Genome-scale metabolic modelling of human gut microbes to inform rational community design by Juan Pablo Molina Ortiz, Dale David McClure, Andrew Holmes, Scott Alan Rice, Mark Norman Read, Erin Rose Shanahan

“…The resulting functional database indicated that DRC-degrading abilities are rare among gut microbes, suggesting that the presence or absence of specific taxa can determine the success of DRC-based interventions. …”
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Psychometric properties of the Arabic version of the McMaster family assessment device–general functioning subscale (FAD-GF) among a sample of Lebanese adults by Melyssa Assaf, Rabih Hallit, Diana Malaeb, Fouad Sakr, Mariam Dabbous, Feten Fekih-Romdhane, Sahar Obeid, Souheil Hallit

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Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4 by Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu

“…Here, our findings revealed that sleep fragmentation (SF) displayed notable hepatic detrimental phenotypes, including steatosis and oxidative damage, along with significant abnormalities in cardiac structure and function. All these pathological changes persisted even after sleep recovery for 2 consecutive weeks or more, displaying memory properties. …”
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Thyroid Dysfunction and Cytological Patterns among Patients Requested for Thyroid Function Test in an Endemic Goiter Area of Gondar, North West Ethiopia by Daniel Asmelash, Kumlgn Tesfa, Belete Biadgo

“…For early diagnosis and appropriate intervention in goiter endemic areas, the thyroid function test should be closely monitored.…”
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ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle by Mao Chen, Xiaoyu Huang, Bingshu Li, Ya Xiao, Liying Chen, Fangyi Zhu, Shasha Hong, Jianming Tang, Suting Li, Jie Min, Wenyi Jin, Yubiao Zhang, Lian Yang, Yang Li, Shufei Zhang, Li Hong

“…Methods Mouse models of natural ageing and D‐gal (D‐galactose)–induced ageing were subject to analyse the structure, function and pathological alterations of the PFM and the expression of ArfGAP3. …”
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Cognitive flexibility is associated with the age of onset and duration among patients with type 1 diabetes by Ding Mojun, Yuan Dongling, He Jing, Zou Wenjing, Li Xia, Li Chuting, Zhu Xiongzhao

“…Longitudinal studies are needed to further understand these relationships and guide targeted interventions to preserve cognitive function.…”
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Longitudinal Reciprocal Effects of Physical Exercise, Executive Function, and Subjective Well-Being: A Three-Wave Random-Intercept Cross-Lagged Panel Model in Chinese Minority Coll... by Xueyan Bai, Lin Yang

“…Objective: This study investigates the longitudinal reciprocal relationships among physical exercise (PE), executive function (EF), and subjective well-being (SWB) in ethnic minority college students in China, with the aim of providing theoretical and practical guidance for their psychological and cognitive development. …”
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Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis by Seda Sevilay Koldaş, Osman Uğur Sezerman, Emel Timuçin

“…Specifically, Streptococcus was found to be significantly associated with mediating the decline in lung function on treatment compared to exacerbation, while Gemella was associated with the decline in lung function on recovery. …”
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Enhancing cognitive abilities through transcutaneous auricular vagus nerve stimulation: Findings from prefrontal functional connectivity analysis and virtual brain simulation by Sora An, Se Jin Oh, Shinhee Noh, Sang Beom Jun, Jee Eun Sung

“…Current results indicate that the efficacy of taVNS interventions for cognitive enhancement may vary according to the pre-intervention structural and functional states of individual brains. …”
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Targeted maximum likelihood based estimation for longitudinal mediation analysis by Wang Zeyi, Laan Lars van der, Petersen Maya, Gerds Thomas, Kvist Kajsa, Laan Mark van der

“…Causal mediation analysis with random interventions has become an area of significant interest for understanding time-varying effects with longitudinal and survival outcomes. …”
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Interplay of fatty acids, insulin and exercise in vascular health by Kara C. Anderson, Jia Liu, Zhenqi Liu

“…Importantly, these effects are both functionally and structurally dependent, with saturated fatty acids as the primary culprits, while polyunsaturated fatty acids may support insulin sensitivity and endothelial function. …”
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Bibliometric mapping of diabetes mellitus and sarcopenia research: hotspots and emerging trends by Min Wang, Qiyang Zhou, Xinyu Guo, Xiaolong Cui, Zhongquan Tang, Ting Ou, Xiaomin Zhao, Chen Liang, Peiyu Xu, Xinyu Dai, Jingqing Yao, Guozhong Ji, Yuntao Li

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Understanding the role of family functioning, dietary adherence, and culture on glycemic control among adults with type 2 diabetes: A mediation and moderation analysis. by Halimatou Alaofè, Abidemi Okechukwu, Waliou Amoussa-Hounkpatin, Iman A Hakim, Carmelle Mizéhoun-Adissoda, Jules Gninkoun, Edward John Bedrick, John Ehiri

“…Mediation and moderation analyses were conducted using Stata's structural equation model (SEM).<h4>Results</h4>Healthy family functioning, good dietary adherence and good glycemic control rates were 56.8%, 33%, and 30.5% respectively. …”
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Myths and facts about functional neurological disorders: a cross-sectional study of knowledge and awareness among medical students and healthcare professionals in Iraq by Ahmed Hashim, Essam M Al-Sibahee, Sajjad Al-Badri, Nabeel Al-Fatlawi

“…Background Functional neurological disorder (FND) is a complex condition with neurological symptoms but no clear structural or biochemical explanation. …”
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The mediating role of family adaptability in the relationship between insecure attachment and family functioning in patients with major depression disorder: a cross-sectional study by Xinlei Cheng, Xinlei Cheng, Xinfei Li, Jinlong Zhao, Jinlong Zhao, Lei Wang, Lei Wang, Xiaoning Shi, Xiaoning Shi

“…IntroductionDepression ranks as the second leading cause of the global health burden; therefore, identification of its risk and influencing factors is essential to develop more effective multidimensional interventions. The aim of the present study was to analyze the mediating role of family adaptability (FA) on the relationship between insecure attachment (IA) and family functioning (FF) in patients with major depressive disorder (MDD), which currently remains unclear. …”
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Evaluating Heart Rate Variability as a Biomarker for Autonomic Function in Parkinson’s Disease Rehabilitation: A Clustering-Based Analysis of Exercise-Induced Changes by Ahmed M. Basri, Ahmad F. Turki

“…The identification of response subgroups suggests the need for personalized rehabilitation strategies to optimize autonomic function. Further research is warranted to explore the long-term impact of HRV-guided rehabilitation interventions in PD management.…”
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Wearable Focal Muscle Vibration Device for Reducing Spasticity and Improving Upper Limb Function: Device Co-Design and Results From a Feasibility Study in People With Stroke by Moeez Ashfaque, Elizabeth Mills, Jamie Grant, Charlotte Vye, Alison Watt, Amy Dennis Jones, Simon F. Farmer, Amit N. Pujari

“…Objective: This study set out to co-design a wearable Focal Muscle Vibration (FMV) device and test its feasibility as a rehabilitation tool to reduce spasticity and improve upper limb function in stroke population. Methods: The objective was achieved through carrying out: a) a semi-structured workshop involving chronic stroke patients, clinicians and researchers to gather systematic user feedback, b) changes to the device design based on this feedback, c) feasibility study comparing effectiveness of 40 minutes of INTERVENTION (FMV+ conventional therapy) with CONTROL (conventional therapy alone), in reducing spasticity and improving upper limb function in 10 stroke participants, d) Quantitative (Fugl Meyer Upper Limb (FMUL), Modified Ashworth (MASh), Pittsburgh Rehabilitation Participation Scale (PRPS), Recruitment Rate and Retention Rate)) and Qualitative (verbal and written feedback), measures to assess participants perception of the wearable technology and its potential as a rehabilitation tool in reducing spasticity and improving function. …”
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Pilot Randomised Controlled Trial of a Web-Based Intervention to Promote Healthy Eating, Physical Activity and Meaningful Social Connections Compared with Usual Care Control in Peo... by Jose Lara, Nicola O'Brien, Alan Godfrey, Ben Heaven, Elizabeth H Evans, Scott Lloyd, Suzanne Moffatt, Paula J Moynihan, Thomas D Meyer, Lynn Rochester, Falko F Sniehotta, Martin White, John C Mathers

“…Thematically analysed, semi-structured, qualitative interviews assessed acceptability of the intervention, trial design, procedures and outcome measures.…”
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Development of a Methodology Based on ALS Data and Diameter Distribution Simulation to Characterize Management Units at Tree Level by Jean A. Magalhães, Juan Guerra-Hernández, Diogo N. Cosenza, Susete Marques, José G. Borges, Margarida Tomé

“…MUs within a forest intervention zone in northern Portugal, the research initially assesses the suitability of two highly flexible Probability Density Functions (PDFs), Johnson’s SB and Weibull, for simulating diameter distribution in maritime pine stands in Portugal using the PINASTER database. …”
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The impact of flatfeet on the correlation between functional movement scores, balance, agility, and core muscle strength in young females: a cross-sectional study by Maryam Ghorbani, Rasoul Yaali, Hassan Sadeghi, George A. Koumantakis

“…Abstract Changes in foot structure, particularly the presence of flatfeet, have been associated with various limitations in physical performance. …”
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