Patient Voices: Multimethod Study on the Feasibility of Implementing Electronic Patient-Reported Outcome Measures in a Comprehensive Cancer Center by Cinzia Brunelli, Sara Alfieri, Emanuela Zito, Marco Spelta, Laura Arba, Linda Lombi, Luana Caselli, Augusto Caraceni, Claudia Borreani, Anna Roli, Rosalba Miceli, Gabriele Tine', Ernesto Zecca, Marco Platania, Giuseppe Procopio, Nicola Nicolai, Luigi Battaglia, Laura Lozza, Morena Shkodra, Giacomo Massa, Daniele Loiacono, Giovanni Apolone

“…In addition, these findings may be relevant to other organizations willing to systematically collect PROMs or ePROMs in their clinical routines. Trial RegistrationClinicalTrials.gov NCT03968718; https://clinicaltrials.gov/study/NCT03968718…”
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Development and Validation of a Nomogram for Predicting Long-Term Net Adverse Clinical Events in High Bleeding Risk Patients Undergoing Percutaneous Coronary Intervention by Junyan Zhang, Zhongxiu Chen, Ran Liu, Yuxiao Li, Hongsen Zhao, Yanning Li, Minggang Zhou, Hua Wang, Chen Li, Li Rao, Yong He

“…Conclusions: This study presents a nomogram to predict 1-year NACE outcomes in PCI-HBR patients. Internal validation showed strong predictive capability and clinical utility. …”
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Fermented Cassava Residue Meal Improves Meat Quality by Regulating Muscle Fiber and Enhancing Lipid Metabolism in Huanjiang Mini-Pigs by Huijiao Jiang, Md. Abul Kalam Azad, Qian Zhu, Hengjia Ni, Xiangfeng Kong

“…The meat quality analysis showed that dietary CRM and FCRM improved the meat quality by increasing the intramuscular fat content and redness (a*) value and decreasing the lightness (L*) value. …”
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A mixed-methods observational study of strategies for success in implementation science: overcoming emergency departments hurdles by Deonni P. Stolldorf, Alan B. Storrow, Dandan Liu, Cathy A. Jenkins, Rachel A. Hilton, Karen F. Miller, Joy Kim, Deepika Boopathy, Satheesh Gunaga, Bory Kea, Joseph Miller, Sean P. Collins

“…Comparison of scores by profession showed a significant difference in the context score among providers (3.9 [3.5, 4.0]), leaders (3.7 [3.5, 4.0]), and nurses (3.6 [3.0, 3.9]) (p = 0.048). …”
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PhantomAR: gamified mixed reality system for alleviating phantom limb pain in upper limb amputees—design, implementation, and clinical usability evaluation by Cosima Prahm, Korbinian Eckstein, Michael Bressler, Zhixing Wang, Xiaotong Li, Takashige Suzuki, Adrien Daigeler, Jonas Kolbenschlag, Hideaki Kuzuoka

“…Feedback on the Game Experience Questionnaire was overwhelmingly positive, showing high immersion (m = 4.46, SD = 0.08) and positive affect (m = 4.97, SD = 0.05). …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Furthermore, two Phase II clinical trials in dialysis and non-dialysis chronic kidney disease (CKD) patients with anemia, respectively CTR20140533 and CTR20140539, assessed PK-PD and safety following repeated administration. …”
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HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma by Michal Frelich, Marek Bebej, Jan Pavlíček, Filip Burša, Vojtěch Vodička, Zdeněk Švagera, Adéla Kondé, Ondřej Jor, Markéta Bílená, Tereza Romanová, Peter Sklienka

“…Admission HMGB-1 levels reliably predict severe bleeding requiring MTP activation in the emergency department and correlate with the amount of blood products and fibrinogen administered during the first 6 h of hemorrhagic shock resuscitation. Trial registration: NCT03986736. Registration date: June 4, 2019.…”
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Establishment and Maintenance of a Digital Therapeutic Alliance in People Living With Negative Symptoms of Schizophrenia: Two Exploratory Single-Arm Studies by Cassandra Snipes, Cornelia Dorner‑Ciossek, Brendan D Hare, Olya Besedina, Tim Campellone, Mariya Petrova, Shaheen E Lakhan, Abhishek Pratap

“…The second 7-week study showed maintenance of the DWA to the end of the study. …”
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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

“…Of 39 osmolarity equations, 5 showed reasonable agreement with directly measured osmolality and 3 had good predictive accuracy in subgroups with diabetes and poor renal function. …”
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Predictive factors of fibrotic interstitial lung abnormality on high-resolution computed tomography scans: a prospective observational study by Kazuya Ichikado, Hidenori Ichiyasu, Kazuhiro Iyonaga, Kodai Kawamura, Yuko Yasuda, Keisuke Anan, Hiroko Okabayashi, Kimitaka Akaike, Noritaka Higashi, Takeshi Johkoh, Kiminori Fujimoto, Tetsuo Saito, Jun Morinaga, Minoru Yoshida, Katsuhiko Mitsuzaki, Takuro Sakagami

“…These findings may assist non-radiological physicians in referring patients to specialists for early intervention in progressive fibrotic interstitial lung diseases. Trial registration number/date UMIN000045149/2021.12.1.…”
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The Current Role of Androgen Deprivation in Patients Undergoing Dose-Escalated External Beam Radiation Therapy for Clinically Localized Prostate Cancer by Michael J. Smith, Naveed H. Akhtar, Scott T. Tagawa

“…Other studies failed to show significant benefits with the addition of ADT to dose-escalated RT. …”
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PRODUCTIVITY, ADAPTABILITY AND GRAIN QUALITY OF MODERN UKRAINIAN WINTER TRITICALE CULTIVARS by G. V. Shchipak, Yu. V. Tsupko, A. P. Petrova, V. G. Shchipak

“…Grain-type winter triticale cultivars were studied in comparative long-term (2000–2009) trials in two agroeco logical zones of Ukraine. Since 1977, 16 triticale cultivars have been enrolled into the register in Ukraine, and their potential productivity has increased by 1.52 t/ha. …”
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Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges by Lipska Katarzyna, Gumieniczek Anna, Filip Agata A.

“…The present manuscript summarizes the most important information from the literature about their potent anticancer activities to show some future perspectives related to epigenetic therapy.…”
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The evaluation of different levels diets protein for growth performance of Clarias sp. fry cultured in biofloc-based system by Noviati Rohmatul Khasanah, Nur Bambang Priyo Utomo, Mia Setiawati, Munti Yuhana

“…Feeding was conducted twice a day at 5% of the biomass weight. At the end of trial treatment (D) showed the highest survival rate (88.15±5.25%), the body lenght variance coefficient (9.58±0.51%) and protein retention (39.87±2.77%). …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Human bone marrow-derived mesenchymal stem cells (hBMSCs) are promising candidates for stem cell therapy in clinical trials. Applications of hBMSCs in clinical therapy are limited by cellular senescence due to long-term ex vivo expansion. …”
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GLP-1 Receptor Agonists and Cardiovascular Disease in Patients with Type 2 Diabetes by María Isabel del Olmo-Garcia, Juan Francisco Merino-Torres

“…On the other hand, recent clinical trials aimed at studying cardiovascular episodes have been conducted with GLP-1 RAs. …”
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Arm Propulsion in Front Crawl Stroke by Cristian Romagnoli, Vincenzo Bonaiuto, Giorgio Gatta

“…The athletes conducted the crawl trials at a constant velocity using only the upper limbs. …”
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The Role of Immunotherapy in Extensive Stage Small-Cell Lung Cancer: A Review of the Literature by Ioanna Tsiouprou, Athanasios Zaharias, Dionisios Spyratos

“…During the past few years, several clinical trials have evaluated the effect of addition of immunotherapy to conventional chemotherapy in patients with extensive SCLC. …”
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ERP and Behavioral Effects of Physical and Cognitive Training on Working Memory in Aging: A Randomized Controlled Study by Patrick D. Gajewski, Michael Falkenstein

“…Before and after the training, n-back task during an EEG recording was applied. The results show that cognitive training enhanced the target detection rate in the 2-back task. …”
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A novel paradigm for fast training data generation in asynchronous movement-based BCIs by Markus R. Crell, Kyriaki Kostoglou, Kathrin Sterk, Gernot R. Müller-Putz, Gernot R. Müller-Putz

“…Such paradigms tend to introduce long delays between trials, thereby extending training times. To address this, we propose a novel experimental paradigm that enables the collection of 300 cued movement trials in 18 min.MethodsBy obtaining measurements from ten participants, we demonstrate that the data produced by this paradigm exhibits characteristics similar to those observed during self-paced movement.Results and discussionWe also show that classifiers trained on this data can be used to accurately detect executed movements with an average true positive rate of 31.8% at a maximum rate of 1.0 false positives per minute.…”
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