Efficacy and safety of NeoAdjuvant chemotherapy with or without tIslelizumab followed by debulking surgery for oVarian cancEr (NAIVE study) in China: study protocol of an open-labe... by Ying Zhu, Jianwei Zhou, Zhigang Zhang, Jiaojiao Zhang, Jing Fei, Xiaoqing Zhu

“…The NeoAdjuvant chemotherapy with or without tIslelizumab followed by debulking surgery for oVarian cancEr(NAIVE) study aims to assess the clinical efficacy and safety of NACT in combination with tislelizumab (a monoclonal antibody for programmed cell death protein 1) for advanced EOC.Methods and analysis The NAIVE study is an investigator-initiated, prospective, single-centre, open-label, randomised controlled trial for advanced EOC with the International Federation of Gynaecology and Obstetrics (FIGO) stage IIIc with a Suidan CT score of 3 or greater or a Fagotti laparoscopic score of 8 or greater; or FIGO stage IV. …”
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Serial measurements in COVID-19-induced acute respiratory disease to unravel heterogeneity of the disease course: design of the Maastricht Intensive Care COVID cohort (MaastrICCht) by Steven J R Meex, Walther N K A van Mook, Iwan C C van der Horst, Jeanette Tas, Coen D A Stehouwer, Rob J J van Gassel, Serge J H Heines, Mark M G Mulder, Nanon F L Heijnen, Melanie J Acampo-de Jong, Julia L M Bels, Frank C Bennis, Marcel Koelmann, Rald V M Groven, Moniek A Donkers, Frank van Rosmalen, Ben J M Hermans, Otto Bekers, Astrid M L Oude Lashof, Fabian H Tijssen, Jan-Willem E M Sels, Chahinda Ghossein-Doha, Rob G H Driessen, Pieter L Kubben, Marcus L F Janssen, Gerry A F Nicolaes, Ulrich Strauch, Zafer Geyik, Thijs S R Delnoij, Kim H M Walraven, Jeanine A M C F Verbunt, Susanne van Santen, Ronny M Schnabel, Marcel J H Aries, Marcel C G van de Poll, Bas C T van Bussel, Joachim E Wildberger, Sander M J van Kuijk, Dennis C J J Bergmans, Paul H M Savelkoul, Alma M A Mingels, Wolfgang F F A Buhre

“…Therefore, a major part of the data collection is aligned with an existing national intensive care data registry and two international COVID-19 data collection initiatives. Additionally, we create a flexible design, so that additional measures can be added during the ongoing study based on new knowledge obtained from the rapidly growing body of evidence. …”
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TIKROVĖS POSTMODERNIOS GRIMASOS by Audronė Žukauskaitė

“… Straipsnyje detaliai analizuojama tikrovės sąvoka, kuri interpretuojama kaip teorinis įrankis, leidžiantis pasiprie šinti postmodernioms diskurso teorijoms. Slovėnų filosofas Slavojus Žižekas tikrovės sąvoką pasiskolina iš Jacques'o Lacano psichoanalizės; Žižeko teigimu, tikrovė yra nereprezentuojamas, trauminis branduolys, plytintis "kažkur anapus" simbolinės tvarkos. …”
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Specific Features of the Formation and Development of Mediation in Foreign Countries with Anglo-Saxon and Romano-Germanic Legal Systems by S. S. Myrza

“…Using the epistemological method of the research, the author has defined the essence of mediation as a separate alternative way of resolving disputes, which was initiated in the 60-70s of the XX century in the United States of America. …”
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Le port antique de Saintes/Mediolanum (Charente-Maritime) by Jean-Philippe Baigl, Adrien Camus, Olivier Dayrens, Vincent Lebaron, Jonathan Letuppe, Vivien Mathé

“…More recently, underwater and geophysical surveys carried out in 2013 and 2014, as well as an initial underwater survey evaluation carried out in the Charente river in 2015, led to the discovery of numerous wooden remains (piles, planks, etc.), suggesting the presence of various Roman riverbank structures, as well as the discovery of a stone structure approximately 3 m thick and over 100 m long, on the right bank of the river. …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Objectives The project “acERca las enfermedades raras” (in English: “bringing RDs closer”) is an initiative primary designed to generate a consensus by a multidisciplinary group of experts to detect the strengths and weaknesses in the public healthcare system concerning the comprehensive care of persons living with a RD (PLWRD) in the region of Catalonia, Spain, where a Network of Clinical Expert Units (Xarxa d’Unitats de Expertesa Clínica or XUEC) was created and is being implemented since 2015. …”
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Pegloticase and Methotrexate Cotherapy in Patients With Uncontrolled Gout With Prior Pegloticase Monotherapy Failure: Findings of an Open‐Label Trial by Orrin M. Troum, John K. Botson, Katie Obermeyer, Bo Chao, Yang Song, Jennifer Zarzoso, Kjerstina Gutierrez, Supra Verma, Lissa Padnick‐Silver, Brian LaMoreaux

“…These findings demonstrate the challenge of overcoming established antipegloticase antibodies and emphasize the importance of initiating immunomodulation before the first pegloticase exposure.…”
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Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study by Yanning Qu, Rui Tang, Zhuyan Duan, Mengyi Sheng, Hui Wang, Shuang Liu, Jiao Li, Linlin Guo, Linying Guo, Si Zheng, Si Zheng

“…Advocating for enhanced safety regulations or educations and public health initiatives to mitigate the incidence of such exposures is still important for protecting children's health.…”
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From a dictionary to an atlas: segmental mapping of the linguistic picture of the world by S. N. Gagarin

“…These, in turn, can be used for creating maps, or rather atlases, initially of the smaller segments of linguistic pictures of the world, which may over time, and with enough methodological evolution, transform into larger-scale projects covering different languages, which arguably contains a hitherto unexplored potential for comparing them at a new systemic level, that of the structure and internal semantic delimitation of linguistic pictures of the world.…”
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Diagenetic Modifications and Reservoir Heterogeneity Associated with Magmatic Intrusions in the Devonian Khyber Limestone, Peshawar Basin, NW Pakistan by Mumtaz M. Shah, Saifullah Afridi, Emad U. Khan, Hamad Ur Rahim, Muhammad R. Mustafa

“…Dolomitic marble shows a marked depletion in δ18O and δ13C (-13.7 to -8.5‰ and -2.3 to 1.95‰, respectively). The initial phase of dolomitisation (Dol. I) did not alter porosity (5.4-6.6%) and permeability (0.0-0.1 mD) with respect to the unaltered limestone (5.6-6.9%; 0.1-0.2 mD). …”
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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Abstract Background Despite extensive analysis, the dynamic changes in prostate epithelial cell states during tissue homeostasis as well as tumor initiation and progression have been poorly characterized. …”
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Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study by Henriette Louise Möllmann, Eman Alhammadi, Soufian Boulghoudan, Julian Kuhlmann, Anica Mevissen, Philipp Olbrich, Louisa Rahm, Helmut Frohnhofen

“…ResultsRecruitment started in August 2022, with 421 patients already recruited at the time of submission. Initial analyses of the data are to be published at the end of 2024 or the beginning of 2025. …”
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De Novo Acute Myeloid Leukemia with Combined CBFB-MYH11 and BCR-ABL1 Gene Rearrangements: A Case Report and Review of Literature by Venkata Rakesh Sethapati, Ra’ed Jabr, Leyla Shune, Wissam El Atrouni, Patrick R. Gonzales, Wei Cui, Shivani Golem

“…KIT mutations were negative. The patient was initially treated with standard induction regimen; 7 daily doses of cytarabine from day 1–day 7, 3 daily doses of daunorubicin from day 1–day 3, and 1 dose of Mylotarg (gemtuzumab ozogamicin) on day 1. …”
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Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…Among the adjusted covariates, CD4 cell count<50 cells/mm3 (adjusted CSH (aCSH) 8.61, 95% CI: 4.75 to 15.60), uncontrolled viremia (aCSH 1.95, 95% CI: 1.20 to 3.17), 10-year increase in age (aCSH 2.41, 95% CI: 1.89 to 3.07), schizophrenia (aCSH 2.85, 95% CI: 1.69 to 4.80), traumatic brain injury (aCSH 2.43, 95% CI: 1.59 to 3.71), delirium (aCSH 2.27, 95% CI: 1.45 to 3.55), substance use disorder (SUD) (aCSH 1.94, 95% CI: 1.18 to 3.21) and mood/anxiety disorders (aCSH 1.80, 95% CI: 1.13 to 2.86) were associated with an increased hazard for dementia. Initiating ART in 2005–2010 (versus<2000) produced an aCSH of 0.51 (95% CI: 0.30 to 0.89).Conclusions We demonstrated the negative role of immunosuppression and inflammation on the incidence of dementia among PLWH. …”
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Les chutes de la Lobé, un patrimoine géoculturel exceptionnel sur la côte camerounaise entre tourisme durable et préservation des identités culturelles by Mesmin Tchindjang, Marcel Hugues Etoga

“…Ce milieu pourvu d’abondantes ressources naturelles, culturelles et touristiques demeure encore sous-valorisé en dépit des timides initiatives des populations locales et de l’administration centrale pour lancer le tourisme. …”
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Centering community-based maternal and child nutrition services in Bangladesh’s rural primary healthcare: what has potential to scale by Safina Abdulloeva, Arti Bhanot, Mohd. Aziz Khan, Md. Mofijul Islam Bulbul, Mijanur Rahman, Kaosar Afsana, Thomas Forissier, Deepika Sharma, Abul Bashar Mohammad Khurshid Alam

“…However, minimum dietary diversity among pregnant women (69% intervention, 72% control), early initiation of breastfeeding (55% intervention, 51% control), and complementary feeding practices were comparable in intervention and control areas. …”
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Penyusunan Solusi Model Konseptual untuk Pembangunan Strategi Sistem Informasi pada Perusahaan Bisnis TI: Metode Systematic Mapping by Ariani Dwi Wulandari, Bima Ajie Bahari, Bq. Zuyyina Hilyatur Rozalia, Mudjahidin Mudjahidin

“…Further studies related to the development of the SI strategy formulation model will be carried out using the concept of systematic mapping with the initiation stage of searching, collecting and classifying papers, analyzing the results and discussion involving various perspectives of researchers and practitioners in the field of strategy management, and designing conceptual models will be built. …”
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Diagnosis and treatment of descending optic neuritis developed as a manifestation of local viral encephalitis (a clinical case) by N.V. Korsakova, E.I. Korsakova

“…It should be recognized that during the process of opticoencephalitis development, its ophthalmic manifestations for a long time will not only remain a single sign of this focal neurological disorder, but will require timely initiation of etiotropic drugs, using the appropriate routes of administration, doses, and duration of treatment. …”
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TIKROVĖS POSTMODERNIOS GRIMASOS by Audronė Žukauskaitė

“… Straipsnyje detaliai analizuojama tikrovės sąvoka, kuri interpretuojama kaip teorinis įrankis, leidžiantis pasiprie šinti postmodernioms diskurso teorijoms. Slovėnų filosofas Slavojus Žižekas tikrovės sąvoką pasiskolina iš Jacques'o Lacano psichoanalizės; Žižeko teigimu, tikrovė yra nereprezentuojamas, trauminis branduolys, plytintis "kažkur anapus" simbolinės tvarkos. …”
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A scoping review of HIV epidemiologic, sociocultural and programmatic studies related to transgender women and men who have sex with men in Cambodia, 1999-2019. by Jan W de Lind van Wijngaarden, Frits van Griensven, Ly Penh Sun, Stephen Wignall

“…The epidemiology of HIV infection in these groups has been relatively well-described and analyzed. While initially MSM and TGW were grouped together, in more recent years they have been studied in their own right, recognizing their specific HIV and other prevention needs. …”
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