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841
The use of stem cells and organoids for modeling host-microbe interactions in low-biomass tissues
Published 2025-08-01“…Together, these in vitro models realistically recapitulate structural and functional elements of the in vivo organ, allowing for studies of cellular, molecular, and genetic features that underpin various diseases that are difficult to observe in low-biomass tissues. …”
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842
Shared interactions of six neurotropic viruses with 38 human proteins: a computational and literature-based exploration of viral interactions and hijacking of human proteins in neu...
Published 2025-02-01“…Abstract Introduction Viral infections may disrupt the structural and functional integrity of the nervous system, leading to acute conditions such as encephalitis, and neuropsychiatric conditions as mood disorders, schizophrenia, and neurodegenerative diseases. …”
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843
Impact of surgical and non-surgical weight loss on echocardiographic and strain parameters in Asian patients
Published 2024-10-01“…However non-surgical versus SWL and the subsequent impact on myocardial function in overweight Asian subjects has not been evaluated. 66 patients underwent a 16-week lifestyle intervention (LSI) programme consisting of dietary interventions and exercise prescription. …”
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844
Hand-Related Activities of Daily Living Challenges Among Individuals With Diabetic Peripheral Neuropathy: A Scoping Review
Published 2025-06-01“…The findings were categorised using relevant ICF codes linked to hand function issues. The analysis identified four major themes: (1) the impact of DPN on daily activities and participation; (2) sensory impairments affecting hand function; (3) muscle weakness and functional limitations; and (4) unaddressed areas, such as structural changes, driving, assisting others, and preparing meals. …”
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845
Optimizing alternate replacement strategy of k-out-of-n: F systems with common-mode degradation: An application to railway grid.
Published 2025-01-01“…A dynamic and alternate replacement strategy is proposed, focusing on both system-level and component-level interventions. The degradation of each steel rail is modeled using a Gamma process, while the dependence structure of the system is characterized through a copula function. …”
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846
Muscular robusticity and strength in the lower extremities in elite handball players
Published 2024-11-01“…The exploration and understanding of asymmetric structural and functional adaptations can help athletes and trainers in planning the training and training interventions to reduce the risk of injuries.…”
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847
Reconfiguring Realities: On the Intra-active Liminality of Bridges
Published 2025-07-01“…Analyses of Kafka’s short story The Bridge and multimedia interventions by Svetlana Volic posit the bridge as a performative space that transcends its original utilitarian function to emerge as a dynamic platform for posthumanist inquiry. …”
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848
Comparing the effects of physical activity and cognitive training on cognitive performance, physical fitness, and mental health in 9- to 10-year-old children: a randomized clinical...
Published 2025-06-01“…The study found that all cognition and mental health parameters improved significantly in the PA, CT, and PA+CT groups than in the control group (p < 0.05), with the strongest effects in PA+CT.ConclusionThis study demonstrates that structured interventions administered four times each week can differentially improve physical fitness, cognition, and mental health outcomes in school-aged children. …”
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849
Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging
Published 2017-01-01“…Indeed, a multiplicity of studies has demonstrated relationships between lifestyle factors, brain structure and function, and cognitive function in aging adults. …”
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850
Sociological Analysis of the Phenomenon of Honor Killing with the Social Interpretation Approach
Published 2024-06-01“…In these contexts, honor killings function as a technique of social control, with women's sexuality and social behavior being key markers of communal honor. …”
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851
The link between stigmatization, mental health, disability, and quality of life
Published 2025-10-01“…Mental health disabilities, including conditions such as depression, anxiety, and schizophrenia, significantly impact individuals' daily functioning and overall well-being. Stigmatization, in its public, self, and structural forms, exacerbates these conditions, leading to social exclusion, reduced self-esteem, and limited access to essential resources. …”
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852
Microbial metabolites and immune modulation
Published 2024-12-01“…The human microbiota, a complex ecosystem of microorganisms, has garnered significant attention for its profound influence on host health. Beyond their structural roles, these microbes produce a diverse array of bioactive metabolites that interact with the host immune system. …”
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853
Research progress on brain network imaging biomarkers of subjective cognitive decline
Published 2025-02-01“…PurposeSubjective cognitive decline (SCD) is an early manifestation of the Alzheimer’s disease (AD) continuum, and accurately diagnosing SCD to differentiate it from neurotypical aging in older adults is a common challenge for researchers.MethodsThis review examines and summarizes relevant studies regarding the neuroimaging of the AD continuum, and comprehensively summarizes and outlines the SCD clinical features characterizing along with the corresponding neuroimaging changes involving structural, functional, and metabolic networks.ResultsThe clinical characteristics of SCD include a subjective decline in self-perceived cognitive function, and there are significant imaging changes, such as reductions in gray matter volume in certain brain regions, abnormalities in the integrity of white matter tracts and diffusion metrics, alterations in functional connectivity between different sub-networks or within networks, as well as abnormalities in brain metabolic networks and cerebral blood flow perfusion.ConclusionThe 147 referenced studies in this paper indicate that exploring the structural, functional, and metabolic network changes in the brain related to SCD through neuroimaging aims to enhance the goals and mission of brain science development programs: “Understanding the Brain,” “Protecting the Brain,” and “Creating the Brain,” thereby strengthening researchers’ investigation into the mechanisms of brain function. …”
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854
Left amygdala alterations mediate the effects of negative symptoms on social dysfunction in schizophrenia
Published 2025-07-01“…Structural and resting-state functional MRI data were acquired. …”
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855
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856
Multimodal dynamic retinal vessel analysis offers new insights in microvascular defects in Fabry’s disease
Published 2025-06-01“…This principle of multimodal analysis of dynamic retinal vascular behavior has been applied to demonstrate specific structural and functional retinal microvascular changes in Fabry’s disease. …”
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857
Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.
Published 2011-01-01“…Brain vascular casts revealed exercise-induced structural modifications associated with improved endothelial function in the periphery. …”
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858
A review of the complex interplay between chemoresistance and lncRNAs in lung cancer
Published 2024-12-01“…The development of new pathways and interventions for treating LC holds promise in overcoming this resistance.…”
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859
Retinal degenerative diseases: role of dietary supplements in retinal health
Published 2024-12-01“…Dietary supplements have been proposed as an ideal source for preventing retinal degeneration, especially supplements containing significant levels of antioxidants that help to reduce the damage to retinal cells. Notably, dietary interventions with carotenoids, flavonoids, alkaloids, amino acids, fatty acids, vitamins, and minerals have shown positive effects in both preclinical and clinical studies by preserving the retinal structure, revitalizing retinal health, delaying disease progression, and improving visual function. …”
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860
Neonatal scrotochesis following artificial rupture of membrane in breech delivery
Published 2025-07-01“…Birth trauma refers to structural or functional impairments in newborns caused by mechanical forces during labour and delivery, with breech presentation significantly increasing the risk of neonatal injuries. …”
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