Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…For individual cancer types with prespecified statistical power, adjusted rwOS comparing TMB≥10 vs TMB<10 significantly favored TMB≥10 in 9 of 10 cancer types. …”
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Fact-finding and risk factor analysis of chemotherapy-induced nausea and vomiting in children with solid tumors: a prospective observational study by Miaomiao Shao, Ying Li, Jing Qin, Yuchen Zhou, Yixin Sun, Peiyi Yang, Xisi Wang, Cheng Huang, Yan Su, Wen Zhao

“…. >6 years: OR = 0.322, 95% CI 0.145 ~ 0.715), female (OR = 2.034, 95% CI 1.035 ~ 3.994), duration of chemotherapy block (OR = 1.611, 95%CI 1.039 ~ 2.499), and antiemetic regimen (5-hydroxytryptamine-3 receptor antagonists (5HT3RA) vs. 5HT3RA + dexamethasone: OR = 0.395, 95% CI 0.171 ~ 0.914) were statistically significant in complete CIV control (P < 0.05). …”
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Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…At disease onset, the latest classification criteria for TRAPS were fulfilled by 64/80 (80%) patients (clinical plus genetic items) and 46/80 (57.5%) patients (clinical items only). No statistically significant differences were found in the sensitivity of the classification criteria according to age at onset and according to genotype (p<0.05). …”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…Heterogeneity was assessed using I 2 statistics.ResultsThirteen articles including 582 eligible patients were analyzed. …”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…Disease duration (β = 0.0250, <i>p</i> = 0.102) and smoking status (β = 0.4529, <i>p</i> = 0.078) were not statistically significant. Lastly, correlation analysis revealed a significant association between SS-A antibodies and infection rate (r = 0.291, <i>p</i> = 0.003). …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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Recommender Systems for Unified Modeling Language and Vice Versa&#x2014;A Systematic Literature Review by Elaheh Azadi Marand, Amir Sheikhahmadi, Moharram Challenger, Parham Moradi, Alireza Khalilipour

“…The analysis revealed that the following challenges were identified: 19 studies dealt with the cold start problem, 20 studies with sparsity issues, 11 studies with scalability concerns, 3 studies with diversity challenges, and 12 studies with other types of challenges.…”
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1922 — the best year of the Comintern. Soviet Russia, German communists and the Genoa conference by A. Yu. Vatlin

“…The policy of the united workers front got a broader definition as the Communist International started to recognize the threat posed by fascism.…”
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Distribution features of the red squirrel (Sciurus vulgaris) in the south of Ukraine: a case study of Mykolaiv Oblast by Kostiantyn Redinov

“…In some places, the animals have established themselves and started breeding, such as in the cities of Novyi Buh, Mykolaiv, and Pervomaisk, and also in forest tracts, etc. …”
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Accuracy of Two Methods in Estimating Target Muscle Force During Shoulder Submaximal Isometric Contractions by Sean F. Griech, Christos Karagiannopoulos

“…Both methods (NR and RR), direction of force (IR and ER), and starting test-side (right or left) were randomized. …”
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The Fake Diary of a Historical Figure: Klementyna Tańska-Hoffmanowa’s Journal of Countess Françoise Krasińska (1825) by Magdalena Ożarska

“…The Journal of Countess Françoise Krasińska (1825) was one of her early works, designed for adolescent readers (first serialised in Rozrywki [Amusements], a youth magazine which she had started but a year earlier). Françoise (Polish: Franciszka) Krasińska was a historical character: born into a Polish aristocratic family of the Corvin-Krasińskis in 1742, she set her mind on rising above the social station originally allocated to her. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…Five depressed CVID patients (Hamilton Depression Rating Scale, HDRS >12) could be treated with Tα1 (8 weeks, 1.6 mg daily subcutaneously, 1st week, thereafter 1.6 mg twice weekly). At the start, at 8 weeks and 8 weeks after the last injection, the HDRS was recorded and blood samples drawn for measuring naïve and memory T cells, Th17 and Treg cells, hsCRP, IL-6 and IL-7. …”
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PSYCHOLOGICAL DIAGNOSTICS OF STUDENTS ADAPTATION TO UNIVERSITY STUDIES by Olga A. Molokova

“…Timely detection of difficulties which are experienced by students, starting training in higher education institution, helps improve educational process. …”
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Understanding the impact of racism on surgical outcomes in settler nation-states USA and Canada: a protocol for a systematic review and meta-analysis by Mary Brindle, Oluwatomilayo Daodu, Tyara Marchand, Saffa Aziz, Ifeoluwa Adedipe, Mirna Matta

“…Identifying preventable adverse outcomes for equity-deserving patient populations is an important starting point to begin to address these gaps in care. …”
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Shaking Table Test on the Seismic Response of Buried Oil and Gas Pipelines under the Bidirectional Nonuniform Seismic Excitation by Jianbo Dai, Chengtao Hu, Li Wang, Guidi Zhang

“…The soil displacement curve starts to smooth out when the loading level reaches 1.0 g, and the axial displacement decreases, which indicates that the interaction between the pipe and soil is more intense and the relative motion between the pipe and soil is more obvious under the nonuniform excitation, and the soil is more likely to be damaged and enter the nonlinear stage. …”
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Cimetidine Pharmacodynamics and Pharmacokinetics in Healthy Subjects: A Comparison of Tablets and Suspension by ABR Thomson, P Kirdeikis, L Zuk, RE Samuels, P Zarevics

“…The intragastric pH of each subject was measured over 6 h starting immediately before dosing on each of five study days. …”
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Coverage and effectiveness of conditional cash transfer for people with drug resistant tuberculosis in Zimbabwe: A mixed methods study. by Collins Timire, Charles Sandy, Rashida A Ferrand, Regina Mubau, Peter Shiri, Obert Mbiriyawanda, Fredrick Mbiba, Rein M G J Houben, Debora Pedrazzoli, Virginia Bond, Nicola Foster, Katharina Kranzer

“…The End TB strategy recommends social protection to mitigate socio-economic impacts of tuberculosis. Zimbabwe started implementing a conditional cash transfer (CCT) programme for people on drug resistant tuberculosis (DR-TB) treatment in 2013. …”
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Photodiagnosis and photodynamic recognition of cervical cancer with SEM and AFM images. by Sevcan Aytaç, Gürkan Özbey

“…This article, Photodiagnosis and Photodynamics with SEM and AFM images are valuable in recognizing cervical cancer and starting treatment early. Simultaneous examination of the, Photodiagnosis and Photodynamics with SEM and AFM cervix images of patients will provide us with a far more powerful solution than a one-way solution. …”
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Late Onset of Antiretroviral Therapy in Adults Living with HIV in an Urban Area in Brazil: Prevalence and Risk Factors by Priscila Ribeiro Guimarães Pacheco, Ana Laura Sene Amâncio Zara, Luiz Carlos Silva e Souza, Marília Dalva Turchi

“…However, a significant number of people living with HIV (PLHIV) still start treatment late. Objective. This study aimed to analyze characteristics and factors associated with late initiation of ART among HIV-infected treatment-naïve patients. …”
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Incompatible Aedes aegypti male releases as an intervention to reduce mosquito population-A field trial in Puerto Rico. by Liliana Sánchez-González, Jacob E Crawford, Laura E Adams, Grayson Brown, Kyle R Ryff, Mark Delorey, Jose Ruiz-Valcarcel, Nicole Nazario, Nexilianne Borrero, Julieanne Miranda, Sara N Mitchell, Paul I Howell, Johanna R Ohm, Charlie Behling, Brian Wasson, Craig Eldershaw, Bradley J White, Vanessa Rivera-Amill, Roberto Barrera, Gabriela Paz-Bailey

“…In 2021, we shifted to a phased release strategy starting in four clusters, reducing the mosquito population by 49% (CI 29-63%). …”
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