Infant and Young Child Feeding (IYCF) Practices in Rural and Urban Regions of Indonesia by Demsa Simbolon, Desri Suryani, Heidy Dayanti, Agustina Setia, Tobianus Hasan

“…The practice of IYCF in Indonesia starting from giving early breastfeeding initiation, exclusive breastfeeding, and complementary feeding according to recommendations is still low. …”
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Virtual Integration of Satellite and In-situ Observation Networks (VISION) v1.0: In-Situ Observations Simulator (ISO_simulator) by M. R. Russo, M. R. Russo, S. L. Bartholomew, S. L. Bartholomew, D. Hassell, D. Hassell, A. M. Mason, E. Neininger, A. J. Perman, D. A. J. Sproson, D. Watson-Parris, D. Watson-Parris, N. L. Abraham, N. L. Abraham

“…Although this code was initially tested within the Unified Model (UM) framework, which is shared by the UK Earth System Model (UKESM), it was written as a flexible tool and it can be extended to work with other models.…”
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Evolution of Sleep Apnea and Arousals in Patients with Ischemic Stroke: A Longitudinal Follow-Up Study by PR Srijithesh, Sivasubramanian Mythirayee, Doniparthi Venkata Seshagiri, Nitish L Kamble, Sanjib Sinha, Ravi Yadav

“…The median ArI decreased from 15.4 (IQR: 0.5–50.5) initially to 11.54 (IQR: 0.5-21.1) at follow-up. Numerical change in AHI severity categories were noted during the follow-up (mild: 8 vs 15; moderate: 17 vs 11; severe 19vs 7). …”
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Nose-to-Brain Delivery of Chitosan-Grafted Leciplexes for Promoting the Bioavailability and Antidepressant Efficacy of Mirtazapine: In Vitro Assessment and Animal Studies by Amani M. El Sisi, Essam M. Eissa, Ahmed H. E. Hassan, Marina A. Bekhet, Fatma I. Abo El-Ela, Eun Joo Roh, Rasha M. Kharshoum, Adel A. Ali

“…By virtue of its extensive initial-pass metabolic process with poor water solubility, the ultimate bioavailability when taken orally is a mere 50%, necessitating repeated administration. …”
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Application of case-based learning combined with problem-based learning in standardized training of cerebrospinal fluid drainage (CBL结合PBL教学模式在脑脊液外引流规范化培训中的应用)... by YIN Yating (殷亚婷), ZHEN Qin (郑琴), LIU Fang (刘芳), CHEN Lishan (陈丽珊), XUE Qiang (薛强)

“…It is able to inspire the nurses' initiative to learn, participate and interact actively. …”
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Assessment of the Social-Economic Contributions of Mgahinga National Park to Local Communities in Muramba Sub-County, Kisoro District, South-Western Uganda. by Mahoro, Shallon

“…The challenges faced by people living near the National Parks were limited livelihood alternatives, increased competition on other development initiatives, inadequate innovation and human capital, crop animal raiding, prostitution and lack of mass education on conservation.The possible solutions to the challenges faced by communities near Mgahinga National park were community`s involvement in conservation activities, community-based natural resource management, ensuring environmental sustainability, practical field-based monitoring of illegal activities, use of wildlife friendly products and implementation of policies. …”
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Assessing The Impact of Tea Production on The Economic Development of Local Community: A Case Study of Kayonza Tea Factory in Kayonza Sub- County Kanungu District. by Tukwasibwe, Joab

“…The government of Uganda under the Ministry of Agriculture initiated a strategy to support priority agricultural enterprises at the zone level and it is under this approach that tea production has been promoted over the years in Kanungu District. …”
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Examining the Challenges Faced by Women Employees in Tourism Industry in Kabale District. by Kamugisha, Serestine

“…From objective three, the study indicated measures to solve the challenges women employees are facing in the tourism industry in Kabale district including regular training of the new workforce (female) on a regular basis is the only remedy available, need to create a more inclusive and equitable work environment, anti-discrimination policies, leadership and management training, flexible work arrangements, diversity and Inclusion Initiatives, education and skill development.…”
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Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…However, the selection of the appropriate single-chain variable fragment (scFv) significantly affects the therapeutic efficacy of CAR-T cells by defining their specific behavior towards the target antigen. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…On multivariate Cox regression analysis, absence of portal vein tumor thrombus, ECOG <2, and continued active treatment were predictors of better PPS. mPPS was significantly longer for patients who continued active treatment vs. …”
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Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome by Lingmei Li, Ce Cao, Hao Guo, Li Lin, Lei Li, Yehao Zhang, Gaojie Xin, Zixin Liu, Shujuan Xu, Xiao Han, Qiong Zhang, Jianhua Fu

“…However, the contents of inflammatory factors and the expression of inflammatory-related proteins, p62/SQSTM1 and mTOR were increased, while PI3K, p-AKT, LC3-II/LC3-I were significantly decreased in OGD/R + SYI + CQ group. Conclusions SYI can promote myocardial tissue autophagy by regulating NLRP3, thereby attenuating the myocardial inflammatory response and protecting damaged myocardium in I/R rats.…”
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Implementing a nurse-enabled, integrated, shared-care model involving specialists and general practitioners in early breast cancer post-treatment follow-up (EMINENT): a single-cent... by Raymond J. Chan, Fiona Crawford-Williams, Chad Yixian Han, Lee Jones, Alexandre Chan, Daniel McKavanagh, Marissa Ryan, Christine Carrington, Rebecca L. Packer, Megan Crichton, Nicolas H. Hart, Emma McKinnell, Melissa Gosper, Juanita Ryan, Bethany Crowe, Ria Joseph, Carolyn Ee, Jane Lee, Steven M. McPhail, Katharine Cuff, Laisa Teleni, Jon Emery

“…No differences were observed between groups for health-related quality of life and the other effectiveness outcomes measures listed above at all timepoints (P > 0.05 for all). There were significantly fewer average post-treatment radiation oncology appointments per patient in the intervention group compared to the control group (0.69 versus 1.27, P = 0.013) at 24-months. …”
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Promotion and practice of an online service offering Traditional Chinese Medicine constitution conditioning under the normalization of epidemic prevention and control (疫情防控常态化背景下中医... by MA Qian (马茜), YU Hong (俞红), XU Junhua (徐俊华), XU Lidan (许丽丹), FANG You (方友), ZHEN Yanping (郑艳平), LI Yanlan (李燕兰), LIANG Xiao (梁肖), LU Mingya (陆明雅), ZHANG Yijun (张轶俊)

“…Results Compared with before intervention, the conversion score of Qi-deficiency, the frequency of respiratory infection in 6 months, the negative emotion score and total score of the five dimensions of depression, nervous decline, fear, compulsion-anxiety and hypochondria of the subjects decreased, with statistical significance(P<0. 01). Conclusion The online service of TCM constitution conditioning can regulate TCM constitution, prevent respiratory tract infection and regulate negative emotions of Qi-deficiency people susceptible to the virus, and can be popularized under the normalization of epidemic prevention and control. …”
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Study of anti-inflammatory, antioxidant, antimicrobial and mineralizing effects of an N-isopropenylimidazole zinc metal complex derivative in experimental endodontic-periodontal le... by Pavel A. Galenko-Yaroshevsky, Ivan I. Pavlyuchenko, Olga V. Shelemekh, Boris A. Trofimov, Lidiya N. Parshina, Viktor L. Popkov, Svetlana A. Demyanenko, Oleg V. Tsymbalov, Andrey V. Zadorozhniy, Anait V. Zelenskaya, Irina B. Nektarevskaya, Alina V. Sergeeva, Nikolay E. Korovaykin, Svetlana A. Lebedeva

“…Results and Discussion: In the gum in EPL, Pilim-1 and, especially, the combination Pilim-1+M-D more significantly than M-D have a pronounced anti-inflammatory, antioxidant and antimicrobial (reduce a microbial content level) effects. …”
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Application of Shenling lotion in nursing of perineal injury after vaginal delivery (参苓洗液在经阴道分娩产妇产后会阴损伤护理中的应用效果研究) by TANG Yang (唐杨), PENG Hong (彭鸿), WU Qiuxiang (吴秋香), WANG Yan (王燕), WANG Mingyang (王明洋), CHEN Lingfang (陈陵芳)

“…The Visual Analogue Scale of pain was (1. 66+-0. 76) in the observation group and (2. 00+-0. 68) in the control group, with a significant difference (P＜0. 05). The comfort level of puerperal women in the observation group was higher than that of puerperal women in the control group(P＜0. 05). …”
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Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosisResearch in context by Caihong Ning, Hui Ouyang, Jie Xiao, Di Wu, Zefang Sun, Baiqi Liu, Dingcheng Shen, Xiaoyue Hong, Chiayan Lin, Jiarong Li, Lu Chen, Shuai Zhu, Xinying Li, Fada Xia, Gengwen Huang

“…Furthermore, SHAP algorithm revealed insightful nonlinear interactive associations between important predictors and mortality, identifying 9 features pairs with high interaction SHAP value and clinical significance. Two interactive web-based Shiny apps were developed to enhance clinical practicability: https://rsfmodels.shinyapps.io/IPN_app/ for cases where the APACHE II score was available and https://rsfmodels.shinyapps.io/IPNeasy/ for cases where it was not. …”
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EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents by Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Olga Kordonouri, Agnieszka Szypowska, Ezio Bonifacio, Parth Narendran, Christiane Winkler, R Ribeiro, Sandra Hummel, Przemysława Jarosz-Chobot, Emanuele Bosi, R Lahesmaa, K Casteels, M Peakman, P Jarosz-Chobot, O Kordonouri, Chantal Mathieu, Vito Lampasona, J F Raposo, H Hyöty, F Pociot, João Filipe Raposo, R Berner, R Bergholdt, E Bonifacio, Flemming Pociot, B Petersen, J Van Rampelbergh, L Overbergh, B Van der Schueren, V Lampasona, C Winkler, R Coelho, O Cohen, C Mathieu, E Bosi, Stefanie Arnolds, Lut Overbergh, Zdenek Sumnik, A Koralova, G Sebastiani, Luisa Hoffmann, Mirjam Kohls, Regine Bergholdt, Bianca K Hoefelschweiger, Jurgen Vercauteren, P Gillard, J Vercauteren, A G Ziegler, P Achenbach, F Haupt, S Hummel, T Pieber, J Mader, S Moitzi, S Del Prato, B Torbeyns, Z Sumnik, O Cinek, V Neuman, B Berka, J Antvorskov, J H Klaebel, J E Laiho, F Reschke, T von dem Berge, A Hommel, A Loff, G Gemulla, N Zubizarreta, L Piemonti, F Dotta, A Szypowska, K Karczewski, E Niemoeller, M Baccara-Dinet, K Fogh, M I Buompensiere, C Hurtado del Pozo, E Latres, G Agiostratidou

“…These include a reduced risk of diabetic ketoacidosis (DKA) at the clinical manifestation of the disease and a significant reduction in clinical symptoms. The European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) represents a pioneering effort to advance early detection of type 1 diabetes through public health screening. …”
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…Although LGR4 has regenerative, anti-inflammatory, and anti-apoptotic effects in other tissues, its functional significance in β-cells remains unknown. We have previously identified Receptor Activator of Nuclear Factor Kappa B (NFκB) (RANK) as a negative regulator of β-cell health. …”
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Harnessing root phenotyping and root growth plasticity of landraces of maize (Zea mays L.) for enhancing waterlogging tolerance in fragile and challenging agro-ecologies of Eastern... by E. Lamalakshmi Devi, Krishnappa Rangappa, Ayam Gangarani Devi, S.K. Chongtham, Ingudam Bhupenchandra, Konsam Sarika, Harendra Verma, Rumi Narzari, Samarendra Hazarika, Sankar Prasad Das, B.U. Choudhury, Anil Kumar Choudhury, T.L. Bhutia, V.K. Mishra

“…Maize is a major crop of the Eastern Himalayan Region (EHR) which faces significant environmental challenges including waterlogging (WL) under changing climate. …”
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Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections by Emily Lydon, Christina M. Osborne, Brandie D. Wagner, Lilliam Ambroggio, J. Kirk Harris, Ron Reeder, Todd C. Carpenter, Aline B. Maddux, Matthew K. Leroue, Nadir Yehya, Joseph L. DeRisi, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, Charles R. Langelier, Peter M. Mourani

“…Comparative analysis of paired TA and plasma specimens demonstrated limited concordance, although the interferon-stimulated protein ISG15 was significantly upregulated with vLRTI in both compartments. …”
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