Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzhe... by Melissa J. Alldred, Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg

“…To date, RNA-sequencing (RNA-seq) analysis of hippocampal neuronal gene expression including the characterization of discrete circuit-based connectivity in DS remains a major knowledge gap. We postulate that spatially characterized hippocampal neurons display unique gene expression patterns due, in part, to dysfunction of the integrity of intrinsic circuitry.MethodsWe combined laser capture microdissection to microisolate individual neuron populations with single population RNA-seq analysis to determine gene expression analysis of CA1 and CA3 pyramidal neurons and dentate gyrus granule cells located in the hippocampus, a region critical for learning, memory, and synaptic activity.ResultsThe hippocampus exhibits age-dependent neurodegeneration beginning at ~6 months of age in the Ts65Dn mouse model of DS/AD. …”
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The Italian contribution to the Synoptic Arctic Survey programme: the 2021 CASSANDRA cruise (LB21) through the Greenland Sea Gyre along the 75° N transect by M. Bensi, G. Civitarese, D. Borme, C. Caroppo, G. Caruso, F. Cerino, F. Decembrini, A. de Olazabal, T. Diociaiuti, M. Giani, V. Kovacevic, M. Kralj, A. Lo Giudice, G. Maimone, M. Monti, M. Papale, L. Patrolecco, E. Putelli, A. C. Rappazzo, F. Relitti, C. Rizzo, C. Rizzo, F. Spataro, V. Tirelli, C. Turetta, M. Azzaro

“…The enzyme patterns vary spatially, with activity peaks at the ends and in the middle of the transect. …”
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Earth's future climate and its variability simulated at 9 km global resolution by J.-Y. Moon, J.-Y. Moon, J. Streffing, J. Streffing, J. Streffing, S.-S. Lee, S.-S. Lee, T. Semmler, T. Semmler, M. Andrés-Martínez, M. Andrés-Martínez, J. Chen, E.-B. Cho, E.-B. Cho, J.-E. Chu, C. L. E. Franzke, C. L. E. Franzke, J. P. Gärtner, R. Ghosh, J. Hegewald, J. Hegewald, S. Hong, D.-W. Kim, D.-W. Kim, N. Koldunov, J.-Y. Lee, J.-Y. Lee, Z. Lin, C. Liu, S. N. Loza, W. Park, W. Park, W. Roh, W. Roh, D. V. Sein, D. V. Sein, D. V. Sein, S. Sharma, S. Sharma, D. Sidorenko, J.-H. Son, J.-H. Son, J.-H. Son, M. F. Stuecker, Q. Wang, G. Yi, G. Yi, M. Zapponini, T. Jung, T. Jung, A. Timmermann, A. Timmermann

“…Examples of enhanced regional information include projected changes in temperature, rainfall, winds, extreme events, tropical cyclones, and the hydroclimate teleconnection patterns of the El Niño–Southern Oscillation and the North Atlantic Oscillation on scales of less than 1000 km. …”
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Assessing Gonipterus defoliation levels using multispectral unmanned aerial vehicle (UAV) data in Eucalyptus plantations by Phumlani Nzuza, Michelle L. Schröder, Rene J. Heim, Louis Daniels, Bernard Slippers, Brett P. Hurley, IIaria Germishuizen, Benice Sivparsad, Jolanda Roux, Wouter. H Maes

“…As conventional insect pest monitoring methods are time-consuming and spatially restrictive, this study assessed the potential of UAV monitoring. …”
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Associations between forest vertical structure and habitat preferences of black-and-white snub-nosed monkeys (Rhinopithecus bieti) in high-elevation environments by Zhipang Huang, Yuling Chen, Haitao Yang, Yihao Fang, Kai Cheng, Hongcan Guan, Cyril C. Grueter, Wen Xiao, Qinghua Guo

“…Vertical forest structure, particularly canopy height and vegetation layering, showed strong associations with foraging and sleeping locations across both wet and dry seasons. These patterns varied depending on behavioral context, supporting the idea that R. bieti adjusts its space use in response to seasonal and structural variation. …”
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Spotted! Remote camera traps used in a novel design reveal a perilous situation for the Critically Endangered Northwest African cheetah (Acinonyx jubatus hecki) in a conflict‐affec... by Marine Drouilly, Audrey Ipavec, Oksana Grente, Robin Horion, Aurlus Ouindeyama, Philipp Henschel, Vincent Lapeyre, Yekini Chabi N'Diaye, Ali Shams, Christine Breitenmoser, Sarah M. Durant

“…Cheetahs showed strong crepuscular activity patterns, but males were also active before sunrise and after sunset. …”
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Pola Distribusi Spasial-Temporal Hotspot dan Variasi Standardized Precipitation Index pada Lahan Gambut Tropis di Kepulauan Meranti, Riau by Maulana Dwi Putra Riyadi, Yudi Setiawan, Muh Taufik

“…This study aims to identify the distribution pattern of hotspots and Standardized Precipitation Index (SPI) variations and determine their correlation to forest and land fires. …”
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Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial CellsSUMMARY by Siyuan Ma, Nawras W. Habash, Mrunal K. Dehankar, Nidhi Jalan-Sakrikar, Shawna A. Cooper, Abid A. Anwar, Sofia Jerez, Papawee Sutthirat, Jinhang Gao, Tamir Diamond, Jing Jiao, Caixin Qiu, Jingchun Yang, Sumera I. Ilyas, Markcus Lee, Usman Yaqoob, Sheng Cao, Rebecca G. Wells, Vijay H. Shah, Moira B. Hilscher

“…Background & Aims: Congestion alters the microenvironment of the liver sinusoid along the portal-central axis. We studied spatial changes in immune cells in the sinusoid that contribute to congestive fibrosis and portal hypertension (PHTN). …”
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Temperature-VPD-evapotranspiration interactions modulated asynchronous dynamics of vegetation photosynthesis and net ecosystem production in Eurasia by Rui Yang, Hao Yuan, Ruohua Du, Litao Zhou, Jianjun Wu, Liang Gao, Ting Mao

“…The results showed that the rate of increase in NEP standardized anomalies (0.004 yr−1, p < 0.05) lagged behind NDVI/SIF/GPP standardized anomalies (0.009 − 0.014 yr−1, p < 0.01), particularly after 2000, and it was more pronounced in drylands. Spatially, vegetation photosynthesis and NEP changed asynchronously in nearly one-third of Eurasia, with a slightly higher proportion in non-dryland areas and the most obvious patterns in forests and croplands. …”
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Neurochemical and molecular characteristics of altered brain functional activity in the anti-NMDAR encephalitis by Xiarong Gong, Wei Li, Chengsi Luo, Yanghua Tian, Jiaojian Wang, Yuan Gao, Yuanyuan Guo, Meiling Chen, Qiang Meng

“…This study aimed to investigate whether functional alterations in anti-NMDAR encephalitis are spatially associated with neurotransmitter receptor distributions and transcriptomic profiles, to uncover their neurochemical, molecular, and cellular signatures. …”
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Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study by Xiaobo Liu, Bin Wan, Xi-Han Zhang, Ruifang Cui, Siyu Long, Ruiyang Ge, Lang Liu, Jinming Xiao, Zhen-Qi Liu, Jiadong Yan, Ke Xie, Meng Yao, Xin Wen, Sanwang Wang, Yujun Gao

“…Finally, we compared the reorganization patterns with normative maps of clinical symptomatology, cellular composition, and receptor distribution to elucidate symptom-related and molecular-level associations. …”
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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases by Ketian Hou, Wenhan Pan, Lianhui Liu, Qianqian Yu, Jiahao Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang

“…Pathogen-associated molecular patterns synergistically interact with cytokine storms, and oncogenic stress to active PANoptosis, establishing this programmed cell death pathway as a critical nexus in inflammatory pathogenesis and tumor immunomodulation. …”
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A multimodal Neuroimaging-Based risk score for mild cognitive impairment by Elaheh Zendehrouh, Mohammad S.E. Sendi, Anees Abrol, Ishaan Batta, Reihaneh Hassanzadeh, Vince D. Calhoun

“…Additionally, 46 UK Biobank participants diagnosed with AD showed FNC and GM patterns similar to the high-risk groups. Conclusion: Validation using the ADNI dataset confirmed our results, highlighting the potential of FNC and sMRI-based BRS in early Alzheimer’s detection.…”
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Local nutrient addition drives plant diversity losses but not biotic homogenization in global grasslands by Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew MacDougall, Jason P. Martina, Jonathan D. Bakker, Pedro M. Tognetti, Eric W. Seabloom, Pedro Daleo, Sally Power, Christiane Roscher, Peter B. Adler, Ian Donohue, George Wheeler, Carly Stevens, G. F. Ciska Veen, Anita C. Risch, Glenda M. Wardle, Yann Hautier, Catalina Estrada, Erika Hersch-Green, Yujie Niu, Pablo L. Peri, Anu Eskelinen, Daniel S. Gruner, Harry Olde Venterink, Carla D’Antonio, Marc W. Cadotte, Sylvia Haider, Nico Eisenhauer, Jane Catford, Risto Virtanen, John W. Morgan, Michelle Tedder, Sumanta Bagchi, Maria C. Caldeira, Miguel N. Bugalho, Johannes M. H. Knops, Chris R. Dickman, Nicole Hagenah, Anke Jentsch, Petr Macek, Brooke B. Osborne, Lauri Laanisto, Jonathan M. Chase

“…These patterns of diversity changes are generally consistent across species groups. …”
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A strontium isoscape of southwestern Australia and progress toward a national strontium isoscape by P. de Caritat, P. de Caritat, A. Dosseto, F. Dux

“…Results demonstrate a wide range of quite elevated Sr isotopic values (0.7152 to 1.0909, with a median of 0.7560) over the survey area, reflecting a large diversity of source rock lithologies, geological processes, and bedrock ages. The spatial distribution of <span class="inline-formula"><math xmlns="http://www.w3.org/1998/Math/MathML" id="M6" display="inline" overflow="scroll" dspmath="mathml"><mrow class="chem"><msup><mi/><mn mathvariant="normal">87</mn></msup><mi mathvariant="normal">Sr</mi><msup><mo>/</mo><mn mathvariant="normal">86</mn></msup><mi mathvariant="normal">Sr</mi></mrow></math><span><svg:svg xmlns:svg="http://www.w3.org/2000/svg" width="49pt" height="15pt" class="svg-formula" dspmath="mathimg" md5hash="a97dd5d5ad53911d125562a9ee29d24d"><svg:image xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="essd-17-79-2025-ie00004.svg" width="49pt" height="15pt" src="essd-17-79-2025-ie00004.png"/></svg:svg></span></span> shows coherent (multi-point anomalies and smooth gradients) large-scale (<span class="inline-formula">&gt;</span> 100 km) patterns that appear to be broadly consistent with surface geology, regolith/soil type, and/or nearby outcropping bedrock. …”
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More than just mud: the importance of wallows to Javan rhino ecology and behaviour by Steven G. Wilson, Georgina Hockings, Jo-Anne M. Deretic, Salit Kark

“…We identified and categorised eight behavioural patterns at and near wallows related to rhino daily activities and found that wallows have several key features for the Javan rhinos. …”
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Effect of transport stress on apoptosis and autophagy in goat lung cells by Yu Zhuo, Yunhai Hu, Yangshan Jin, Tian Ye, Yanzhen Yang, Ben Liu, Ben Liu, Ben Liu, Wenya Zheng, Wenya Zheng, Songlin Ding, Xue Yang, Xue Yang, Lucheng Zheng, Lucheng Zheng, Wei Hu, Wei Hu, Manxin Fang, Manxin Fang, Wanting Yi, Wenjing Xing

“…Protein localization analyses revealed compartment-specific responses, with Bcl-2/Bax primarily in bronchial epithelia and LC3B/PINK1/Parkin in alveolar cells, suggesting spatially distinct stress adaptation mechanisms. Observed molecular changes coincided with histological evidence of pulmonary alterations, implying a potential interplay between apoptosis and autophagy in transport-induced cellular stress. …”
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Tracer-based Rapid Anthropogenic Carbon Estimation (TRACE) by B. R. Carter, B. R. Carter, J. Schwinger, R. Sonnerup, A. J. Fassbender, J. D. Sharp, J. D. Sharp, L. M. Dias, L. M. Dias, D. E. Sandborn

“…A notable limitation of this and similar projections made with TRACEv1 is that ongoing and potential future warming and changing oceanic circulation patterns with climate change are not captured by the method. …”
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Compound events in Germany in 2018: drivers and case studies by E. Xoplaki, E. Xoplaki, F. Ellsäßer, F. Ellsäßer, J. Grieger, K. M. Nissen, J. G. Pinto, M. Augenstein, T.-C. Chen, T.-C. Chen, H. Feldmann, P. Friederichs, D. Gliksman, D. Gliksman, L. Goulier, K. Haustein, K. Haustein, J. Heinke, L. Jach, F. Knutzen, S. Kollet, J. Luterbacher, J. Luterbacher, N. Luther, S. Mohr, S. Mohr, C. Mudersbach, C. Müller, E. Rousi, F. Simon, L. Suarez-Gutierrez, L. Suarez-Gutierrez, L. Suarez-Gutierrez, S. Szemkus, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, S. M. Vallejo-Bernal, O. Vlachopoulos, F. Wolf

“…We provide new insights into the drivers of spatially and temporally compound events, such as heat and drought, and heavy precipitation combined with extreme winds, and their adverse effects on ecosystems and society, using large-scale atmospheric patterns. …”
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The Relation between AGN and Host-galaxy Properties in the JWST Era. I. Seyferts at Cosmic Noon are Obscured and Disturbed by Nina Bonaventura, Jianwei Lyu, George H. Rieke, Stacey Alberts, Christopher N. A. Willmer, Pablo G. Pérez-González, Andrew J. Bunker, Meredith Stone, Francesco D’Eugenio, Christina C. Williams, Michael V. Maseda, Chris J. Willott, Zhiyuan Ji, William M. Baker, Stefano Carniani, Stephane Charlot, Jacopo Chevallard, Emma Curtis-Lake, Daniel J. Eisenstein, Kevin Hainline, Ryan Hausen, Erica J. Nelson, Marcia J. Rieke, Brant Robertson, Irene Shivaei

“…Placing the observed pattern of disturbances in the context of the other average host-galaxy properties, we conclude that mergers are common among obscured AGN. …”
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