Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era by Yoko Kataoka

“…TARC has a different meaning than it did previously, and its significance and limitations are discussed. First, a more appropriate topical therapy monitoring TARC would be useful in selecting truly necessitated patients for expensive new therapies. …”
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Downregulation of the keratins CK13 and CK14 does not significantly affect cell viability of human urinary bladder carcinoma cells by Anna Scherping, Antje Schinlauer, Piotr Czapiewski, Christoph Garbers

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Expression of ERα, ERβ and Co-Regulator PELP1/MNAR in Colorectal Cancer: Prognostic Significance and Clinicopathologic Correlations by Petros D. Grivas, Vassiliki Tzelepi, Georgia Sotiropoulou-Bonikou, Zinovia Kefalopoulou, Athanasios G. Papavassiliou, Haralabos Kalofonos

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Boosting the synthesis of 3-acetamido-5-acetylfuran from N-acetyl-D-glucosamine: understanding the significant role of homogeneous Cl - by Delong Yang, Jinhang Dai, Ziting Du, Qingya Cao, Gang Chen, Ting Qi, Weilu Wang, Fukun Li

“…Abstract Since 3-acetylamino-5-acetylfuran (3A5AF) has been regarded as a promising nitrogen-containing synthon, the conversion of renewable chitin and its monomer N-acetyl-D-glucosamine (NAG) to 3A5AF is of significance. In this paper, we compared the catalytic activity of several Cl-containing compounds and found that LiCl exhibited superior performance. …”
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The Significance of a Cerebrovascular Accident Outcome Prediction Model for Patients, Family Members, and Health Care Professionals: Qualitative Evaluation Study by Corinne G Allaart, Sanne van Houwelingen, Pieter HE Hilkens, Aart van Halteren, Douwe H Biesma, Lea Dijksman, Paul B van der Nat

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The significance of evaporation heat and mass transfer through a spray sheet with two-phase transitional momentum transport and vapour dispersion by Ahmed Abed Al-Kadhem Majhool, Ammar Muslim Hadi, Faris Alqurashi, Sara Falih Kareem, Noor M. Jasim, Mujtaba A. Flayyih

“…In close proximity to the injector, the evaporation rate is significantly higher. There was no significant increase in the evaporation rate of the pressure swirl nozzle as the distance from the injector increased. …”
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Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages by Jo Wol Soon, Kim Sung Dae, Jeong Soo Kyung, Oh Su Jung, Baik Ji Sue, Seo Ji An, Baek Jeong-Hwa, Lee Chang Geun, Kang Young-Rok, Jeong Min Ho, Park Moon-Taek

“…M2-polarized macrophages and interleukin (IL)-6 significantly alter the tumor microenvironment and promote the malignant behaviors of tumor cells. …”
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Integrative bioinformatics and immunohistochemical analysis unravel the prognostic significance and immunological implication of LIMCH1 in breast cancer: a retrospective study by Xin Yu, Bei Li, Wenge Li, Jingping Yuan, Shengrong Sun, Juanjuan Li

“…Our analysis revealed that high LIMCH1 expression in breast cancer patients was significantly associated with unfavourable clinical outcomes and served as an independent prognostic indicator. …”
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SIGNIFICANT WASTE FACTORS INFLUENCING DELIVERY COST PERFORMANCE OF DESIGN AND BUILD LOW COST HOUSING PROJECTS IN IMO STATE NIGERIA by Lovelin OBI, Mohammed ARIF, Bankole AWUZIE

“…Findings revealed the significant waste factors influencing poor cost performances of DBLcH projects . …”
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The Combination of D-TACE-HAIC, Lenvatinib, and PD-1 Inhibitors Shows Significant Clinical Efficacy in Patients with Unresectable Hepatocellular Carcinoma by Wu Y, Zhu J, Zhang H, Xia N

“…Group A also exhibited significantly higher rates of overall adverse events including hypertension, abdominal pain, leukopenia, thrombocytopenia, and hypoproteinemia as compared to Group B, although the incidence of hand-foot syndrome in Group A was significantly reduced as compared to Group B (13.3% vs 42.8%). …”
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Introduction of Panax notoginseng into pine forests significantly enhances the diversity, stochastic processes, and network complexity of nitrogen-fixing bacteria in the soil by Xiaoyan Zhao, Shu He, Rui Rui, Jingying Hei, Xiahong He, Shu Wang

“…Therefore, assessing the variability in NFB due to the cultivation of sanqi in the SPA system becomes crucial.MethodsThe seasonal dynamics in the abundance, diversity, and community structure of NFB in the soil of monocropping pine (MP) and SPA systems were assessed using real-time quantitative polymerase chain reaction and high-throughput sequencing technology.Results and discussionSanqi cultivation triggered a decrease in the abundance of NFB but increased α diversity. Additionally, significant differences in the community structure of NFB were noted between the MP and SPA systems. …”
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Significant reduction in Hepatitis B virus infections following 32 years of universal Hepatitis B vaccination as part of EPI, Thailand by Pornjarim Nilyanimit, Nasamon Wanlapakorn, Preeyaporn Vichaiwattana, Lakkhana Wongsrisang, Sirapa Klinfueng, Nungruthai Suntronwong, Wichan Bhunyakitikorn, Piyada Angsuwatcharakon, Chaninan Sonthichai, Narong Thawinwisan, Pichet Puedkuntod, Sunsanee Phattharasrivongchai, Parichaya Loprakhon, Watcharanan Tinnaitorn, Thawatchai Luankaew, Sasithorn Vinothai, Somjet Chaijaroen, Pornsawan Meechin, Chalermpol Pongpichit, Yong Poovorawan

“…Anti-HBc was found at very low rates in children but increased significantly after age 30. Thailand’s HBV NPI significantly reduced HBV infection rates, especially in younger populations. …”
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LETERMOVIR PRIMARY CYTOMEGALOVIRUS PROPHYLAXIS IN ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS: COULD INFECTION AND DISEASE NO LONGER BE A SIGNIFICANT PROBLEM? by Fabian Herrera

“… Background: Cytomegalovirus (CMV) infection remains the most common clinically significant infection after allogeneic hematopoietic stem cell transplantation (allo-HCT) and is associated with considerable morbidity and mortality. …”
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Repeat FNA Significantly Lowers Number of False Negative Results in Patients with Benign Nodular Thyroid Disease and Features of Chronic Thyroiditis by Dorota Słowińska-Klencka, Ewa Woźniak-Oseła, Bożena Popowicz, Stanisław Sporny, Mariusz Klencki

“…Repeat biopsy significantly lowers percentage of FN results in patients with BL-CT in the first FNA.…”
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Spatial accuracy of dose delivery significantly impacts the planning target volume margin in linear accelerator-based intracranial stereotactic radiosurgery by Yuta Takahashi, Riki Oshika, Rie Tachibana, Katsuyuki Shirai, Hiroshi Asakura, Masayoshi Miyazaki, Tomohiro Sagawa, Shinichi Takahashi, Tsunekazu Kuwae, Hironori Kojima, Shiro Nishiyama, Hikaru Nemoto, Yoshitomo Ishihara, Mariko Umeda, Kotaro Kijima, Daisuke Kobayashi, Keiji Suzuki, Yuki Nozawa, Kento Hoshida, Tomoki Kitagawa, Hiromitsu Endo, Yuki Matsunaga, Hiroya Itagaki, Mayumi Ishida, Shigeru Kanahara, Ryo Horita, Daisuke Hori, Hidenobu Tachibana

“…The findings indicate significant millimeter-level variability in 3D dose delivery accuracy among linacs installed in clinical settings. …”
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I know what I shouldn’t say, but what should I say? An approach to present results without statistical significance by Brian C. Healy, Brian C. Healy, Brian C. Healy

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Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer by Haitao Zhong, Yiming Lai, Wenhao Ouyang, Yunfang Yu, Yongxin Wu, Xinxin He, Lexiang Zeng, Xueen Qiu, Peixian Chen, Lingfeng Li, Jie Zhou, Tianlong Luo, Hai Huang

“…Survival analysis suggested that patients could be divided into high- and low-risk groups according to model scores and that there was a significant difference in disease-free survival (DFS) (P < 0.01). …”
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Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

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Correlation and clinical significance of placental tissue selectin (E), angiotensin II and its receptors, and oxidized lipid levels in patients with preeclampsia by Yan Gao, Guohong Wu, Haiting Huang, Xiaoyan Lu, Peifen Wu, Zou Suiyi, Zhenyan Liu

“…Background: The purpose was to analyze the levels of placental tissue selectins (E), angiotensin II (AngII) and its receptors (ATRs), and oxidized lipids (malondialdehyde (MDA), 8-isoprostane 2a) in patients with preeclampsia (PE). (8-iso-PGF2a)) correlation and clinical significance. Methods: Select 30 PE pregnant women who were admitted to our hospital from March 2023 to January 2024 as the case group, and select another 30 normal pregnant women who were registered in our hospital during the same period as the health group .The general information of the two groups and placental tissue selectin (E), plasma AngII, ATRs, placental tissue MDA, 8-iso-PGF2a and blood pressure levels (systolic blood pressure (SBP), diastolic blood pressure (DBP)) were compared. …”
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Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer by Yuan Xu, Dongjie Ma, Yingzhi Qin, Hongsheng Liu

“…Lymph node status significantly influences prognosis, even in initially unresectable cases. …”
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