melanoma: a topological and deep learning approach by Xiwei Cui, Xiwei Cui, Jipeng Song, Qingfeng Li, Jieyi Ren

“…Advanced network analysis tools were employed to identify structural disparities and functional module shifts. …”
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Comprehensive characterization of high-risk coding and non-coding single nucleotide polymorphisms of human CXCR4 gene. by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md Ismail Hosen, Atiqur Rahman

“…This comprehensive analysis shed light on the potential functional consequences of genetic variation in the CXCR genes, offering valuable insights into the implications of disease susceptibility and may pave the way for future therapeutic interventions.…”
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Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets by Gen Li, Wu He, Dao Wen Wang

“…Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune mechanisms in HF. …”
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Salt, Aldosterone, and Parathyroid Hormone: What Is the Relevance for Organ Damage? by Cristiana Catena, Gian Luca Colussi, Gabriele Brosolo, Nicole Bertin, Marileda Novello, Andrea Palomba, Leonardo A. Sechi

“…Structured interventions on lifestyle have been suggested as a cost-effective strategy for prevention of cardiovascular disease. …”
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Telerehabilitation Guidelines for Patients with Breast Cancer by Oleksandr A. Vladymyrov, Tetiana V. Semykopna, Dmytro V. Vakulenko, Oksana V. Syvak, Mykola M. Budnyk

“…The document also explores telerehabilitation interventions for BC. A detailed description of the software and hardware tools is provided, including the structural and functional overview of the Telerehabilitation Platform (TRP), software modules such as "Telerehabilitation," "Medical Reports," the Administrative Subsystem, the Information-Analytical Subsystem, which encompass the PM&R physician’s digital workspace, the PM&R Expert Subsystem, and the Patient’s digital workspace. …”
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Mitochondrial dysfunction in the regulation of aging and aging-related diseases by Xianhong Zhang, Yue Gao, Siyu zhang, Yiqi Wang, Xinke Pei, Yufei Chen, Jinhui Zhang, Yichen Zhang, Yitian Du, Shauilin Hao, Yujiong Wang, Ting Ni

“…In this review, we first outline the basic structure of mitochondria and their essential biological functions in cells. …”
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The critical role of Toxoplasma gondii GRA1 in nutrient salvage by Bolin Fan, Biyun Qin, Mingjun Li, Yuchao Zhu, Fuqiang Fan, Hao Xu, Lilan Xue, Yukun Chen, Ming Pan, Bang Shen

“…These findings reveal the functional mode of GRA1 in T. gondii and highlight its potential as a target for developing new interventions against toxoplasmosis.…”
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Varied cellular abnormalities in thin vs. normal endometrium in recurrent implantation failure by single-cell transcriptomics by Xiaoying Fu, Xiaoyan Guo, Han Xu, Yini Li, Bihui Jin, Xirong Zhang, Chongyi Shu, Yuhang Fan, Yiqi Yu, Yuqing Tian, Jiao Tian, Jing Shu

“…These insights may pave the way for targeted therapeutic interventions aimed at improving endometrial receptivity and enhancing reproductive outcomes in patients undergoing ART. …”
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Automated prediction of fibroblast phenotypes using mathematical descriptors of cellular features by Alex Khang, Abigail Barmore, Georgios Tseropoulos, Kaustav Bera, Dilara Batan, Kristi S. Anseth

“…Abstract Fibrosis is caused by pathological activation of resident fibroblasts to myofibroblasts that leads to aberrant tissue stiffening and diminished function of affected organs with limited pharmacological interventions. …”
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Experiences and outcomes of older adults with obesity transitioning from gym- to home-based resistance training due to COVID-19 lockdowns: a mixed-methods analysis of a RCT by Costas Glavas, Jakub Mesinovic, Anoohya Gandham, Mavil May Cervo, Carrie-Anne Ng, Peter R. Ebeling, Elena S. George, Robin M. Daly, Belinda R. Beck, Paul Jansons, David Scott

“…HOME participants were prescribed bodyweight RT and AT exercises, while maintaining the weight loss intervention. Eight HOME participants completed semi-structured interviews post-intervention. …”
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Rehabilitation of the Upper Extremity after Stroke: A Case Series Evaluating REO Therapy and an Auditory Sensor Feedback for Trunk Control by G. Thielman, P. Bonsall

“…Outcomes. With both interventions, clinically relevant improvements were found for measures of body function and structure, as well as for activity, for two participants. …”
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A high fat, high sugar diet exacerbates persistent post-surgical pain and modifies the brain-microbiota-gut axis in adolescent rats by Sabrina Salberg, Matthew Macowan, Angela Doshen, Glenn R. Yamakawa, Marissa Sgro, Benjamin Marsland, Luke A. Henderson, Richelle Mychasiuk

“…Persistent post-surgical pain (PPSP) occurs in a proportion of patients following surgical interventions. Research suggests that specific microbiome components are important for brain development and function, with recent studies demonstrating that chronic pain results in changes to the microbiome. …”
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The role of hepatic sinusoidal microenvironment in NASH: pathogenesis, animal models, and therapeutic prospects by Wanying Tan, Jiangting Deng, Jiangting Deng, Lingjun Qi, Zhenghuai Tan

“…The hepatic sinusoid, which serves as the fundamental structural and functional unit of the liver, is intricately composed of endothelial cells, Kupffer cells, and hepatic stellate cells. …”
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Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious Diseases by Nidhi Varshney, Rajan Kumar Pandey, Amit Mishra, Sunil Kumar, Hem Chandra Jha

“…This review explores AURKA’s structural and functional roles, emphasizing its involvement in cell cycle progression. …”
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Medical students’ attitudes towards healthcare for people with intellectual disabilities: an experience from Al-Jouf, Saudi Arabia by Adel Saber Alanazi

“…These findings suggest several specific interventions: (1) integration of structured PwIDs-focused modules within medical curricula, emphasizing both theoretical knowledge and practical skills; (2) implementation of mandatory clinical rotations with PwIDs populations to enhance experiential learning; and (3) development of communication training programs focusing on patient-doctor and interprofessional interactions. …”
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Designing hydrogel for application in spinal surgery by Rongpeng Dong, Shuang Zheng, Xueliang Cheng

“…Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conservative treatments. …”
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