Comparative efficacy and safety of first-line neoadjuvant therapy for early-stage non-small cell lung cancer based on immune checkpoint inhibitor therapy: a systematic review and n... by Linfeng Wang, Guangda Zheng, Yue Hu, Ayidana Maolan, Yue Luo, Yue Li, Rui Liu

“…Methods We searched PubMed, EMBASE, Cochrane Library, ClinicalTrials.go and randomised controlled trials (RCTs) from major international conferences for literature related to neoadjuvant immunotherapy combinations published as first-line treatment options for non-small cell lung cancer from the start of the library to 20 February 2024, and performed a systematic review and network meta-analysis. …”
Get full text

Chasing the Beginning of Reionization in the JWST Era by Christopher Cain, Garett Lopez, Anson D’Aloisio, Julian B. Muñoz, Rolf A. Jansen, Rogier A. Windhorst, Nakul Gangolli

Get full text

Exploring the value of digital twins for information management in highway asset maintenance by Mengtian Yin, Varun Kumar Reja, Ran Wei, Ioannis Brilakis, Brian Sheil, Federico Perrotta, Alix Marie d'Avigneau, Linjun Lu

Get full text

Epidermal Growth Factor Receptor Exon 19 Deletion Subtypes Do Not Influence Survival Outcomes Following First-line Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitors in Ad... by Yan-Jei Tang, John Wen-Cheng Chang, Chen-Yang Huang, Yueh-Fu Fang, Ching-Fu Chang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu, Chiao-En Wu

Get full text

Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Biomarker analyses of serial blood and tumor samples are planned to clarify predictive markers and molecular mechanisms underlying treatment resistance by multifaceted analytical methods (e.g., flow cytometry, DNA sequencing [DNAseq]/RNA sequencing [RNAseq]). Recruitment started in November 2022. Discussion The PADDLE trial is expected to clarify the efficacy of nab-paclitaxel plus ramucirumab in combination with nivolumab as second-line treatment in patients with AGC refractory to first-line treatment including an anti-PD-1/PD-L1 antibody and to identify potential biomarkers for predicting clinical responses in patients with AGC undergoing this triplet regimen. …”
Get full text

Case report: PD-L1-targeted high-affinity natural killer cells and IL-15 superagonist N-803-based therapy extend overall survival of advanced metastatic pancreatic cancer patients by Tara Seery, Lennie Sender, Omid Jafari, Frank Jones, Patricia Spilman, Sandeep B. Reddy, Patrick Soon-Shiong

“…Duration of spIND treatment and responses, for some patients including imaging and carbohydrate antigen 19-9 (CA19-9) levels, and OS from initial diagnosis and the start of spIND therapy were assessed.FindingsThe line/duration of spIND therapy was, for patients 1 through 5, respectively, second line/6.4 months, sixth line/3.5 months, third line/25.4 months, third line/7.4 months, and fourth line/23.2 months. …”
Get full text

Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase: a case report by Alaina P. Vidmar, Linus Kaiser, Matthew J. Martin, Stuart Abel, Aimee G. Kim, Madeleine Weitzner, Cynthia E. Muñoz, Lynda K. Fisher, Mimi S. Kim, Kamran Samakar

Get full text

The Polynomial Pivots as Initial Values for a New Root-Finding Iterative Method by Mario Lázaro, Pedro Martín, Antonio Agüero, Ignacio Ferrer

“…Both the recursive functions (linear) and the corrected (quadratic convergence) are validated with two nontrivial numerical examples. …”
Get full text

Transcutaneous Bilirubin Measurements Can Be Used to Measure Bilirubin Levels during Phototherapy by Saad Abdullah Alsaedi

“…During phototherapy, TSB and TcB were 191.8±39.4 and 187.8±45.3 μmol/l, respectively. Linear regression analysis showed a significant correlation between TcB and TSB before starting phototherapy and during phototherapy (r: 0.85; p<0.001 and r: 80.0; p<0.001), respectively. …”
Get full text

Due-Window Assignment and Resource Allocation Scheduling with Truncated Learning Effect and Position-Dependent Weights by Shan-Shan Lin

“…This paper studies single-machine due-window assignment scheduling problems with truncated learning effect and resource allocation simultaneously. Linear and convex resource allocation functions under common due-window (CONW) assignment are considered. …”
Get full text

A Novel Elastic Metamaterial with Multiple Resonators for Vibration Suppression by Saman Ahmadi Nooraldinvand, Hamid M. Sedighi, Amin Yaghootian

“…The model with one DOF is built by assembling several unite cells in which each unite cell consists of a rectangular frame as the base structure and a rack-and-pinion mechanism that is joined to the frame with a linear spring on both sides. In the second model with two DOF, a small mass is added while its center is attached to the center of the pinion on one side and the other side is connected to the rectangular frame via a linear spring. …”
Get full text

A Method for Quantifying Automobile Brake Creep Groan Intensity Based on Friction-Induced Vibration and Noise by Lijun Zhang, Jianfeng Wu, Dejian Meng

“…Analytically, four vibration indexes and four noise indexes are established to evaluate the intensity of creep groan, the validity of which is verified by linear regression analysis. Finally, by combining all effective indexes, multiple linear regression analysis is performed, based on which the mapping relationship between the subjective evaluation of creep groan and effective indexes is obtained. …”
Get full text

Metric-affine cosmological models and the inverse problem of the calculus of variations. Part II: Variational bootstrapping of the $$\Lambda $$ Λ CDM model by Ludovic Ducobu, Nicoleta Voicu

“…In particular, they allow for a subclass of quadratic metric-affine theories restricted to linear terms in the curvature tensor.…”
Get full text

Cosmology, the big bang and the BKL conjecture by Ringström, Hans

“…It continues with a review of future global non-linear stability results, stable big bang formation results, results concerning solutions to linear equations on cosmological backgrounds and numerical results. …”
Get full text

Variational Approaches to Characterize Weak Solutions for Some Problems of Mathematical Physics Equations by Irina Meghea

“…In this way generalized versions for some results which use Ekeland variational principle, critical points for nondifferentiable functionals, and Ghoussoub-Maurey linear principle have been proposed. Three sequences of generalized statements have been developed starting from the most abstract assertions until their applications in characterizing weak solutions for some mathematical physics problems involving the abovementioned operators.…”
Get full text

On Sequences of J. P. King-Type Operators by Tuncer Acar, Mirella Cappelletti Montano, Pedro Garrancho, Vita Leonessa

“…This survey is devoted to a series of investigations developed in the last fifteen years, starting from the introduction of a sequence of positive linear operators which modify the classical Bernstein operators in order to reproduce constant functions and x2 on [0,1]. …”
Get full text

Driver’s Anticipation and Memory Driving Car-Following Model by Ammar Jafaripournimchahi, Lu Sun, Wusheng Hu

“…The changes of headway, relative velocity, and driver memory to the vehicle in front are introduced as factors of driver’s anticipation behavior. Linear and nonlinear stability analyses are both applied to study the linear and nonlinear stability conditions of the new model. …”
Get full text

Treatment Patterns and Healthcare Costs Among Patients with Stroke and Spasticity: A 2-Year Longitudinal Study by Michael Hull, Vamshi Ruthwik Anupindi, Jing He, Mitchell DeKoven, Jumaah Goldberg, Jonathan Bouchard

“…A generalized linear model was developed to estimate cost ratios between patients with and without PSS. …”
Get full text

Pseudo 3D Imaging of Dielectric and Magnetic Anomalies from GPR Data by Raffaele Persico, Sergio Negri, Francesco Soldovieri, Elena Pettinelli

“…This paper deals with the reconstruction of buried targets exhibiting both dielectric and magnetic characteristics, starting from GPR data collected at the interface air/soil. …”
Get full text

Analytical control in metallurgical production by M. N. Kovalenko, V. A. Chekan, L. V. Markova, V. V. Kolęda, A. F. Turutin

“…The capabilities of the atomic-emission analysis in the foundry industry are shown when the composition of the starting raw material and final production are controlled. …”
Get full text