Mesenchymal stromal cells promote the formation of lung cancer organoids via Kindlin-2 by Zhilin Sui, Xianxian Wu, Jiaxin Wang, ShihJye Tan, Chao Zhao, Zhentao Yu, Chuanyue Wu, Xiaoxiao Wang, Ling Guo

“…Results Our findings demonstrate that the addition of MSCs/fibroblasts to three tumor samples, initially incapable of forming organoids by traditional methods, successfully facilitated the cultivation of tumor organoids. …”
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A contentious intervention to support the medical workforce: a case study of the policy of introducing physician associates in the United Kingdom by Martin McKee, Louella K. Vaughan, Giuliano Russo

“…As a consequence, professional bodies that were initially in favour are now expressing serious concerns and it seems likely that the roles and responsibilities of physician associates (and related occupations) will be curtailed. …”
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Real-world survival outcomes with immune checkpoint inhibitors in large-cell neuroendocrine tumors of lung by Samuel Kareff, Jair Bar, Amir Onn, Alona Zer, Chul Kim, Stephen V Liu, Elizabeth Dudnik, Mor Moskovitz, Anastasiya Lobachov, Teodor Gottfried, Damien Urban, Ofer Rotem, Mira Wollner

“…Overall survival since advanced disease diagnosis (OS DX) and OS since ICI initiation (OS ICI) were captured.Results With a median follow-up of 11.8 months (mo) (IQR 7.5–17.9) and 6.0mo (IQR 3.1–10.9), 66% and 76% of patients died in groups A and B, respectively. …”
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Study on the Dynamic Parameters of Plantar Pressure Applicable to the Elderly Screened by Delphi Method by YAN Yifeng, OU Jianlin, ZHENG Jiaxing, SUN Chenming, SHANG Yaru, CHEN Zhuoming

“…The final index screening criteria were "the arithmetic mean of total score ≥ the <italic>P</italic>₂₅ of the arithmetic mean" or "the full score ratio of total score ≥ <italic>P</italic>₂₅ of full score ratio" and "coefficient of variation of total score ≤ <italic>P</italic>₇₅ of the coefficient of variation".ResultsThe 24 of 25 experts were actively involved in the initial consultation, and none of these experts reported being unfamiliar with the indicators. …”
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Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia by Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

“…Conclusions In vitro and in vivo experiments verified that H. pylori SlyD enhances TPT1 stability through hnRNPK, leading to OCT1-mediated transcriptional activation of CDX2 and the initiation of the GIM process. Our study offers novel perspectives on the pathogenesis of H. pylori-related gastric precancerous conditions.…”
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Trajectories of systemic immune inflammation index and mortality risk in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study by Zhiyong Tang, Zhiyong Tang, Canlin Liao, Zerui Zhuang, Zhennan Xu, Mingfa Liu, Haixiong Xu

“…Group-Based Trajectory Modeling (GBTM) was used to analyze daily SII trajectories during the initial 0–7 days of hospitalization. Logistic regression was employed to assess the relationship between different SII trajectory groups and hospital mortality. …”
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Ocean equity: from assessment to action to improve social equity in ocean governance by Nathan J. Bennett, Nathan J. Bennett, Nathan J. Bennett, Nathan J. Bennett, Veronica Relano, Katina Roumbedakis, Katina Roumbedakis, Katina Roumbedakis, Jessica Blythe, Mark Andrachuk, Joachim Claudet, Neil Dawson, David Gill, Natali Lazzari, Natali Lazzari, Natali Lazzari, Shauna L. Mahajan, Ella-Kari Muhl, Maraja Riechers, Mia Strand, Sebastian Villasante

“…Indeed, many governmental, non-governmental, and philanthropic organizations are striving to advance social equity across their ocean sustainability focused agendas, policies, programs, initiatives, and portfolios. To date, however, there has been limited attention to how to meaningfully assess status and monitor progress on social equity in ocean governance (aka “ocean equity”) across different marine policy realms. …”
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Sucrose-Sweetened Drinks Reduce the Physical Performance and Increase the Cardiovascular Risk in Physically Active Males by Raianne dos Santos Baleeiro, Aparecida Patricia Guimarães, Perciliany Martins de Souza, Rafael da Silva Andrade, Karina Barbosa de Queiroz, Daniel Barbosa Coelho, Emerson Cruz de Oliveira, Lenice Kappes Becker

“…The cardiorespiratory response to exercise (VO2max) (48.15 ± 10.42 vs. 40.98 ± 11.20), peak heart rate (186.64 ± 8.00 vs. 179.64 ± 6.28), total exercise time (15.02 ± 1.57 vs. 14.00 ± 2.18), and mechanical work (15.83 ± 4.53 vs. 13.68 ± 5.67) decreased after eSSBd intake (all values expressed in initial mean ± DP vs. final). The rates of perceived exertion were higher (1.300 vs.1.661 slope and −0.7186 vs. −1.118 y-intercept) after eSSBd intake. …”
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Qualitative evaluation of the Rehabilitation Exercise and psycholoGical support After COVID-19 InfectioN (REGAIN) randomised controlled trial (RCT): ‘you are not alone’ by Gordon McGregor, Susanne Finnegan, Martin Underwood, Joyce Yeung, James Mason, Peter Heine, Nigel Edwards, Julie Bruce, Kate Seers, Harbinder Kaur Sandhu, Helen Atherton, Sharisse Alleyne, Katie Booth, Ranjit Lall, Vivien P Nichols, Stuart Ennis, Scott McGuire, Rachel Potter, Jessica Smith, Chen Ji, Shilpa Patel, Henry Nwankwo, Kate Evans, Susie Hennings, Alastair Canaway, Grace Lobley, David Mcwilliams, Christina Jones, Emma Padfield, David Montgomery, Beatriz Lara, Becky Haley, Francesca Denton, Bartholomew Sheehan, Mariam Ratna, Elaine Fairbrother, Zoe Noakes, Bogdan Zutic, Lee Austin, Tom Forsyth, Anne Bush, Alan Bush, Patrick Sawdon, Jonathon Prosser, Lee Tompkins, Jonathon Guck, Danielle Hale, Juwairia Said, Georgie Ray, Rowena Williams, Gail Evans, Thillini Hettiarachchi, Abeesh Panicker

“…The themes from group exercise were: (1) monitoring and modification of the online exercise; (2) catering for differing abilities; (3) feeling safe and confident to exercise; (4) progression of fitness; (5) optimal timing in the recovery trajectory; (6) group effect; (7) initial apprehension about exercise group; (8) gauging exercise capabilities; (9) translating exercises into life; and (10) on-demand supplementary videos. …”
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Investigation of Information Overload in Electronic Health Records: Protocol for Usability Study by Saif Khairat, Jennifer Morelli, Marcella H Boynton, Thomas Bice, Jeffrey A Gold, Shannon S Carson

“…ResultsThis EHR usability study was funded in 2021. The study was initiated in 2022 with a completion date of 2025. Data collection for this study was completed in December 2023 and data analysis is ongoing with a total of 81 provider sessions recorded. …”
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Spermatogenesis of male catfish Clarias sp. fed diet supplemeted with purwoceng extract by Poppy Dea Bertha, Muhammad Zairin Junior, Dinar Tri Soelistyowati

“…Experimental fish used were male catfish Clarias sp. with initial body weight of 200–300 g at the density of 10 fish/tank. …”
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The choice of the content of training process for mass-category athletes in view of the subjectivity of competitive activity by Orlov, Andrey I., Talantseva, Valentina K., Shilenko, Olga V., Petrova, Tatyana N., Kudratova, Lola A.

“…It should be noted that this problem is most acute when choosing the content of the mass-category athletes&rsquo; training process at the stages of initial training and sports specialization. Whereas at the stages of sports mastery improvement and perfection, for a number of reasons, it is not so clearly defined. …”
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A comparative study evaluating three line immunoassays available for serodiagnosis of equine Lyme borreliosis: Detection of Borrelia burgdorferi sensu lato-specific antibodies in s... by Cornelia V Broeckl, Stephanie Hiereth, Reinhard K Straubinger

“…It included groups of non-vaccinated horses, immunized horses (vaccinations against LB on days 0 and 14), and horses that had received an initial immunization plus an additional booster on day 180. …”
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Solar Energy Forecasting Framework Using Prophet Based Machine Learning Model: An Opportunity to Explore Solar Energy Potential in Muscat Oman by Mazhar Baloch, Mohamed Shaik Honnurvali, Adnan Kabbani, Touqeer Ahmed, Sohaib Tahir Chauhdary, Muhammad Salman Saeed

“…After analyzing the correlation between the abovementioned features, model training and the testing procedure are initiated. In this research, different models, named Linear Regression (LR), Support Vector Machine (SVR), KNN Regressor, Decision Forest Regressor, XGBoost Regressor, Neural Network (NN), Autoregressive Integrated Moving Average (ARIMA), Long Short-Term Memory (LSTM), Random Forest Regressor, Categorical Boosting (CatBoost), Deep Autoregressive (DeepAR), and Facebook Prophet, are trained and tested under both identical features and a training–testing ratio. …”
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Replacing rice straw with peanut vine and Broussonetia papyrifera silage in beef cattle feed reduced the use of soybean meal by Xin Yi, Yueming Li, Yue Liu, Minzhe Zhang, Zhenming Zhou, Qingxiang Meng, Hao Wu

“…Forty-five Simmental crossbred bulls (initial body weight = 484.29 ± 8.49 kg) were randomly allotted into three dietary treatment groups (n = 15): (1) CON, 5% rice straw (DM basis); (2) PEV, 5% peanut vine (DM basis); and (3) BPS, 5% B. papyrifera silage (DM basis). …”
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What's the role of kindness in the healthcare context? A scoping review by Angela Greco, Laura G. González-Ortiz, Luca Gabutti, Daniel Lumera

“…The purpose of this scoping review is to provide an overview of the current research landscape regarding initiatives based on acts of kindness in healthcare organizations. …”
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“We Argued for a Long Time — Until the Tears of Stress…” (Scientific Controversy in the Community of Russian Logicians on the Pages of Public Press in the Early 20th Century)... by N.Kh. Orlova

“…The aim of the paper is to show the huge potential and value of polemic motivation to initiate publication activity of university scientists and academics. …”
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Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…Abstract Background A growing body of research suggests that the provision of social support can have benefits not only for the recipients but also for the provider. Although initial evidence for affective, self-evaluative and physiological outcomes has been established, the beneficial effects of support provision do not occur consistently across all support interactions, and some interactions may even have detrimental effects on providers. …”
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THE PHENOMENON OF AESTHETICAL ANTROPLOGY IN KONTEST OF DEVELOPMENT OF THE UKRAINIAN POETIC CINEMA ФЕНОМЕН ЭСТЕТИЧЕСКОЙ АНТРОПОЛОГИИ В КОНТЕКСТЕ РАЗВИТИЯ УКРАИНСКОГО ПОЭТИЧЕСКОГО КИ... by S. G. Pichenikova

“…In the structure of the poetic cinema aesthetical anthropology will be realized foremost in an author idea, and also by interpretation of cultural sense initiator through the prism of spectator. A question of development of the cinema art in the context of aesthetical anthropology, is actual and from a&#13; practical side represent «plural» and «many» approaches, in relation to the problems of self - development and self-knowledge of a man.…”
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Self-rated health status and associated factors in Ilam, west of Iran: results of a population-based cross-sectional study by Mohammad Bazyar, Hojatollah Kakaei, Hamed Azadi, Mohsen Jalilian, Mohammad Ali Mansournia, Kamran Malekan, Reza Pakzad, Reza Pakzad, Reza Pakzad, Reza Pakzad

“…It is also necessary for local health officials to allocate financial resources and introduce other kinds of supportive initiatives to provide targeted support for those who are struggling with poverty and suffering chronic diseases.…”
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