Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Abstract Background 3D-spatial interaction between cancer cells influences tumor behavior, making it essential to replicate tumor structures for predicting patient outcomes. …”
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Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats by Zhang Chunhua, Zhang Chunhua, Zhang Chunhua, Fu Le, Fu Le, Fu Le, Li Shengli, Li Shengli, Li Shengli, Wu Sachula, Wu Sachula, Wu Sachula, Hua Bao, Hua Bao, Hua Bao, Mu Lan, Mu Lan, Mu Lan, Marco Antonini, Sun Haizhou, Sun Haizhou, Sun Haizhou

“…This review highlights recent discoveries in miRNA-mediated regulation of hair follicles, focusing on their dynamic expression patterns and cell-specific functions in keratinocytes, dermal papilla cells, and follicular stem cells. …”
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Imaging-based assessment of response to olaparib in platinum-sensitive relapsed ovarian cancer patients by Maria Delgado-Ortet, Maria Delgado-Ortet, Vlad Bura, Vlad Bura, Vlad Bura, Vlad Bura, Ionut-Gabriel Funingana, Ionut-Gabriel Funingana, Ionut-Gabriel Funingana, Ionut-Gabriel Funingana, David Hulse, David Hulse, David Hulse, Leonardo Rundo, Leonardo Rundo, Leonardo Rundo, James D. Brenton, James D. Brenton, James D. Brenton, James D. Brenton, Evis Sala, Evis Sala, Evis Sala, Evis Sala, Evis Sala, Lorena Escudero Sanchez, Lorena Escudero Sanchez

“…Anatomical networks of the metastatic sites were constructed to represent patterns of disease distribution. Volume and first-order radiomic features were computed and compared to different assessments of treatment response.ResultsThe average number of edges per patient in the anatomical networks and total volumetric burden decreased with treatment were measured, differentiating between responders and nonresponders. …”
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Vegetation greening does not significantly enhance ecosystem resilience in the Northern Hemisphere by Jingjing Zhang, Xingming Hao, Yongchang Liu, Xuewei Li, Qixiang Liang, Fan Sun, Mengtao Ci, Yupeng Li

“…Resilience estimates derived from the Normalized Difference Vegetation Index (NDVI), kernel NDVI (kNDVI), Leaf Area Index (LAI), Gross Primary Production (GPP), and GOSIF exhibited similar spatial patterns and trends. Specifically, resilience was lower in water-limited regions and increased with higher aridity index values; it peaked in humid regions (AI > 0.65), with average values (quantified by λAC1) ranging from −2.20 to −2.00. …”
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The Effect of Land Use Change on Runoff Using the SWAT Model in the Tajan Watershed by hayede bayani, ali bagheri, Davod Akbari Nodehi, Valiollah Karimi

“…However, the effect of the pattern of landscape and the trend of its characteristics has not been observed to date. …”
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HMGB1 Inhibition Alleviates Chronic Nonbacterial Prostatitis by Suppressing M1 Polarization of Macrophages by Zhou J, Ding L, Chen J, Chen C, Jiang P, Mei Z, Jiang Q, Hua X

“…High-mobility group box 1 (HMGB1), a danger-associated molecular pattern that has been identified as a key mediator in various inflammatory diseases. …”
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Helminth Community Dynamics in Populations of Blue-Winged Teal (Anas discors) Using Two Distinct Migratory Corridors by Jason M. Garvon, Alan M. Fedynich, Markus J. Peterson, Danny B. Pence

“…The influence of spatially distinct host subpopulations on helminth community structure and pattern was examined in a migratory avian host species. …”
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Integrating multiple indices of habitat quality to inform habitat management for a sagebrush indicator species by Megan C. Milligan, Peter S. Coates, Shawn T. O'Neil, Brianne E. Brussee, Michael P. Chenaille, Derek A. Friend, Kathleen Steele, Justin R. Small, Timothy S. Bowden, Arlene D. Kosic, Katherine Miller, Michael L. Casazza

“…We evaluated habitat selection and survival patterns of sage-grouse across six distinct annual life stages and seasons to generate predictive habitat map surfaces, mapped the distribution of current occupancy, and combined maps of potential selection and survival patterns with space use and occupancy indices to delineate example habitat management categories. …”
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Smoothed monthly Greenland ice sheet elevation changes during 2003–2023 by S. A. Khan, H. Seroussi, M. Morlighem, W. Colgan, V. Helm, G. Cheng, D. Berg, V. R. Barletta, N. K. Larsen, W. Kochtitzky, M. van den Broeke, K. H. Kjær, A. Aschwanden, B. Noël, J. E. Box, J. A. MacGregor, R. S. Fausto, K. D. Mankoff, K. D. Mankoff, I. M. Howat, K. Oniszk, D. Fahrner, A. Løkkegaard, E. Y. H. Lippert, A. Bråtner, J. Hassan

“…<p>The surface elevation of the Greenland Ice Sheet is constantly changing due to the interplay between surface mass balance processes and ice dynamics, each exhibiting distinct spatiotemporal patterns. Here, we employ satellite and airborne altimetry data with fine spatial (1 km) and temporal (monthly) resolutions to document this spatiotemporal evolution from January 2003 to August 2023. …”
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The Fractional Series Solutions for the Conformable Time-Fractional Swift-Hohenberg Equation through the Conformable Shehu Daftardar-Jafari Approach with Comparative Analysis by Muhammad Imran Liaqat, Eric Okyere

“…One of the universal equations used in the description of pattern formation in spatially extended dissipative systems is the Swift-Hohenberg equation. …”
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Graines d'histoire by Claire Newton, Jean-Frédéric Terral, Sarah Ivorra, Muriel Gros-Balthazard, Claire Tito de Morais, Sandrine Picq, Margareta Tengberg, Jean-Christophe Pintaud

“…Within Phoenix dactylifera, the agrobiodiversity appears complex in terms of geographical structure; the distribution pattern of seed shapes points to human dispersal routes that spread cultivation from one or more initial ‘domestication centres’.In addition, this work provides a powerful tool to identify ancient forms as demonstrated by the analysis of well-preserved desiccated seeds from Egyptian archaeological sites (14th c. …”
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Improving the performance of hospitals by Dejian Peng

“…The system of spatialized patient journeys helps architects and hospital managers broaden their understanding of hospital. …”
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Energy Efficient Operation of Cellular Network Using On/Off Base Stations by Yong-Hoon Choi, Jungerl Lee, Juhoon Back, Suwon Park, Young-uk Chung, Hyukjoon Lee

“…The cell zooming mechanism was formulated as an optimization problem with consideration of varying traffic patterns and interference, as well as the service availability of the whole area. …”
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Multi-year observations of near-bed hydrodynamics and suspended sediment at the core of the estuarine turbidity maximum of the Changjiang Estuary by Z. Zhou, J. Ge, J. Ge, D. S. van Maren, D. S. van Maren, D. S. van Maren, H. Luan, H. Luan, W. Guo, J. Ma, Y. Tao, P. Xu, F. Dao, W. Yang, K. Ke, S. Shi, J. Zhang, Y. Kuai, C. Li, J. Gu, P. Ding

“…</p> <p>This dataset is especially valuable due to its extensive temporal and spatial coverage, as well as the high concentrations characterizing many of the observations (from several grams per liter to tens of grams per liter). …”
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Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma by Xuan-Hao Liu, Guang-Rui Wang, Nian-Nian Zhong, Zheng-Rui Zhu, Yao Xiao, Zheng Li, Lin-Lin Bu, Lin-Lin Bu, Bing Liu, Bing Liu

“…The R package monocle3 was employed to calculate the cell trajectory and infer evolutionary patterns. The MuSiC2 package was employed to enable the evaluation of cell proportions. …”
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Advancing knowledge on the paleoproductivity and climate in the Guaymas Basin, Gulf of California, over the past 31,200 years: geochemical proxies in IODP expedition 385 sediments by Alejandro Aldama-Cervantes, Ligia Pérez-Cruz, Ligia Pérez-Cruz, Jaime Urrutia-Fucugauchi, Jaime Urrutia-Fucugauchi, María Adela Monreal-Gómez, Martín Merino-Ibarra, Mauricio Velázquez-Aguilar, Rafael Venegas-Ferrer, Joan Albert Sanchez-Cabeza, Abdelfettah Sifeddine, Tobias W. Höfig

“…Our findings underscore the key role of dynamic physical processes in shaping long-term productivity patterns in marginal seas at high resolution.…”
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A novel ddPCR™ assay for eDNA detection and quantification of Greater Amberjack Seriola dumerilli and three congeners in US waters: challenges and application to fisheries independ... by P. Joana Dias, Ryan Lehman, Bryan L. Huerta-Beltrán, Ana Wheeler, Crystal L. Hightower, Jessica Heise, Theodore Switzer, Clint Rhode, J. Marcus Drymon, Lynne Stokes, Mark A. Albins, Sean Powers, Nicole Phillips

“…Both eDNA and camera gears detected the presence of S. dumerili and S. rivoliana at both sites and all sampling days, but not S. fasciata and S. zonata. eDNA concentration data was higher for S. dumerili than S. rivoliana at both sites for all sampling days, in line with abundance patterns obtained from camera gears. The highest correlation (r = 0.97) was obtained between the measures of eDNA between gear deployments and ROV. …”
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Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study by Bernard A Fox, Chichung Wang, Kristin Roman, Carla Coltharp, Carmen Ballesteros-Merino, Shawn M Jensen, Janis M Taube, David L Rimm, Cliff Hoyt, Mei Jiang, Edwin R Parra, Ignacio Wistuba, Elizabeth L Engle, John McGuire, Bethany Remeniuk, Darren Locke

“…Background Emerging data suggest predictive biomarkers based on the spatial arrangement of cells or coexpression patterns in tissue sections will play an important role in precision immuno-oncology. …”
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Multi-field information fusion-based analysis of the macroscopic and mesoscopic damage evolution and location identification of caving and water-conducting fracture zones for minin... by Jiangbo WEI, Shuangming WANG, Lang LIU, Baoning WEI, Deyu CHONG, Zhizhen LIU, Dongkui LI, Dengdeng ZHUANG, Jing ZHOU

“…Using this model, this study conducted a simulation analysis of the damage characteristics and patterns of the mining overburden, including microfracture development, the distribution of broken rock blocks, changes in vertical displacement, structural evolution of force chains, and the void fraction evolution. …”
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Expression Analysis and SNP Mining of the Parkin Co-Regulated Gene (PACRG) and parkin in Penaeus vannamei Against White Spot Syndrome Virus by Qian XUE, Xupeng LI, Yang LI, Sheng LUAN, Kun LUO, Jie KONG, Qun XING, Xianhong MENG

“…Post-WSSV infection, PACRG and parkin exhibited similar expression patterns in the eyestalk. The location of PACRG mRNAs mostly overlapped with the WSSV replication site in the shrimp muscle, suggesting that PACRG plays a functional role in the interaction between P. vannamei and WSSV. …”
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