A High-Precision Micro-Roll Forming Facility for Fuel Cell Metal Bipolar Plate Production by Matthias Weiss, Peng Zhang, Michael Pereira

“…Proof of concept is provided through micro-roll forming trials performed on ultra-thin titanium sheets that show that the proposed technology can achieve tight dimensional tolerances in the sub-millimeter scale that suits bipolar plate applications.…”
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The Role of Clopidogrel in 2020: A Reappraisal by Giuseppe Patti, Giuseppe Micieli, Claudio Cimminiello, Leonardo Bolognese

“…Although newer, more potent P2Y12 inhibitors (prasugrel and ticagrelor) show a greater reduction in ischemic risk compared with clopidogrel in randomized trials of ACS patients, these newer P2Y12 inhibitors are often associated with an increased risk of bleeding. …”
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Multimodal machine learning enables AI chatbot to diagnose ophthalmic diseases and provide high-quality medical responses by Ruiqi Ma, Qian Cheng, Jing Yao, Zhiyu Peng, Mingxu Yan, Jie Lu, Jingjing Liao, Lejin Tian, Wenjun Shu, Yunqiu Zhang, Jinghan Wang, Pengfei Jiang, Weiyi Xia, Xiaofeng Li, Lu Gan, Yue Zhao, Jiang Zhu, Bing Qin, Qin Jiang, Xiawei Wang, Xintong Lin, Haifeng Chen, Weifang Zhu, Dehui Xiang, Baoqing Nie, Jingtao Wang, Jie Guo, Kang Xue, Hongguang Cui, Jinwei Cheng, Xiangjia Zhu, Jiaxu Hong, Fei Shi, Rui Zhang, Xinjian Chen, Chen Zhao

“…This proof-of-concept study highlights the potential of chatbot-based multimodal AI for self-diagnosis and self-triage. (The clinical trial was registered on June 26, 2023, on ClinicalTrials.gov under the registration number NCT05930444.).…”
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The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…For example, in acute respiratory distress syndrome (ARDS) and pneumonia patients, MSCs-Exo and MSCs provide similar healing properties and some clinical trials have used cell-based inhalation therapy which show great promise. …”
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Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat... by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

“…Background Oncolytic virus V937 showed activity and safety with intratumoral administration. …”
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Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…BackgroundPralsetinib is a selective RET inhibitor. The ARROW trial revealed that RET fusion-positive non-small-cell lung cancer (NSCLC) can benefit from pralsetinib with tolerable adverse events (AEs). …”
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N-acetylcysteine increased the growth performance of Leuciscus waleckii by improving mitochondrial function, enhancing antioxidant and anti-inflammatory, and inhibiting apoptosis i... by Deng Lai Li, Rui Zhu, Si Tong Meng, Yin Tao Wang, Si Ying Liu, Zhi Yong Yang, Li Fang Wu

“…NAC supplementation upregulates the mRNA expression of Claudin-3, Claudin-f, ZO-1, and Occludin-a and reduces intestinal permeability-related markers, thereby maintaining intestinal physical barrier function. HE staining results showed that NAC maintained the morphological and structural integrity of the hepatopancreas and intestine. …”
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Regulatory role of lnc-MAP3K13-3:1 on miR-6894-3p and SHROOM2 in modulating cellular dynamics in hepatocellular carcinoma by Kuai Chen, Manqin Zhu, Qinghua Hu, Hui Huang, Ka Chen, Xia Shuai, Jinshi Huang, Qiang Tao, Zhibin Guo

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Evaluation of circulating tumor DNA as a prognostic and predictive biomarker in BRAF V600E mutated colorectal cancer—results from the FIRE‐4.5 study by Susanne Klein‐Scory, Alexander Baraniskin, Wolff Schmiegel, Thomas Mika, Roland Schroers, Swantje Held, Kathrin Heinrich, David Tougeron, Dominik P. Modest, Ingo Schwaner, Jan Eucker, Rudolf Pihusch, Martina Stauch, Florian Kaiser, Christoph Kahl, Meinolf Karthaus, Christian Müller, Christof Burkart, Sebastian Stintzing, Volker Heinemann

“…The randomized FIRE‐4.5 (AIO KRK0116) trial compared first‐line therapy with FOLFOXIRI (folinic acid, fluorouracil, oxaliplatin, and irinotecan) plus either cetuximab or bevacizumab in B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) V600E‐mutant metastatic colorectal cancer (mCRC) patients. …”
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Application of probiotic microcapsules Bacillus cereus BR2 with different doses for the prevention of Aeromonas hydrophila NFC1 infection in catfish Clarias sp. by Nurul Faoziyatunnisa, Munti Yuhana, Dinamella Wahjuningrum, Sri Nuryati, Usamah Afiff

“…A feed supplementation trial was performed for 40 days with feeding times three times a day; and a 5% feeding rate reevaluated based on biomass. …”
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High SUVs Have More Robust Repeatability in Patients with Metastatic Prostate Cancer: Results from a Prospective Test-Retest Cohort Imaged with 18F-DCFPyL by Rudolf A. Werner, Bilêl Habacha, Susanne Lütje, Lena Bundschuh, Takahiro Higuchi, Philipp Hartrampf, Sebastian E. Serfling, Thorsten Derlin, Constantin Lapa, Andreas K. Buck, Markus Essler, Kenneth J. Pienta, Mario A. Eisenberger, Mark C. Markowski, Laura Shinehouse, Rehab AbdAllah, Ali Salavati, Martin A. Lodge, Martin G. Pomper, Michael A. Gorin, Ralph A. Bundschuh, Steven P. Rowe

“…In this prospective, IRB-approved trial (NCT03793543), 21 patients with history of histologically proven PC underwent two 18F-DCFPyL PET/CTs within 7 days (mean 3.7, range 1 to 7 days). …”
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A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke by Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H. Zhang

“…These stem cell therapies provide a promising effect on stimulation of endogenous neurogenesis, neuroprotection, anti-inflammatory effects, and improved cell survival rates. Clinical trials performed using various stem cell types show promising results to their safety and effectiveness on reducing the effects of ischemic stroke in humans. …”
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Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure by Mathew J. Gregoski, Vernon A. Barnes, Martha S. Tingen, Yanbin Dong, Haidong Zhu, Frank A. Treiber

“…Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. …”
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Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage by Peter Succar, Michael Medynskyj, Edmond J. Breen, Tony Batterham, Mark P. Molloy, Benjamin R. Herbert

“…Reports of OA-patients show reductions in cartilage defects and regeneration of hyaline-like-cartilage with MSC-therapy. …”
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Comparative Effectiveness of Anti-Inflammatory Drug Treatments in Coronary Heart Disease Patients: A Systematic Review and Network Meta-Analysis by Ivan Wudexi, Elica Shokri, Mohamed Abo-Aly, Kazuhiro Shindo, Ahmed Abdel-Latif

“…We conducted a network meta-analysis of randomized controlled trials that studied the effects of anti-inflammatory medications on cardiovascular outcomes of coronary artery disease patients. …”
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Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…Mesenchymal stem cells (MSC) are adult multi-potent cells that can be isolated from many types of tissues including adipose tissue, bone marrow, and umbilical cord. They show great potential for cell therapy-based treatments, which is why they are being used in numerous clinical trials for a wide range of diseases. …”
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A comprehensive review and meta-analysis of the relationships between interleukin-7 levels and COVID-19 severity by Michal MATUSZEWSKI, Michal PRUC, Lukasz SZARPAK, Alla NAVOLOKINA, Katarzyna KIEZUN, Francesco CHIRICO, Gabriella NUCERA, Yuriy STEPANOVSKYY, Murat YILDIRIM, Anna HILFANOVA, Anastasia BONDARENKO

“…Despite the first hyper-inflammatory phase, emerging data show that virus-induced poor host immunity may be the true cause of mortality in many individuals. …”
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INTRAVENOUS VITAMIN C (IVC) TREATMENT OUTCOME OF COVID 19 PATIENTS ADMITTED IN HOSPITAL: A SYSTEMATIC REVIEW by Auria Ekanti Pratiwi, Oki Suwarsa, Achadiyani, Nur Atik

“…Hence, further research and evaluation in clinical trials are needed.…”
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Application of sewage sludge for cereal production in a Mediterranean environment (Lebanon) by Danny Romanos, Nabil Nemer, Yara Khairallah, Marie Therese Abi Saab

“…Heavy metals outcome increased significantly after amendment, microbiological analysis didn’t show any contamination by Salmonella, E.Coli, Staphylococcus Aureus and Helminth eggs. …”
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Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…However, de novo synthesis of antibiotics is expensive and time-consuming since the development of a new drug has to go through several clinical trials. Repurposing of old drugs for the treatment of antimicrobial resistant pathogens has been explored as an alternative strategy in the field of antimicrobial drug discovery. …”
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