Health-Related Quality of Life in Patients with Friedreich Ataxia Using Mobility Assistive Technologies: Limited Fit of the EQ-5D-3L Mobility Dimension by Maresa Buchholz, Michelle Pfaff, Audrey Iskandar, Kathrin Reetz, Jörg B. Schulz, Marcus Grobe-Einsler, Thomas Klockgether, Bernhard Michalowsky, EFACTS Study Group

“…Trial Registration ClinicalTrials.gov identifier NCT02069509.…”
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Machine Learning Approaches in High Myopia: Systematic Review and Meta-Analysis by Huiyi Zuo, Baoyu Huang, Jian He, Liying Fang, Minli Huang

“…Specifically, deep learning (DL) showed an SROC of 0.97 (95% CI 0.95-0.98), sensitivity of 0.92 (95% CI 0.90-0.93), and specificity of 0.96 (95% CI 0.95-0.97), while conventional ML (non-DL) showed an SROC of 0.86 (95% CI 0.75-0.92), sensitivity of 0.77 (95% CI 0.69-0.84), and specificity of 0.85 (95% CI 0.75-0.92). …”
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Foliar application of 24-epibrassinolide enhances leaf nicotine content under low temperature conditions during the mature stage of flue-cured tobacco by regulating cold stress tol... by Haiyang Chen, Shuaitao Zhang, Jianbo Chang, Hongru Wei, Hongchen Li, Chaoyang Li, Junjie Yang, Zhengxiong Song, Zhaojun Wang, Jin Lun, Xuelin Zhang, Lihua Li, Xiaoquan Zhang

“…And further research is needed to elucidate the molecular mechanisms of EBR on enhancing leaf nicotine content. Clinical trial number Not applicable.…”
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Cecum microbiota composition, fermentation characteristics, and immunometabolic biomarkers of Yunshang black goat fed varying dietary energy and protein levels by Binlong Fu, Xiaoqi Zhao, Muhammad Khan, Yanting Jiang, Weijuan Li, Maida Mushtaq, Baiji Danzeng, Xiaojun Ni, Zobia Azeem, Qingyong Shao, Bai Xue, Yina Ouyang

“…Although species richness (Chao1 index) remained consistent, the HEHP group showed higher diversity (Shannon and Simpson indices) than LEHP (p < 0.05). …”
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Application of fourier transform infrared vibrational spectroscopy in identifying early biochemical changes in lipid profiles of individuals undergoing Roux-en-y gastric bypass by Amanda Motta de Bortoli, Márcia Helena Cassago Nascimento, Blanca Elena Guerrero Daboin, Beatriz Bobbio de Brito, Luiza Recla Pessotti, Paulo Roberto Filgueiras, Andressa Bolsoni Lopes, Valerio Garrone Barauna, Fabiano Kenji Haraguchi

“…Notably, serum triglycerides showed a significant correlation with the lipid-specific spectral region (1796–1685 cm− 1) at both time points (p < 0.05). …”
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Complications Associated with Uterine Artery Embolisation for Fibroids by Maria Memtsa, Hayden Homer

“…Long-term outcome data from randomised trials involving UAE have very recently become available and show that whilst high satisfaction rates previously identified during early-stage followup are sustained, one notable drawback is a substantial risk of reintervention. …”
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Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? by Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon

“…For this reason, more studies and trials are needed to clarify the real effectiveness of MSC-based therapy in ALS.…”
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Efficacy of Adjunctive Treatments Added to Olanzapine or Clozapine for Weight Control in Patients with Schizophrenia: A Systematic Review and Meta-Analysis by Yun-Jung Choi

“…Methods. Candidate clinical trials were identified through searching the Cochrane Central Register of Controlled Trials, PubMed, and PsycINFO. …”
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Short-term effects of olive-mill-wastes-derived biochars amendment and arbuscular mycorrhizal fungi inoculation on growth of maize (Zea mays) and mycorrhizal colonization by Minkosse, Christiane, Langenfeld, Aude, Azzaz, Ahmed Amine, Jeguirim, Mejdi, El-Bassi, Leila, Akrout, Hanene, Jellali, Salah, Ghimbeu, Camélia Matei, Nassr, Najat

“…The results of the formulation trial showed that arbuscular mycorrhizal fungi (AMF) spores had short-term viability and are sensitive to the presence of biochar. …”
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Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases by Shih-Wen Huang, Yein-Gei Lai, Hao-Ting Liao, Chin-Ling Chang, Ruo-Yu Ma, Yung-Hsiang Chen, Yae-Huei Liou, Zhen-Qi Wu, Yu-Chen Wu, Ko-Jiunn Liu, Yen-Tsung Huang, Jen-Lung Yang, Ming-Shen Dai, Nan-Shih Liao

“…We conducted an investigator-initiated clinical trial of autologous NK cell therapy in six patients with advanced cancer and observed that the NK cell therapy was safe and showed signs of effectiveness. …”
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Leukodepleted Packed Red Blood Cells Transfusion in Patients Undergoing Major Cardiovascular Surgical Procedure: Systematic Review and Meta-Analysis by Daniel Simancas-Racines, Ingrid Arevalo-Rodriguez, Gerard Urrutia, Diana Buitrago-Garcia, Solange Núñez-González, María José Martínez-Zapata, Eva Madrid, Xavier Bonfill, Ricardo Hidalgo-Ottolenghi

“…Data were extracted, and risk of bias was assessed according to Cochrane guidelines. In addition, trial sequential analysis (TSA) was used to assess the need of conducting additional trials. …”
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Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study by Ilya Tsimafeyeu, Vyacheslav Chubenko, Olga Baklanova, Alexey Kalpinskiy, Sufia Safina, Andrei Lebedinets, Vladislav Petkau, Elvira Parsadanova, Maria Turganova, Aleksei Shkurat, Natalia Tovbik, Elena Tkacheva, Yulia Anzhiganova, Olga Novikova, Varvara Bragina, Ruslan Zukov, Rashida Orlova

“…Conclusions: Avelumab in combination with axitinib showed clinical benefits in a real-world setting, consistent with findings from a pivotal trial. …”
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Mechanism Design and Analysis of Rehabilitation Training Robot based on Gait Regularity by Liang Qisong, Jiang Lijie, Wang Yong

“…Through the comprehensive analysis,a rehabilitation training robot based on two DOF five-bar metamorphic mechanism is designed,and then a prototype production and clinical trials are carried out. The experimental results show that the proposed design of sitting rehabilitation robot is qualified to meet the demands of personalized training of hemiplegic patients.…”
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Du paysage de l’écologie à celui du développement by Philippe Fleury, Julie Delclaux, Emmanuel Guisepelli, Claire Heinisch

“…This article is about the design and the implementation of the Green and Blue Network strategy in farming areas in the Rhônes-Alpes region. We show how this strategy has been subjected to different trials before being successfully deployed for mobilising farmers. …”
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Incidence and risk of endocrine and metabolic abnormalities linked to PARP inhibitors in solid tumors: a meta-analysis by Shunlian Fu, Pingjin Zou, Zengyi Fang, Xinxiang Zhou, Junyang Chen, Cuicui Gong, Li Quan, Bing Lin, Qiu Chen, Jinyi Lang, Meihua Chen

“…Purpose Our aim was to evaluate the potential impact of PARPi on endocrine and metabolic disruptions in clinical trials. Data sources We conducted a comprehensive search across the Medline, EMBASE, PubMed, and Web of Science databases, along with the ClinicalTrials.gov registry. …”
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Knowledge, attitudes and practices regarding pulmonary rehabilitation among patients with chronic respiratory diseases: a cross-sectional questionnaire-based study in a tertiary ho... by Xueli Bai, Yuan Chen, Xiansheng Liu, Lingling Wang, Xiaohong Zhang, Jie Ding, Lin Su, Ruiying Wang, Shuang Wei

“…Tailored educational interventions focusing on bridging the knowledge gap and promoting positive behavioural changes are essential for improving pulmonary rehabilitation engagement among chronic respiratory disease patients.Trial registration number ChiCTR2400080271.…”
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Assessment of the efficacy of palliative sedation in advanced cancer patients by evaluating discomfort levels: a prospective, international, multicenter observational study by Maaike Rijpstra, Kris Vissers, Alazne Belar, Michael Van der Elst, Séverine Marie Surges, Claudio Adile, Rocío Rojí, Yasmine Grassi, Ewald Bronkhorst, Sebastiano Mercadante, Lukas Radbruch, Johan Menten, Carlos Centeno, Evelien Kuip, Jeroen Hasselaar

“…The measurement of discomfort levels might provide a more specific and detailed evaluation of adequate sedation. Trial registration This study is registered at ClinicalTrials.gov since January 22, 2021, registration number: NCT04719702.…”
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A novel gene signature for predicting outcome in colorectal cancer patients based on tumor cell-endothelial cell interaction via single-cell sequencing and machine learning by Lina Pang, Qingxia Sun, Wenyue Wang, Mingjie Song, Ying Wu, Xin Shi, Xiaonan Shi

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Correlation between Therapeutic Efficacy of CD34+ Cell Treatment and Directed In Vivo Angiogenesis in Patients with End-Stage Diffuse Coronary Artery Disease by Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Pei-Hsun Sung, Chi-Hsiang Chu, Mel S. Lee, Yuan-Ping Lin, Hon-Kan Yip, Fan-Yen Lee

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Knowledge and beliefs on breast cancer screening and uptake among Yemeni female school teachers in Malaysia by Sarah Noman, Nadya Mohamed Elfeturi Elarusy, Hejar Abdul Rahman, Suriani Ismail, Meram Azzani, Khalda Mohamed Khamis, Musheer A. Aljaberi

“…A cross-sectional study was conducted as part of a large cluster-randomized controlled trial (CRT) among 180 Yemeni female teachers aged 20 years and above. …”
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