Numerical Shear Tests on the Scale Effect of Rock Joints under CNL and CND Conditions by Xige Liu, Wancheng Zhu, Lankun Li

“…However, for shear tests under low initial normal stress, the peak shear strength achieved under the CND condition is much higher than that under the CNL condition, as the normal stresses of enlarged joints increase to greater extent than the repeated ones during shearing.…”
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Childhood-Onset Takayasu Arteritis: Clinical Features of Disease and Relapse Risk Factors by Vera Podzolkova, Galina Lyskina, Olga Shpitonkova, Angelina Polyanskaya, Svetlana Chebysheva, Marina Shakhnazarova, Jinbo Zhao, Aleksandr Suvorov, Vera Khudoroshkova, Natalia Geppe

“…<b>Conclusions:</b> Pediatric patients with an initial ITAS.A score above 12 have a higher risk of relapse when treated with a combination of GCs and nbDMARDs as first-line treatment. …”
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Ultrasound-triggered drug release and cytotoxicity of microbubbles with diverse drug attributes by Chi-Fen Chuang, Chia-Wei Lin, Chih-Kuang Yeh

“…DOX-lipid aggregates delayed initial uptake, leading to less pronounced short-term (2 h) effects compared to the rapid release of free CPT from CPT-MBs. …”
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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…A five-stage approach will be adopted; 1) Developing an Initial Programme Theory (IPT): develop an IPT with key stakeholder input and evidence from informal searching; 2) Searching and screening: conduct a thorough search of relevant research databases and other literature sources and perform screening in duplicate; 3) Relevance and rigour assessment: assess documents for relevance and rigour in duplicate; 4) Extracting and organising data: code relevant data into conceptual “buckets” using qualitative data analysis software; and 5) Synthesis and Programme Theory (PT) refinement: utilise a realist logic of analysis to generate context-mechanism-outcome configurations (CMOCs) within and across conceptual “buckets”, test and refine the IPT into a realist PT. …”
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Clinical characteristics and management outcomes of pediatric patients with Coats disease complicated with retinoschisis (retinal cyst) by Tingyi Liang, Shaochi Zhang, Xiang Zhang, Xiaohan Wang, Xunda Ji, Peiquan Zhao

“…Clinical findings from multimodal ophthalmic imaging were recorded to characterize retinal cyst in Coats disease. All eyes were initially treated with endolaser photocoagulation combined with external drainage of cystic fluid and intravitreal ranibizumab injection. …”
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Supporting Smart Manufacturing in the Space Industry: A Case Study by Ala Arman, Andrea Lombardo, Flavia Monti, Massimo Mecella

“…Results show low CPU usage (below 20%), consistent network throughput, and stable average data insertion times after initial peaks, demonstrating the architecture's scalability and efficiency.…”
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Performance of iopamidol degradation by MoS2@Fe3O4 Fenton-like system by LI Hao, SHI Nan, WU Daoji, FU Kaifang, LUO Congwei

“…Under the conditions of initial pH of 4, MoS2@Fe3O4 dosage of 0.15 g/L, H2O2 concentration of 0.5 mmol/L, and IPM concentration of 5 μmol/L, the degradation rate of IPM by MoS2@Fe3O4/H2O2 system reached 89.85% after 30 minutes of reaction. …”
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The Management of the Aortic Arch in Type A Aortic Dissection: Replace, Repair with the AMDS, or Leave for Another Day? by Ryaan EL-Andari, Michael C. Moon

“…The management strategy for ATAAD should always involve performing the best surgery for the patient, although in cases where a total arch is indicated but cannot be performed safely by a non-aortic surgeon, the safest approach may be to perform a hemiarch initially and to plan for an elective arch reoperation in the case it is required following close surveillance.…”
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Computer modeling of the peculiarities in the interaction of IL-1 with its receptors in schizophrenia by N. Yu. Chasovskikh, A. A. Bobrysheva, E. E. Chizhik

“…The results indicate that the presence of SNP rs315952 in the IL-1RA protein gene, associated with schizophrenia, may lead to a weakening of the IL-1RA binding to receptors, potentially triggering the initiation of the IL-1 signaling pathway by disrupting or weakening the IL-1RA binding to receptors and facilitating the binding of IL-1 to them. …”
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Model of the DGEBA-EDA Epoxy Polymer: Experiments and Simulation Using Classical Molecular Dynamics by Andreas Gavrielides, Thomas Duguet, Maëlenn Aufray, Corinne Lacaze-Dufaure

“…In this work, all-atom molecular dynamics (MD) simulations are performed with LAMMPS and the GAFF 1.8 force field. In the initial liquid mixture of reactants (600 molecules), proper mixing is demonstrated by the calculation of the partial radial distribution functions (RDF), which show a minimum intermolecular distance of 2.8 Å and similar distributions for EDA-EDA, DGEBA-DGEBA, and DGEBA-EDA molecules in the simulation boxes. …”
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Two rare cases of primary clear cell adenocarcinoma of the urethra: clinical experience, case report and literature review by Bohao Jiang, Jiyuan Hu, Benqiao Wang, Xujia Liu, Ling Tong, Yitong Xu, Hao Zhang

“…Case 1 undergone progression 6 months after initial treatment with transurethral resection and chemotherapy with a 15-month overall survival. …”
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Strengthening Maternal and Infant Health in an impoverished peri urban community in Lima, Peru: The SAMI Project by Anna KOHLER-SMITH, Karen RAMOS, Carmen CONTRERAS, Milagros DUEÑAS, Leonid LECCA, Jerome T. GALEA

“…Of the 40 participants who had given birth, 92.5% of newborns had normal birthweight between 2.5 to 4 kilos. These initial results are encouraging, and the project anticipates positive results in new communities where it will be extended in the future. …”

Dengue Situation in Bangladesh: An Epidemiological Shift in terms of Morbidity and Mortality by Pulak Mutsuddy, Sanya Tahmina Jhora, Abul Khair Mohammad Shamsuzzaman, S. M. Golam Kaisar, Md Nasir Ahmed Khan

“…The CDC, in collaboration with other research organizations, may come forward to initiate and coordinate a large-scale randomized clinical trial of an effective dengue vaccine in Bangladesh.…”
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Advancing Orthodontic Aesthetics: Exploring the Potential of Injectable Composite Resin Techniques for Enhanced Smile Transformations by Davide Spadoni, Cristina Valeri, Vincenzo Quinzi, Ute Schneider Moser, Giuseppe Marzo

“…<b>Conclusions:</b> The IMT is a valuable tool for pediatric patients undergoing orthodontic treatment, both at its initiation and completion. The technique assists orthodontists in finalising treatment by addressing Bolton index discrepancies and correcting tooth shape anomalies. …”
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Retrograde Percutaneous Coronary Intervention in a Case of Takayasu Arteritis with Left Main Coronary Artery Chronic Total Occlusion by Prathap Kumar, Blessvin Jino, Stalin Roy, Manu Rajendran

“…Takayasu arteritis (TA) frequently involves the coronary arteries, and restenosis is common after initial percutaneous coronary intervention (PCI). …”
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Microbial-based natural products as potential inhibitors targeting DNA gyrase B of Mycobacterium tuberculosis: an in silico study by Tilal Elsaman, Magdi Awadalla Mohamed, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla

“…Consequently, targeting this enzyme is of particular interest in developing new drugs for the treatment of drug-resistant tuberculosis, including multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).MethodsIn the present study, multiple computational tools were adopted to screen a microbial-based natural products database (NPAtlas) for potential inhibitors of the ATPase activity of MBT DNA gyrase.Results and discussionTwelve hits were initially identified as the top candidates based on their docking scores (ranging from −9.491 to −10.77 kcal/mol) and binding free energies (−60.37 to −73.21 kcal/mol). …”
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Effectiveness of workplace health promotion programs for industrial workers: a systematic review by Sasha Javanmardi, Ludwig Rappelt, Sascha Zangenberg, Lars Heinke, Christian Baumgart, Daniel Niederer, Jürgen Freiwald

“…Results Of the 25,555 studies initially identified, 39 were included. Generally, the mean quality of the studies was moderate, with most studies judged with a high overall risk of bias. …”
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Mapping evidence on the regulations affecting accessibility, availability and management of snake antivenom globally: a scoping review protocol by Kabelo Kgarosi, Ramsha Majeed, Janette Bester, Morné Strydom

“…The search results were collated, duplicates were removed and results were exported to Rayyan (https://www.rayyan.ai/) for screening. The initial screening for titles and abstracts is currently in progress, and thereafter the second round of screening will be done for full texts. …”
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COVID-19 in the context of pregnancy, infancy and parenting (CoCoPIP) study: protocol for a longitudinal study of parental mental health, social interactions, physical growth and c... by Topun Austin, Jane Barlow, Ezra Aydin, Staci M Weiss, Kevin A Glasgow, Mark H Johnson, Sarah Lloyd-Fox

“…This study (CoCoPIP) will investigate: (1) how parent’s experiences of the social, medical and financial changes during the pandemic have impacted prenatal and postnatal parental mental health and parent–infant social interaction; and (2) the extent to which these COVID-19-related changes in parental prenatal and postnatal mental health and social interaction are associated with fetal and infant development.Methods and analysis The CoCoPIP study is a national online survey initiated in July 2020. This ongoing study (n=1700 families currently enrolled as of 6 May 2021) involves both quantitative and qualitative data being collected across pregnancy and infancy. …”
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Comparison of Effectiveness and Safety between Intraoperative 3D-CT-Guided and C-Arm-Guided Percutaneous Balloon Compression for Idiopathic Trigeminal Neuralgia:  A  Multi-Center R... by Xiong Xiao, Zhengjun Wei, Hao Ren, Hongtao Sun, Fang Luo

“…The groups shared similar initial relief rates (P=0.749) and similar recurrence-free survival during follow-ups for a median of 22 months (P=0.839). …”
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