The Effect of Adjuvant Radiotherapy on One- and Two-Stage Prosthetic Breast Reconstruction and on Autologous Reconstruction: A Multicenter Italian Study among 18 Senonetwork Breast... by Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio De Santis, Matteo Murolo, Michele Riccio, Angelica Aquinati, Francesco Cavaliere, Nicola Vaia, Giulia Pagura, Erica Dalla Venezia, Franco Bassetto, Vincenzo Vindigni, Luigi Ciuffreda, Maria Alessandra Bocchiotti, Alberto Sciarillo, Nadia Renzi, Graziano Meneghini, Tajna Kraljic, Andrea Loreti, Lucio Fortunato, Valentina Pino, Valeriano Vinci, Marco Klinger

“…The trial is registered with NCT04783818, and the date of registration is 1 March, 2021, retrospectively registered.…”
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Improving Anxiety Related to Chronic Pain Through a Sleep Circadian Intervention Program: A Pilot Study by Sonia López-Monzoni, Gloria Hernando Benito, Sofía Romero-Peralta, Laura Silgado-Martínez, Maria Esther Viejo-Ayuso, Leticia Álvarez-Balado, Enrique Rodríguez Matarranz, Carles Forné Izquierdo, Manuel Sánchez-de-la-Torre, Juan Fernando Masa, Ferrán Barbé, Francisco García-Río, Antonio Martínez-Nicolás, Belén García-Mediano, Esther Solano-Pérez, Olga Mediano

“…This was a randomized clinical trial (NCT03646084), in which 49 CMP patients were assigned to SCIP (<i>n</i> = 15, mean age 51 years and 40% women) or non-SCIP groups (<i>n</i> = 26, 53 years and 61.5% women). …”
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Effect of multispecies swards on ruminal fermentation, methane emission and potential for climate care cattle farming − an in vitro study by M.U. Hassan, P. Sidoruk, D. Lechniak, M. Szumacher-Strabel, J. Bocianowski, S. Ślusarczyk, P.R. Hargreaves, D. Ruska, A. Dorbe, Dz. Kreismane, K. Klumpp, J. Bloor, R.M. Rees, A. Kuipers, P. Galama, Z. Váradyová, K. Čobanová, A. Cieślak

“…The control blend included perennial ryegrass (PRG), and red clover (RC) cultivated with fertiliser. The in vitro trial showed a reduction in CH4 production and ruminal NH3 concentration (by 14.7 and 28.8%, respectively; P < 0.01) in the PLA+RC blend compared to the control. …”
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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…Here, we used data from the ASCENT trial to estimate the potential long-term epidemiological and economic impact of DAT interventions in Ethiopia.Methods We developed a compartmental transmission model for TB, calibrated to Ethiopia and parameterised with patient and provider costs. …”
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The association of physical activity and carotid intima-media-thickness in adolescents—data of the prospective early vascular ageing-tyrol cohort study by Bernhard Winder, Bernhard Winder, Bernhard Winder, Sophia J. Kiechl, Sophia J. Kiechl, Benoît Bernar, Benoît Bernar, Nina Gande, Anna Staudt, Anna K. Stock, Anna K. Stock, Christoph Hochmayr, Ralf Geiger, Andrea Griesmacher, Stefan Kiechl, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Michael Knoflach, the Early Vascular Ageing (EVA)-Tyrol Study Group, Carmen Reiter, Christina Schreiner Julia Klingenschmid, Julia Marxer, Martina Kothmayer, Maximilian Pircher, Manuela Bock-Bartl, Mandy Asare, Maximilian Bohl, Raimund Pechlaner

“…Using cfPWV in a multivariate model an inverse correlation with the BS (p = 0.023) was observed, but not for minutes sports per day (p = 0.554).ConclusionIn our large community-based cohort of adolescents, PA was associated with an increased cIMT but shows a trend towards lower aortic stiffness measured by cfPWV. …”
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Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity by Markus Engelmann, Markus Engelmann, Juliane Götze, Juliane Götze, Philipp Baumbach, Philipp Baumbach, Charles Neu, Charles Neu, Utz Settmacher, Michael Ardelt, Hermann Kissler, Sina M. Coldewey, Sina M. Coldewey

“…Further studies in larger cohorts are needed to confirm these findings.Clinical trial registrationhttps://www.bfarm.de/DE/Das-BfArM/Aufgaben/Deutsches-Register-Klinischer-Studien/_node.html, identifier DRKS00015891.…”
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Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis by Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin

“…The neuromuscular blocking effects showed a significant age dependence in DMD patients, and the safe use of 2 mg/kg sugammadex to antagonize deep neuromuscular blockade and rapid recovery has been reported. …”
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PRODUCTIVITY, ADAPTABILITY AND GRAIN QUALITY OF MODERN UKRAINIAN WINTER TRITICALE CULTIVARS by G. V. Shchipak, Yu. V. Tsupko, A. P. Petrova, V. G. Shchipak

“…Grain-type winter triticale cultivars were studied in comparative long-term (2000–2009) trials in two agroeco logical zones of Ukraine. Since 1977, 16 triticale cultivars have been enrolled into the register in Ukraine, and their potential productivity has increased by 1.52 t/ha. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…The present manuscript summarizes the most important information from the literature about their potent anticancer activities to show some future perspectives related to epigenetic therapy.…”
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Accuracy of ESAT6-CFP10 skin test compared with tuberculin skin test in a healthy population: a randomized, blind, parallel controlled phase III clinical study by Xiaoyan Ding, Weixin Du, Qiao Liu, Lifeng Tao, Yan Shao, Peng Lu, Huaiyu Yang, Xiaoxue Teng, Cheng Chen, Zhongqi Li, Jinbiao Lu, Aihua Zhao, Guozhi Wang, Miao Xu, Limei Zhu

“…Methods We conducted a randomized, double-blind, parallel controlled trial in healthy population. The experiment was divided into two stages. …”
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Long-Term Safety of Ixekizumab Treatment in Patients with Psoriasis, Psoriatic Arthritis, or Axial Spondyloarthritis: a Post Hoc Analysis of Cerebro-Cardiovascular Events by Mark Lebwohl, Atul Deodhar, Sergio Schwartzman, Carlo Salvarani, Meghan Feely McDonald, Natalia Bello, Elsie L. Grace, Elsa Inman, Andris Kronbergs, Marcus Ngantcha, Proton Rahman, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Andrew Blauvelt

“…Conclusion This integrated safety analysis of 25 randomized clinical trials showed that the incidence of adjudicated MACE was low among adult patients with PsO, PsA, and axSpA and that the rates did not increase with increasing IXE exposure. …”
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Correlation of HER2 expression and clinicopathological characteristics in patients with urothelial carcinoma in China by WANG Shanshan, YE Dingwei, YANG Li, CHENG Fan, YANG Tiejun, ZHANG Xiaoping, YU Zhixian, ZHANG Qingyun, YANG Yong

“…Conclusion: Retrospective analysis of multi-center data shows that HER2 expression is frequently observed in Chinese UC patients, with an overexpression rate of up to 58.4%. …”
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Thoracolumbar fascia ultrasound shear strain differs between low back pain and asymptomatic individuals: expanding the evidence by Norio Tomita, Marie-Hélène Roy-Cardinal, Boris Chayer, Stacey Daher, Ameer Attiya, Aline Boulanger, Nathaly Gaudreault, Guy Cloutier, Nathalie J. Bureau

“…Critical relevance statement Ultrasound shows elevated TLF shear strain in lower back pain sufferers compared to controls. …”
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A Mobile Health Intervention to Support Collaborative Decision-Making in Mental Health Care: Development and Usability by Kristin Lie Romm, Mari Skoge, Elizabeth Ann Barrett, Lars-Christian Berentzen, Dagfinn Bergsager, Pål Fugelli, Thomas Bjella, Erlend Strand Gardsjord, Kristine Kling, Sindre Hembre Kruse, Kari Jorunn Kværner, Ingrid Melle, Erlend Mork, Henrik Myhre Ihler, Eline Borger Rognli, Carmen Simonsen, Tor Gunnar Værnes, Sofie Ragnhild Aminoff

“…A beta test of iTandem was conducted to refine the app and plan for a pilot trial in a clinical setting. After 6 weeks of app use, 5 clinicians and 4 service users were interviewed to provide feedback on the concept, implementation, and technical issues. …”
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Ion homeostasis and coordinated salt tolerance mechanisms in a barley (Hordeum vulgare L.)doubled haploid line by Hongwei Xu, Hui Chen, Nigel G. Halford, RugenXu, Ting He, Bangwei Yang, Longhua Zhou, HuiminGuo, ChenghongLiu

“…Compared to Hua30, the relative expression levels of the HvSOS1, HvSOS2, HvSOS3, HvHKT1;3, HvNHX1, HvNHX2, and HvNHX3 genes, which showed a strong correlation with Na+, K+, and H+ efflux, exhibited significant differences at 24 h under salt stress in DH20. …”
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Effectiveness of shared decision-making for glycaemic control among type 2 diabetes mellitus adult patients: A systematic review and meta-analysis. by Edosa Tesfaye Geta, Dufera Rikitu Terefa, Wase Benti Hailu, Wolkite Olani, Emiru Merdassa, Markos Dessalegn, Miesa Gelchu, Dereje Chala Diriba

“…As a result, the pooled MD showed that the SDM significantly lowered HbA1c by 0.14% compared to the usual care (95% CI = [-0.26, -0.02], P = 0.02). …”
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In vitro evaluation of hypochlorous acid-silver nanoparticle waterline disinfectant for dental unit waterline disinfection by Tingting Yin, Qiaowen Li, Huan Sun, Jin Zheng, Yuanyuan Wang, Yi Luo, Li Wang

“…Therefore, this combination is expected to be a viable option for disinfection of DUWL in the oral healthcare setting. Clinical trial number Not applicable.…”
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Changes in muscle performance among older adults with myeloid malignancies engaging in a mobile health (mHealth) exercise intervention: a single arm pilot study by Marielle Jensen-Battaglia, Po-Ju Lin, Chandrika Sanapala, Erin E. Watson, Jason H. Mendler, Jane Liesveld, Ying Wang, Elisabeth Hayward, Marissa LoCastro, Soroush Mortaz, Richard F. Dunne, Karen Mustian, Kah Poh Loh

“…Several measures of peak torque/total work and all measures of muscle activation showed ES ≥ 0.20 for improvement. There were no statistically significant decreases from baseline to post-intervention. …”
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An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation st... by Weigang Jiang, Tao Liu, Baisheng Sun, Lixia Zhong, Zhencan Han, Minhua Lu, Mingxing Lei

“…Conclusions The AI model shows potential as a valuable tool for stratifying patients with a high risk of prolonged dependence on mechanical ventilation. …”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…A tumor-selective oncolytic vaccinia vector was then engineered to encode this novel, strongly Treg-depleting, checkpoint-blocking, αCTLA-4 antibody or a matching surrogate antibody, and Granulocyte-macrophage colony-stimulating factor (GM-CSF) (VVGM-αCTLA-4).Results The identified 4-E03 antibody showed significantly stronger Treg depletion, but equipotent checkpoint blockade, compared with clinically validated αCTLA-4 ipilimumab against CTLA-4-expressing Treg cells in a humanized mouse model in vivo. …”
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