Elevated LIF and JAK-STAT activation drive severe COVID-19 in myeloma patients receiving the BCMA-CD3 bispecific antibody Elranatamab by Ziping Li, Fujing Zhang, Xianghong Jin, Junling Zhuang

“…Conclusions BiTe therapy is linked to a higher risk of severe COVID-19 due to an inflammatory cytokine storm, with LIF and the JAK-STAT pathway playing key roles. …”
Get full text

A SDGs-oriented evaluation of the ecological sustainability of international horticultural exposition sites in Chengdu, China by Biao Huang, Haolin Yang, Kankan Shang, Ruoyu Wang, Yufei Meng, Hongming Peng, Yonghong Hu, Zehui Jiang

“…The anticipated forest loss, along with declines in vegetation coverage, three-dimensional green volume, and vegetation carbon stock will adversely affect the highest sustainability. …”
Get full text

Spaced Seed Data Structures for De Novo Assembly by Inanç Birol, Justin Chu, Hamid Mohamadi, Shaun D. Jackman, Karthika Raghavan, Benjamin P. Vandervalk, Anthony Raymond, René L. Warren

“…Further, we note that Bloom filters would be suitable to implicitly store spaced seeds and be tolerant to sequencing errors. …”
Get full text

Content Analysis of the articles in Journal of Linguistic and Rhetorical Studies of Semnan University (2010 - 2023) by Hossein Moradi Moghadam

“…The remaining ten topics of the 370 articles were related to literary devices, literary elements, language structure, literature, story, simile, music, aesthetics, literary layers, grammar, and other fields. …”
Get full text

Prediction of Global Ionospheric Total Electron Content (TEC) Based on SAM‐ConvLSTM Model by Hanze Luo, Yingkui Gong, Si Chen, Cheng Yu, Guang Yang, Fengzheng Yu, Ziyue Hu, Xiangwei Tian

“…In order to confirm the efficiency of the proposed model, the other two prediction models based on convolutional long short‐term memory (LSTM) are used for comparison. …”
Get full text

The rapid infilling of a tide-dominated channel on the southern Yangtze Delta plain during the Medieval Climate Anomaly by Zhuoxuan Wu, Jianwen Wang, Xiaomei Nian, Fengyue Qiu, Zhanghua Wang, Zhanghua Wang

“…This rapid infilling is attributed to the increased storm frequency during the Song dynasty, which enhanced the mud import into the channel. …”
Get full text

Financial security as a factor of military security by O. P. Getmanets, D. V. Korobtsova

“…It has been noted that the constant deficit of the state budget and the associated significant debt burden, insufficient development of long-term investment lending to the economy and the stock market, the growth of economic crime, and low financial culture in society are negative factors affecting the state of the financial system. …”
Get full text

Lossless and reference-free compression of FASTQ/A files using GeneSqueeze by Foad Nazari, Sneh Patel, Melissa LaRocca, Alina Sansevich, Ryan Czarny, Giana Schena, Emma K. Murray

“…Abstract As sequencing becomes more accessible, there is an acute need for novel compression methods to efficiently store sequencing files. Omics analytics can leverage sequencing technologies to enhance biomedical research and individualize patient care, but sequencing files demand immense storage capabilities, particularly when sequencing is utilized for longitudinal studies. …”
Get full text

Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease by Yan Wu, Narayan R. Bhat, Meng Liu

“…Histological analysis revealed stark decreases of orexin immunoreactive (orexin-IR) neuron number and soma size in these Tg-SwDI mice (cell number: 2187 ± 97.1 in Tg-SwDI versus 3318 ± 137.9 in WT. soma size: 109.1 ± 8.1 μm2 in Tg-SwDI versus 160.4 ± 6.6 μm2 in WT), while the number and size of melanin-concentrating hormone (MCH) immunoreactive (MCH-IR) neurons remained unchanged (cell number: 4256 ± 273.3 in Tg-SwDI versus 4494 ± 326.8 in WT. soma size: 220.1 ± 13.6 μm2 in Tg-SwDI versus 202.0 ± 7.8 μm2 in WT). …”
Get full text

СИСТЕМА ВИНАГОРОД І МОТИВАЦІЇ СТУДЕНТІВ ЗА ДОПОМОГОЮ ВІРТУАЛЬНОЇ ВАЛЮТИ by Галина Вікторівна Марчук, Віталій Леонідович Левківський, Дмитро Костянтинович Марчук, Денис Валеріанович Любченко

“…Середовищем розробки додатка є JetBrains WebStorm на JavaScript, CSS та HTML. Серверна частина додатка знаходиться під управлінням Firebase. …”
Get full text

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases by Marek J. Konieczny, Murad Omarov, Lanyue Zhang, Rainer Malik, Tom G. Richardson, Sebastian-Edgar Baumeister, Jürgen Bernhagen, Martin Dichgans, Marios K. Georgakis

“…Integration with transcriptomic data point to key regulatory mechanisms, such as the buffering function of the Atypical Chemokine Receptor 1 (ACKR1) acting as scavenger for multiple chemokines and the role of tumor necrosis factor receptor-associated factor 1 (TRAFD1) in modulating the cytokine storm triggered by TNF signaling. Applying Mendelian randomization (MR), we detected a network of complex cytokine interconnections with TNF-b, VEGF, and IL-1ra exhibiting pleiotropic downstream effects on multiple cytokines. …”
Get full text

Accounting treatment of tax credits arising from the exclusion of ICMS from the PIS and COFINS calculation base of publicly traded companies by Douglas Willian Nascimento Schmidt, José Antonio Cescon, Antônio Carlos Brunozi Junior, Julio César Ferreira

“…The initial sample was composed of the financial statements (Balance Sheet, Income Statement for the Year and Notes and Explanations) of 80 companies in the Novo Mercado segment of Brazil, Stock Exchange and Counter - B3, between 2018 and 2021 (including). …”
Get full text

WETLAND AND BIOCULTURAL HERITAGE REGENERATION THROUGH THEMATIC ECOLOGICAL TOURISM PRACTICE: THE CASE OF PATAN SUB-DISTRICT, KHUN TAN DISTRICT, CHIANG RAI, THAILAND by Siripen YIAMJANYA, Kannapat KANKAEW, Bussaba SITIKARN, Parinya NAKPATHOM, Ali Mohsin Salim Ba AWAIN, Teerarat JABJAINAI

“…Future success factors that should be essentially developed involve inventory of local data that will be useful for establishing identity and meaning making, local individuals’ learning and understanding of their local knowledge, training and tourism interpretation and narratives for story-telling of its cultural landscape. …”
Get full text

Sudden Commencements and Geomagnetically Induced Currents in New Zealand: Correlations and Dependance by A. W. Smith, C. J. Rodger, D. H. Mac Manus, I. J. Rae, A. R. Fogg, C. Forsyth, P. Fisher, T. Petersen, M. Dalzell

“…We find that GICs are (on average) greater if they are related to: (a) Storm Sudden Commencements (SSCs; 27% larger than Sudden Impulses, SIs); (b) SCs while New Zealand is on the dayside of the Earth (27% larger than the nightside); and (c) SCs with a predominantly East‐West magnetic field change (14% larger than North‐South equivalents). …”
Get full text

Nexus between risk factors and financial performance: The case of Ukrainian advertising and marketing companies by Tetiana Zavalii, Serhii Lehenchuk, Nina Poyda-Nosyk, Yana Ishchenko, Oleksandr Hrabchuk

“…Of the 11 independent variables that characterized companies’ risk factors, only three were confirmed to significantly impact financial performance indicators (risk factor “Location in the housing stock” reduces ROA and ROE; risk factor “Frequent institutional changes” increases ROA; risk factor “Found match by full name with a politically exposed person” reduces ROE).…”
Get full text

ESTIMACIÓN DE EROSIÓN HIDRICA DE SUELOS PARA PLAN DE MANEJO DEL CAMPO FORESTAL AGUAS FRÍAS, PATAGONIA ARGENTINA by Ana C. Dufilho, María C. Frugoni, Pablo Macchi, Alan Toth

“…In this area, some Mapuche (araucanian) communities carry out stock breeding (mainly goats) using a migrating system. …”
Get full text

Co-designing a film showcasing the dental experiences of community returners (ex-offenders) by Joelle Booth, Joelle Booth, Heather McMullen, Andrea Rodriguez, Vanessa Muirhead

“…They developed the character stories and wrote the script in the second workshop. …”
Get full text

Music Drama as a Christian Parable: Mozart’s <i>Idomeneo</i> by Nils Holger Petersen

“…Mozart’s <i>Idomeneo</i> is based on a short episode in François Fénelon’s <i>Télémaque</i>, but also on Antoine Danchet’s adaptation of this episode for the theater in his tragédie lyrique <i>Idoménée</i> (1712; set to music by André Campra). …”
Get full text

Distribution and Evolution of Chorus Waves Modeled by a Neural Network: The Importance of Imbalanced Regression by Xiangning Chu, Jacob Bortnik, Wen Li, Xiao‐Chen Shen, Qianli Ma, Donglai Ma, David Malaspina, Sheng Huang

“…The IR‐based chorus model will improve radiation belt prediction by providing chorus wave distributions, especially storm‐time strong chorus. Since data imbalance is ubiquitous and inherent in space physics and other physical systems, imbalanced regressive methods deserve more attention in space physics.…”
Get full text

Das Menschliche in der Musik . August Halms prozessuale Metaphorik im Brennpunkt analysetheoretischer Fragestellungen by Astrid Bolay

“…Um seine formalästhetische Position zu rechtfertigen, ist er in seiner ›Sturmsonaten‹-Analyse – in Abgrenzung zu einer inhaltsästhetischen Ausdeutung desselben Stücks von Paul Bekker – allerdings gezwungen, eine Grenze zwischen einer ›zulässigen‹ und einer ›nicht mehr zulässigen‹, allzu stark ›vermenschlichenden‹ Metaphorik zu definieren. …”
Get full text