In Silico Identification and Functional Impact of Deleterious Nonsynonymous Single-Nucleotide Polymorphisms (nsSNPs) in Type 2 Diabetes–Associated Genes in South Asian Populations... by Md. Hafizur Rahman, Md. Numan Islam, Md. Golam Rabby, Salina Shaheen Parul, Md. Mahmudul Hasan, Mrityunjoy Biswas

“…The nsSNPs are genetic variations that alter amino acids within proteins, affecting protein structure and function. This study investigated seven candidate genes associated with T2D pathogenesis from genome-wide association studies (GWASs) catalog datasets. …”
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Investigation of functionally graded triply periodic minimal surfaces with graphene-reinforced AlSi10Mg powder: Design, fabrication and impact resistance by Mengyuan Hu, Xueqing Wu, Yangyang Xu, Xin Huang, Da Lu, Baoqing Pei

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Protection against lethal HAdV-4 challenge in STAT1 mice by novel human monoclonal antibodies by Xinyi Zhang, Xinyi Zhang, Zhongge Zhu, Peijie Zhai, Peijie Zhai, Peng Lv, You Yang, Chuanhang Cheng, Busen Wang, Ting Fang, Guanying Zhang, Xiangyang Chi, Jianmin Li, Wei Chen, Yunzhu Dong

“…Subsequently, we predicted key functional residues through structural modeling of antigen-antibody complexes and validated their roles via mutagenesis studies. …”
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Dietary resistant starch protects against post-antibiotic intestinal damage by restoring microbial homeostasis and preserving intestinal barrier function in meat duck by Simeng Qin, Yifeng Zhu, Gang Tian, Martin Blomberg Jensen, Keying Zhang, Xuemei Ding, Shiping Bai, Jianping Wang, Yue Xuan, Qiufeng Zeng

“…To directly assess the effects of RS on gut microbiota and its role in improving intestinal barrier function in meat ducks, this study first established an antibiotic-induced microbial dysbiosis model, which was characterized by reduced gut microbial diversity, intestinal dysfunction, and an inflammatory outburst following antibiotic exposure. …”
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Comparison between the motor function of school-aged children with normal birth weight and children with low birth weight: a cross-sectional study by Amitava Pal, Sourav Manna, Prakash C Dhara

“…Different socio-demographic variables of the participants were studied by using a pre-structured schedule questionnaire. Gross motor function was studied by standing broad jump and vertical jump whereas fine motor function was studied by hand reaction time and speed of movement. …”
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Tensiomyography, functional movement screen and counter movement jump for the assessment of injury risk in sport: a systematic review of original studies of diagnostic tests by Álvaro Velarde-Sotres, Álvaro Velarde-Sotres, Álvaro Velarde-Sotres, Antonio Bores-Cerezal, Josep Alemany-Iturriaga, Josep Alemany-Iturriaga, Josep Alemany-Iturriaga, Julio Calleja-González

“…The main objective of this systematic review was to compile, synthesize and integrate international research published in different scientific databases on Countermovement Jump (CMJ), Functional Movement Screen (FMS) and Tensiomyography (TMG) tests and technologies for the assessment of injury risk in sport. …”
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Effects of a Digital Functional Exercise Program on the Disease Activities and Physical Capabilities of Patients With Ankylosing Spondylitis: Protocol for a Randomized Controlled T... by Xingkang Liu, Xiaojian Ji, Lidong Hu, Tianyu Jiang, Ang Min, Lulu Zeng, Yiwen Wang, Meihui Zhao, Jian Zhu, Feng Huang, Changshui Weng, Zheng Zhao

“… BackgroundAnkylosing spondylitis (AS), a chronic inflammatory disease, causes spinal stiffness, functional impairment, and reduced quality of life. …”
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The Acute Effects of Non-concussive Head Impacts on Brain Microstructure, Chemistry and Function in Male Soccer Players: A Pilot Randomised Controlled Trial by Nathan Delang, Rebecca V. Robertson, Fernando A. Tinoco Mendoza, Luke A. Henderson, Caroline D. Rae, Stuart J. McDonald, Ben Desbrow, Christopher Irwin, Aimie L. Peek, Elizabeth A. Cairns, Paul J. Austin, Michael A. Green, Nicholas W. Jenneke, Jun Cao, William T. O’Brien, Shane Ball, Michael E. Buckland, Katherine Rae, Iain S. McGregor, Danielle McCartney

“…Blood was also sampled, and cognitive function assessed, pre-, post-, 2.5 h post-, and 24 h post-task. …”
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Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) protein-derived antioxidant peptides: mechanisms of action and structure-activity relationship in Caco-2 cell models by Yiming Zhou, Xuanming She, Zhidong Chen, Yun Wei, Ying Xiao, Xiaoli Zhou

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Does Urban Polycentric Structure Improve Carbon Emission Efficiency? A Spatial Panel Data Analysis of 279 Cities in China from 2012 to 2020 by Shihan Zhang, Yanxin Xue, Shuzhen Jin, Zhenghong Chen, Suiying Cheng, Wei Wang

“…Urban spatial structure, shaped by human intervention in the natural environment, impacts the functional space and socioeconomic efficiency of cities. …”
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Bridging nutrition and neurology: malnutrition's role in perioperative neurocognitive disorders by Li Luo, Li Luo, Qihai Gong, Miao He, Yuhang Zhu, Wanqiu Yu, Taowu Gong, Pengcheng Zhao, Zhaoqiong Zhu

“…Studies suggest that preoperative malnutrition may heighten the risk of PND, and that preoperative nutritional diagnosis and perioperative nutritional interventions could reduce the occurrence of PND. The review discusses the definition, diagnosis, and indicators of malnutrition, as well as the mechanisms by which malnutrition leads to PND, including direct pathways such as psychological factors, abnormal neurotransmitter synthesis, and changes in brain structure and function, and indirect pathways like impaired immune function, neuroinflammation, mitochondrial dysfunction, intestinal barrier damage, disruption of the gut-brain axis, lymphatic system dysfunction, and endocrine disruption. …”
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Rehabilitation of the lower extremities, standing and walking function in people with spinal cord injury or disease: Guideline of the German-Speaking Medical Society for Spinal Cor... by Irrgang, Sophie, Himmelhaus, Sandra, Allek, Kirstin, Bartholet, Claudio, Bersch-Porada, Ines, Curt, Armin, Huber, Burkhart, Kuhn, Daniel, Kynast, Karen, Weidner, Norbert, Scheel-Sailer, Anke

“…Recommendations on assessments were grouped to the categories “activity and participation” or “body functions/body structures”. Recommendations on interventions were labeled with outcomes standing, walking, strength, range of motion, pain and muscle tonus. …”
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Remediation Program with Working Memory and Reading for Students with Learning Difficulties: Elaboration and Pilot Study by Isabella Nicolete Xavier, Simone Aparecida Capellini

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Effects of aerobic exercise on body composition and exerkines in colorectal cancer survivors by Eunhan Cho, Miranda Chodzko, Stephanie L. E. Compton, Shengping Yang, Steven Heymsfield, Guillaume Spielmann, Guillaume Spielmann, Justin C. Brown, Justin C. Brown, Justin C. Brown, Justin C. Brown, Justin C. Brown

“…This study investigated whether a 12-week structured exercise training intervention increases IL-7 and IL-15 in colorectal cancer survivors.MethodsSixty colorectal cancer survivors were randomized to a moderate-intensity home-based aerobic exercise group (150 min/week) or a control group for 12 weeks. …”
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Evaluating the functional and genomic analysis of pathogenic junctophilin-2 variants and their association with the pathogenesis of cardiomyopathy to understand their molecular imp... by Muhammed Ali Siham

“…Mutations in JPH2 have been associated with a range of clinical phenotypes including early-onset heart failure and cardiomyopathies, a diverse group of diseases affecting heart muscle structure and function that contribute to heart failure and sudden cardiac death. …”
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Effects of device-assisted practice of activities of daily living in a close-to-normal pattern on upper extremity motor recovery in individuals with moderate to severe stroke: stud... by Justin M. Drogos, Carolina Carmona, Riegele Arceo, Jun Yao

“…The focus on the more impaired chronic stroke population provides the opportunity to improve the rehabilitation of this overlooked population. Functional and structural measures using advanced imaging techniques offer the possibility to further delineate recovery and compensation at the neuronal level. …”
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Human-Prosthetic Interaction (HumanIT): A study protocol for a clinical trial evaluating brain neuroplasticity and functional performance after lower limb loss. by Elke Lathouwers, Bruno Tassignon, Alexandre Maricot, Ahmed Radwan, Maarten Naeyaert, Hubert Raeymaekers, Peter Van Schuerbeek, Stefan Sunaert, Johan De Mey, Kevin De Pauw, Kevin De Pauw

“…<h4>Background</h4>Lower limb amputation contributes to structural and functional brain alterations, adversely affecting gait, balance, and overall quality of life. …”
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Engineering a Dual-Function Starch–Cellulose Composite for Colon-Targeted Probiotic Delivery and Synergistic Gut Microbiota Regulation in Type 2 Diabetes Therapeutics by Ruixiang Liu, Yikang Ding, Yujing Xu, Qifeng Wu, Yanan Chen, Guiming Yan, Dengke Yin, Ye Yang

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Effects of Maillard reaction and its product AGEs on aging and age-related diseases by Huan Peng, Yuqi Gao, Chenye Zeng, Rui Hua, Yannan Guo, Yida Wang, Zhao Wang

“…Despite certain advantages based on Maillard reaction products (MRPs) found in some food for health and storage application have appeared, however, the MR occurring in human physiological environment can produce advanced glycation end products (AGEs) by non-enzymatic modif ication of macromolecules such as proteins, lipids and nucleic acid, which could change the structure and functional activity of the molecules themselves. …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…We found strong evidence that cognitive function was lower in CBHF compared to CHU across multiple domains. …”
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