Revitalizing neurosurgical frontiers: The EANS frontiers in neurosurgery committee's strategic framework by Aaron Lawson McLean, Ignazio G. Vetrano, Anna C. Lawson McLean, Alfredo Conti, Patrick Mertens, Michael Müther, Jakob Nemir, Simone Peschillo, Antonio Santacroce, Can Sarica, Constantin Tuleasca, Cesare Zoia, Jean Régis

Get full text

Single-cell transcriptomic analysis identifies a stress response Schwann cell subtype by Lan Xianfeng, Zheng Yanmei, You Yongliang, Wu Xuejun, Wu Shaojie, Chen Nengfu, Wang Lihong, Yang Wenfu

Get full text

Single-cell transcriptomic dynamics of scallop heart reveals the heterogeneous response to heat stress by Danyang Wang, Na Liu, Xiangfu Kong, Xinghai Zhu, Yangfan Wang, Jingjie Hu, Zhenmin Bao

“…Our results unraveled that the severity of cardiac structure damage increased progressively with rising temperature, accompanied by widespread mitochondrial dysfunction and neurohumoral response. We identified two subpopulations within cardiomyocytes (CMs), including ventricular myocytes (VMs) and atrial myocytes (AMs), which exhibited specialized functional roles in response to thermal stress. …”
Get full text

Visual functioning and cerebral visual impairment in children with infantile spasms - West syndrome by Vučinić Vesna, Martać Valentina, Cerovac Nataša, Stamenković Miroslav

Get full text

THE FUNCTIONING OF CROP-PRODUCING FARMS IN THE CONTEXT OF CLIMATE CHANGE IN THE WARMIŃSKO-MAZURSKIE VOIVODESHIP by Renata Marks-Bielska, Babuchowska Karolina

Get full text

Biochar enhances soil hydrological function by improving the pore structure of saline soil by Angyuan Jia, Xiaojun Song, Shengping Li, Zhipeng Liu, Xiaotong Liu, Zixuan Han, Huizhou Gao, Qiqi Gao, Yan Zha, Ying Liu, Xueping Wu, Gang Wang

“…The poor soil structure caused by salinization is a major factor affecting crop growth and soil structure will further affect hydrological function. Biochar is widely used to improve soil physical structure because of its special porous material. …”
Get full text

Structure and function of the lysine methyltransferase SETD2 in cancer: From histones to cytoskeleton by Christina Michail, Fernando Rodrigues Lima, Mireille Viguier, Frédérique Deshayes

“…Recently, SETD2 was further shown to methylate non-histone proteins particularly the cytoskeletal proteins tubulin and actin with subsequent impacts on cytoskeleton structure, mitosis and cell migration.Herein, we provide a review of the role of SETD2 in different cancers with special emphasis on the structural basis of the functions of this key lysine methyltransferase. …”
Get full text

Functional Aspects of TRPC Channels in Physiology and Clinical Practice: a Systematic Review by Razina R. Nigmatullina, Dinara I. Sadykova, Ilnara R. Sakhipgaraeva, Evgeniya S. Slastnikova, Aleksey V. Bezbryazov

“…The review highlights the importance of TRPC channels in regulating cellular function, including vascular tone, renal filtration, and cardiac hypertrophy, as well as mediating cellular responses to hormones and growth factors. …”
Get full text

Regulation of proliferative potential: insights into key signaling cascades and te-lomerase functions by O. Tolok, Kh. Malysheva

“…Telomerase, a ribonucleoprotein traditionally recognized for its function in telomere maintenance, is revisited in this review for its non-canonical roles. …”
Get full text

Comprehensive functional profiling of yeasts: gastrointestinal resistance, metabolic capacities, and psychobiotic potential by Amir Shazad, Ali Zein Alabiden Tlais, Claudia Cappello, Sara Casagrande Bacchiocchi, Pasquale Filannino, Marco Gobbetti, Raffaella Di Cagno

“…Phenomic analyses unveiled distinct metabolic fingerprints, with each strain demonstrating unique carbon and nitrogen utilization profiles, indicative of specialized functional pathways. Notably, W. anomalus significantly outperformed others in the production of short-chain fatty acids and gamma-aminobutyric acid (GABA), key metabolites linked to gut-brain axis modulation. …”
Get full text

Interleukin-6 in synovial fluid drives the conversion of DC2s to DC3s in inflammatory arthritis by Annika H. Decker, Lucas L. van den Hoogen, Tom van Oorschot, Liliana Sanchez-Rocha, Martine A. Boks, Ghaith Bakdash, Ranjeny Thomas, Calin D. Popa, Martijn Verdoes, Rogier M. Thurlings, Anouk M.D. Becker, I. Jolanda M. de Vries

Get full text

LRO biogenesis and function: what can we learn from mast cells? by Juan Eduardo Montero-Hernández, Kerui Zhang, Ulrich Blank, Ulrich Blank, Gaël Ménasché

“…Lysosome-related organelles (LROs) are specialized compartments with cell type-specific roles. …”
Get full text

Dietary resilience of termite gut microbiota and enzymatic function reflects feeding strategy by Letícia R. Menezes, João Paulo L. F. Cairo, Ana Maria Costa-Leonardo, Maria Teresa Pedrosa Silva Clerici, Isabela da Costa Barreto, Bianca Suriano Francisco dos Santos, Alberto Arab

“…IntroductionTermites rely on complex gut microbiomes to digest lignocellulosic substrates, with dietary specialization potentially shaping microbial diversity and function. …”
Get full text

Effect of Dexmedetomidine on Cardiopulmonary Bypass Induced Inflammatory Response in Patients Undergoing Aortic Valve Replacement by Zrinka Safaric Oremus, Nikola Bradic, Ivan Gospic, Ivana Presecki, Sanja Sakan, Natasa Sojcic, Kresimir Oremus, Davor Baric, Vlatka Sotosek, Igor Rudez

Get full text

Intestinal non-canonical NFκB signaling shapes the local and systemic immune response by Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Xiang Xue, Melody Y. Zeng, Yinling Hu, Richard M. Mortensen, Joel K Greenson, Marilia Cascalho, Christiane E. Wobus, Justin A. Colacino, Gabriel Nunez, Liangyou Rui, Yatrik M. Shah

“…The function of M-cells in systemic inflammatory responses are still unclear. …”
Get full text

Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming by Dinesh K. Deochand, Marija Dacic, Michael J. Bale, Andrew W. Daman, Vidyanath Chaudhary, Steven Z. Josefowicz, David Oliver, Yurii Chinenov, Inez Rogatsky

Get full text

Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…At the behavioral level, we found that, compared to heat shock, cold exposure did not result in a Garcia effect (i.e., a “special form” of conditioned taste aversion). The difference in memory outcomes was associated with changes in the expression levels of selected targets involved in neuronal plasticity and the stress response. …”
Get full text

Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response by Chi Zhou, Qian Qiu, Xinyu Liu, Tiantian Zhang, Leilei Liang, Yihang Yuan, Yufo Chen, Weijie Sun

Get full text

Haploid-specific variations of kiwifruit WAKL genes modulate immune-related responses in Nicotiana benthamiana by Zupeng Wang, Zhenting Sun, Hui Pan, Caihong Zhong, Li Li

“…Wall-Associated Kinase-like (WAKL) proteins play crucial roles in plant stress responses, but their evolutionary divergence and functions in kiwifruit remain unclear. …”
Get full text

Genome-Wide Identification and Stress Responses of Cowpea Thaumatin-like Proteins: A Comprehensive Analysis by Carolline de Jesús-Pires, José Ribamar Costa Ferreira-Neto, Roberta Lane de Oliveira-Silva, Jéssica Barboza da Silva, Manassés Daniel da Silva, Antônio Félix da Costa, Ana Maria Benko-Iseppon

“…Moreover, the gene expression data suggested that VuTLPs exhibit functional specialization depending on the stress condition, highlighting their diverse roles and biotechnological potential.…”
Get full text