New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice by Xiangpei Yue, Yufei Mei, Yun Zhang, Zheng Tong, Dehua Cui, Jun Yang, Aibo Wang, Rui Wang, Xuechao Fei, Li Ai, Yalan Di, Hongjun Luo, Hui Li, Wenhong Luo, Yu Lu, Rui Li, Chunli Duan, Ge Gao, Hui Yang, Binggui Sun, Rongqiao He, Weihong Song, Hongbin Han, Zhiqian Tong

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Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease by Chika Onochie, Keturah Evi, Cristian O’Flaherty

“…Reversible oxidative modifications regulate enzymatic activity, signaling cascades, and structural stability, supporting normal sperm function, whereas irreversible oxidative damage impairs motility, acrosome reaction, and DNA integrity, contributing to male infertility. …”
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Causal AI Recommendation System for Digital Mental Health: Bayesian Decision-Theoretic Analysis by Mathew Varidel, Victor An, Ian B Hickie, Sally Cripps, Roman Marchant, Jan Scott, Jacob J Crouse, Adam Poulsen, Bridianne O'Dea, Sarah McKenna, Frank Iorfino

“…ResultsThe causal AI recommendation system recommends intervention targets as a function of a user’s baseline presentation, the causal effects of the intervention on itself and other domains, and the utility function. …”
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Relationship between social activities and cognitive impairment in Chinese older adults: the mediating effect of depressive symptoms by Qianke Yang, Shichong Lin, Zhuyun Zhang, Shuhao Du, Dan Zhou

“…BackgroundThe differential impacts of various social activities on dementia prevention and the mediating role of depression in this relationship remain unclear.ObjectivesThis study aimed to identify the effects of different social activities on cognitive function, examine the mediating role of depression, and provide evidence for targeted interventions to prevent cognitive decline.MethodsUsing data from CHARLS, we employed RCS analysis and Structural Equation Modeling to examine the relationships between social activities, depression, and cognitive function in older adults.ResultsSocial activity participation is non-linearly inversely related to both cognitive impairment and depression risk. …”
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The Effect of Overcoming the Digital Divide on Middle Frontal Gyrus Atrophy in Aging Adults: Large-Scale Retrospective Magnetic Resonance Imaging Cohort Study by Yumeng Li, Xinyue Zhang, Jiaqing Sun, Junying Zhang, Aiqin Zhu, Xin Li, Zhanjun Zhang

“…ResultsThe DD group showed significant deficits in executive function (tPdtPdPtPP ConclusionsOlder adults who overcome the DD demonstrate preserved gray matter structure and slower cognitive decline, particularly in frontotemporal regions critical for executive function. …”
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Contemporary treatment of right ventricular failure by Bibhuti B. Das, MD, Shashi Raj, MD, FAAP, FACC

“…Right ventricular failure (RVF) is a clinical syndrome resulting from structural and functional changes in the right ventricle (RV), leading to inadequate blood flow to the pulmonary circulation and elevated systemic venous pressures. …”
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Mitochondrial metabolism and cancer therapeutic innovation by Hongxiang Du, Tianhan Xu, Sihui Yu, Sufang Wu, Jiawen Zhang

“…Although targeting mitochondrial function represents a promising therapeutic strategy, mitochondrial heterogeneity and adaptive resistance mechanisms complicate interventional approaches. …”
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Brain-Inspired Multisensory Learning: A Systematic Review of Neuroplasticity and Cognitive Outcomes in Adult Multicultural and Second Language Acquisition by Evgenia Gkintoni, Stephanos P. Vassilopoulos, Georgios Nikolaou

“…Methods: The analysis included randomized controlled trials and longitudinal studies employing diverse neuroimaging techniques (fMRI, MEG, DTI) to assess structural and functional brain network changes. Interventions varied in terms of immersion intensity (ranging from limited classroom contact to complete environmental immersion), multimodal approaches (integrating visual, auditory, and kinesthetic elements), feedback mechanisms (immediate vs. delayed, social vs. automated), and learning contexts (formal instruction, naturalistic acquisition, and technology-enhanced environments). …”
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The properties of TREM1 and its emerging role in pain-related diseases by Zhenzhen Fan, Longde Wang, Songtang Sun, Zhaoming Ge

“…This article provides an extensive review on the structural characteristics and distribution patterns, ligand, signaling pathways, inhibitors, and pathophysiological roles of TREM1 in pain disorders aiming to further elucidate its biological function and offer novel insights for clinical interventions targeting pain-related diseases.…”
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Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues by Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li

“…Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. …”
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Protocol for a feasibility trial of digital mindfulness and cognitive-motor exercise for subclinical depression in older adults by Haifeng Zhang, Caixia Xie, Mang Zhang, Xingyu Zhang, Tao Li, Huali Wang, Xin Yu

“…Improvements are expected in depressive and anxiety symptoms, cognition, and function, along with reduced cortisol levels. MRI may reveal structural and functional changes in brain regions associated with emotional regulation and cognition. …”
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Exploring the c.406 C > T variant in TNNI3 gene: pathogenic insights into restrictive cardiomyopathy by Tannaz Masoumi, Hamed Hesami, Majid Maleki, Samira Kalayinia

“…In silico tools and structural protein modeling were employed to assess the functional impact of the identified variant. …”
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Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head by Weihong Zhu, Zhenmu Xu, Ding Zhou, Jiankun Xu, Yuchen He, Zhong Alan Li

“…This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. …”
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Potential Moderators of Physical Activity on Brain Health by Regina L. Leckie, Andrea M. Weinstein, Jennifer C. Hodzic, Kirk I. Erickson

“…Age-related cognitive decline is linked to numerous molecular, structural, and functional changes in the brain. However, physical activity is a promising method of reducing unfavorable age-related changes. …”
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Long-term Azithromycin Prophylaxis in Pediatric Respiratory Disorders: A Narrative Review and Applications in Hong Kong by Nicole Wing Hei Tung

“…Childhood chronic respiratory conditions often involve heightened and sustained airway inflammation, presenting with recurrent symptoms ultimately resulting in lung function decline and structural disease. Thus, there is a growing interest in prophylactic interventions that may improve quality of life and reduce long-term sequelae. …”
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What do people really think about the RSV vaccine? Study of unsolicited text replies from adults over 60 by E. Susanne Blazek, Sarah Deedat, Olivia Kinney, Allison M. Londerée, Stacey Frede, Amy Bucher

“…The analyses reveal 10 topics from the thematic analysis and 30 more granular topics from the structural topic modelling. Expressed attitudes shifted over the course of the DHI, with less negativity later in the intervention. …”
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Scaffolding theory of maturation, cognition, motor performance, and motor skill acquisition: a revised and comprehensive framework for understanding motor–cognitive interactions ac... by Thomas Jürgen Klotzbier, Nadja Schott

“…For example, in aging populations, SMART COMPASS can guide tailored interventions combining cardiovascular training with task-specific motor learning to maintain executive function and reduce fall risk. …”
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Mechanism and Treatment of Right Ventricular Failure Due to Pulmonary Hypertension in Children by Bibhuti B. Das

“…RVF is a clinical syndrome resulting from complex structural and functional remodeling of the right heart, leading to inadequate pulmonary circulation, reduced cardiac output, and elevated venous pressure. …”
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Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies by Li Nan, Pengchao Guo, Wang Hui, Fang Xia, Chenggang Yi

“…Aging is a multifactorial process that affects skin integrity through the progressive decline of dermal fibroblast function. Dermal fibroblasts are key regulators of extracellular matrix (ECM) composition, wound healing, and tissue homeostasis. …”
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In situ optical mapping of voltage and calcium in the heart. by Peter Lee, Fouad Taghavi, Ping Yan, Paul Ewart, Euan A Ashley, Leslie M Loew, Peter Kohl, Christian Bollensdorff, Christopher E Woods

“…Optical mapping of cardiac electrophysiology combines high spatiotemporal resolution of anatomy and physiological function with fast and simultaneous data acquisition. …”
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