GENETIC PREDICTORS OF SEVERITY AND EFFICACY OF COVID-19 PHARMACOTHERAPY by I. N. Shishimorov, O, V. Magnitskaya, Yu. V. Ponomareva

“…The studies aimed at finding predictors of the severe course of this novel coronavirus infection, as well as the factors that determine the efficacy and safety of this disease pharmacotherapy, are acquiring special social significance.The aim of this work is to find and summarize information on genetic predictors of severe COVID-19, as well as pharmacogenetic aspects that determine the variability of the therapeutic response to the drugs recommended for COVID-19 treatment.Materials and methods. The article provides a review of scientific results on the research of gene polymorphism that determine a body’s response to the introduction of SARS-CoV-2 infection and the effects of pharmacotherapy for this disease, obtained from open and available sources within the period of 2019 – March 2021. …”
Get full text

Research Advance of Causal Inference in Clinical Medicine: A Bibliometrics Analysis via Citespace by Qin G, Wei J, Sun Y, Du W

“…The future integration of various data sources to improve causal inference methods is anticipated to enhance the sensitivity and specificity of trials, ultimately elucidating the complex mechanisms of diseases and drug effects. …”
Get full text

Patient Participation in Healthcare Safety Practices: A Scoping Review by Shabnam Ghasemyani, Kobra Movalled, Shafi Habibi, Rahim Khodayari Zarnaq

“…Materials and Methods: A scoping review of the English-language literature published from 2000 to 2021 was performed. …”
Get full text

Meta-analysis of mesenchymal stem cell therapy for intrauterine adhesions: a comprehensive consideration of efficacy and safety by Jiawei Gao, Xinyue Zhou, Nan Jiang, Yongjuan Zhang, Jianpeng Han, Tianyu Jia, Tianyu Jia, Yanbiao Jiang, Xiaoling Ma, Xiaoling Ma, Haofei Shen, Haofei Shen

“…Subgroup analyses were performed based on stem cell sources and transplantation methods.ResultsTwelve studies with 233 patients were included. …”
Get full text

Establishment of jujube anther culture and plant regeneration system by GUO Kaiwen, XU Chongchong, HU Yaning, HUANG Jian

“…In this study, three jujube varieties, Dongzao, Junzao and Qiyuexian, were used as materials. By optimizing the ratios of plant growth regulators, carbon sources, and cultivation conditions, an efficient anther culture regeneration system was established. …”
Get full text

Adaptive agroforestry—mitigating climate change impacts by farmers’ perception in different climate conditions in Iran by Sajad Ghanbari, Mostafa Jafari, Javad Ghasemi, Ivan L. Eastin, Pedro Álvarez-Álvarez, Samira Sasanifar, Mohsen Azizi, Leila Eskandari

“…This approach enhances the sustainability of agroforestry by optimizing resource use and maintaining agricultural productivity.…”
Get full text

Manufacturing Process Development for <i>Bison bison</i> Organ-Specific Lyophilized Extracts: Formulation and Benchmarking of Antioxidant Activities for Nutraceutical Preparations by Alexandre Porcello, Kim Girardet, Basste Hadjab, Kelly Lourenço, Corinne Scaletta, Philippe Abdel-Sayed, Nathalie Hirt-Burri, Lee Ann Applegate, Alexis E. Laurent

“…Functional benchmarking of the obtained extracts was performed using orthogonal methods of antioxidant activity determination (TEAC, FRAP, and H₂O₂ challenge assays). …”
Get full text

Polypharmacy in Pediatric Palliative Care: Exploring Discrepancies Between Physicians and Pharmacists by Daniele Mengato, Anna Zanin, Fernando Baratiri, Lisa Pivato, Laura Camuffo, Franca Benini, Francesca Venturini

“…Differences in perception between healthcare professionals regarding off-label prescriptions underscore the complexity of this practice and highlight the need for improved collaboration to optimize therapeutic outcomes. <b>Methods</b>: A cross-sectional observational study was conducted from August to October 2021 at the PPC center of the University Hospital of Padova, Italy. …”
Get full text

The performance evolution of Xue and Yamada-Ota models for local thermal non equilibrium effects on 3D radiative casson trihybrid nanofluid by Ahmed M. Galal, Ali Akgül, Sahar Ahmed Idris, Shoira Formanova, Talib K. Ibrahim, Murad Khan Hassani, Abdullah A. Faqihi, Munawar Abbas, Ibrahim Mahariq

Get full text

Bolus Use in Postmastectomy Radiation Therapy for Breast Cancer: A Systematic Literature Review by Fengyan Li MD, Wendie Hu MS, Hanzong Li MS, Bohan Li MS, Yaxue Wang MS

“…Methods This study includes a systematic literature review of sources such as websites, books, and articles from January 2013 to December 2023. …”
Get full text

In vivo keratotomy by mid-infrared femtosecond laser resonant with amide vibrational mode by Jinmiao Guo, Pengfan Chen, Maoxing Xiang, Kan Tian, Zhongjun Wan, Linzhen He, Wenkai Li, Xu Peng, Yujie Peng, Xiangyi Wen, Longqian Liu, Qi Jie Wang, Yuxin Leng, Houkun Liang

“…Methods The mid-infrared (MIR) femtosecond lasers at a central wavelength of 6.1 μm resonating with amide modes has an output power of 100 mW and a pulse width of ~200 fs. …”
Get full text

The efficacy of low-level laser therapy in oral surgery: A systematic review of randomized controlled trials by Alain Chaple Gil, Leonardo Díaz, Alfredo Von Marttens, Claudio Sotomayor, Javier Basualdo, Víctor Beltrán, Gilbert Jorquera, Rodrigo Caviedes, Eduardo Fernández

“…It also aimed to identify optimal laser parameters for future clinical application. …”
Get full text

Probiotics in Sports: Modulating the Microbiome for Performance and Health by Katarzyna Moliszewska, Paweł Kukiełka, Joanna Kośka, Gabriela Łocik, Julia Mazurek, Julia Załęcka, Alicja Nowik, Kacper Dywan, Martyna Musiorska, Michał Błaszkiewicz

“…AimThis review synthesizes current evidence on factors influencing gut microbiota composition across the lifespan, the systemic impacts of dysbiosis, and the roles of diet, physical activity, and probiotics—particularly in athletic populations—in fostering a health-promoting microbiome. Material and MethodsA narrative review was conducted using peer-reviewed studies, meta-analyses, and clinical trials sourced from PubMed, Scopus, and Web of Science. …”
Get full text

Advanced technological integration for swine wastewater: Enhancing treatment with photo-Fenton and electrocoagulation by Tatiana Luque, María Jimenez, Anyie Aguilar, Brayan A. Parra-Orobio, Jesús Alvarez, Angelica Hernandez, Cristian Mejia-Parada, Viviana Mora-Ruiz, Claudia Tavera -Ruiz, Jonathan Soto-Paz

“…The increase in pork consumption and its reputation as one of the best sources of protein has led to growth in this industry, however, its production generates a significant amount of swine wastewater (SWW). …”
Get full text

Multi-machine learning model based on radiomics features to predict prognosis of muscle-invasive bladder cancer by Bin Wang, Zijian Gong, Peide Su, Guanghao Zhen, Tao Zeng, Yinquan Ye

“…Abstract Objective This study aims to construct a survival prognosis prediction model for muscle-invasive bladder cancer based on CT imaging features. Materials and methods A total of 91 patients with muscle-invasive bladder cancer were sourced from the TCGA and TCIA dataset and were divided into a training group (64 cases) and a validation group (27 cases). …”
Get full text

HIV susceptibility to second-generation integrase strand transfer inhibitors among people with multidrug resistance: a systematic review and meta-analysis protocol by Vincent Kamaël Mekel, Ezechiel Ngoufack Jagni Semengue, Aude Christelle Ka’e, Alex Durand Nka, Collins Ambe Chenwi, Hugues Germain Mimfe’e Mba, Naomi-Karell Etame, Aurelie Minelle Kengni Ngueko, Audrey Rachel Mundo Nayang, Bouba Yagai, Desiré Takou, Maria Mercedes Santoro, Nicaise Ndembi, Vittorio Colizzi, Carla Montesano, Carlo-Federico Perno, Francesca Ceccherini-Silberstein, Joseph Fokam

“…The results will, therefore, contribute to set up baseline data for optimal management of people living with HIV harboring multidrug-resistant viruses. …”
Get full text

Cost-effectiveness analysis of penpulimab plus carboplatin-paclitaxel as first-line treatment for metastatic squamous non-small-cell lung cancer in China by Luwei Wang, Jiasheng Chen, Lihui Lin, Xiaowei Huang

“…Clinical efficacy data were sourced from the AK105-302 trial, while drug costs were derived from national tender prices. …”
Get full text

The impact of deregressed foreign breeding values on national beef cattle single-step genomic evaluation by Damilola Adekale, Zengting Liu, Ross Evans, Thierry Pabiou, Reinhard Reents, Dierck Segelke, Jens Tetens

“…A forward validation study with and without integrating foreign data across the three deregression methods showed improvement in reducing dispersion bias, as indicated by the regression coefficient. …”
Get full text

Incident HIV during pregnancy and postpartum and risk of mother-to-child HIV transmission: a systematic review and meta-analysis. by Alison L Drake, Anjuli Wagner, Barbra Richardson, Grace John-Stewart

“…<h4>Methods and findings</h4>We searched PubMed, Embase, and AIDS-related conference abstracts between January 1, 1980, and October 31, 2013, for articles and abstracts describing HIV acquisition during pregnancy/postpartum. …”
Get full text

Are tailored primary care services for social inclusion good value for money? A health economics evaluation with Monte-Carlo probabilistic sensitivity analysis comparing tailored s... by Síle Kelly, Anne Dee, Patrick O’Donnell

“…The analysis compares cost outcomes between SEP who have access to a tailored SIPC service with those who do not. Methods A cost analysis of the part-time SIPC service, based on available Irish-sourced data on the usage and costs of acute care in the Health Service Executive (HSE), and a literature review were used to identify the cost and outcome parameters of the economic framework. …”
Get full text