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821
Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives
Published 2025-07-01“…Diabetic cardiomyopathy (DCM) is a major complication of diabetes mellitus, characterized by microvascular dysfunction and progressive structural and functional deterioration of the heart. …”
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822
Research progress on NAT10-mediated acetylation in normal development and disease
Published 2025-08-01“…This review summarizes the structural and functional roles of NAT10-mediated acetylation in physiological contexts, including cell division, differentiation, inflammation, aging, and viral infection, as well as its emerging roles in cancer. …”
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823
Description of the Human Penile Urethra Epithelium
Published 2025-04-01“…<i>Background and Objectives</i>: The male urethra is a complex structure that plays a critical role in genitourinary health and function. …”
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824
Peritoneal Dialysis -Associated Fibrosis: Emerging Mechanisms and Therapeutic Opportunities
Published 2025-08-01“…The spectrum of PD-associated peritoneal fibrosis encompasses a diverse range of collective mechanisms: peritoneal fibrogenesis, epithelial to mesenchymal transition (EMT), peritonitis, angiogenesis, sub-mesothelial immune cells infiltration, and collagen deposition in the sub-mesothelial compact zone of the membrane that accompany deteriorating membrane function. In this narrative review, we summarize the repertoire of current knowledge about the structure, function, and pathophysiology of the peritoneal membrane, focusing on biomolecular mechanisms and signalling pathways that potentiate the development and progression of peritoneal fibrosis. …”
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825
Advanced Agrivoltaics in Italy: Innovation, Sustainability, and Regulation for the Future of Rural Energy
Published 2025-06-01“…Distinct from conventional ground-mounted photovoltaics, these systems support the simultaneous performance of agricultural and energy-producing functions. The study examines recent regulatory interventions – most notably the Unified Renewable Energy Act and the NRRP incentive programme – while addressing persistent implementation challenges. …”
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826
Decellularized Adipose Matrix Rejuvenates Photoaged Skin through Immune Microenvironment Modulation
Published 2025-01-01“…Current clinical interventions primarily target structural defects, while immune modulation remains underexplored. …”
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827
Integrating Physical Activity and Artificial Intelligence in Burn Rehabilitation: Muscle Recovery and Body Image Restoration
Published 2025-07-01“…Structured physical activity, including resistance and aerobic training, plays a central role in counteracting muscle atrophy, improving cardiovascular function, enhancing scar quality, and promoting psychological resilience and body image restoration. …”
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828
Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies
Published 2025-05-01“…This review systematically summarizes the physicochemical properties of Diquat, with a focus on analyzing the mechanisms by which it damages the gut tissue structure, barrier function, and microbiota after digestive tract exposure. …”
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829
Home-Based Lower Limb Exercises for Individuals with Diabetes: A Scoping Review
Published 2025-04-01“…Results: Nine studies met the inclusion criteria, featuring a range of home-based exercise interventions, such as muscle strengthening, stretching routines, proprioceptive training, functional mobility exercises, and range-of-motion activities. …”
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830
Mapping and modeling age-related changes in intrinsic neural timescales
Published 2025-02-01“…Our findings reveal how age-related structural brain changes may drive alterations in brain dynamics, offering testable predictions and informing possible interventions targeting cognitive decline.…”
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831
Selective Plasticity of Hippocampal Sub‐Regions in the Amnestic Mild Cognitive Impairment After Acupuncture
Published 2025-08-01“…Conclusion: These results suggested that acupuncture could selectively induce structural plasticity in hippocampal subregions associated with cognitive effects in patients with aMCI, which provided potential biomarkers—particularly the right subiculum body—for effective and timely interventions for aMCI. …”
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832
The impact of farming household differentiation on the non-grain conversion of cultivated land
Published 2024-11-01“…[Conclusion] Overall, farming household differentiation intensified the non-grain conversion of cultivated land, especially among production-oriented and function-oriented small farmers. The government can address the issue of non-grain conversion by optimizing farmers’ cropping structures, reasonably guiding the development of the three major factor markets, and implementing tailored measures according to local conditions to effectively solve the problem of non-grain conversion of cultivated land.…”
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833
A Review of Transcranial Electrical and Magnetic Stimulation Usefulness in Major Depression Disorder—Lessons from Animal Models and Patient Studies
Published 2025-04-01“…Chronic depression causes long-term structural and functional brain damage, making new effective therapies for depressed patients essential. …”
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834
Crisis Response Modes in Collaborative Business Ecosystems: A Mathematical Framework from Plasticity to Antifragility
Published 2025-07-01“…., adaptability, learning, innovation, structural flexibility) and strategic interventions (e.g., optionality, buffering, information sharing, fault-injection protocols), linking them to pre- and post-crisis performance via dynamic adjustment functions. …”
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835
Origins and Molecular Mechanisms Underlying Renal Vascular Development
Published 2024-11-01“…Kidneys play a crucial role in maintaining homeostasis within the body, and this function is intricately linked to the vascular structures within them. …”
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836
Efficacy and safety of stem cells in the treatment of glaucoma: systematic review and meta-analysis based on animal experiments
Published 2025-07-01“…Emerging preclinical evidence further highlights dual neuroprotective mechanisms (i.e., paracrine neurotrophic support and cellular replacement) of stem cell-based interventions. Accordingly, this systematic review and meta-analysis evaluated the therapeutic efficacy and safety of stem cell transplantation in experimental glaucoma models, with a focus on functional outcomes (IOP modulation), structural preservation (RGC survival, and nerve fiber layer integrity), and neuroprotective efficacy.MethodsA systematic literature retrieval from multiple online databases (e.g., PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, WFSD, VIP, and CBM) was conducted through 3 January 2025, to identify relevant animal experimental studies. …”
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837
Calycosin ameliorates albuminuria in nephrotic syndrome by targeting Notch1/Snail pathway
Published 2025-04-01“…Results Calycosin reversed adriamycin-induced increase in proteinuria content, kidney index, and concentrations of renal function indicators. Calycosin ameliorated glomerular structural damage, inflammatory cell infiltration, and basement membrane thickening in model rats. …”
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838
Pathological and Inflammatory Consequences of Aging
Published 2025-03-01“…Aging is a complex, progressive, and irreversible biological process that entails numerous structural and functional changes in the organism. These changes affect all bodily systems, reducing their ability to respond and adapt to the environment. …”
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839
Farming system typology construction for the adoption of new technologies in north-west India
Published 2025-03-01“…By examining socio-economic factors and enterprise contributions, it identifies farm diversity to enhance technology adoption, improve incomes and recommend targeted policy interventions to the farmers. Using multivariate statistical techniques, structural and functional farm characteristics were analysed to construct specific farm typologies. …”
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840
The corneoscleral shell of the eye: potentials of assessing biomechanical parameters in normal and pathological conditions
Published 2016-07-01“…This is probably the cause of reduced CH in children with progressive myopia and a weakened supportive function of the sclera, as well as such reduction in glaucomatous adult patients. …”
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