Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…A longitudinal, large prospective study is necessary to guide the initiation of dupilumab treatment for childhood EoE, and long-term follow-up data on dupilumab are required. …”
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Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis by Cheng Z, Wu J, Xu C, Yan X

“…The primary analytic approach was inverse variance weighted (IVW).Results: LDSC analysis revealed moderate genetic correlations between frailty and Global Biobank Meta-Analysis Initiative (GBMI) COPD (rg = 0.643, P = 6.66× 10− 62) as well as FinnGen COPD (rg = 0.457, P = 8.20× 10− 28). …”
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Citizenship in Lithuanian Lexicographical Sources, Youth Worldview, and Media Texts by Marius Smetona

“…As a result, various initiatives, competitions, lessons, and programs are offered. …”
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Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center by Rhodri Saunders, Carlo Calabrese, Dania Gelli, Jason Davis, Rafael Torrejon Torres

“…Input data were sourced from a physician-initiated study from Sant'Orsola-Malpighi Hospital in Bologna, Italy, and the literature. …”
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The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer by Hao Luo, Bin Hu, Xiang-Rong Gu, Jing Chen, Xiao-Qing Fan, Wei Zhang, Ren-Tao Wang, Xian-Dong He, Wei Guo, Nan Dai, Dan Jian, Qing Li, Cheng-Xiong Xu, Hua Jin

“…The overexpression of all miRNAs in the miR-23a/27a/24 − 2 cluster upregulated PD-L1 expression by targeting Cbl proto-oncogene B (CBLB) and downregulated MHC-I expression by increasing the level of eukaryotic initiation factor 3B (eIF3B) via the targeting of microphthalmia-associated transcription factor (MITF). …”
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Barriers facilitators and needs of female sex workers in Arak to access sexual health services a qualitative study by Iman Navidi, Elham Shakibazadeh, Firoozeh Raisi, Samaneh Akbarpour

“…This qualitative study, the initial study conducted in Iran, explored the sexual health needs, barriers, and facilitators to accessing sexual health services among women at high risk of STIs in Arak. …”
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L’École de journalisme d’Alger (1964-1990) : les défis d’une formation professionnelle by Chloé Nejma Rondeleux

“…., left by the principal role-players of the École de journalisme (directors, lecturers and students), have been enriched by previously unpublished interviews and personal archives collected from the above-mentioned, making it possible to approach as closely as possible to the functioning of the institute.The article first recounts the context of birth and dwells on the initial project of the years 1964–1965. The description of the first journalism training course since independence, organised at the start of 1964, just a few months before the opening of the École de journalisme in October 1964, highlights the influence of the socialist countries and the practical dimension of the training provided. …”
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Eco-anthropologie et primatologie pour la conservation de la biodiversité : un projet collaboratif dans le Parc National de Moukalaba-Doudou, Gabon by Naoki Matsuura, Yuji Takenoshita, Juichi Yamagiwa

“…The negative aspect of great apes for local people, such as crop-raiding, is also pointed out.Finally, the authors demonstrate how their interdisciplinary collaborative project integrates biodiversity conservation and local development, and then discuss the importance of ecotourism projects based on local initiatives. The synthesis of the scientific knowledge and close relationships that primatologists established with local people with the deep understanding of local culture acquired by ecological anthropologists, leads us to suggest implementing an ecotourism based on various narratives created through collaborative research activities.…”
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Benzodiazepine agonist treatment for patients with benzodiazepine dependence undergoing opioid agonist treatment: a study protocol for the randomized controlled trial BMX-BAR by Fatemeh Chalabianloo, Lars Thore Fadnes, Jörg Assmus, Jon Mordal, Kristin K. Solli, Kjetil S. Dale, Christina D. Andersen, Silvia Zavenova, Beathe H. Rønning, Andreas W. Blomkvist, Martin Ryssdal, Wasifa S. J. Butt, Anne Marciuch, Anne G. Ørmen, Christian Ohldieck, Else-Marie Løberg, Kjell Arne Johansson, for the BMX-BAR and NORCATS study group

“…Participants will be randomly assigned to receive either a 26-week benzodiazepine stabilizing treatment (15–30 mg diazepam or 50–100 mg oxazepam daily), or a 20-week tapering using the same medications and equivalent initial dosages. All participants will be given access to consultations from OAT therapists with psychosocial follow-up in accordance with current clinical practice. …”
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Effectiveness and utilization of a cognitive screening program for primary geriatric care by David P. Salmon, Anna Malkina, Melanie L. Johnson, Christina Gigliotti, Emily A. Little, Douglas Galasko

“…Classification accuracy was shown by high agreement with the eventual clinical diagnosis in the medical record (69%; Cohen’s Kappa = .38; p < .001; 77% if MCI and dementia were collapsed; Cohen’s Kappa = .58; p < .001) and longitudinal decline in cognitive test scores only in those initially classified as having MCI or dementia. Medical records documented discussion of screening results with the patient in 69% of cases (80% if MCI or dementia was detected) and often referral to a specialist (62%), new brain imaging (54%), or change in medication (58%) when screening indicated potential cognitive impairment. …”
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Impact of Different Serum Potassium Levels on Postresuscitation Heart Function and Hemodynamics in Patients with Nontraumatic Out-of-Hospital Cardiac Arrest by Yan-Ren Lin, Yuan-Jhen Syue, Tsung-Han Lee, Chu-Chung Chou, Chin-Fu Chang, Chao-Jui Li

“…Sustained return of spontaneous circulation (ROSC) can be initially established in patients with out-of-hospital cardiac arrest (OHCA); however, the early postresuscitation hemodynamics can still be impaired by high levels of serum potassium (hyperkalemia). …”
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Network Resilience and Rehabilitation Strategies for an Airport Movement Area Considering Traffic Flow and Road Class by Ruiling Mou, Rui Kang

“…Under the FDBC-based recovery strategy, as traffic flow weights increase, the comprehensive resilience index of the network initially shows a smooth trend, followed by a decrease, then another period of smoothness before decreasing again. …”
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Water-Based Supplementation Technology for Grazing Cattle in the Tropics: A Large-Scale Commercial Case Study by Eliéder Prates Romanzini, Vivienne McCollum, Sarah Mcilveen, Evandro Maia Ferreira, William Luiz de Souza, Marcelo Augusto Oliveira Castro, Priscila Arrigucci Bernardes, Ryan J. Batley, Mark G. Trotter, Diogo Fleury Azevedo Costa

“…A total of 120 steers [initial liveweight (LW) 322.5 ± 28.3 kg] were assigned to three groups: water only (Control), a water supplement containing nutrients such as nitrogen and phosphorus, known as uPRO GREEN^® (Green), and uPRO GREEN^® combined with Agolin Ruminant L^® (Blue). …”
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Structure-Based Virtual Screening, Docking, ADMET, Molecular Dynamics, and MM-PBSA Calculations for the Discovery of Potential Natural SARS-CoV-2 Helicase Inhibitors from the Tradi... by Ahmed M. Metwaly, Alaa Elwan, Abdul-Aziz M. M. El-Attar, Sara T. Al-Rashood, Ibrahim H. Eissa

“…Continuing our antecedent work against COVID-19, a set of 5956 compounds of traditional Chinese medicine have been virtually screened for their potential against SARS-CoV-2 helicase (PDB ID: 5RMM). Initially, a fingerprint study with VXG, the ligand of the target enzyme, disclosed the similarity of 187 compounds. …”
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Modelling district heating demand: A synthetic dataset for two residential neighbourhoodsZenodo by Katia Ritosa, Ina De Jaeger, Dirk Saelens, Staf Roels

“…However, the generated artificial datasets offer a wide range of typically hard-to-measure inputs, making them ideal for evaluating the impact of simulated components on the overall energy balance. While the initial focus was on the behaviour of individual buildings, these datasets are also valuable for urban-scale analyses, particularly in energy planning contexts.…”
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Aménagements de berge monumentaux d’époque laténienne et romaine à Besançon (Doubs) by Christophe Gaston

“…As regards the protohistoric period, initial development work was carried out on the bank in the form of a dry wall (end of the 2nd c. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Background Successful development of chimeric antigen receptor (CAR) T cell immunotherapy for children and adults with relapsed/refractory acute myeloid leukemia (AML) is highly desired given their poor clinical prognosis and frequent inability to achieve cure with conventional chemotherapy. Initial experiences with CD19 CAR T cell immunotherapy for patients with B-cell malignancies highlighted the critical impact of intracellular costimulatory domain selection (CD28 vs 4-1BB (CD137)) on CAR T cell expansion and in vivo persistence that may impact clinical outcomes. …”
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Circular economy: A sustainable model for waste reduction and wealth creation in the textile supply chain by Anik Kumar Das, Md. Farhad Hossain, Borhan Uddin Khan, Md. Mahfuzur Rahman, M. A. Z. Asad, Mahmuda Akter

“…Furthermore, how internet of things (IoT) (Internet of things) can be contributed to CE initiatives by providing a transparent traceability along the whole textile supply chain. …”
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Complications following reverse total shoulder arthroplasty for proximal humeral fractures: a systematic review by Easton J. Bents, BS, Javier Ardebol, MD, Mathew Noble, DO, Lisa Galasso, MD, Patrick J. Denard, MD, Mariano E. Menendez, MD

“…A total of 102 studies were identified for inclusion after initial screening of 3800 query results. Extracted data from each article included the publishing journal, level of evidence, study design, number of patients, mean age, age range, percent female, mean follow-up, specific postoperative complications, total complications, complication rate, number of revisions, and revision rate. …”
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Effectivity of Musa paradisiaca extract to control Saprolegnia sp. infection on giant gourami larvae by Sri Nuryati, Nadia Aulia, , Rahman

“…Eight-day old gorami larvae (at the initial of 0.5±0.03 cm) was reared in an aquarium sized 25×25×25 cm3 at the density of 8 fry/L. …”
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