Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin by Michał Biernacki, Elżbieta Skrzydlewska

“…Therefore, it is believed that dysregulation of eicosanoid levels may contribute to the development of skin diseases, such as psoriasis or atopic dermatitis, which in turn suggests that targeted control of the generation of specific eicosanoids may have diagnostic significance and beneficial therapeutic effects. This review is the first systemic and very detailed approach presenting both the causes and consequences of changes in phospholipid metabolism leading to the generation of eicosanoids, changes in the level of which result in specific metabolic disorders in skin cells leading to the development of various diseases. …”
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A Case of Pulmonary Sarcoma with Significant Extension into the Right Lung by Yoshiaki Inoue, Yotaro Izumi, Kenjiro Sakaki, Keiko Abe, Teruaki Oka, Jun-Ichi Tamaru, Ato Sugiyama, Kohei Aoki, Hiroki Fukuda, Masatoshi Gika, Kazuhito Imanaka, Mitsuo Nakayama

“…Collectively, intimal sarcoma originating from the right main pulmonary artery with extension into the right lung was diagnosed. Significant extension of pulmonary artery sarcoma into the lung, as was observed in the present case, is considered to be rare, and to our knowledge this is the first report in which the primary lesion was biopsied by bronchoscopy.…”
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Significant Bradycardia in Critically Ill Patients Receiving Dexmedetomidine and Fentanyl by Channing Hui, Maria Cardinale, Balaji Yegneswaran

“…To report a case series of three patients who developed significant bradycardia while receiving the combination of dexmedetomidine and fentanyl for sedation and analgesia. …”
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CT and MRI image fusion based on variance and pixel significance by Boubakeur Latreche

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D. A. Ọbasá: The Man and the Significance of his Cultural Activism by Adekemi Agnes Taiwo

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Prevalence and clinical significance of granulomas in perianal fistulizing Crohn's disease by Hui hui Wu, Su min Zhang, Kang Ding, Yuan yuan Ge

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Movement in the streets: Significant spatial features of the historic center of Quito by Estefanía Piñeiros

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Activities and significance of the bilateral Lithuanian - Polish History Teaching Commission by Algis Povilas Kasperavičius

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Variations of Gastrocolic Trunk of Henle and Its Significance in Gastrocolic Surgery by Yuan Gao, Yun Lu

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Predictors of Relapse to Significant Alcohol Drinking after Liver Transplantation by Zamil Karim, Pongphob Intaraprasong, Charles H Scudamore, Siegfried R Erb, John G Soos, Elsie Cheung, Polly Cooper, Andrzej K Buzckowski, Stephen W Chung, Urs P Steinbrecher, Eric M Yoshida

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Ecological significance of protected areas in the tropical mountains of Eastern Africa by Marco Andrew Njana

“…Furthermore, carbon storage varied statistically significantly between PA categories and between PAs and other land uses where PA category I had disproportionally higher carbon storage. …”
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Diagnosis and clinical significance of prostate calcification using computed tomography by Seong Cheol Kim, Tae Young Lee, Woocheol Kang, Hoyoung Bae, Ji Hyung Yoon, Sungchan Park, Kyung Hyun Moon, Sang Hyeon Cheon, Taekmin Kwon

“…Abstract This study aimed to assess the exact location, size, and clinical significance of prostatic calcification using computed tomography (CT). …”
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Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 by Mark A Wainberg, Ronald Rooke, Michel Tremblay, XuGuang Li, Michael A Parniak, Qing Gao, Xiao-Jian Yao, Chris Tsoukas, JSG Montaner, M Fanning, J Ruedy

“…Furthermore, the development of drug resistance soon after initiation of AZT therapy may potentially be correlated with the likelihood of AZT treatment failure. …”
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Significance of regions in export diversification of the RF (by example of Dagestan Republic) by Z. G. Magomedova

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Significant Decline of Malaria Incidence in Southwest of Iran (2001–2014) by Shokrollah Salmanzadeh, Masoud Foroutan-Rad, Shahram Khademvatan, Sasan Moogahi, Shahla Bigdeli

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Concept and Significance of Criminalistics Classification of Crimes Related to Proxy Battle by O. M. Luhovyi

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The power of social capital: the significance of relationships in third space practice by Diane Nutt, Emily McIntosh

“…This article considers the literature on third space working and social capital, explores findings from qualitative data collected during practice-based research, and examines in more detail the nature and significance of relationships in third space practice, and in particular the power of social capital (Bourdieu, e.g. 1990; Nahapiet and Ghosal, 1998; Lin 2001). …”
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Prognostic Analysis of Driving Style: The Significance of Demographic and Cognitive Factors by Justina Slavinskienė, Auksė Endriulaitienė

“… This study aimed to compare four driving styles among professional and non-professional Lithuanian drivers and to assess the significance of demographic and cognitive factors in predicting investigated driving styles. …”
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State of the practice on energy-based liquefaction evaluation and research significance by Takaji Kokusho

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Significant achievements: Major milestones for the Turkish Journal of Vascular Surgery by Nevzat Erdil

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