Optimization of bioactive polyphenols recovery from Flammulina velutipes stem waste using nonionic surfactant-integrated ultrasound-assisted extraction by Huimin Huo, Haiying Bao, Hao Yin

“…The process of cultivating edible and medicinal mushrooms results in considerable biomass waste, which can be a rich source of bioactive compounds. This research aimed at optimizing the yield of polyphenols and improving the antioxidant potential of extracts derived from the stem waste of Flammulina velutipes (FVS). …”
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Cost-effective medium optimization and functional enhancement of Lactiplantibacillus plantarum 22F for industrial-scale probiotic production in swine feed by Nay Zin Myo, Ratchnida Kamwa, Benjamas Khurajog, Pawiya Pupa, Wandee Sirichokchatchawan, David J. Hampson, Nuvee Prapasarakul

“…This study aimed to develop a cost-effective medium for cultivating Lactiplantibacillus plantarum 22F (L22F), a probiotic candidate isolated from swine feces, while evaluating its industrial viability and functional metabolic profile. Materials and Methods: Carbon (glucose, sucrose, and dextrose) and nitrogen (yeast extract, soy protein isolate, and whey protein concentrate) sources were screened using one-variable-at-a-time and Plackett–Burman design, followed by Response Surface Methodology for optimization. …”
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Optimization of Sugar Extraction Process from Date Waste Using Full Factorial Design Toward Its Use for New Biotechnological Applications by Islam Sayah, Mondher Njehi, Nicola Cicero, Vincenzo Nava, Manel Ben M’hadheb, Hatem Majdoub, Sami Achour, Teresa Gervasi

“…However, dates are rich in sugars, which offer a renewable source of nutrients for various applications. In this study, sugar extraction from two low-grade pitted date fruits (Alig and Kentichi) under ultrasound, was optimized using full factorial design. …”
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Optimization of factors affecting biogas production from dairy wastewater using Response Surface Methodology and its kinetic and microbial analysis by Sadok Saadia, Benmehdi Houcine, Baraka Abdelhak, Makhloufi Ahmed

“…Anaerobic digestion is one of the most widely used treatment methods for producing methane as an alternative energy source. …”
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Optimal Allocation of Shared Energy Storage in Low-Carbon Parks Taking into Account the Uncertainty of Photovoltaic Output and Electric Vehicle Charging by Shang Jiang, Jiacheng Li, Wenlong Shen, Lu Liang, Jinfeng Wu

“…To address these challenges, this study proposes a two-stage robust optimization method for shared energy storage configuration in a park-level integrated PV–storage–charging system (PV-SESS-CS). …”
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Intelligent Operation Dynamic Characteristics of Heat Pump System in Integrated Electric-thermal Cooperative Grid Based on Game Optimization Algorithm by Liang Anqi, Zeng Shuang, Ren Jiahang, Zhang Xinyue, Cao Feng, Yu Xiaoling, Song Yulong, Xing Qijing, Yang Xu, Ma Lin

“…software is used to simulate and study the dynamic characteristics of the system under six climate conditions in Beijing, and the game theory is used for intelligent operation, which is then compared with the logic control method. The results show that the logic control method can meet the load demand but cannot realize the efficient operation of the heat pump unit and the charge and discharge balance of the energy storage device. …”
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Intelligent Fault Diagnosis of Inter-Turn Short Circuit Faults in PMSMs for Agricultural Machinery Based on Data Fusion and Bayesian Optimization by Mingsheng Wang, Wuxuan Lai, Hong Zhang, Yang Liu, Qiang Song

“…Thirdly, to tackle the issue of hyperparameter tuning in deep learning models, a hyperparameter optimization method based on Bayesian optimization is proposed. …”
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Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework by Sani Ega Priani, Taufik Muhammad Fakih, Gofarana Wilar, Anis Yohana Chaerunisaa, Iyan Sopyan

“…This narrative review provides an in-depth analysis of Quality by Design (QbD), Design of Experiment (DoE), and in silico approach applications in SNEDDS development. <b>Methods</b>: The review is based on publications from 2020 to 2025, sourced from reputable scientific databases (Pubmed, Science direct, Taylor and francis, and Scopus). …”
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Optimal Allocation of Irrigation Water Under Different Flow Scenarios Using Multi-stage Stochastic Programming by Emphasizing Economic Productivity by Leila Amanat.Behbahani, Mahnoosh Moghaddasi, Hossain Ebrahimi, Hossein Babazadeh

“…In this study, the aim was to allocate and distribute water between networks and lower crops of Maroon reservoir dam The multi-stage stochastic programming method was used to develop the optimization model under three scenarios of arid, normal and wet years in two management modes and the results were compared with the traditional management figures. …”
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Human-Centered Design of an mHealth Tool for Optimizing HIV Index Testing in Wartime Ukraine: Formative Research Case Study by Nancy Puttkammer, Elizabeth Dunbar, Myroslava Germanovych, Mariia Rosol, Matthew Golden, Anna Hubashova, Vladyslav Fedorchenko, Larisa Hetman, Liudmyla Legkostup, Jan Flowers, Olena Nesterova

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Crucial heat damage analysis and optimization of a mid-sized pickup truck based on a deep Gaussian process model by Zebin Zhang, Sisi Liu, Xianzong Meng, Tingting Wang, Shizhao Jing, Chuanrui Wang, Dongchen Qin

“…Based on simulation results, a multi-objective two-layer deep Gaussian process model predicted heat source temperatures. The positions of cooling components were optimized using a genetic algorithm with heat-sensitive locations as the objectives. …”
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Comparative analysis and selection of the geometry of the microphone array based on MEMS microphones for sound localisation by Andrii Riabko, Tetiana Vakaliuk, Oksana Zaika, Roman Kukharchuk, Yuriy Smorzhevsky

“…The tasks to be addressed include analyzing spatial-frequency characteristics of various microphone array geometries (Uniform Linear Array, Uniform Planar Array, Uniform Circular Array, and Uniform Concentric Array), comparing beamforming algorithms (delay-and-sum, differential, and superdirective), and evaluating their performance under isotropic noise fields and coherent noise sources. The methods used involve the application of both established and author-derived analytical models for transfer functions and directivity coefficients, as well as experimental validation using a prototype device built on a Raspberry Pi 5 platform with an Adafruit PCA9548 8-Channel STEMMA QT expansion board and SPH0645LM4H-B omnidirectional MEMS microphones. …”
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Quantification of Minerals in Edible Mushrooms via Optimized Microwave-Assisted Digestion: Nutritional Contributions of Fe, Mg, Na, K, and Ca by Alejandro R. López, Elena Ortega-Caneda, Estrella Espada-Bellido, Oscar R. Taracena-Zepeda, Miguel Palma, Gerardo Fernández-Barbero

“…Thus, the aim of this study was to determine the mineral composition of different cultivated (<i>A. bisporus</i> and <i>P. ostreatus</i>) and wild edible mushrooms (<i>A. crocodilinus</i>, <i>A. arvensis</i>, <i>A. silvicola</i>, <i>A. impudicus</i>, <i>M. mastoidea</i>, <i>M. rhacodes,</i> and <i>P. ostreatus</i>) collected in the south of Spain and north of Morocco. First, the optimization of a microwave-assisted digestion method was carried out using a Box–Behnken design with a response surface methodology to quantify the total content of five metals: Fe, Mg, Na, K, and Ca in mushrooms. …”
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Optimization of sago starch and sodium alginate crosslink, including calcium chloride as a capsule alternative using the simplex lattice design by Sabtanti Harimurti, Putri Nur Amalia, Dyani Primasari Sukamdi, Hari Widada, Sri Nabawiyati Nurul Makiyah, Tri Wulandari Kesetyaningsih, Muhammad Thesa Ghozali, Hari Susanti

“…Methods: Utilizing calcium chloride (CaCl₂) as a crosslinking agent, three formulations were developed: F1 (100% sago starch), F2 (50% sago starch, 50% sodium alginate), and F3 (100% sodium alginate). …”
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Design and Implementation of Single Axis Solar Tracking System: Utilizing GPS, Astronomical Equations, and Satellite Dish Actuator for Optimal Efficiency by Rizgar Ahmed Salih, Karzan Qadir Mohammed, Peshawa Osman Hama, Rawaz Othman Hassan, Barham Kamal Noori

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RMDNet: RNA-aware dung beetle optimization-based multi-branch integration network for RNA–protein binding sites prediction by Jiangbo Zhang, Yunhui Peng, Feifei Cui, Zilong Zhang, Shankai Yan, Qingchen Zhang

“…Although experimental methods like CLIP-seq accurately identify RNA–protein binding sites, they are time-consuming and costly. …”
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JASBO: Jaya Average Subtraction Based Optimization with Deep Learning Model for Multi-Classification of Infectious Disease from Unstructured Data by Vian Sabeeh, Ahmed Bahaaulddin A. Alwahhab, Ali Abdulmunim Ibrahim Al-kharaz

“…Medical documents are considered an essential source for modern, invented, and robust analysis methods for accurate infection diagnoses. …”
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Harmonization of multi-center diffusion tensor tractography in neonates with congenital heart disease: Optimizing post-processing and application of ComBat by Benjamin Meyers, Vincent K. Lee, Lauren Dennis, Julia Wallace, Vanessa Schmithorst, Jodie K. Votava-Smith, Vidya Rajagopalan, Elizabeth Herrup, Tracy Baust, Nhu N. Tran, Jill V. Hunter, Daniel J. Licht, J. William Gaynor, Dean B. Andropoulos, Ashok Panigrahy, Rafael Ceschin

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Refined prognostication of pathological complete response in breast cancer using radiomic features and optimized InceptionV3 with DCE-MRI by Satyabrata Pattanayak, Tripty Singh, Rishabh Kumar

“…This study introduces a novel predictive approach to identify patients likely to achieve pCR using radiomic features extracted from MR images, enhanced by the InceptionV3 model and cutting-edge validation methodologies. Methods In our study, we gathered data from 255 unique Patient IDs sourced from the -SPY 2 MRI database with the goal of classifying pCR (pathological complete response). …”
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Lipase production from Bacillus safensis VC-6 isolated from the volcanic region of Copahue: optimization and functional genomic insights by Valeria Foronda, Valeria Foronda, Valeria Castellanos, Claudia Hoepfner, Claudia Hoepfner, Daniel Guzmán, Héctor Guzmán, Jerry L. Solis

“…Lipase production from various microorganisms is well-studied. However, optimization studies remain limited for lipases sourced from halotolerant bacteria, such as Bacillus safensis strain VC-6, known to grow above 10% (w/v) NaCl and 50°C. …”
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