Separable roles of the DNA damage response kinase Mec1ATR and its activator Rad24RAD17 during meiotic recombination. by Margaret R Crawford, Jon A Harper, Tim J Cooper, Marie-Claude Marsolier-Kergoat, Bertrand Llorente, Matthew J Neale

“…Despite these differences, complex multi-chromatid events initiated by closely spaced DSBs-rare in wild-type cells-occur more frequently in the absence of either Rad24 or Mec1, suggesting a loss of spatial regulation at the level of DSB formation in both. …”
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Chronic Atrophic Gastritis Presenting as Hemolytic Anemia due to Severe Vitamin B12 Deficiency by Amanda M. Woodford, Rabhea Chaudhry, Gabriella A. Conte, Varsha Gupta, Madhurima Anne

“…This clinical entity is described as pseudothrombotic microangiopathy and is crucial to identify in order to prevent the initiation of invasive treatment strategies such as plasmapheresis.…”
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Construction of a Real-Scene 3D Digital Campus Using a Multi-Source Data Fusion: A Case Study of Lanzhou Jiaotong University by Rui Gao, Guanghui Yan, Yingzhi Wang, Tianfeng Yan, Ruiting Niu, Chunyang Tang

“…Firstly, oblique photography based on unmanned aerial vehicles (UAVs) is used to capture large-scale, high-resolution images of the campus area, which are then processed using open-source software to generate an initial 3D model. Afterward, a high-resolution model of the campus buildings is then created by integrating the UAV data, while 3D Digital Elevation Model (DEM) and OpenStreetMap (OSM) building data provide a 3D overview of the surrounding campus area, resulting in a comprehensive 3D model for a real-scene digital campus. …”
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Suprainguinal fascia iliaca compartment block in pediatric-aged patients: An educational focused review by Anuranjan Ghimire, Sidhant Kalsotra, Joseph D. Tobias, Giorgio Veneziano

“…Although neuraxial techniques were initially the primary techniques used for intraoperative and postoperative anesthesia and analgesia, many of these techniques have been replaced by selective nerve blockade. …”
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Characterisation of internal tremors and vibration symptoms by Harlan M Krumholz, Mitsuaki Sawano, Richa Sharma, Tianna Zhou, Dorothy Massey, Anna D Baker, Diana Berrent Güthe, Nick Güthe, Suzanne Pincus Shidlovsky, Liza Fisher, Connor B Grady, Cesar Caraballo

“…These domains were as follows: (1) symptom experience, description and anatomic location; (2) initial symptom onset; (3) symptom timing; (4) symptom triggers or alleviators; (5) change from baseline health status; (6) experience with medical establishment and (7) impact on individuals’ lives and livelihood. …”
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Piezoresistive Cantilever Microprobe with Integrated Actuator for Contact Resonance Imaging by Tianran Ma, Michael Fahrbach, Erwin Peiner

“…A novel piezoresistive cantilever microprobe (PCM) with an integrated electrothermal or piezoelectric actuator has been designed to replace current commercial PCMs, which require external actuators to perform contact-resonance imaging (CRI) of workpieces and avoid unwanted “forest of peaks” observed at large travel speed in the millimeter-per-second range. Initially, a PCM with integrated resistors for electrothermal actuation (ETA) was designed, built, and tested. …”
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The Role of Therapeutic Anticoagulation in COVID-19 by Ruth McGovern, Patrick Conway, Isabell Pekrul, Omar Tujjar

“…We report the case of a patient admitted to our intensive care unit (ICU) with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19 whose clinical trajectory improved dramatically after initiation of a therapeutic dose of LMWH. The patient showed progressive elevation of fibrinogen and D-dimers despite a prophylactic dose of LMWH during her ICU stay. …”
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An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study by Yingfeng Ge, Jianan Yin, Caie Chen, Shuo Yang, Yuduan Han, Chonglong Ding, Jiaming Zheng, Yifan Zheng, Jinxin Zhang

“…Early prediction of whether aMCI will progress to AD is of paramount importance, as it can provide pivotal guidance for subsequent clinical interventions in an early and effective manner.MethodsA total of 107 aMCI cases were enrolled and their electroencephalogram (EEG) data were collected at the time of the initial diagnosis. During 18-month follow-up period, 42 individuals progressed to AD (PMCI), while 65 remained in the aMCI stage (SMCI). …”
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Fatty Acid Profile and Chemical Composition of Three Populations of Southern Cattail (Typha domingensis) from South of Iran by Mona Shojaee Barjouee, Massoumeh Farasat, Mehrnoosh Tadayoni

“…This plant's high fiber content with the capacity to grow quickly and widely in fresh and saline water make it a viable candidate for inclusion in human diet and animal feed through agricultural breeding initiatives.…”
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Symbiotic Root-Endophytic Soil Microbes Improve Crop Productivity and Provide Environmental Benefits by Gary E. Harman, Norman Uphoff

“…The development and spread of EPHs as part of such initiatives has potential both to enhance farm productivity and incomes and to decelerate global warming.…”
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PORTERAGE OPERATION IN RURAL MARKETS - A PIVOTAL LINK AND TRANSFORMATION IN AGRICULTURAL COMMODITIES TRANSPORTATION SYSTEM: CASE OF SOUTH-WESTERN NIGERIA by D.O TORIMIRO, D.L. ALABI, A.S. OLAWORE

“…They operate on an average of 6 days/week and about 21/2hrs/day without requiring any special skills and initial capital. They are mostly exposed to harsh weather condition and diverse physical risks. …”
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Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or toleran... by Michael O’Sullivan, Michael S Gold, Francesca Orsini, Adriana Chebar Lozinsky, Paxton Loke, Susan L. Prescott, Patrick Quinn, Audrey DunnGalvin, Mimi LK Tang, Anne-Louise Ponsoby, Ee Lyn Su, Marnie Robinson, Dean Tey, Kuang-Chih Hsiao, Molly O’Sullivan, Christine Axelrad, Sigrid Pitkin, Jessica Metcalfe, Susan Fahy-Scheer, Thalayasingam Meera, Jovanka King, Fuad Abass, Abigail Cheung, Rachel Wallace, Samara Baldwin

“…We have previously shown that a novel treatment comprising a combination of the probiotic Lactobacillus rhamnosus CGMCC 1.3724 with peanut OIT (Probiotic Peanut Oral ImmunoTherapy (PPOIT)) is highly effective at inducing SU, with benefit persisting to 4 years after treatment cessation in the majority of initial treatment responders. Here we describe the protocol for a Phase IIb multicentre, double-blind, randomised, controlled trial (PPOIT-003) with dual primary objectives to evaluate the effectiveness of PPOIT at inducing SU (assessed at 8 weeks after treatment cessation) compared with placebo treatment and peanut OIT alone, in children with peanut allergy.Methods and analysis 200 children 1 to 10 years of age with current peanut allergy confirmed by failed double-blind placebo-controlled food challenge (DBPCFC) at study screening will be recruited from three tertiary paediatric hospitals in Australia. …”
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Insights from a codesigned dynamic modelling study of child and adolescent obesity in Australia by Alison Hayes, Rebecca Wyse, Anna Lene Seidler, Kylie E Hunter, Rebecca K Golley, Louise A Baur, Anthony D Okely, Kenny Lawson, Jo-An Occhipinti, Louise Freebairn, Simon Keith Chiu, Joseph Carrello, L Kurt Kreuger

“…Insights from the model emphasise the value of public health programmes over the life course. Implementing initiatives with broad reach that support healthy choices may reduce obesity, resulting in a healthier Australian population.…”
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Computational study on water based hybrid photovoltaic systems with different absorber configurations by Jitendra Satpute, Gouri Ghongade, Jana Petrů, Srinidhi Campli, Sunita Yadav, PavanKumar Sonawane, Harish Venu, Muhammad Nasir Bashir, Manzoore Elahi M. Soudagar, Shylesha Channapattana

“…The zigzag thermal absorber PVT system had a high initial investment of INR 38809.00. It showed a simple payback of 4.63 years, a 28% return on investment with a promising 2.1 Debt Service Coverage Ratio. …”
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Rapid Verbal Persuasion to increase influenza vaccine uptake: protocol for a randomized hybrid type 2 effectiveness -implementation trial by Siyuan Liu, Lan Gao, Yingying Jin, Jiangyun Chen, Dadong Wu, Yiyuan Cai, Tao Wang, Sanhao Huang, Ciling Yan, Run Wang, Dong Roman Xu

“…Method This study will be conducted as a two-tiered cluster of randomized controlled trials over three months. Initially, 32 vaccination clinics will be randomly allocated to one of two study arms: (a) implementation of RVP or (b) no implementation. …”
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New taphonomic approach applied to the Late Pleistocene bone remains from Pikimachay Cave, Ayacucho Basin, Peru: possible implications for the debate on human colonisation of weste... by Hugo G Nami, Karina V Chichkoyan, Juan Yataco Capcha, José L Lanata

“…The conventional uncalibrated radiocarbon dates initially obtained suggest that these layers span a period of ~14.0 to 25.0 thousand years before present (kybp). …”
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Access to evidence-based care: a systematic review of trauma and surgical literature costs across resource settings by Eduardo Huaman, Lacey LaGrone, Megan Wojick, Hannah Conner, Ashley Farley, Marianne Luyo, Sam Thomas-Pate

“…When considering purchasing power parity, APCs and subscription costs ranged from 2 to 15 times more expensive in LMICs when compared with those in the USA.Limitations Primary search term was in English only, and only peer-reviewed journal articles were reviewed.Conclusions or implications of key findings Although initiatives exist to support peer-reviewed journals in LMICs, there is an exorbitant cost for authors in these countries, as well as those in high-income countries that are not affiliated with a large institution, to either publish in, or access, a majority of surgical journals. …”
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Developing a virtual reality application for online arts and psychomotor therapies using action research by Nathalie Jans, Nathalie Jans, Hans Wouters, Joep Kolijn, Suzanne Haeyen, Suzanne Haeyen, Suzanne Haeyen

“…All cycles were held in groups.ResultsWe redeveloped an initial multiplayer full body VRhExp application based on users’ preferences, and ideas. …”
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Sustainable and smart multi-analyte HPTLC determination of tolperisone HCl together with three pain killers using smartphone camera as a detector: Comparative study with benchtop d... by Mohamed Rizk, Emad Ramzy, Safaa Toubar, Amr M. Mahmoud, Marwa I. Helmy

“…Our innovative approach combines high-performance thin-layer chromatography (HPTLC) with a smartphone's camera. Initially, chromatographic separation has been achieved utilizing HPTLC plates, employing an environmentally friendly mobile phase consisting of a mixture of ethyl acetate, methanol, and glacial acetic acid (8.5:1.5:0.25, by volume). …”
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Advanced Machine Learning to Predict Coronary Artery Disease Severity in Patients with Premature Myocardial Infarction by Yu-Hang Wang, Chang-Ping Li, Jing-Xian Wang, Zhuang Cui, Yu Zhou, An-Ran Jing, Miao-Miao Liang, Yin Liu, Jing Gao

“…These groups were further randomly assigned to a training or test set in a ratio of 7:3. Lasso–logistic was initially used to screen out target factors. Subsequently, Lasso–logistic, random forest (RF), k-nearest neighbor (KNN), support vector machine (SVM), and eXtreme Gradient Boosting (XGBoost) were used to establish prediction models based on the training set. …”
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