Effect of Pulsed Injection on Continuous Adductor Block for Postoperative Analgesia after Total Knee Joint Operation by Xiangfeng WANG, Huiqin LUO, Wenzhong TANG, Tingting CHEN, Haojie LU, Guanghui LIU

“…In the CSI group, continuous dose was started right after prime dose injection, with a background dose of 6 mL/h;in the PI group, the pulse dose was 6 mL/h 60 minutes after prime dose;Both groups were set up PCA 10 mL each time, lock time was 30 minutes. …”
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Prediction of long-term drug-free outcomes in ACPA-positive and ACPA-negative rheumatoid arthritis by combined clinical and ultrasound assessment of residual disease: a 5-year pros... by Carlomaurizio Montecucco, Garifallia Sakellariou, Claudia Alpini, Catherine Klersy, Serena Bugatti, Ludovico De Stefano, Emanuele Bozzalla Cassione, Antonio Manzo, Blerina Xoxi, Terenzj Luvaro, Ylenia Sammali

“…Pre-selected clinical, serological and ultrasound (US) exposure variables at MTX withdrawal were analysed using multivariable Cox regression to predict time-to-flare.Results Of 761 EAC patients with RA, 132 started DF follow-up (person-months: 3678). 62 experienced a flare after a median (range) of 9 (3–60) months, resulting in a progressive decline in flare-free survival throughout the observation period. …”
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Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors by Alejandro Diaz-Barreiro, Dominique Talabot-Ayer, Arnaud Huard, Gea Cereghetti, Jenna Tonacini, Mike Maillasson, Antonio Francés-Monerris, Erwan Mortier, Gaby Palmer

“…Results Analysis of its native N-terminus revealed that the IL-38 protein produced by human keratinocytes starts at cysteine 2. In cell-based assays, neither full-length amino acid 2-152 IL-38 nor two N-terminally truncated forms of the protein showed efficient antagonist activity on IL-36R- and IL-1R1-mediated responses. …”
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Managing Post COVID-19 Patient with Breathlessness by Yen Shen Wong, Muhammad Amin Ibrahim, Mohd Arif Mohd Zim, Mohd Fauzi Abdul Rani

“…He received oral baricitinib and intravenous methylprednisolone for 3 days, which was then followed by tapering prednisolone starting dose of 1 mg/kg/day (60 mg/day) with reduction of 10 mg prednisolone every 3 days. …”
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Early versus late nephrology referral and patient outcomes in chronic kidney disease: an updated systematic review and meta-analysis by Linan Cheng, Nan Hu, Di Song, Li Liu, Yuqing Chen

“…The early referral was associated with shorter durations of initial hospitalization, a higher rate of kidney transplantation (RR = 1.41, 95% CI: 1.12–1.78), a lower likelihood of emergency start (RR = 0.39, 95% CI: 0.28–0.54), a higher likelihood of permanent access creation (RR = 3.34, 95% CI: 2.43–4.59), increased initial use of permanent access (RR = 2.60, 95% CI: 2.18–3.11), and reduced initial catheter use (RR = 0.43, 95% CI: 0.32–0.58). …”
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The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study by Federico Banchelli, Carlo Gagliotti, Angela De Paoli, Rossella Buttazzi, Elena Narne, Enrico Ricchizzi, Silvia Pierobon, Ugo Fedeli, Gisella Pitter, Elisa Fabbri, Michele Tonon, Elisa Gentilotti, Maurizia Rolli, Evelina Tacconelli, Maria Luisa Moro, Francesca Russo, Elena Berti

“…The pooled outputs showed an increase in rates of outpatient visits and diagnostics starting from month 2 after SARS-CoV-2 infection (IRR = 1.68, 95% CI = 1.56–1.81) with a peak at month 4 (IRR = 2.05, 95% CI = 1.95–2.15); the increase continued with reduced intensity up to month 15. …”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

“…While AS reduces overtreatment (and quality of life impact), long-term compliance can be poor, with many men undergoing radical treatment after starting AS.Methods and analysis Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer (FINESSE) is a prospective, open-label, two-arm, phase 3 trial, in which men with low or intermediate PCa are randomised (1:1) to receive AS with or without finasteride (5 mg once a day for 2 years). …”
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Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-U... by Chuan Wang, Lingshu Wang, Kai Liang, Fei Yan, Xinguo Hou, Fuqiang Liu, Li Chen

“…Compared with patients with constantly abnormal TG levels, the risks were even higher in the subjects who experienced a transition from normal TG to hypertriglyceridemia (OR=2.576 versus OR=2.184, after multiple adjustment), and by tight controlling of TG, patients started with abnormal baseline TG levels could reduce the risk of DKD progression to the same low levels as the TG-constantly-normal group. …”
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Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Low-dose Aspirin (LDA) has been shown to be beneficial in lowering the occurrence of EOP, especially when started before 16 weeks of pregnancy. Calcium supplementation is advantageous for women with poor dietary calcium intake, reducing endothelium activation and hypertension. …”
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Outcomes of Pediatric Patients with Crohn’s Disease Received Infliximab or Exclusive Enteral Nutrition during Induction Remission by Yao Lv, Yue Lou, Gan Yang, Youyou Luo, Jingan Lou, Qi Cheng, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Jie Chen

“…The median follow-up after starting IFX or EEN was 12.2 months (6.5–18.0months) and 18.9 months (7.1–30.7months), respectively. …”
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SYNERGISTIC EFFECT OF QUERCETIN AND EPIGALLOCATECHIN-3-GALLATE AS AGENTS TO PREVENT CONNECTIVE TISSUE DISINTEGRATION IN THE PERIODONTIUM OF RATS UNDER SYSTEMIC AND LOCAL ADMINISTR... by A.M. Yelins’ka, V.O. Kostenko

“…The studies were conducted on 30 white rats of the Wistar line weighing 180-220 g, divided into 5 groups: the 1st included intact animals, the 2nd was made up of animals after the combined systemic and local LPS administration, the 3rd and 4th groups included animals, which were being given injections with water-soluble form of quercetin (10 mg / kg) and EGCG (21.1 mg / kg) respectively 3 times a week, starting on the 30th day of the systemic LPS administration, and the 5th group involved rats, which were injected with co-administered water-soluble form of quercetin and EGCG. …”
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Structural Alteration, Hydration Stability, Heavy Metal Removal Efficiency, and Montmorillonite Porosity Fate by Coupling the Soil Solution pH and a Thermal Gradient by Chadha Mejri, Walid Oueslati, Abdesslem Ben Haj Amara

“…To explore the structural alteration, the hydration stability, and the evolution of montmorillonite porosity under a first order of external applied constraints coupling, a reference Na-rich montmorillonite specimen is used as a starting material, and three exchangeable heavy metal cations (Ba2+, Cu2+, and Co2+) have been selected. …”
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Long-term mortality in patients with end-stage renal disease undergoing hemodialysis and peritoneal dialysis: a propensity score matching retrospective study by Pengjie Zhang, Liru Xun, Nan Bao, Ding Tong, Bin Duan, Du Peng

“…This study aimed to investigate the differences in survival and the factors that influence it in patients with end-stage renal disease treated with HD or PD.Methods We retrospectively analyzed factors related to all-cause death with renal replacement therapy and compared the long-term mortality between HD and PD strategies in patients with ESRD who started HD or PD treatment in our renal HD center between January 1, 2008, and December 1, 2021.Results Overall, 1,319 patients were included, comprising 690 and 629 patients in the HD and PD groups, respectively, according to the inclusion criteria. …”
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More of the Same? D’Holbach and the Temptation of Self-Quotation by Ruggero Sciuto

“…In his ‘Voltaire autoplagiaire’, Nicholas Cronk looks at Voltaire’s tendency to self-quote (either openly or more stealthily) and argues that, while in the eighteenth century classical and Renaissance attitudes towards repetitions were already starting to be questioned, the patriarche de Ferney turned self-plagiarism into something of a stylistic signature, putting forward a ‘véritable esthétique du “copier/coller”’. …”
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Study on the evolution law of the ‘Butterfly-type’ plastic zone in the surrounding rock of deep dynamic pressure roadway by Yiwen Liang, Jianqiang Jin, Wenhua Zha, Tao Xu, Wenbo Cheng

“…The results show that: (1) When the lateral pressure coefficient λ ≠ 1.0, the plastic zone of the surrounding rock expands in the direction of inclination to the corners of the roadway, and the whole is similar to the “butterfly-type”, and the more the value of λ deviates from l.0, the more the shape of the plastic zone is similar to the “butterfly-type”. (2) Regarding the dynamic pressure coefficient and the change curve of the radius of the plastic zone, whether it is the shallow stress field or the deep stress field, the curve is the first smooth growth, and the dynamic pressure coefficient reaches a certain value (about D i  = 2.5), and the radius of the plastic zone starts to show a sharp nonlinear growth, which is a ‘sharp lifting type’. …”
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Shifts in northern Arizona plant and insect pollinator communities between 2 years with substantially different precipitation totals by P. R. Chesshire, P. R. Chesshire, L. M. Holeski

“…Additionally, the timing of plant and pollinator activity periods was less consistent in the dry year; there was delayed blooming for many floral resources until after monsoon rains began, and insect activity tended to start and continue later in the season for all life zones. …”
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LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord by Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao

“…In this study, rats received PNI surgery on their right lower legs followed by LIFU stimulation of the L4–L5 section of the spinal cord for 4 weeks, starting 3 days after surgery. We used the 50% paw withdraw threshold (PWT50) to evaluate mechanical allodynia. …”
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Coincidental or Connected: Synchronous Giant Gastric GIST and Malignant Colonic Polyp: A Case Report by Terukumar Chandrasekaran, Lim Li Yi, JJ Mah, RK Sriram, Nik Amin Sahid

“…The polyp base showed no malignancy. The patient was started on imatinib 400 mg once a day. GIST and colon malignant polyps are two distinct types of neoplasms that can occur synchronously. …”
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Cost-effectiveness of watchful waiting versus immediate emergency department transfer after epinephrine autoinjector use in Canada by Yiwei Yin, Moshe Ben Shoshan, Marcus Shaker, Matthew Greenhawt, Kate M. Johnson

“…Methods We developed a probabilistic Markov model of individuals starting at age of one year who are at risk of severe food-related allergic reactions requiring epinephrine. …”
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Associations between health, productive performance and oral fluid biomarkers in commercial pig farms by Mario Andre S. Ornelas, Edgar Garcia Manzanilla, José J. Cerón, Alba Ortín-Bustillo, María José López-Martínez, Carla Correia-Gomes, Finola C. Leonard, Lorena Franco-Martínez

“…Further, high creatine kinase and low procalcitonin early after weaning were associated with low piglet mortality, whereas low daily gain was related to high alpha-amylase in late weaners and high creatine kinase in pigs at the start of the finisher stage. Conclusions Haptoglobin, procalcitonin, oxytocin, creatine kinase and alpha-amylase, measured in oral fluid, should be further studied as good candidates to assess pig herds and predict performance at a batch level, through a non-invasive approach. …”
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