Effectiveness and cost-effectiveness of a structured integrated post-pulmonary embolism follow-up care model (Attend-PE): a rationale and protocol for a multicentre clinical pre-po... by Thomas Kümler, Søren Paaske Johnsen, Anette Arbjerg Højen, Erik Lerkevang Grove, Frederikus A Klok, Bettina Wulff Risør, Stavros Konstantinides, Jan Brink Valentin, Nanna Rolving, Stine Foged Lindegaard

“…Introduction Patients with pulmonary embolism (PE) experience impaired functional ability and reduced quality of life long after discharge from the hospital. …”
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Evolution of Budget Expenditures on Agriculture in Poland Over Two Decades of Membership in the European Union by Ryszard Kata, Andrzej Czyżewski, Anna Matuszczak

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Facilitators and barriers to implementation of early intensive manual therapies for young children with cerebral palsy across Canada by Divya Vurrabindi, Alicia J. Hilderley, Adam Kirton, John Andersen, Christine Cassidy, Shauna Kingsnorth, Sarah Munce, Brenda Agnew, Liz Cambridge, Mia Herrero, Eleanor Leverington, Susan McCoy, Victoria Micek, Keith O. Connor, Kathleen O’ Grady, Sandra Reist-Asencio, Chelsea Tao, Stephen Tao, Darcy Fehlings

“…Play-based early intensive manual therapies (EIMT) is an evidence-based practice to improve long-term hand function particularly for children with asymmetric hand use due to CP. …”
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Secretome of human amniotic membrane stem cells promote recovery and testicular functions through modulating SIRT1/NRF2/TNF-α pathway in mice testicular torsion: An experimental st... by Roghayeh Esfehani, Farnaz Khadivi, Jamal Valipour, Maryam Shabani, Mahya Ramesh, Parinaz Javanbakht, Davood Zarini, Sina Mojaverrostami, Masih Hoseini

“…Serum testosterone levels, hematoxylin and eosin staining, and sperm quality parameters were used to evaluate the therapeutic effects of hAMSCs secreted factors on the testicular structure and function. Tissue oxidative stress was measured by determining malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase-1. …”
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Rhythm Interactive Special Enablers (R.I.S.E) - A collaborative community engagement program by Wen Fen Beh, Edwin Lawrance Nathaniel, Swee Chuan Tan, Kenny S.L. Cheah, Florence Kuek, Joanne Pei Sze Yeoh, Yiing Siing Wong

“… Rhythm Interactive Special Enablers (R.I.S.E.) is a collaborative community engagement program designed to improve motor function, engagement and self-esteem through music-based intervention in children with cerebral palsy (CP). …”
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Deciphering the Metabolic Impact and Clinical Relevance of N‐Glycosylation in Colorectal Cancer through Comprehensive Glycoproteomic Profiling by Guobin Liu, Lu Chen, Jingxiang Zhao, Yue Jiang, Yarong Guo, Xiang Mao, Xuelian Ren, Kun Liu, Qi Mei, Qunyi Li, He Huang

“…Through analysis of glycoform expression profiles and structural characteristics, a glycosylation site–protein function association network is constructed to uncover metabolic dysregulation driven by N‐glycosylation in CRC. …”
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Nonregular Physical Activity and Handgrip Strength as Indicators of Fatigue and Psychological Distress in Cancer Survivors by Ilaria Pepe, Alessandro Petrelli, Francesco Fischetti, Carla Minoia, Stefania Morsanuto, Livica Talaba, Stefania Cataldi, Gianpiero Greco

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Effect of Xingbi Gel Nasal Drops on Rats with Allergic Rhinitis Based on the Nasal Mucosa-Hippocampus Neuroimmune Mechanism by FAN Xueqi, QIU Caixia, YAN Shuiping, ZHUANG Xiangli, AI Si, GUO Lihua, ZHENG Jian

“…After the model was successfully established, the normal group and model group were both given normal saline nasal drops (50 μL once), the traditional Chinese medicine group was given Xingbi gel nasal drops (50 μL once), and the western medicine group was given budesonide nasal spray (20 μL once), twice a day, and the interventions were continued for 12 days. The AR rat behavioral scoring criteria was used to evaluate rhinitis behavior of rats; Morris water maze test was used to evaluate learning and memory function of rats; enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of immunoglobulin E (IgE) and transforming growth factor-β1 (TGF-β1); hematoxylin-eosin (HE) staining was used to observe pathological changes of nasal mucosa and eosinophil (EOS) count; immunohistochemistry method was used to detect expression levels of non-receptor tyrosine kinases Fyn, substance P (SP), vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in the hippocampus; and real-time polymerase chain reaction (RT-PCR) was used to detect mRNA transcription levels of Fyn, SP, VIP and NPY in the hippocampus.Results(1) Behavioral scores of rhinitis: compared with the normal group, behavioral scores of rhinitis were significantly higher in the model group, the traditional Chinese medicine group and the western medicine group before treatment (<italic>P</italic>&lt;0.05). …”
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Rationale and Design of the REPEAT Trial: A Multicenter Randomized Trial Comparing Redo Surgical Aortic Valve Replacement to Valve‐in‐Valve Transcatheter Aortic Valve Replacement... by Matthias Raschpichler, Suzanne de Waha, Stefan Blankenberg, Marcio A. Diniz, Emilia Bagiella, Annetine C. Gelijns, Vinicius F. Calsavara, Aakriti Gupta, Niklas Schofer, Tsuyoshi Kaneko, Mohamed Abdel‐Wahab, Holger Thiele, Raj Makkar, Michael A. Borger

“…Secondary end points include each of the individual components of the primary composite end point, Valve Academic Research Consortium‐3–based conduction disturbances and arrhythmia, Valve Academic Research Consortium‐3–based wound and bleeding complications, functional status (ie, 6‐minute walk test, Kansas City Cardiomyopathy questionnaire), and treatment costs. …”
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Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training: protocol for a Hybrid Type I effectiveness–implementation study employing... by Paul Estabrooks, Jessica D Austin, Brenda Ernst, Diane K Ehlers, Lindsey L Page, Edward Ofori, Gwenndolyn C Porter, Jason Fanning, Gabriella Hickman, Paul McKim, Melissa Cole, Maliyah Donaldson, B Blair Braden, Katie L Kunze, Richard J Butterfield, Leslie C Baxter, Tim A Ahles

“…Cognitive performance (primary), self-reported cognition, patient-reported outcomes, physical activity and cardiorespiratory fitness are measured at baseline, 6 months (postintervention) and 12 months (follow-up). Brain structure and function are measured via magnetic resonance imaging (MRI) at baseline and 6 months. …”
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Effects of CBT on Planning Skills in Male Adolescents with ADHD: by Sahar Sayyah, sina Sayyah

“…Attention Deficit Hyperactivity Disorder (ADHD) impairs executive functions, especially planning skills, in adolescents. …”
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Protocol for the development and validation of a Core Set for exercise-based rehabilitation of adults with multiple long-term conditions (multimorbidity) based on the World Health... by Fanuel M. Bickton, James R. Manifield, Felix Limbani, Justin Dixon, Anne E. Holland, Rod S. Taylor, Claire Calderwood, Walter Wittich, Celia L. Gregson, Martin Heine, Zahira Ahmed, Ronel Roos, Sally J. Singh

“…Conclusion An ICF Core Set created for multimorbidity rehabilitation will (1) benefit patients with multimorbidity who are often excluded from clinical trials of single-disease rehabilitation programs, (2) ensure precise and comprehensive assessment and documentation of functioning and disability relevant to this patient population, (3) help rehabilitation providers and their patients and/or caregivers when setting rehabilitation goals and planning rehabilitative interventions to achieve those goals, (4) help researchers in the synthesis of evidence for multimorbidity rehabilitation and facilitate the comparability of data across studies and countries, and (5) provide the scientific basis from which assessment tools can be derived for use in clinical and research settings and health care administration. …”
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Cognitive abilities in a sample of young Swedish children by Ingela Clausén Gull, Johanna Stålnacke, Lilianne Eninger, Laura Ferrer-Wreder, Kyle Eichas

“…Furthermore, this study contributes to the theoretical discussion on EF structure during childhood, and provides a sound empirical rationale for the further development of early interventions that consider young children’s executive functions and preliteracy skills.…”
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Evaluating the Clinical Efficacy of an Exergame-Based Training Program for Enhancing Physical and Cognitive Functions in Older Adults With Mild Cognitive Impairment and Dementia Re... by Aoyu Li, Wei Qiang, Jingwen Li, Yan Geng, Yan Qiang, Juanjuan Zhao

“… BackgroundCognitive impairment is an important public health challenge among older adults, particularly in long-term care facilities (LTCFs), where prevalence is higher due to staffing shortages, limited resources, and difficulty maintaining structured exercise programs. Furthermore, older adults often lose interest in repetitive interventions. …”
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Thalidomide alleviated IgA nephropathy through “gut-kidney axis” by Rui-hua Wang, Zhi-jian Zha, Zi-yang Ye, Ya-feng Li

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Person-centered support for patients with a pituitary tumor following surgery by Sofie Jakobsson, Oskar Ragnarsson, Tobias Hallén, David Krabbe, Ann-Charlotte Olofsson, Daniel S Olsson, Penelope Trimpou, Thomas Skoglund, Gudmundur Johannsson

“…The study does, however, suggest that the intervention may reduce anxiety 12 months after surgery and that certain subgroups of patients may benefit more from a structured person-centered practice following pituitary surgery.…”
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On the issue of critical arterial stenosis by A. A. Suprunovich, A. Ya. Bedrov, A. A. Vrabiy, A. A. Moiseev, A. V. Baykova, R. V. Kalmykova, A. S. Dolzhikova

“…Therefore, to analyze such changes, functional tests were introduced to clarify the indications for surgical intervention. …”
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Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Given its central involvement in cell division and proliferation, katanin represents a promising target for therapeutic intervention, particularly in cancer treatment. Inhibiting katanin’s function could potentially hinder the uncontrolled growth of cancerous cells, making it an attractive target for novel anti-cancer therapies. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…The primary outcomes are the changes in the Fugl-Meyer Assessment-Upper Extremity and Modified Ashworth Scale after the 3-week intervention. Secondary outcomes include neurophysiological metrics and neuroimaging results from diffusion tensor imaging and resting-state functional MRI.Ethics and dissemination The trial is registered with the Chinese Clinical Trial Registry (Registration No. …”
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In between, an artifact: multiscale hybrid architectural projects for the peri-urban landscape by Ezequiel Collantes, Iñigo García Odiaga

“…The case studies share several characteristics that enable them to have a transformative impact on peri-urban areas. First, they function across the multiple scales of the peri-urban landscape. …”
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