Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification by Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng

“…Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and protein subunits can serve as valuable sources of potent and selective drug candidates. …”
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Relationship between ecological spatial network and vegetation carbon use efficiency in the Yellow River Basin, China by Chenglong Xu, Xiang Chen, Qiang Yu, Buyanbaatar Avirmed, Jikai Zhao, Wei Liu, Weijie Sun

“…Subsequently, the interrelationship between topological metrics and vegetation CUE was analyzed, and optimization strategies were proposed based on the significance of the structure and function. The findings revealed that: (1) Vegetation CUE exhibited a spatially decreasing trend from the western to eastern regions, with spatial patterns correlated with vegetation types, temperature, and precipitation distribution; (2) The ecological spatial network demonstrated a denser configuration in the upper and middle reaches and a sparser and shorter pattern in the lower reaches, with seamless connectivity among all regions; (3) Significant correlations were observed between topological metrics and vegetation CUE, prompting the adoption of ecological construction and protection measures when functional importance is deficient, and enhancing the connectivity of ecological sources through the augmentation of ecological corridors when structural importance is lacking. …”
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NaCl-induced soil stress regulates the diversity of soil bacteria and their ability to metabolize low molecular weight organic acids by Adhari Al-Kalbani, Daniel Menezes-Blackburn, Jinan Waladwadi, Said Al-Ismaily, Buthaina Al-Siyabi

“…This study demonstrated that soil salinity is a strong regulator of soil microbial diversity and function, as reflected by a marked decrease in the responsiveness of soil microbes to various root exudate carbon sources.…”
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Feasibility, Added Value, and Radiation Dose of Combined Coronary CT Angiography and Stress Dynamic CT Myocardial Perfusion Imaging in Moderate Coronary Artery Disease: A Real-Worl... by Marco Fogante, Enrico Paolini, Fatjon Cela, Paolo Esposto Pirani, Liliana Balardi, Gian Piero Perna, Nicolò Schicchi

“…Materials and Methods: This retrospective study included 65 patients (mean age: 51.2 ± 11.5 years; 21 female) with moderate CAD, selected from the Radiological Database of our hospital between May 2022 and December 2024. …”
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Stealth missiles with precision guidance: A novel multifunctional nano-drug delivery system based on biomimetic cell membrane coating technology by Yuyan Zhou, Xinyue Wang, Xiaorong Tian, Deyu Zhang, Hanxiao Cui, Wei Du, Zhenghui Yang, Jiayu Li, Wanshun Li, Jiaheng Xu, Ying Duanmu, Ting Yu, Fengping Cai, Wenhao Li, Zhendong Jin, Wencheng Wu, Haojie Huang

“…This approach enables nanocarriers to inherit the intrinsic biological properties of different cell sources, endowing them with immune evasion, prolonged circulation, dynamic targeting, biocompatibility, and biodegradability, while supporting the integration of diverse biomedical functions. …”
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Targeting NADPH oxidase-driven oxidative stress in diabetic cardiomyopathy: mechanisms and therapeutic perspectives by Zilv Ye, Zilv Ye, Sutong Wang, Zhengdong Wan, Birun Huang, Jiawei Guo, Jiawei Guo

“…Emerging strategies, such as selective NOX inhibitors, antioxidant therapies, and agents modulating signaling transduction, offer promising avenues for mitigating oxidative injury and improving cardiac function. …”
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Identification and Comprehensive Evaluation of Drought Tolerance in Sorghum During Germination and Seedling Stages by Manhong Wang, Irshad Ahmad, Bin Qin, Lei Chen, Weicheng Bu, Guanglong Zhu, Guisheng Zhou

“…In this study, 19 sorghum varieties from both domestic and international sources were selected as experimental materials. At the seedling stage, 11 above-ground and below-ground phenotypic traits were investigated. …”
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Prevalence of autoimmune thyroid disease in patients with psoriasis: a meta-analysis by Peng Zhang, Ruifang Wu, Xiaochao Zhang, Suhan Zhang, Siying Li, Yuwen Su

“…This meta-analysis aims to determine the association between psoriasis and AITD.Design A meta-analysis of observational studies.Data sources PubMed, EMBASE, Scopus and the Cochrane Library were searched up to 1 November 2021.Eligibility criteria for selecting studies We included non-randomised studies, each with over 50 cases in every group, focusing on the rate of comorbidity between psoriasis and AITD.Data extraction and synthesis Two independent reviewers screened the articles and extracted data. …”
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Towards the Question on the Zero Subject in English by I. S. Stepanenko, L. A. Ulianitckaia, T. V. Shulzhenko

“…The examples illustrating the functional features of the implicit subject in English sentence were selected by means of the method of continuous sampling from 7 corpora. …”
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A systematic literature review of the impact and measurement of mobility impairment in rare bone diseases by Inês Alves, Ingunn Westerheim, Edward C. Hsiao, Jaymin Upadhyay, Luca Sangiorgi, Alexander Artyomenko, Kim Croskery, Juliet Johns, Emma Warnants, Gabor Barton

“…There were 34 functional assessments, 22 questionnaires, and 5 technologies described. …”
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Epidemiological Informing of the Population in Cities: Models and Their Application by Vasiliy Osipov, Marina Osipova, Sergey Kuleshov, Alexandra Zaytseva, Aleksey Aksenov

“…The method is characterized by a new objective function that links economic efficiency with the state of health of the population in an epidemic. …”
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Application Of The Denitrification-Decomposition (DNDC) Model To Retrospective Analysis Of The Carbon Cycle Components In Agrolandscapes Of The Central Forest Zone Of European Russ... by Olga E. Sukhoveeva, Dmitry V. Karelin

“…In growing  season, the agrolandscapes function as a net carbon  sink and accumulate C from the atmosphere  into plant biomass. …”
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Combined application of FTAN and cross-spectra analysis to ambient noise recorded by a microseismic monitoring network by Ilaria Barone, Alessandro Brovelli, Giorgio Tango, Sergio Del Gaudio, Giorgio Cassiani

“…Group and phase velocity dispersion curves have been jointly inverted to retrieve as many shear-wave velocity profiles as selected station pairs. While the average model can be used for a more accurate location of the local natural seismicity, the associated standard deviations give us an indication of the lateral heterogeneity of seismic velocities as a function of depth. …”
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Camellia sinensis phytochemical profiling, drug-likeness, and antibacterial activity against gram-positive and gram-negative bacteria: in vitro and in silico insights by Farouk Boudou, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum, Ahmed Barhoum

“…Drug-likeness modeling indicated favorable profiles for most compounds, although EGCG violated Lipinski’s rule due to its molecular weight (458.4 g/mol). Density Functional Theory analysis revealed significant variations in electronic properties among the selected compounds, with quercetin exhibiting the smallest HOMO-LUMO gap (2.31 eV), suggesting high reactivity. …”
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Comparative study of nosZI and nosZII clade isolates: insights into their responses to environmental variables and soil fertilization types by Haoran Li, Qishi Luo, Lichao Sun, Huicui Xu, Xiaodong Hao, Kai Zhu, Ming Li, Bao Li, Wei Jiao, Jibiao Geng, Zhiqun Chen, Lihua Huang, Zongwei Xia

“…In contrast, the nosZI strain tended to increase emissions, except under the mixed fertilization regime.DiscussionThese findings highlight the importance of selecting N2O-reducing microbial strains based on their functional capacity and environmental tolerance. …”
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Quantifying Streambed Grain Size, Uncertainty, and Hydrobiogeochemical Parameters Using Machine Learning Model YOLO by Yunxiang Chen, Jie Bao, Rongyao Chen, Bing Li, Yuan Yang, Lupita Renteria, Dillman Delgado, Brieanne Forbes, Amy E. Goldman, Manasi Simhan, Morgan E. Barnes, Maggi Laan, Sophia McKever, Z. Jason Hou, Xingyuan Chen, Timothy Scheibe, James Stegen

“…Abstract Streambed grain sizes control river hydro‐biogeochemical (HBGC) processes and functions. However, measuring their quantities, distributions, and uncertainties is challenging due to the diversity and heterogeneity of natural streams. …”
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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer by Qing Wang, Maha Ayyoub, Olivia Le Saux, Paola Bonaventura, Isabelle Treilleux, Nicolas Chopin, Clarisse Dubois, Virginie Mutez, Nicolas Chuvin, Yann Estornes, Jenny Valladeau-Guilemond, Stephane Depil, Nicolas Gadot, Marie Michelas, Audrey Page, Olivier Tabone, Marie Delles, Sarah Moran, Thibault Richard, Marjorie Lacourrège, Dina M Tawfik, Ema Etchegaray, Adrian Valente, Rasha E Boulos, Gabriel Jimenez Dominguez

“…Human endogenous retroviruses (HERVs) are aberrantly expressed by tumor cells and may represent a source of shared T-cell epitopes for cancer immunotherapy regardless of the tumor mutational burden.Methods A transcriptomic analysis based on RNA sequencing was developed to quantify the expression of HERV-K sequences containing the selected epitopes. …”
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DUALZ—Deep UNCOVER-ALMA Legacy High-Z Survey by Seiji Fujimoto, Rachel Bezanson, Ivo Labbe, Gabriel Brammer, Sedona H. Price, Bingjie Wang, John R. Weaver, Yoshinobu Fudamoto, Pascal A. Oesch, Christina C. Williams, Pratika Dayal, Robert Feldmann, Jenny E. Greene, Joel Leja, Katherine E. Whitaker, Adi Zitrin, Sam E. Cutler, Lukas J. Furtak, Richard Pan, Iryna Chemerynska, Vasily Kokorev, Tim B. Miller, Hakim Atek, Pieter van Dokkum, Stéphanie Juneau, Susan Kassin, Gourav Khullar, Danilo Marchesini, Michael Maseda, Erica J. Nelson, David J. Setton, Renske Smit

“…We also detect a marginal dust emission from an X-ray-detected galaxy at z _spec = 10.07, suggesting an active coevolution of the central black hole and its host. …”
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Strategi Komunikasi PT Jasa Raharja Cabang D.I. Yogyakarta dalam Program Millennial Road Safety by Devin Airlangga, Pratiwi Wahyu Widiarti

“…Informants in this study were selected using a purposive sampling te chnique, and there were two primary informants selected, public relations officer and PKBL division at PT Jasa Raharja Branch of Special Region of Yogyakarta. …”
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Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…The application compares and detects changes in fish individuals at each location. …”
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