Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster by Wei Zhang, Rong Zhou, Xinjuan Lei, Mofei Wang, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Xinjie Li, Zhang Zutong, Liyang Wang, Odell D. Jones, Mengmeng Xu, Joseph Bryant, Jianjie Ma, Yingli Liu, Xuehong Xu

“…The beneficial effects of several interventions that enhance cardiac function, including exercise and cold stress, can influence autophagy-dependent TOR activity of the serine/threonine protein kinase signaling in both mammals and Drosophila. …”
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DeSPPNet: A Multiscale Deep Learning Model for Cardiac Segmentation by Elizar Elizar, Rusdha Muharar, Mohd Asyraf Zulkifley

“…Background: Cardiac magnetic resonance imaging (MRI) plays a crucial role in monitoring disease progression and evaluating the effectiveness of treatment interventions. Cardiac MRI allows medical practitioners to assess cardiac function accurately by providing comprehensive and quantitative information about the structure and function, hence making it an indispensable tool for monitoring the disease and treatment response. …”
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Cystatin F-a key player in central nervous system disease by Yi-Ting Wang, Qiang Li, Jun-Chao Liu, Chen Chen, He-Xuan Ding, Xu Zha, Ke Zhang

“…It has several unique characteristic structures that determine some of its specific functions. …”
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Small-molecule inhibitors of the CD40–CD40L costimulatory interaction are effective in pancreatic islet transplantation and prevention of type 1 diabetes models by Sung-Ting Chuang, Oscar Alcazar, Brandon Watts, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Midhat H. Abdulreda, Peter Buchwald, Peter Buchwald

“…SMI-treated mice maintained the structural integrity and function of their islet allografts with concomitant reduction in immune cell infiltration as evidenced by direct longitudinal imaging in situ. …”
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Types of combined neurovascular injuries of the extremities by I. V. Pertsov

“…Combined injuries of neurovascular structures are associated with poor results of limb function restoration, often lead to disability and lower quality of life. …”
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Cerebellar microglia: On the edge between neuroinflammation and neuroregulation by Marina S. Dukhinova, Jingwen Guo, Enwei Shen, Wanting Liu, Wanqi Huang, Ying Shen, Luxi Wang

“…These immune cells communicate with intrinsic and systemic factors and contribute to the structural and functional compartmentalization of the cerebellum. …”
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Impact of Exercise on Physiological, Biochemical, and Analytical Parameters in Patients with Heart Failure with Reduced Ejection Fraction by Francisco Epelde

“…Exercise, once avoided in HFrEF patients due to safety concerns, is now recognized as an important therapeutic intervention. Structured exercise improves various physiological, biochemical, and analytical parameters, including cardiac output, endothelial function, skeletal muscle performance, and autonomic regulation. …”
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Cerebral Palsy Link to Sensorimotor System, Cognition, Emotion and Nociplastic Pain by Wolfgang Laube, Mathilde Sengoelge

“…This damage results in a functional developmental disorder that also affects the structure and function of the neuromatrix in a graded manner due to chronic deconditioning. …”
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Effects of exercise with music in frail older adults: a systematic review and meta-analysis by NamHee Kim, Gwang Suk Kim, Min Kyung Park, Layoung Kim, Jae Jun Lee, Seungbum Yang

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Cardiac Remodeling and Arrhythmic Burden in Pre-Transplant Cirrhotic Patients: Pathophysiological Mechanisms and Management Strategies by Charilila-Loukia Ververeli, Yannis Dimitroglou, Stergios Soulaidopoulos, Evangelos Cholongitas, Constantina Aggeli, Konstantinos Tsioufis, Dimitris Tousoulis

“…Structural changes, such as increased left ventricular mass, myocardial fibrosis, and ion channel dysfunction, further impair cardiac function. …”
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Sepsis beyond bundles: contextualising paediatric care in resource-limited settings through situational analysis by John Adabie Appiah, Leah Ratner, Sheila Agyeiwaa Owusu, Ahmet Uluer, Gustav Nettey, Allysa Warling, Charles Martyn-Dickens, Emma Otchere, R. Elaine Cagnina, Maame Fremah Kotoh- Mortty, Eugene Martey

“…Paediatric sepsis bundles, which include prompt administration of antibiotics, fluid resuscitation and continuous organ function monitoring, are crucial for improving outcomes, especially when initiated within the first ‘golden hour’ of sepsis recognition. …”
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Compensation of acetabular defects in primary and revision hip arthroplasty by Maria Yu. Udintseva, Elena A. Volokitina, Denis A. Kolotigin, Sergey M. Kutepov

“…Introduction Total hip arthroplasty in defects of the acetabulum is a complex type of surgical intervention, and the search for optimal implants and bone substituting materials to restore the integrity of the acetabulum is one of the current problems. …”

Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies by Ji-Hung Wang, Yu-Li Lin, Bang-Gee Hsu

“…In the kidney, endothelial cells maintain vascular integrity and function, contribute to filtration, and support other renal structures. …”
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Expert Consensus on Full-Cycle Rehabilitation for Elderly Patients with Chronic Heart Failure by HE Jing, JIA Jie, CHEN Xin, DONG Anqin, DING Yipeng, LIAO Weijing, ZHENG Jiejiao, YU Binbing, CHEN Zuobing, FANG Yuan, YAO Liqing, ZHU Yiping, JIANG Zewu, LI Lei, ZHANG Xiu, REN Ling

“…It outlines a full-cycle rehabilitation work model, encompassing management processes, assessment of functional impairments, rehabilitation evaluations and therapeutic interventions. …”
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Lingual and Maxillary Labial Frenuloplasty with Myofunctional Therapy as a Treatment for Mouth Breathing and Snoring by Chirag Govardhan, Janine Murdock, Leyli Norouz-Knutsen, Sanda Valcu-Pinkerton, Soroush Zaghi

“…Mouth breathing is a multifactorial problem that can be attributed to structural, functional, and neurological etiologies, which are not all mutually exclusive. …”
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Investigating the neural correlates of the left thalamus in women with fibromyalgia: A Granger causality and voxel-based morphometry approach by Elijah Agoalikum, Hongzhou Wu, Benjamin Klugah-Brown, Michael Maes

“…Our findings underscore the necessity for a multi-faceted understanding of fibromyalgia that integrates neuroimaging, psychological assessments, and their implications for future therapeutic interventions. Further research is warranted to explore the longitudinal effects of treatment on structural and functional brain changes in fibromyalgia.…”
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Long-term senolytic therapy with Dasatinib and Quercetin alleviates lipofuscin-dependent retinal degeneration in mice by Bo Yang, Kunhuan Yang, Ruitong Xi, Shiying Li, Jingmeng Chen, Yalin Wu

“…Currently, there are no effective interventions for dry AMD. Although there is already evidence suggesting a link between cellular senescence and age-related diseases, it is still unclear whether long-term senolytic therapy with Dasatinib and Quercetin (D + Q) can slow the progression of dry AMD and ultimately prevent retinal structural damage and function loss. …”
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Transport and InsP8 gating mechanisms of the human inorganic phosphate exporter XPR1 by Qinyu Zhu, Madeleine F. Yaggi, Nikolaus Jork, Henning J. Jessen, Melinda M. Diver

“…Here, cryo-electron microscopy structures of dimeric XPR1 and functional characterization delineate the substrate translocation pathway and how InsP8 initiates Pi transport. …”
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Weighted Hybrid Random Forest Model for Significant Feature prediction in Alzheimer’s Disease Stages by M. Rohini, D. Surendran

“…As a consequence of this challenge discussed, whether all the mild cognitively impaired people change to AD cohorts or remain in normal cognition and identification of the structural and functional features remains underexplored. …”
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Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights by Chen-Ying Zhu, Pei-Han Yu, Qi Sun, De-Fei Hong, Chang Yang, Hua Naranmandura

“…Additionally, future investigations employing integrated multi-omics approaches, advanced structural biology techniques, and AI-driven analyses will further unravel their precise regulatory mechanisms, paving the way for personalized therapeutic interventions, while critically evaluating their translational potential and clinical applications.…”
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