Machine learning models for dementia screening to classify brain amyloid positivity on positron emission tomography using blood markers and demographic characteristics: a retrospec... by Noriyuki Kimura, Kotaro Sasaki, Teruaki Masuda, Takuya Ataka, Mariko Matsumoto, Mika Kitamura, Yosuke Nakamura, Etsuro Matsubara

“…Conclusions The machine learning models used in this study were useful for classifying PET Aβ-positivity using data from routine physician visits. Trial registration UMIN Clinical Trials Registry (UMIN000051776, registered on 31/08/2023).…”
Get full text

Cardiomeds, an mHealth App for Self-Management to Support Swiss Patients With Heart Failure: 2-Stage Mixed Methods Usability Study by Lisa Simioni, Elena Tessitore, Hamdi Hagberg, Aurélie Schneider-Paccot, Katherine Blondon, Liliane Gschwind, Philippe Meyer, Frederic Ehrler

“…The app will be further tested in a randomized clinical trial (2022-00731) after acute HF hospitalization to assess its impact on patients’ knowledge about HF, self-care, and quality of life.…”
Get full text

Effect of the season on blood changes of oxidative stress index (OSi) in the Italian Mediterranean Buffalo (Bubalis bubalis by Giovanna De Matteis, Emanuela Rossi, Maria Chiara La Mantia, Roberto Steri, Vittoria Lucia Barile, David Meo Zilio

“…Temperature and humidity were recorded daily during the trial to calculate the Temperature Humidity Index (THI). …”
Get full text

Analysis of Effective Broodstock Management and Breeding of Patin Siam (Pangasius hypophthalmus) in BBAT Jambi by Mimid A. Hamid, Wahyu B. W, Rangga W, Reni A. Lubis, Atomu Furusawa

“…Accumulated parameters during the year showed negative correlation of egg somatic index (ESI) with fish body weight.  …”
Get full text

The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…Despite extensive preclinical evidence that peroxisome proliferator-activated receptor (PPAR)γ activation protects against tumourigenesis, results from a few clinical trials using PPARγ ligands as monotherapy show modest success. …”
Get full text

Minimising harms of tight glycaemic control in older patients with type 2 diabetes by Wade Thompson

“…Large randomised controlled trials show that intensive glycaemic control (HbA1c ≤ 7%) does not reduce cardiovascular risk, but increases hypoglycaemia and mortality, particularly in older adults. …”
Get full text

Habituation to a predatory stimulus in a harvester (Arachnida, Opiliones) by Guilherme Ferreira Pagoti, Jerry A. Hogan, Rodrigo Hirata Willemart

“…During the trials we also observed other defensive behaviors. …”
Get full text

Investigation Of Plasma Stability Of The Prototype Plasma Lens For Positron Matching by Hamann Niclas, Jones Harry, Loisch Gregor, Formela Manuel, Ludwig Kai, Osterhoff Jens, Moortgat-Pick Gudrid

“…Furthermore, the results show splitting and bending discharge instabilities and heavy copper coating. …”
Get full text

Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Factors associated with mortality included male gender (HR: 3.63, p=0.02), diabetes (HR: 2.49, p=0.03), oxygen saturation below 90% at admission (HR: 5.23, p<0.01), high blood glucose levels (HR: 3.68, p=0.01), age (HR: 1.04, p=0.02), and more than 25% lesion extension on chest CT scan (HR: 2.28, p=0.03).ConclusionsLPV/r, but not DRV/r, showed a survival benefit in patients hospitalised with COVID-19, but these findings deserve further investigation in a randomised clinical trial.…”
Get full text

Acquired Aorto-Right Ventricular Fistula following Transcatheter Aortic Valve Replacement by Muhammad Tariq Shakoor, Ashequl M. Islam, Samia Ayub

“…Transcatheter aortic valve replacement (TAVR) techniques are rapidly evolving, and results of published trials suggest that TAVR is emerging as the standard of care in certain patient subsets and a viable alternative to surgery in others. …”
Get full text

The biomechanical effects of treating double-segment lumbar degenerative diseases with unilateral fixation through interlaminar fenestration interbody fusion surgery: a three-dimen... by Kai-Kai Feng, Xiao-Bing Xiang, Cheng-Peng Li, Kai-Yin Gao, Wei-Wei Zhang, Zhen-Yu Nie, Wen-Xin Liao, Dong Zhao, Guang-Ru Cao

“…All reconstructed conditions showed decreased motion from L3 to L5. Unilateral fixation had greater lumbar spine range of motion (ROM) in all directions compared to bilateral fixation. …”
Get full text

Exploring the Feasibility of a 5-Week mHealth Intervention to Enhance Physical Activity and an Active, Healthy Lifestyle in Community-Dwelling Older Adults: Mixed Methods Study by Kim Daniels, Sharona Vonck, Jolien Robijns, Kirsten Quadflieg, Jochen Bergs, Annemie Spooren, Dominique Hansen, Bruno Bonnechère

“…These enhancements will ensure that the app remains user-friendly, relevant, and sustainable, promoting sustained PA and healthy behaviors among older adults. Trial RegistrationClinicalTrials.gov NCT05650515; https://clinicaltrials.gov/study/NCT05650515…”
Get full text

High-fat diet-induced liver injury in Channa argus through lipid metabolism, anti-oxidative status, apoptosis, and inflammation by Jiaxin Tian, Ying Li, Jiwu Wan, Zhinan Yang, Guiqin Wang

“…Liver condition and the expression of genes related to lipid metabolism were assessed. The results showed that a 22 % fat level diet can influence liver cell status. …”
Get full text

Interaction of Straw Mulching and Nitrogen Fertilization on Ammonia Volatilization from Oilseed Rape–Maize Rotation System in Sloping Farmland in Southwestern China by Li Yao, Hong Wang, Haitao Liu, Xie Wang, Yueying Wu, Lin Wang, Honglin Chen, Chaowen Lin

“…Furthermore, SM + U, SM + U + NBPT, SM + U + CRU, and SM + U + OF showed average annual emission factors (AEFs) of 14.01%, 5.81%, 12.14%, and 11.64%, respectively. …”
Get full text

Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients... by Merete Lund Hetland, Inge Juul Sørensen, Mikkel Østergaard, Mikael Boesen, Susanne Juhl Pedersen, Sara Nysom Christiansen, Ole Rintek Madsen, Mette Klarlund, Marie Wetterslev, Mate Lorincz, Mads Bakkegaard, Anne Duer, Kasper Kjærulf Gosvig

“…ASAS HI had a large responsiveness in MANGO (standardised response mean (SRM)=−1.3, effect size (ES)=−1.7) and moderate responsiveness in DOBIS (SRM=0.7, ES=0.6).Conclusion ASAS HI showed good construct validity, discriminatory ability and responsiveness.Trial registration number ClinicalTrials.gov: NCT02011386.…”
Get full text

Novel Antiplatelet Agent Use for Acute Coronary Syndrome in the Emergency Department: A Review by M. Curial, E. Nath, E. Lang

“…Current evidence supports the use of several agents with the final decision based on treatment protocols conjointly developed between cardiology and emergency medicine (EM). Further clinical trials involving head-to-head trials or comparisons of drug-based strategies are required to show superiority in reducing cardiac endpoints with regard to ED initiation of treatment.…”
Get full text

The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis by Andreas Römpp, Axel Treu, Julia Kokesch-Himmelreich, Franziska Marwitz, Julia Dreisbach, Nadine Aboutara, Doris Hillemann, Moritz Garrelts, Paul J. Converse, Sandeep Tyagi, Sina Gerbach, Luzia Gyr, Ann-Kathrin Lemm, Johanna Volz, Alexandra Hölscher, Leon Gröschel, Eva-Maria Stemp, Norbert Heinrich, Florian Kloss, Eric L. Nuermberger, Dominik Schwudke, Michael Hoelscher, Christoph Hölscher, Kerstin Walter

“…BTZ-043 is a novel antibiotic showing good bactericidal activity in humans in a phase IIa trial. …”
Get full text

Endoscopic Vein Harvesting for Coronary Bypass Grafting: A Blessing or a Trojan Horse? by Ryan Accord, Jos Maessen

“…Most recent publications could not confirm these findings, however larger randomised controlled trials focusing on graft quality are being awaited.…”
Get full text

Closing the loop in minimally supervised human–robot interaction: formative and summative feedback by Mayumi Mohan, Cara M. Nunez, Katherine J. Kuchenbecker

“…Twenty-eight adults completed seventy-five 30-s-long trials with no explicit instructions or experimenter help. …”
Get full text

The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Natural phytochemicals, especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose. …”
Get full text