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    Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: a prospective cohort study by Yoriko Heianza, Dianjianyi Sun, Lu Qi, Louis R Pasquale, Jian-Min Yuan, Tao Huang, Frank B Hu, Tiange Wang, Janey Wiggs, Hyon-Kyoo Choi, Jin Fang Chai, Xueling Sim, Chiea Chuen Khor, Yechiel Friedlander, Andrew T Chan, Gary Curhan, Immaculata De Vivo, Rob Martinu van Dam, Chew Kiat Heng, Charles Fuchs, Woon Puay Koh

    Published 2019-07-01
    “…Objective We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).Design Three FADS variants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.Setting Population based study.Participants 11 323 women from the Nurses’ Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women’s Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).Main outcomes Long-term (~10 years) changes in BMI and body weight.Results In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). …”
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